{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:43:55Z","timestamp":1787510635380,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blut"],"published-print":{"date-parts":[[1987,5]]},"DOI":"10.1007\/bf00320876","type":"journal-article","created":{"date-parts":[[2004,10,18]],"date-time":"2004-10-18T20:51:58Z","timestamp":1098132718000},"page":"281-288","source":"Crossref","is-referenced-by-count":10,"title":["Increased factor VIII\/vWf levels in patients with reduced platelet number"],"prefix":"10.1007","volume":"54","author":[{"given":"A.","family":"Casonato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boscaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Girolami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"231","volume":"33","author":"M Brozovic","year":"1978","unstructured":"Brozovic M (1978) Physiological mechanism in coagulation and fibrinolysis. Br J Haematol 33: 231?238","journal-title":"Br J Haematol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1182\/blood.V64.5.981.981","volume":"64","author":"U Budde","year":"1984","unstructured":"Budde U, Schaeffer G, Mueller N, Egli H, Ruggeri ZM, Zimmerman TS (1984) Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood 64: 981?985","journal-title":"Blood"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ajcp\/84.1.107","volume":"84","author":"A Casonato","year":"1985","unstructured":"Casonato A, Fabris F, Vicariotto M, Girolami A (1985) The evaluation of factor VIII Antigen by means of a simple slide test. Am J Clin Pathol 84: 107?111","journal-title":"Am J Clin Pathol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000206119","volume":"75","author":"A Casonato","year":"1986","unstructured":"Casonato A, Fabris F, Zancan L, Girolami A (1986) Acquired type I von Willebrand's disease in a patient with essential thrombocytosis. Acta Haematol 75: 188?189","journal-title":"Acta Haematol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1182\/blood.V61.1.99.99","volume":"61","author":"BS Coller","year":"1983","unstructured":"Coller BS, Peerschke FI, Schudder LE, Sullivan CA (1983) Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GP Ib as a platelet receptor for von Willebrand factor. Blood 61: 99?110","journal-title":"Blood"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-0038-1657142","volume":"47","author":"R Bo Zanon Dal","year":"1982","unstructured":"Dal Bo Zanon R, Fornasiero L, Boscaro M, Capellato G, Fabris F, Girolami A (1982) Increased factor VIII associated activities in Cushing's syndrome. A probable hypercoagulable state. Thromb Haemost 47: 116?117","journal-title":"Thromb Haemost"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1172\/JCI110259","volume":"68","author":"L Marco De","year":"1981","unstructured":"De Marco L, Shapiro SS (1981) Properties of human asialo factor VIII. A ristocetin independent platelet aggregating agent. J Clin Invest 68: 321?327","journal-title":"J Clin Invest"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1172\/JCI111816","volume":"75","author":"L Marco De","year":"1985","unstructured":"De Marco L, Girolami A, Russel S, Ruggeri ZM (1985) Interaction of asialo von Willebrand factor with Glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb?IIIa complex and mediates platelet aggregation. J Clin Invest 75: 1198?1203","journal-title":"J Clin Invest"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI112430","volume":"77","author":"L Marco De","year":"1986","unstructured":"De Marco L, Girolami A, Zimmerman TS, Ruggeri ZM (1986) Von Willebrand factor interaction with the glycoprotein IIb?IIIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia. J Clin Invest 77: 1272?1277","journal-title":"J Clin Invest"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1182\/blood.V62.1.186.186","volume":"62","author":"G Minno Di","year":"1983","unstructured":"Di Minno G, Sandor S, Shaprio SS, Catalano PM, De Marco L, Murphy S (1983) The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets. Blood 62: 186?190","journal-title":"Blood"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0049-3848(77)90084-6","volume":"10","author":"KWE Denson","year":"1977","unstructured":"Denson KWE (1977) The ratio of factor VIII related antigen and factor VIII biological activity as an index of hypercoagulability and intravascular clotting. Thromb Res 10: 107?119","journal-title":"Thromb Res"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0609.1981.tb01634.x","volume":"26","author":"N Eche","year":"1981","unstructured":"Eche N, Sie P, Caranobe C, Nouvel C, Pris J, Boneou B (1981) Platelets in myeloproliferative disorders. III: glycoproteins profile in relation to platelet function and platelet density. Scand J Haematol 26: 123?129","journal-title":"Scand J Haematol"},{"key":"CR13","first-page":"223","volume":"146","author":"F Fabris","year":"1985","unstructured":"Fabris F, Casonato A, Crociani E, Zanchetta R, Busolo F, Girolami A (1985) A new Elisa method for the detection of serum bindable anti-platelet antibodies (SPBIG). Acta Haematol 146: 223?228","journal-title":"Acta Haematol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00320951","volume":"43","author":"F Fabris","year":"1981","unstructured":"Fabris F, Randi ML, Sbrojavacca R, Casonato A, Girolami A (1981) The possible value of platelet aggregation studies in patients with high platelet number. Blut 43: 279?285","journal-title":"Blut"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2141.1986.tb07497.x","volume":"63","author":"F Fabris","year":"1986","unstructured":"Fabris F, Casonato A, Del Ben MG, De Marco L, Girolami A (1986) Abnormalities of von Willebrand factor in myeloproliferative disease: a relationship with bleeding diathesis. Br J Haematol 63: 75?83","journal-title":"Br J Haematol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2141.1970.tb01615.x","volume":"19","author":"A Girolami","year":"1970","unstructured":"Girolami A, Molaro G, Lazzarin M, Scarpa R, Brunetti A (1970) A new congenital haemorrhagic condition due to the presence of abnormal factor X (factor X Friuli): study of a large kindred. Br J Haematol 19: 179?192","journal-title":"Br J Haematol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF01634015","volume":"29","author":"A Girolami","year":"1974","unstructured":"Girolami A, Sticchi A, Barbui T, Bareggi G (1974) Factor VIII immunological assay. An evaluation of several methods using whole plasma. Blut 29: 309?316","journal-title":"Blut"},{"key":"CR18","first-page":"387","volume":"58","author":"HR Granlick","year":"1974","unstructured":"Granlick HR, Williams SB, Morisato DK (1974) Effect of the multimeric structure of the factor VIII\/von Willebrand factor protein on binding to platelets (1981) Blood 58: 387?397","journal-title":"Blood"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V58.1.1.1","volume":"58","author":"LW Hoyer","year":"1981","unstructured":"Hoyer LW (1981) The factor VIII complex: structure and function. Blood 58: 1?13","journal-title":"Blood"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2141.1981.tb07197.x","volume":"49","author":"R Lombardi","year":"1981","unstructured":"Lombardi R, Mannucci PM, Seghatchian MJ, Vincente Garcia V, Coppola R (1981) Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentrations. Br J Haematol 49: 61?68","journal-title":"Br J Haematol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/blood.V60.5.1132.1132","volume":"60","author":"MF Lopez Fernandez","year":"1982","unstructured":"Lopez Fernandez MF, Ginsberg MH, Ruggeri ZM, Batle F, Zimmerman TS (1982) Multimeric structure of platelet factor VIII\/von Willebrand factor: the presence of larger multimers and their reassociation with thrombin stimulated platelets. Blood 60: 1132?1138","journal-title":"Blood"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0038-1651343","volume":"34","author":"DE McFarlane","year":"1975","unstructured":"McFarlane DE, Stibbe J, Kibby EP, Zucher MB, Grant R, McPerson J (1975) A method for assaying von Willebrand factor (ristocetin cofactor). Thromb Diath Haemor 34: 306?308","journal-title":"Thromb Diath Haemor"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1172\/JCI109210","volume":"62","author":"A Moore","year":"1978","unstructured":"Moore A, Ross GD, Nachman RL (1978) Interaction of platelets membrane receptors with von Willebrand factor, Ristocetin and the Fc region of immunoglobulin G. J Clin Invest 62: 1053?1060","journal-title":"J Clin Invest"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0308-2261(21)00376-3","volume":"12","author":"S Murphy","year":"1983","unstructured":"Murphy S (1983) Thrombocytosis and thrombocytopenia. Clin Haematol 12: 89?106","journal-title":"Clin Haematol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2141.1980.tb01210.x","volume":"44","author":"JD Nel","year":"1980","unstructured":"Nel JD, Stevens KA (1980) A new method for the simultaneous quantitation of platelet-bound IgG and C3 employing an Elisa procedure. Br J Haematol 44: 281?290","journal-title":"Br J Haematol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJM198005083021902","volume":"302","author":"ZM Ruggeri","year":"1980","unstructured":"Ruggeri ZM, Pareti FI, Mannucci PM, Ciavarella N, Zimmerman TS (1980) Heightned interaction between platelets and factor VIII\/von Willebrand factor in a new subtype of von Willebrand disease. New Engl J Med 302: 1047?1051","journal-title":"New Engl J Med"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI109795","volume":"65","author":"ZM Ruggeri","year":"1980","unstructured":"Ruggeri ZM, Zimmerman TS (1980) Characterization of two subtypes by analysis of multimeric composition of factor VIII\/von Willebrand factor in plasma and in platelets. J Clin Invest 65: 1318?1325","journal-title":"J Clin Invest"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V57.6.1140.1140","volume":"57","author":"ZM Ruggeri","year":"1981","unstructured":"Ruggeri ZM, Zimmerman TS (1981) The complex multimeric composition of factor VIII\/von Willebrand factor. Blood 57: 1140?1143","journal-title":"Blood"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1073\/pnas.79.19.6038","volume":"79","author":"ZM Ruggeri","year":"1982","unstructured":"Ruggeri ZM, Bader R, De Marco L (1982) Glanzman thromboastenia: deficient binding of von Willebrand factor to thrombin stimulated platelets. Proc Nat Acad Sci USA 79: 6038?6041","journal-title":"Proc Nat Acad Sci USA"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI110946","volume":"72","author":"ZM Ruggeri","year":"1983","unstructured":"Ruggeri ZM, De Marco L, Bader R, Montgomery RR (1983) Platelets have more than one binding site for von Willebrand factor. J Clin Invest 72: 1?12","journal-title":"J Clin Invest"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/279636a0","volume":"279","author":"KS Sakariassen","year":"1979","unstructured":"Sakariassen KS, Bolhuis PA, Sixma JJ (1979) Human blood platelets adhesion to artery subendothelium is mediated by factor VIII\/von Willebrand factor bound to subendothelium. Nature 279: 636?638","journal-title":"Nature"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood.V51.2.267.267","volume":"51","author":"HJ Weiss","year":"1978","unstructured":"Weiss HJ, Baumgartner HR, Tschopp TS, Turitto VT, Cohen D (1978) Correction by factor VIII of the impaired platelet adhesion to subendothelium in von Willebrand's disease. Blood 51: 267?279","journal-title":"Blood"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1056\/NEJM198202113060603","volume":"306","author":"HJ Weiss","year":"1982","unstructured":"Weiss HJ, Meyer D, Rabinowitz R, Pietu G, Girma JP, Vieie WJ, Rogers J (1982) Pseudovon Willebrand's disease, an intrinsic platelet defect with aggregation by a modified human factor VIII\/von Willebrand factor and enhanced adsorption of its high-molecular weight multimers. New Engl J Med 306: 326","journal-title":"New Engl J Med"}],"container-title":["Blut"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00320876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00320876\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00320876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T12:37:40Z","timestamp":1624711060000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00320876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["BF00320876"],"URL":"https:\/\/doi.org\/10.1007\/bf00320876","relation":{},"ISSN":["0006-5242","1432-0584"],"issn-type":[{"value":"0006-5242","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}