{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:08:29Z","timestamp":1786979309371,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[1995,3]]},"DOI":"10.1007\/bf00318168","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T15:18:26Z","timestamp":1097680706000},"page":"565-573","source":"Crossref","is-referenced-by-count":20,"title":["Calcium concretions in the pineal gland of aged rats: an ultrastructural and microanalytical study of their biogenesis"],"prefix":"10.1007","volume":"279","author":[{"given":"Willy","family":"Humbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"P\ufffdvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"309","volume-title":"Handbuch der mikroskopischen Anatomie des Menschen, Bd VI\/1","author":"W Bargmann","year":"1943","unstructured":"Bargmann W (1943) Die Epiphysis cerebri. In: M\u00f6llendorff W von (ed) Handbuch der mikroskopischen Anatomie des Menschen, Bd VI\/1, Springer, Berlin, pp 309?502"},{"key":"CR2","first-page":"183","volume":"64","author":"G Boivin","year":"1975","unstructured":"Boivin G (1975) Etude chez le rat d'une calcinose cutan\u00e9e induite par calciphylaxie locale. I. Aspects ultrastructuraux. Arch Anat Microsc Morphol Exp 64:183?205","journal-title":"Arch Anat Microsc Morphol Exp"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF02564010","volume":"19","author":"AL Boskey","year":"1976","unstructured":"Boskey AL, Posner AS (1976) Extraction of calcium phospholipid complex from bone. Calcif Tissue Int 19:273?283","journal-title":"Calcif Tissue Int"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ar.1092110414","volume":"211","author":"TH Champney","year":"1985","unstructured":"Champney TH, Joshi BN, Vaughan MK, Reiter RJ (1985) Superior cervical ganglionectomy results in the loss of pineal concretions in the adult male gerbil (Meriones unguiculatus). Anat Rec 211:465?468","journal-title":"Anat Rec"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000122036","volume":"9","author":"GF Daramola","year":"1972","unstructured":"Daramola GF, Oloru AO (1972) Physiological and radiological implications of low incidence of pineal calcification in Nigeria. Neuroendocrinology 9:41?57","journal-title":"Neuroendocrinology"},{"key":"CR6","first-page":"359","volume":"195","author":"BJM Diehl","year":"1978","unstructured":"Diehl BJM (1978) Occurrence and regional distribution of calcareous concretions in the rat pineal gland. Cell Tissue Res 195:359?366","journal-title":"Cell Tissue Res"},{"key":"CR7","first-page":"227","volume-title":"Biological mineralization","author":"ED Eanes","year":"1972","unstructured":"Eanes ED (1972) X-ray diffraction of vertebrate hard tissue. In: Zipkin I (ed) Biological mineralization. Wiley, New York, pp 227?256"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ar.1091930307","volume":"193","author":"DR Eisenmann","year":"1979","unstructured":"Eisenmann DR, Ashrafi S, Neiman A (1979) Calcium transport of the secretory ameloblast. Anat Rec 193:403?422","journal-title":"Anat Rec"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/00220345790580021401","volume":"58","author":"J Ennever","year":"1979","unstructured":"Ennever J, Vogel JJ, Boyan-Salyers B, Riggau LJ (1979) Characterization of calcium matrix calcification nucleator. J Dent Res 58:619?623","journal-title":"J Dent Res"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/BF01922244","volume":"33","author":"F Erdin\u00e7","year":"1977","unstructured":"Erdin\u00e7 F (1977) Concrement formation encountered in the rat pineal gland. Experientia 33, 514","journal-title":"Experientia"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1103\/RevModPhys.31.359","volume":"31","author":"MJ Glimcher","year":"1959","unstructured":"Glimcher MJ (1959) Molecular biology of mineralized tissues with particular reference to bone. Rev Mod Phys 31:359?393","journal-title":"Rev Mod Phys"},{"key":"CR12","first-page":"617","volume-title":"The chemistry and biology of mineralized connective tissues","author":"MJ Glimcher","year":"1981","unstructured":"Glimcher MJ (1981) On the form and function of bone: from molecules to organs. Wolff's law. In: Veis A (ed) The chemistry and biology of mineralized connective tissues. Elsevier, New York, pp 617?673"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/BF00219762","volume":"253","author":"M Goldberg","year":"1988","unstructured":"Goldberg M, Lecolle S, Ruch JV, Staubli A, Septier D (1988) Lipid detection by malachite green-aldehyde in the dental basement membrane in the rat incisor. Cell Tissue Res 253:685?687","journal-title":"Cell Tissue Res"},{"key":"CR14","first-page":"139","volume":"196","author":"GV Heidel","year":"1965","unstructured":"Heidel GV (1965) Die H\u00e4ufigkeit des Vorkommens von Kalkkon-krementen im Corpus pineale des Kindes. Anat Anz 196:139?154","journal-title":"Anat Anz"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-079X.1985.tb00635.x","volume":"2","author":"T Heinzeller","year":"1985","unstructured":"Heinzeller T (1985) Impact of psychological stress on pineal structure of male gerbils (Meriones unguiculatus, Cricetidae). J Pineal Res 2:145?159","journal-title":"J Pineal Res"},{"key":"CR16","first-page":"373","volume":"20","author":"JL Houben","year":"1971","unstructured":"Houben JL (1971) Free radicals produced by ionizing radiation in bone and its constituents. Int J Radiat Biol 20:373?389","journal-title":"Int J Radiat Biol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00229605","volume":"187","author":"W Humbert","year":"1978","unstructured":"Humbert W (1978) Cytochemistry and X-ray microprobe analysis of the midgut of Tomocerus minor Lubbock (Insecta, Collembola) with special reference to the physiological significance of the mineral concretions. Cell Tissue Res 187:397?416","journal-title":"Cell Tissue Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF00327294","volume":"263","author":"W Humbert","year":"1991","unstructured":"Humbert W, P\u00e9vet P (1991) Calcium content and concretions of pineal glands of young and old rats. A scanning and X-ray microanalytical study. Cell Tissue Res 263:593?596","journal-title":"Cell Tissue Res"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-079X.1992.tb00031.x","volume":"12","author":"W Humbert","year":"1992","unstructured":"Humbert W, P\u00e9vet P (1992) Permeability of the pineal gland of the rat to lanthanum: significance of dark pinealocytes. J Pineal Res 12:84?88","journal-title":"J Pineal Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/BF00218793","volume":"255","author":"W Humbert","year":"1989","unstructured":"Humbert W, Voegel JC, Kirsch R, Simonneaux V (1989) Role of intestinal mucus in crystal biogenesis: an electron-microscopical diffraction and X-ray microanalytical study. Cell Tissue Res 255:575?583","journal-title":"Cell Tissue Res"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00003086-196801000-00026","volume":"56","author":"JT Irving","year":"1968","unstructured":"Irving JT, Wuthier RE (1968) Histochemistry and biochemistry of calcification with special reference to the role of lipids. Clin Orthop 56:237?260","journal-title":"Clin Orthop"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1159\/000144585","volume":"94","author":"JL Japha","year":"1976","unstructured":"Japha JL, Eder TJ, Goldsmith ED (1976) Calcified inclusions in the superficial pineal gland of the Mongolian gerbil, Meriones unguicutatus. Acta Anat 94:533?544","journal-title":"Acta Anat"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2818.1981.tb02475.x","volume":"123","author":"B Jehl","year":"1981","unstructured":"Jehl B, Bauer R, D\u00f6rge A, Rick R (1981) The use of propane isopentane mixtures for rapid freezing of biological specimens. J Microsc 123:307?309","journal-title":"J Microsc"},{"key":"CR24","first-page":"287","volume":"43","author":"JV Johannessen","year":"1980","unstructured":"Johannessen JV, Sobrinho-Simoes M (1980) The origin and significance of thyroid psammoma bodies. Lab Invest 43:287?296","journal-title":"Lab Invest"},{"key":"CR25","first-page":"156","volume":"35","author":"KM Kim","year":"1976","unstructured":"Kim KM (1976) Calcification of matrix vesicles in human aortic valve and aortic media. Fed Proc 35:156?162","journal-title":"Fed Proc"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-079X.1985.tb00625.x","volume":"2","author":"R Krsti?","year":"1985","unstructured":"Krsti? R (1985) Ultracytochemical localization of calcium in the superficial pineal gland of the Mongolian gerbil. J Pineal Res 2:21?37","journal-title":"J Pineal Res"},{"key":"CR27","first-page":"415","volume":"21","author":"R Krsti?","year":"1986","unstructured":"Krsti? R (1986) Pineal calcification: its mechanism and significance. J Neural Transm [Suppl] 21:415?432","journal-title":"J Neural Transm"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF01922240","volume":"33","author":"R Krsti?","year":"1972","unstructured":"Krsti? R, Golaz J (1972) Ultrastructural and X-ray microprobe comparison of gerbil and human pineal acervuli. Experientia 33:507?508","journal-title":"Experientia"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5320(77)80025-7","volume":"59","author":"WJ Landis","year":"1977","unstructured":"Landis WJ, Paine MC, Glimcher MJ (1977) Electron microscopic observations of bone tissue prepared anhydrously in organic solvents. J Ultrastruct Res 59:1?30","journal-title":"J Ultrastruct Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj1190129","volume":"119","author":"AL Lehninger","year":"1970","unstructured":"Lehninger AL (1970) Mitochondria and calcium ion transport. Biochem J 119:129?138","journal-title":"Biochem J"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/aja.1001430404","volume":"143","author":"A Lukaszyk","year":"1975","unstructured":"Lukaszyk A, Reiter RJ (1975) Histophysiological evidence for the secretion of polypeptides by the pineal gland. Am J Anat 143:451?464","journal-title":"Am J Anat"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02008213","volume":"16","author":"CP Mabie","year":"1974","unstructured":"Mabie CP, Wallace BM (1974) Optical, physical and chemical properties of pineal gland calcifications. Calcif Tissue Res 16:59?71","journal-title":"Calcif Tissue Res"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/36.1.3335770","volume":"36","author":"P Mentr\u00e9","year":"1988","unstructured":"Mentr\u00e9 P, Halpern S (1988) Localization of cations by pyroantimonate. II. Electron probe microanalysis of calcium and sodium in skeletal muscle of mouse. J Histochem Cytochem 36:55?64","journal-title":"J Histochem Cytochem"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00312479","volume":"215","author":"Y Michotte","year":"1977","unstructured":"Michotte Y, Loewenthal A, Knaepen L, Collared M, Massard DL (1977) A morphological and chemical study of calcification of the pineal gland. J Neurol 215:209?219","journal-title":"J Neurol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-0404.1979.tb02928.x","volume":"59","author":"M M\u00f8ller","year":"1979","unstructured":"M\u00f8ller M, Gierris F, Hanen JH, Johnson E (1979) Calcification in a pineal tumor studied by transmission electron microscopy, electron diffraction and X-ray microanalysis. Acta Neurol Scand 59:178?187","journal-title":"Acta Neurol Scand"},{"key":"CR36","first-page":"239","volume-title":"Microprobe analysis of cells and tissues","author":"WAP Nicholson","year":"1974","unstructured":"Nicholson WAP (1974) Experience of diffractive and non diffractive analysis in the Cameca microprobe. In: Hall TA, Echlin P (eds) Microprobe analysis of cells and tissues. Academic Press, London, pp 239?248"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1152\/physrev.1969.49.4.760","volume":"49","author":"AS Posner","year":"1969","unstructured":"Posner AS (1969) Crystal chemistry of bone mineral. Physiol Rev 49:760?792","journal-title":"Physiol Rev"},{"key":"CR38","first-page":"54","volume-title":"Pineal chemistry","author":"WB Quay","year":"1974","unstructured":"Quay WB (1974) Pineal chemistry. Thomas, Springfield, pp 54?58"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/aja.1001460405","volume":"146","author":"RJ Reiter","year":"1976","unstructured":"Reiter RJ, Welsh MG, Vaughan MK (1976) Age related changes in the intact and sympathetically denervated gerbil pineal gland. Am J Anat 146:427?432","journal-title":"Am J Anat"},{"key":"CR40","first-page":"117","volume-title":"Biological mineralization","author":"IM Shapiro","year":"1973","unstructured":"Shapiro IM (1973) The lipids of skeletal and dental tissues: their role in mineralization. In: Zipkin I (ed) Biological mineralization. Wiley, New York, pp 117?138"},{"key":"CR41","first-page":"423","volume":"30","author":"K Simkiss","year":"1976","unstructured":"Simkiss K (1976) Intracellular and extracellular routes in biomineralization. Symp Soc Exp Biol 30:423?444","journal-title":"Symp Soc Exp Biol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/309516b0","volume":"309","author":"AP Somlyo","year":"1984","unstructured":"Somlyo AP (1984) Cellular sites of calcium regulation. Nature 309:516?517","journal-title":"Nature"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02008070","volume":"1","author":"JD Termine","year":"1967","unstructured":"Termine JD, Posner AS (1967) Amorphous\/crystalline interrelationships in bone mineral. Calcif Tissue Res 1:8?23","journal-title":"Calcif Tissue Res"},{"key":"CR44","first-page":"219","volume-title":"Advances of pineal research","author":"GP Trentini","year":"1986","unstructured":"Trentini GP, De Gaetani CF, Pierini G, Criscuolo M, Vidyasagar RI, Fabbri F (1986) Some aspects of human pineal pathology. In: Reiter RJ, Karasek M (eds) Advances of pineal research. Libbey, Paris, pp 219?229"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1679\/aohc.55.477","volume":"55","author":"B Vigh","year":"1992","unstructured":"Vigh B, Vigh-Teichmann I (1992) Two components of the pineal organ of the mink (Mustela vison); their structural similarity to submammalian pineal complexes and calcification. Arch Histol Cytol 55:447?489","journal-title":"Arch Histol Cytol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00492390","volume":"91","author":"B Vigh","year":"1989","unstructured":"Vigh B, Vigh-Teichmann I, Heinzeller T, Tutter I (1989) Meningeal calcification of the rat pineal organ. Fine structural localization of calcium ions. Histochemistry 91:161?168","journal-title":"Histochemistry"},{"key":"CR47","first-page":"153","volume":"2","author":"JC Voegel","year":"1974","unstructured":"Voegel JC, Frank RM (1974) Diffraction \u00e9lectronique monocristalline de l'\u00e9mail humain sain et cari\u00e9. J Biol Buccale 2:153?160","journal-title":"J Biol Buccale"},{"key":"CR48","first-page":"1","volume-title":"Handbuch der mikroskopischen Anatomie des Menschen","author":"L Vollrath","year":"1981","unstructured":"Vollrath L (1981) The pineal organ. In: Oksche A, Vollrath L (eds) Handbuch der mikroskopischen Anatomie des Menschen. Springer, Berlin Heidelberg New York, pp 1?665"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00233954","volume":"212","author":"C Walzer","year":"1980","unstructured":"Walzer C, Boivin G, Sch\u00f6nb\u00f6rner AA, Baud CA (1980) Ultrastructural and cytochemical aspects of the initial phases of an experimental cutaneous calcinosis (calcergy) in the rat. Cell Tissue Res 212:185?202","journal-title":"Cell Tissue Res"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-079X.1984.tb00221.x","volume":"1","author":"MG Welsh","year":"1984","unstructured":"Welsh MG (1984) Cytochemical analysis of calcium distribution in the superficial pineal gland of the Mongolian gerbil. J Pineal Res 1:305?316","journal-title":"J Pineal Res"},{"key":"CR51","first-page":"41","volume":"3","author":"MG Welsh","year":"1985","unstructured":"Welsh MG (1985) Pineal calcification: structural and functional aspects. Pineal Res Rev 3:41?68","journal-title":"Pineal Res Rev"},{"key":"CR52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00209044","volume":"193","author":"MG Welsh","year":"1978","unstructured":"Welsh MG, Reiter RJ (1978) The pineal gland of the gerbil Meriones unguiculatus. I. An ultrastructural study. Cell Tissue Res 193:323?336","journal-title":"Cell Tissue Res"},{"key":"CR53","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0079-6123(08)63453-6","volume":"10","author":"E Wildi","year":"1965","unstructured":"Wildi E, Frauchiger E (1965) Modifications histologiques de l'\u00e9piphyse humaine pendant l'enfance, l'age adulte et le vieillissement. Prog Brain Res 10:218?233","journal-title":"Prog Brain Res"},{"key":"CR54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0022-2275(20)43145-1","volume":"9","author":"RE Wuthier","year":"1968","unstructured":"Wuthier RE (1968) Lipids of mineralizing epiphyseal tissues in the bovine fetus. J Lipid Res 9:68?75","journal-title":"J Lipid Res"},{"key":"CR55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003086-198209000-00035","volume":"169","author":"RE Wuthier","year":"1982","unstructured":"Wuthier RE (1982) A review of the primary mechanism of endochondrial calcification with special emphasis on the role of cells, mitochondria and matrix vesicles. Clin Orthop 169:219?242","journal-title":"Clin Orthop"},{"key":"CR56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1679\/aohc.47.43","volume":"47","author":"T Yajima","year":"1984","unstructured":"Yajima T, Kumegawa M, Hiramatsu M (1984) Ectopic mineralization in fibroblast cultures. Arch Histol Jpn 47:43?55","journal-title":"Arch Histol Jpn"}],"container-title":["Cell & Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00318168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00318168\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00318168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T11:16:17Z","timestamp":1682766977000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00318168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["BF00318168"],"URL":"https:\/\/doi.org\/10.1007\/bf00318168","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}