{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:39:54Z","timestamp":1778924394436,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1991,3]]},"DOI":"10.1007\/bf00315208","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T14:39:09Z","timestamp":1097591949000},"page":"273-278","source":"Crossref","is-referenced-by-count":71,"title":["Effects of caffeine with repeated dosing"],"prefix":"10.1007","volume":"40","author":[{"given":"C. P.","family":"Denaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"P.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. L.","family":"Benowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00315208_CR1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM198610163151601","volume":"315","author":"AZ LaCroix","year":"1986","unstructured":"LaCroix AZ, Mead LA, Liang KY, Thomas CB, Pearson TA (1986) Coffee consumption and the incidence of coronary heart disease. N Engl J Med 315: 977\u2013982","journal-title":"N Engl J Med"},{"key":"BF00315208_CR2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/oxfordjournals.aje.a114717","volume":"126","author":"D LeGrady","year":"1987","unstructured":"LeGrady D, Dyer AR, Shekelle RB, Stamler J, Liu K, Paul O, Lepper M, Shyrock AM (1987) Coffee consumption and mortality in the Chicago Western Electric Company study. Am J Epidemiol 126: 803\u2013812","journal-title":"Am J Epidemiol"},{"key":"BF00315208_CR3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/oxfordjournals.aje.a114648","volume":"126","author":"L Rosenberg","year":"1987","unstructured":"Rosenberg L, Werler MM, Kaufman DW, Shapiro S (1987) Coffee drinking and myocardial infarction in young women: an update. Am J Epidemiol 126: 147\u2013149","journal-title":"Am J Epidemiol"},{"key":"BF00315208_CR4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/oxfordjournals.aje.a115004","volume":"128","author":"L Rosenberg","year":"1988","unstructured":"Rosenberg L, Palmer JR, Kelly JP, Kaufman DW, Shapiro S (1988) Coffee drinking and nonfatal myocardial infarction in men under 55 years of age. Am J Epidemiol 128: 570\u2013578","journal-title":"Am J Epidemiol"},{"key":"BF00315208_CR5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM198306163082405","volume":"308","author":"DS Thelle","year":"1983","unstructured":"Thelle DS, Arnesen E, Forde OH (1983) The Tromso heart study: does coffee raise serum cholesterol? N Engl J Med 308: 1454\u20131457","journal-title":"N Engl J Med"},{"key":"BF00315208_CR6","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJM198911233212103","volume":"321","author":"AAA Bak","year":"1989","unstructured":"Bak AAA, Grobbee DE (1989) The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 321: 1432\u20131437","journal-title":"N Engl J Med"},{"key":"BF00315208_CR7","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jama.1985.03350340059017","volume":"253","author":"PT Williams","year":"1985","unstructured":"Williams PT, Wood PD, Vranizan KM, Albers JJ, Garay SC, Taylor CB (1985) Coffee intake and elevated cholesterol and apolipoprotein B levels in men. JAMA 253: 1407\u20131411","journal-title":"JAMA"},{"key":"BF00315208_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/oxfordjournals.aje.a114935","volume":"128","author":"BR Davis","year":"1988","unstructured":"Davis BR, Curb JD, Borhani NO, Prineas RJ, Molteni A (1988) Coffee consumption and serum cholesterol in the Hypertension Detection and Follow up Program. Am J Epidemiol 128: 124\u2013136","journal-title":"Am J Epidemiol"},{"key":"BF00315208_CR9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1056\/NEJM197801262980403","volume":"298","author":"D Robertson","year":"1978","unstructured":"Robertson D, Frolich JC, Carr RK, Watson JT, Hollifield W, Shand DG, Oates JA (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298: 181\u2013186","journal-title":"N Engl J Med"},{"key":"BF00315208_CR10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/cs0600527","volume":"60","author":"RT Jung","year":"1981","unstructured":"Jung RT, Shetty PS, James WPT, Barrand MA, Callingham BA (1981) Caffeine: Its effect on catecholamines and metabolism in lean and obese humans. Clin Sci 60: 527\u2013535","journal-title":"Clin Sci"},{"key":"BF00315208_CR11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/0026-0495(68)90054-1","volume":"17","author":"S Bellet","year":"1968","unstructured":"Bellet S, Kershbaum A, Finck EM (1968) Response of free fatty acids to coffee and caffeine. Metabolism 17: 702\u2013707","journal-title":"Metabolism"},{"key":"BF00315208_CR12","first-page":"114","volume":"9","author":"P Avogaro","year":"1973","unstructured":"Avogaro P, Capri C, Pais M, Cazzolato G (1973) Plasma and urine cortisol behaviour and fat mobilization in man after coffee ingestion. Isr J Med Sci 9: 114\u2013119","journal-title":"Isr J Med Sci"},{"key":"BF00315208_CR13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1056\/NEJM198304073081405","volume":"308","author":"DJ Dobmeyer","year":"1983","unstructured":"Dobmeyer DJ, Stine RA, Leier CV, Greenberg R, Schaal SF (1983) The arrhythmogenic effects of caffeine in human beings. N Engl J Med 308: 814\u2013816","journal-title":"N Engl J Med"},{"key":"BF00315208_CR14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1378\/chest.87.3.319","volume":"87","author":"DJ Sutherland","year":"1985","unstructured":"Sutherland DJ, McPherson DD, Renton KW, Spencer CA, Montague TJ (1985) The effect of caffeine on cardiac rate, rhythm and ventricular repolarization. Chest 87: 319\u2013324","journal-title":"Chest"},{"key":"BF00315208_CR15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.0954-6820.1985.tb01650.x","volume":"217","author":"BB Fredholm","year":"1985","unstructured":"Fredholm BB (1985) On the mechanism of action of theophylline and caffeine. Acta Med Scand 217: 149\u2013153","journal-title":"Acta Med Scand"},{"key":"BF00315208_CR16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI110124","volume":"67","author":"D Robertson","year":"1981","unstructured":"Robertson D, Wade D, Workman R, Woosley RL, Oates JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67: 1111\u20131117","journal-title":"J Clin Invest"},{"key":"BF00315208_CR17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0002-9343(84)90435-2","volume":"77","author":"D Robertson","year":"1984","unstructured":"Robertson D, Hollister AS, Kincaid D, Workman M, Goldberg R, Tung C, Smith B (1984) Caffeine and hypertension. Am J Med 77: 54\u201360","journal-title":"Am J Med"},{"key":"BF00315208_CR18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/clpt.1990.150","volume":"48","author":"CP Denaro","year":"1990","unstructured":"Denaro CP, Brown CR, Wilson M, Jacob P, Benowitz NL (1990) Dose-dependency of caffeine metabolism. Clin Pharmacol Ther 48: 277\u2013285","journal-title":"Clin Pharmacol Ther"},{"key":"BF00315208_CR19","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/clpt.1982.46","volume":"31","author":"DD Tang-Liu","year":"1982","unstructured":"Tang-Liu DD, Williams RL, Riegelman S (1982) Nonlinear theophylline elimination. Clin Pharmacol Ther 31: 358\u2013369","journal-title":"Clin Pharmacol Ther"},{"key":"BF00315208_CR20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0024-3205(79)90384-9","volume":"25","author":"P Hjemdahl","year":"1979","unstructured":"Hjemdahl P, Daleskog M, Kahan T (1979) Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with a radioenzymatic method. Life Sci 25: 131\u2013138","journal-title":"Life Sci"},{"key":"BF00315208_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0003-2697(77)90285-8","volume":"77","author":"S Higa","year":"1977","unstructured":"Higa S, Suzuki T, Hayashi A, Tsuge I, Yamamura Y (1977) Isolation of catecholamines in biological fluids by boric acid gel. Anal Biochem 77: 18\u201324","journal-title":"Anal Biochem"},{"key":"BF00315208_CR22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0022-2275(20)43094-9","volume":"10","author":"P Belfrage","year":"1969","unstructured":"Belfrage P, Vaughan M (1969) Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides, J Lipid Res 10: 341\u2013345","journal-title":"J Lipid Res"},{"key":"BF00315208_CR23","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1210\/jcem-70-2-410","volume":"70","author":"MS Wu","year":"1990","unstructured":"Wu MS, Jeng CY, Hollenbeck CB, Chen YDI, Jaspan J, Reaven GM (1990) Does glucagon increase plasma free fatty acid concentration in humans with normal glucose tolerance? J Clin Endocrinol Metab 70: 410\u2013416","journal-title":"J Clin Endocrinol Metab"},{"key":"BF00315208_CR24","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/106002808802201204","volume":"22","author":"RW Pfeifer","year":"1988","unstructured":"Pfeifer RW, Notari RE (1988) Predicting caffeine plasma concentrations resulting from the consumption of food or beverages: a simple method and its origin. Drug Intell Clin Pharm 22: 953\u2013959","journal-title":"Drug Intell Clin Pharm"},{"key":"BF00315208_CR25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM198508293130905","volume":"313","author":"J Onrot","year":"1985","unstructured":"Onrot J, Goldberg MR, Biaggioni I, Hollister AS, Kincaid D, Robertson D (1985) Hemodynamic and humoral effects of caffeine in autonomic failure. N Engl J Med 313: 549\u2013554","journal-title":"N Engl J Med"},{"key":"BF00315208_CR26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0002-9149(85)90412-6","volume":"56","author":"P Smits","year":"1985","unstructured":"Smits P, Thien T, van't Laar A (1985) Circulatory effects of coffee in relation to the pharmacokinetics of caffeine. Am J Cardiol 56: 958\u2013963","journal-title":"Am J Cardiol"},{"key":"BF00315208_CR27","first-page":"805","volume":"28","author":"H Yokogoshi","year":"1983","unstructured":"Yokogoshi H, Mochizuki S, Takahata M, Quazi S, Yoshida A (1983) The hypercholesterolemic effect of caffeine-containing beverages and xanthine derivatives in rats. Nutr Rep Int 28: 805\u2013814","journal-title":"Nutr Rep Int"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00315208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00315208\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00315208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00315208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T12:55:15Z","timestamp":1624712115000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00315208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["BF00315208"],"URL":"https:\/\/doi.org\/10.1007\/bf00315208","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}