{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:47:28Z","timestamp":1760622448441},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1990,12]]},"DOI":"10.1007\/bf00316095","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T20:59:18Z","timestamp":1097614758000},"page":"559-563","source":"Crossref","is-referenced-by-count":4,"title":["Measuring the bronchial effect of bronchodilating drugs in healthy subjects after methacholine provocation"],"prefix":"10.1007","volume":"39","author":[{"given":"O. -P.","family":"Sepp\ufffdl\ufffd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Iisalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0091-6749(76)90207-4","volume":"58","author":"CL Casterline","year":"1976","unstructured":"Casterline CL, Evans R, Ward GW (1976) The effect of atropine and albuterol aerosols on the human bronchial response to histamine. J Allergy Clin Immunol 58: 607?613","journal-title":"J Allergy Clin Immunol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.32.4.429","volume":"32","author":"DW Cockcroft","year":"1977","unstructured":"Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE (1977) Protective effect of drugs to histamine-induced asthma. Thorax 32: 429?437","journal-title":"Thorax"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0007-0971(81)90009-7","volume":"75","author":"J Bandouvakis","year":"1981","unstructured":"Bandouvakis J, Cartier A, Roberts R, Ryan G, Hargreave FE (1981) The effect of ipratropium and fenoterol on methacholine- and histamine-induced bronchoconstriction. Br J Dis Chest 75: 295?305","journal-title":"Br J Dis Chest"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/cs0660665","volume":"66","author":"KF Chung","year":"1984","unstructured":"Chung KF, Snashall PD (1984) Methacholine dose-response curves in normal and asthmatic man: effect of starting conductance and pharmacological antagonism. Clin Sci 66: 665?673","journal-title":"Clin Sci"},{"key":"CR5","first-page":"624","volume":"40","author":"M Adachi","year":"1986","unstructured":"Adachi M, Okada T, Kobayashi H, Maruyama S, Sato H, Nishikata H, Takahashi T (1986) A comparison of the protective effect of procaterol aerosol and procaterol tablet on bronchoconstriction induced by methacholine inhalation. Curr Ther Respir 40: 624?633","journal-title":"Curr Ther Respir"},{"key":"CR6","first-page":"903","volume":"129","author":"RC Ahrens","year":"1984","unstructured":"Ahrens RC, Bonham AC, Maxwell GA, Weinberger MM (1984) A Method for Comparing the Peak Intensity and Duration of Action of Aerosolized Bronchodilators Using Bronchoprovocation with Methacholine. Am Rev Respir Dis 129: 903?906","journal-title":"Am Rev Respir Dis"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00555511","volume":"35","author":"A Riba","year":"1988","unstructured":"Riba A, Dal-Re R, Morell F (1988) Protective effect of Tulobuterol on Methacholine-Induced Bronchospasm in Asthmatic Children. Eur J Clin Pharmacol 35: 77?79","journal-title":"Eur J Clin Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/bmj.287.6389.376","volume":"287","author":"J Rees","year":"1983","unstructured":"Rees J (1983) Clinical trials in asthma. Br Med J 287: 376?377","journal-title":"Br Med J"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1164\/ajrccm\/136.6.1412","volume":"138","author":"G O'Connor","year":"1987","unstructured":"O'Connor G, Sparrow D, Taylor D, Segal M, Weiss S (1987) Analysis of dose-response curves to methacholine. Am Rev Respir Dis 138: 1412?1417","journal-title":"Am Rev Respir Dis"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000194008","volume":"37","author":"JC Vermaak","year":"1979","unstructured":"Vermaak JC, Bunn AE, de Kock MA (1979) A New Lung Function Index. The Area under the Maximum Expiratory Flow-Volume Curve. Respiration 37: 61?65","journal-title":"Respiration"},{"issue":"143","key":"CR11","first-page":"18","volume":"68","author":"ARA Sovij\u00e4rvi","year":"1986","unstructured":"Sovij\u00e4rvi ARA (1986) Flow volume response to inhaled methacholine in asthmatics; comparison of area under the curve with conventional parameters. Eur J Resp Dis 68 [Suppl 143]: 18?21","journal-title":"Eur J Resp Dis"},{"key":"CR12","first-page":"1104","volume":"11","author":"ARA Sovij\u00e4rvi","year":"1983","unstructured":"Sovij\u00e4rvi ARA (1983) Area under the flow-volume curve: a new sensitive index to assess bronchodilation. IRCS Med Sci 11: 1104","journal-title":"IRCS Med Sci"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00540956","volume":"34","author":"AD Struthers","year":"1988","unstructured":"Struthers AD, Addis GJ (1988) Respiratory Function Measurements in Clinical Pharmacological Studies Including an Assessment of the Area Under the MEFV Curve as a New Parameter in Chronic Bronchitic Patients. Eur J Clin Pharmacol 34: 277?281","journal-title":"Eur J Clin Pharmacol"},{"issue":"159","key":"CR14","first-page":"5","volume":"41","author":"AA Viljanen","year":"1981","unstructured":"Viljanen AA, Halttunen PK, Kreus K-E, Viljanen BC (1981) Spirometric studies in non-smoking, healthy adults. Scand J Clin Lab Invest 41 [Suppl 159]: 5?20","journal-title":"Scand J Clin Lab Invest"},{"key":"CR15","first-page":"145","volume":"71","author":"MM Nieminen","year":"1987","unstructured":"Nieminen MM, Holli H, Lahdensuo A, Muittari A, Karvonen J (1987) Aerosol deposition in automatic dosimeter nebulisation. Eur J Resp Dis 71: 145?152","journal-title":"Eur J Resp Dis"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1378\/chest.86.3.342","volume":"86","author":"SP Newman","year":"1984","unstructured":"Newman SP, Clarke SW (1984) The proper use of metered dose inhalers. Chest 86: 342?343","journal-title":"Chest"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0091-6749(75)90107-4","volume":"56","author":"H Chai","year":"1975","unstructured":"Chai H, Farr RS, Froelich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SL, Townley RG (1975) Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 56: 323?327","journal-title":"J Allergy Clin Immunol"},{"key":"CR18","first-page":"861","volume":"116","author":"S Larsson","year":"1977","unstructured":"Larsson S, Svedmyr N (1977) Bronchodilating Effect and Side Effects of Beta2-Adrenoceptor Stimulants by Different Modes of Administration (Tablets, Metered Aerosol, and Combinations Thereof). A Study with Salbutamol in Asthmatics. Am Rev Respir Dis 116: 861?869","journal-title":"Am Rev Respir Dis"},{"key":"CR19","volume-title":"Drug Therapy for Asthma. Research and Clinical Practice","author":"DP Tashkin","year":"1987","unstructured":"Tashkin DP (1987) Measurement and Significance of the Bronchodilator Response. In: Jenne JW, Murphy S (eds) Drug Therapy for Asthma. Research and Clinical Practice. Dekker, New York"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/thx.33.6.705","volume":"33","author":"EF Juniper","year":"1978","unstructured":"Juniper EF, Firth PA, Dunnett C, Cockcroft DW, Hargreave FE (1978) Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax 33: 705?710","journal-title":"Thorax"},{"key":"CR21","first-page":"272","volume":"132","author":"PJ Sterk","year":"1985","unstructured":"Sterk PJ, Daniel EE, Zamel N, Hargreave FE (1985) Limited Bronchoconstriction to Methacholine Using Partial Flow-volume Curves in Nonasthmatic Subjects. Am Rev Respir Dis 132: 272?277","journal-title":"Am Rev Respir Dis"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0007-0971(75)90090-X","volume":"69","author":"MK Benson","year":"1975","unstructured":"Benson MK (1975) Bronchial hyperreactivity. Br J Dis Chest 69: 227?239","journal-title":"Br J Dis Chest"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000194610","volume":"45","author":"GH Koeter","year":"1984","unstructured":"Koeter GH, Meurs H, Jonkman JHG, de Vries K (1984) Protective Effect of Choline Theophyllinate on Histamine, Acetylcholine, and Propranolol-Induced Airflow Obstruction. Respiration 45: 139?146","journal-title":"Respiration"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0007-0971(72)90002-2","volume":"66","author":"PL Kamburoff","year":"1972","unstructured":"Kamburoff PL, Griffin JP, Bianco S (1972) The use of histamine induced bronchoconstriction as a method for investigating bronchodilator drugs. Br J Dis Chest 66: 21?26","journal-title":"Br J Dis Chest"},{"key":"CR25","first-page":"135","volume":"10","author":"WS Adamus","year":"1988","unstructured":"Adamus WS, Jansen U, Schilling C, Lohmann HF (1988) Bronchospasm Induced by Methacholine Inhalation as a Model For Testing of Bronchospasmolytics in Healthy Volunteers. Methods Find Exp Clin Pharmacol 10: 135?139","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI106073","volume":"48","author":"A Bouhuys","year":"1969","unstructured":"Bouhuys A, Hunt VR, Kim BM, Zapletal A (1969) Maximum Expiratory Flow Rates in Induced Bronchoconstriction in Man. J Clin Invest 48: 1159?1168","journal-title":"J Clin Invest"},{"key":"CR27","unstructured":"Higgins BG, Britton JR, Chinn S, Burney P, Tattersfield A (1989) Comparison of two methods of expressing results of bronchial challenge tests with reference to their use in epidemiological surveys. Thorax 44 (4); 345P (Abstract)"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0954-6111(08)80073-X","volume":"84","author":"OP Sepp\u00e4l\u00e4","year":"1990","unstructured":"Sepp\u00e4l\u00e4 OP (1990) Reproducibility of methacholine induced bronchoconstriction in healthy subjects. The use of area under the expiratory flow-volume curve (AEFV) to express results. Resp Med 84: 387?397","journal-title":"Resp Med"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00316095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00316095\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00316095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:09:10Z","timestamp":1554318550000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00316095"}},"subtitle":["Salbutamol as a model drug"],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["BF00316095"],"URL":"https:\/\/doi.org\/10.1007\/bf00316095","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}