{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:50:19Z","timestamp":1789617019181,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1984,3,1]],"date-time":"1984-03-01T00:00:00Z","timestamp":446947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[1984,3]]},"DOI":"10.1007\/bf00316585","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T01:44:47Z","timestamp":1097631887000},"page":"47-54","source":"Crossref","is-referenced-by-count":121,"title":["Studies on the mechanism of acute toxicity of nitriles in mice"],"prefix":"10.1007","volume":"55","author":[{"given":"Hideji","family":"Tanii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-4274(81)90057-6","volume":"7","author":"KE Appel","year":"1981","unstructured":"Appel KE, Peter H, Bolt M, Bolt HM (1981) Interaction of acrylonitrile with hepatic microsomes of rats and men. Toxicol Lett 7: 335?340","journal-title":"Toxicol Lett"},{"key":"CR2","volume-title":"Statistical methods in medical research","author":"P Armitage","year":"1971","unstructured":"Armitage P (1971) Statistical methods in medical research. Blackwell Scientific Publ., Oxford Edinburgh"},{"key":"CR3","first-page":"128","volume":"6","author":"H Brieger","year":"1952","unstructured":"Brieger H, Rieders F, Hodes WA (1952) Acrylonitrile: Spectrophotometric determination, acute toxicity, and mechanism of action. Arch Ind Hyg 6: 128?140","journal-title":"Arch Ind Hyg"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1021\/ac60104a044","volume":"27","author":"RB Bruce","year":"1955","unstructured":"Bruce RB, Howard JW, Hanzal RF (1955) Determination of cyanide, thiocyanate, and alpha-hydroxynitriles in plasma or serum. Anal Chem 27: 1346?1347","journal-title":"Anal Chem"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-291X(72)90714-0","volume":"47","author":"JA Castro","year":"1972","unstructured":"Castro JA, D\u00edaz-G\u00f3mez MI, De Ferreyra EC, De Castro CR, D'Acosta N, De Fenos OM (1972) Carbon tetrachloride effect on rat liver and adrenals related to their mixed function oxygenase content. Biochem Biophys Res Commun 47: 315?321","journal-title":"Biochem Biophys Res Commun"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/ac60004a018","volume":"19","author":"J Epstein","year":"1947","unstructured":"Epstein J (1947) Estimation of microquantities of cyanide. Anal Chem 19: 272?274","journal-title":"Anal Chem"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/0006-2952(72)90166-9","volume":"21","author":"EA Glende","year":"1972","unstructured":"Glende EA (1972) On the mechanism of carbon tetrachloride toxicity-coincidence of loss of drug-metabolizing activity with peroxidation of microsomal lipid. Biochem Pharmacol 21: 2131?2138","journal-title":"Biochem Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/0006-2952(76)90128-3","volume":"25","author":"EA Glende","year":"1976","unstructured":"Glende EA, Hruszkewycz AM, Recknagel RO (1976) Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose-6-phosphatase. Biochem Pharmacol 25: 2163?2170","journal-title":"Biochem Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00353240","volume":"33","author":"I Gut","year":"1975","unstructured":"Gut I, Nerudov\u00e1 J, Kopeck\u00fd J, Hole?ek V (1975) Acrylonitrile biotransformation in rats, mice, and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF-525A, cysteine, dimercaprol, or thiosulphate. Arch Toxicol 33: 151?161","journal-title":"Arch Toxicol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm00307a001","volume":"11","author":"C Hansch","year":"1968","unstructured":"Hansch C, Steward AR, Anderson SM, Beutly D (1968) The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics. J Med Chem 11: 1?11","journal-title":"J Med Chem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1021\/ja01062a035","volume":"86","author":"C Hansch","year":"1969","unstructured":"Hansch C, Fujita T (1969) ?-?-?-Analysis. A method for the correlation of biological activity and chemical structure. J Am Chem Soc 86: 1616?1626","journal-title":"J Am Chem Soc"},{"key":"CR12","first-page":"271","volume-title":"Drug design","author":"C Hansch","year":"1971","unstructured":"Hansch C (1971) Quantitative structure-activity relationships in drug design. In: Ariens EJ (ed) Drug design. Academic Press, New York, pp 271?342"},{"key":"CR13","first-page":"4845","volume-title":"Patty's industrial hygiene and toxicology","author":"OR Hartung","year":"1982","unstructured":"Hartung OR (1982) Cyanides and nitriles. In: Clayton GD, Clayton FE (eds) Patty's industrial hygiene and toxicology. Wiley-Interscience Publication, New York, pp 4845?4900"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2486\/indhealth.3.30","volume":"3","author":"K Hashimoto","year":"1965","unstructured":"Hashimoto K, Kanai R (1965) Studies on the toxicology of acrylonitrile metabolism, mode of action and therapy. Ind Health 3: 30?46","journal-title":"Ind Health"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0773.1975.tb00822.x","volume":"37","author":"R Jeppsson","year":"1975","unstructured":"Jeppsson R (1975) Parabolic relationship between lipophilicity and biological activity of aliphatic hydrocarbons, esters and ketones after intravenous injections of emulsion formulations into mice. Acta Pharmacol Toxicol 37: 56?64","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-3-642-68195-0_25","volume-title":"Industrial and environmental xenobiotics","author":"J Kopecky","year":"1981","unstructured":"Kopecky J, Gut I, Nerudov\u00e1 J, Zachardova D, Hole?ek V (1981) Metabolic study on acrylonitrile. In: Gut I, Cikrt M, Plaa GL (eds) Industrial and environmental xenobiotics. Springer, Berlin Heidelberg New York, pp 221?229"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265?275","journal-title":"J Biol Chem"},{"key":"CR18","unstructured":"NIOSH, National Institute for Occupational Safety and Health Criteria and recommended standard for nitriles, U.S. Dept. Health, Education and Welfare, Center for Disease Control, U.S. Govt. Printing Office, Washington, DC 1978"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0006-2952(82)90439-7","volume":"31","author":"T Noguchi","year":"1982","unstructured":"Noguchi T, Fong KL, Lai EK, Olson L, McCay PB (1982) Selective early loss of polypeptides in liver microsomes of CCl4-treated rats. Relationship to cytochrome P-450 content. Biochem Pharmacol 31: 609?614","journal-title":"Biochem Pharmacol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0048-3575(72)90011-9","volume":"2","author":"H Ohkawa","year":"1972","unstructured":"Ohkawa H, Ohkawa R, Yamamoto I, Casida JE (1972) Enzymatic mechanisms and toxicological significance of hydrogen cyanide liberation from various organothiocyanates and organonitriles in mice and houseflies. Pestic Biochem Physiol 2: 95?112","journal-title":"Pestic Biochem Physiol"},{"key":"CR21","first-page":"54","volume":"131","author":"G Paulet","year":"1961","unstructured":"Paulet G, Desnos J, Batting J (1961) L'acrylonitrile, toxicit\u00e9-m\u00e9chanisme d'action, therapeutique. Arch Int Pharmacodyn 131: 54?83","journal-title":"Arch Int Pharmacodyn"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/0006-2952(68)90091-9","volume":"17","author":"HA Sasame","year":"1968","unstructured":"Sasame HA, Castro JA, Gillette JR (1968) Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration. Biochem Pharmacol 17: 1759?1768","journal-title":"Biochem Pharmacol"},{"key":"CR23","first-page":"495","volume":"10","author":"EH Silver","year":"1982","unstructured":"Silver EH, Kuttab SH, Kasan T, Hassan M (1982) Structural considerations in the metabolism of nitriles to cyanide in vivo. Drug Metab Dispos 10: 495?498","journal-title":"Drug Metab Dispos"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj0460243","volume":"46","author":"JN Smith","year":"1950","unstructured":"Smith JN, Williams RT (1950) Studies in detoxication. The isolation of m- and p-cyanophenols as metabolites of cyanobenzene (benzonitrile) and the problem of the orientation of hydroxyl groups formed in vivo. Biochem J 46: 243?248","journal-title":"Biochem J"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00310484","volume":"48","author":"H Tanii","year":"1981","unstructured":"Tanii H, Hashimoto K (1981) Studies on in vitro metabolism of acrylamide and related compounds. Arch Toxicol 48: 157?166","journal-title":"Arch Toxicol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-4274(82)90116-3","volume":"11","author":"H Tanii","year":"1982","unstructured":"Tanii H, Hashimoto K (1982) Structure-toxicity relationship of acrylates and methacrylates. Toxicol Lett 11: 125?129","journal-title":"Toxicol Lett"},{"key":"CR27","unstructured":"Tullar PE (1947) ?Final report on the pharmacology and toxicology of acrylonitrile and acrylon? Kalusowski Memorial Research Laboratories, George Washington University"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2307\/3001557","volume":"8","author":"CS Weil","year":"1952","unstructured":"Weil CS (1952) Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics 8: 249?263","journal-title":"Biometrics"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0041-008X(81)90314-8","volume":"59","author":"CC Willhite","year":"1981","unstructured":"Willhite CC, Smith RP (1981) The role of cyanide liberation in the acute toxicity of aliphatic nitriles. Toxicol Appl Pharmacol 59: 589?602","journal-title":"Toxicol Appl Pharmacol"},{"key":"CR30","first-page":"225","volume":"19","author":"H Zeller von","year":"1969","unstructured":"Zeller von H, Hofmann HTh (1969) Zur Toxizit\u00e4t der Nitrile. Zentralbl Arbeitsmed Arbeitsschutz Prophyl 19: 225?238","journal-title":"Zentralbl Arbeitsmed Arbeitsschutz Prophyl"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00316585.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00316585\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00316585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T13:57:59Z","timestamp":1624715879000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00316585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["BF00316585"],"URL":"https:\/\/doi.org\/10.1007\/bf00316585","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}