{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:27:16Z","timestamp":1773674836212,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[1994,8]]},"DOI":"10.1007\/bf00327768","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T21:05:33Z","timestamp":1098479133000},"page":"201-209","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of the heterogeneity within bovine pineal gland by immunohistochemistry and in situ hybridization"],"prefix":"10.1007","volume":"277","author":[{"given":"Tetsuji","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michinari","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Fujieda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Wake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000121565","volume":"2","author":"VA Arstila","year":"1967","unstructured":"Arstila VA (1967) Electron microscopic studies on the structure and histochemistry of the pineal gland of the rat. Neuroendocrinology [Suppl] 2:1?101","journal-title":"Neuroendocrinology [Suppl]"},{"key":"CR2","first-page":"312","volume":"181","author":"R Benson","year":"1975","unstructured":"Benson R, Satterfield V (1975) Ultrastructural characteristics of mouse pinealocytes following optic enucleation or continous illumination. Anat Rec 181:312","journal-title":"Anat Rec"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cne.901530104","volume":"153","author":"A Bignami","year":"1974","unstructured":"Bignami A, Dahl D (1974) Astrocyte-specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to glial fibrillary acidic protein. J Comp Neurol 153:27?37","journal-title":"J Comp Neurol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00502095","volume":"82","author":"AE Bishop","year":"1985","unstructured":"Bishop AE, Carlei F, Lee V, Trojanowski J, Marangos PJ, Dahl D, Polak JM (1985) Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. A possible means for assessing the morphological and functional status of the enteric nervous system. Histochemistry 82:93?97","journal-title":"Histochemistry"},{"key":"CR5","first-page":"1","volume":"8","author":"M Blumfield","year":"1970","unstructured":"Blumfield M, Tapp E (1970) Measurements of pineal parenchymal cells and their nuclei in the albino rat at different ages. Acta Morphol Neerl-Scand 8:1?8","journal-title":"Acta Morphol Neerl-Scand"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0006-8993(74)90938-X","volume":"81","author":"GA Bubenik","year":"1974","unstructured":"Bubenik GA, Brown GM, Uhlir I, Grota LJ (1974) Immunohistological localization of N-acetylindolealkylamines in pineal gland, retina and cerebellum. Brain Res 81:233?242","journal-title":"Brain Res"},{"key":"CR7","first-page":"405","volume":"138","author":"J Calvo","year":"1984","unstructured":"Calvo J, Boya J (1984) Ultrastructure of the pineal gland in the adult rat. J Anat 138:405?409","journal-title":"J Anat"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ar.1092200412","volume":"220","author":"J Calvo","year":"1988","unstructured":"Calvo J, Boya J, Borregon A, Garcia-Maurino JE (1988) Presence of glial cells in the rat pineal gland: a light and electron microscopic immunohistochemical study. Anat Res 220:424?428","journal-title":"Anat Res"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0005-2795(70)90156-X","volume":"207","author":"DW Cheesman","year":"1970","unstructured":"Cheesman DW (1970) Structure elucidation of a gonadotropin inhibiting substance from the bovine pineal gland. Biochem Biophys Acta 207:247?253","journal-title":"Biochem Biophys Acta"},{"key":"CR10","first-page":"113","volume":"95","author":"VP Collins","year":"1987","unstructured":"Collins VP (1987) Pineocytoma with neuronal differentiation demonstrated immunocytochemically. Acta Pathol Microbiol Immunol Scand [A] 95:113?117","journal-title":"Acta Pathol Microbiol Immunol Scand [A]"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0024-3205(75)80013-0","volume":"16","author":"N Dafny","year":"1975","unstructured":"Dafny N, McClung R, Strada SJ (1975) Neurophysiological properties of the pineal body. 1. Field potentials. Life Sci 16:611?620","journal-title":"Life Sci"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0012-1606(81)90290-6","volume":"81","author":"MJ Dennis","year":"1981","unstructured":"Dennis MJ, Ziskind-Conhaim L, Harris AJ (1981) Development of neuromuscular junctions in rat embryos. Dev Biol 81:266?279","journal-title":"Dev Biol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-8993(71)90668-8","volume":"28","author":"LF Eng","year":"1971","unstructured":"Eng LF, Vanderhaeghen JJ, Bignami A, Gerstl B (1971) An acidic protein isolated from fibrous astrocytes. Brain Res 28:351?354","journal-title":"Brain Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00219983","volume":"181","author":"D Freund","year":"1977","unstructured":"Freund D, Arendt J, Vollrath L (1977) Tentative immunohistochemical demonstration of melatonin in the rat pineal gland. Cell Tissue Res 181:239?244","journal-title":"Cell Tissue Res"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-079X.1993.tb00490.x","volume":"14","author":"H Fujieda","year":"1993","unstructured":"Fujieda H, Sato T, Wake K, Takaoka M, Morimoto S (1993) Tissue kallikrein in the rat pineal gland: an immunocytochemical study. J Pineal Res 14:84?88","journal-title":"J Pineal Res"},{"key":"CR16","first-page":"89","volume-title":"Advances in immunohistochemistry","author":"AM Gown","year":"1984","unstructured":"Gown AM, Gabbiani G (1984) Intermediate-sized (10-nm) filaments in human tumours. In: DeLellis RA (ed) Advances in immunohistochemistry. Masson, New York, pp 89?109"},{"key":"CR17","first-page":"257","volume":"52","author":"H Haimoto","year":"1985","unstructured":"Haimoto H, Takahashi Y, Koshikawa T, Nagura H, Kato K (1985) Immunohistochemical localization of r-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab Invest 52:257?263","journal-title":"Lab Invest"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1210\/endo-96-2-508","volume":"96","author":"I Haulica","year":"1975","unstructured":"Haulica I, Branisteann DD, Rosca V, Stratone A, Berbeleu V, Balan G, Ionescu L (1975) A renin-like activity in pineal gland and hypophysis. Endocrinology 96:530?532","journal-title":"Endocrinology"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00319371","volume":"267","author":"SK Huang","year":"1992","unstructured":"Huang SK, Klein DC, Korf HW (1992) Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland. Cell Tissue Res 267:493?498","journal-title":"Cell Tissue Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/S0021-9258(18)61591-1","volume":"262","author":"I Ishida","year":"1987","unstructured":"Ishida I, Obinata M, Deguchi T (1987a) Molecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands. J Biol Chem 262:2895?2899","journal-title":"J Biol Chem"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0169-328X(87)90025-8","volume":"2","author":"I Ishida","year":"1987","unstructured":"Ishida I, Ohsako S, Nakane M, Deguchi T (1987b) Expression and characterization of hydroxyindole O-methyltransferase from a cloned cDNA in Chinese hamster ovary cells. Mol Brain Res 2:185?189","journal-title":"Mol Brain Res"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1073\/pnas.82.12.4137","volume":"82","author":"R Jahn","year":"1985","unstructured":"Jahn R, Schiebler W, Ouimet C, Greengard P (1985) A 38000 dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 82:4137?4141","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR23","first-page":"2","volume-title":"Pineal Res Rev, vol 1","author":"M Karasek","year":"1983","unstructured":"Karasek M (1983) Ultrastructure of the mammalian pineal gland: Its comparative and functional aspects. In: Reiter RJ (ed) Pineal Res Rev, vol 1. Liss, New York, pp 2?48"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1471-4159.1986.tb00754.x","volume":"47","author":"P Knaus","year":"1986","unstructured":"Knaus P, Betz H, Rehm H (1986) Expression of synaptophysin during postnatal development of the mouse brain. J Neurochem 47:1302?1304","journal-title":"J Neurochem"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00608776","volume":"54","author":"A K\u00f6nig","year":"1967","unstructured":"K\u00f6nig A, Meyer A (1967) Tagesperiodische Schwankungen einer antidiuretischen Aktivit\u00e4t aus der Epiphysis cerebri ausgewachsener m\u00e4nnlicher Ratten. Naturwissenschaften 54:93","journal-title":"Naturwissenschaften"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/09291017109359268","volume":"2","author":"A K\u00f6nig","year":"1971","unstructured":"K\u00f6nig A, Meyer A (1971) The effect of continuous illumination on the circadian rhythm of the antidiuretic activity of the rat pineal. J Interdiscipl Cycle Res 2:255?262","journal-title":"J Interdiscipl Cycle Res"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00214906","volume":"239","author":"HW Korf","year":"1985","unstructured":"Korf HW, M\u00f8ller M, Gery I, Zigler J, Klein D (1985) Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species. Cell Tissue Res 239:81?85","journal-title":"Cell Tissue Res"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(83)90535-8","volume":"274","author":"R Kuwano","year":"1983","unstructured":"Kuwano R, Iwanaga T, Nakajima T, Masuda T, Takahashi Y (1983) Immunocytochemical demonstration of hydroxyindole O-methyltransferase (HIOMT), neuron-specific enolase (NSE) and S-100 protein in the bovine pineal. Brain Res 274:171?175","journal-title":"Brain Res"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0024-3205(75)80006-3","volume":"16","author":"R McClung","year":"1975","unstructured":"McClung R, Dafny N (1975) Neurophysiological properties of the pineal body. II. Single unit recording. Life Sci 16:621?628","journal-title":"Life Sci"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/aja.1001760408","volume":"176","author":"CD McClure","year":"1986","unstructured":"McClure CD, McMillan PJ, Miranda CA (1986) Demonstration of differential immunohistochemical localization of the neuronspecific enolase antigen in rat pinealocytes. Am J Anat 176:461?467","journal-title":"Am J Anat"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1083\/jcb.103.6.2511","volume":"103","author":"F Navone","year":"1986","unstructured":"Navone F, Jahn R, DiGioia G, Stukenbrok H, Greengard P, De Camilli P (1986) Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol 103:2511?2527","journal-title":"J Cell Biol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF01257021","volume":"40","author":"P P\u00e9vet","year":"1977","unstructured":"P\u00e9vet P (1977) On the presence of different populations of pinealocytes in the mammalian pineal gland. J Neural Transm 40:289?304","journal-title":"J Neural Transm"},{"key":"CR33","first-page":"1","volume-title":"The pineal gland","author":"P P\u00e9vet","year":"1983","unstructured":"P\u00e9vet P (1983) Anatomy of the pineal gland of mammals. In: Relkin R (ed) The pineal gland. Elsevier Biomedical, New York, pp 1?75"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/5.2.145","volume":"5","author":"WB Quay","year":"1957","unstructured":"Quay WB (1957) Cytochemistry of pineal lipids in rat and man. J Histochem Cytochem 5:145?153","journal-title":"J Histochem Cytochem"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/ajplegacy.1958.195.2.391","volume":"195","author":"WB Quay","year":"1958","unstructured":"Quay WB (1958) Pineal blood content and its experimental modification. Am J Physiol 195:391?395","journal-title":"Am J Physiol"},{"key":"CR36","first-page":"315","volume":"30","author":"WB Quay","year":"1966","unstructured":"Quay WB, Renzoni A (1966) Twenty-four hour rhythms in pineal mitotic activity and nuclear and nucleolar dimensions. Growth 30:315?324","journal-title":"Growth"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF02433790","volume":"181","author":"P Redecker","year":"1990","unstructured":"Redecker P, Grube D, Jahn R (1990) Immunohistochemical localization of synaptophysin (p38) in the pineal gland of the Mongolian gerbil (Meriones unguiculatus). Anat Embryol 181:433?440","journal-title":"Anat Embryol"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/j.1460-2075.1986.tb04243.x","volume":"5","author":"H Rehm","year":"1986","unstructured":"Rehm H, Wiedenmann B, Betz H (1986) Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. EMBO J 5:535?541","journal-title":"EMBO J"},{"key":"CR39","doi-asserted-by":"crossref","DOI":"10.1515\/9783486777031","volume-title":"Mikroskopische Technik. 15. Auflage","author":"B Romeis","year":"1948","unstructured":"Romeis B (1948) Mikroskopische Technik. 15. Auflage. Leibniz, M\u00fcnchen"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000122373","volume":"17","author":"AA Rosenbloom","year":"1975","unstructured":"Rosenbloom AA, Fisher DA (1975) Radioimmunoassayable AVT and AVP in adult mammalian brain tissue: comparison of normal and Brattleboro rats. Neuroendocrinology 17:345?361","journal-title":"Neuroendocrinology"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00327275","volume":"263","author":"T Sato","year":"1991","unstructured":"Sato T, Deguchi T, Ichikawa T, Fujieda H, Wake K (1991) Localization of hydroxyindole O-methyltransferase-synthesizing cells in bovine epithalamus: immunocytochemistry and in-situ hybridization. Cell Tissue Res 263:413?418","journal-title":"Cell Tissue Res"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(79)91486-1","volume":"12","author":"P Semm","year":"1979","unstructured":"Semm P, Vollrath L (1979) Electrophysiology of the guinea-pig pineal organ: sympathetic influenced cells responding differently to light and darkness. Neurosci Lett 12:93?96","journal-title":"Neurosci Lett"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01250600","volume":"47","author":"P Semm","year":"1980","unstructured":"Semm P, Vollrath L (1980) Electrophysiological evidence for circadian rhythmicity in a mammalian pineal organ. J Neural Transm 47:181?190","journal-title":"J Neural Transm"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01252038","volume":"53","author":"P Semm","year":"1982","unstructured":"Semm P, Vollrath L (1982) Alterations in the spontaneous activity of cells in the guinea pig pineal gland and visual system produced by pineal indoles. J Neural Transm 53:265?275","journal-title":"J Neural Transm"},{"key":"CR45","volume-title":"Immunocytochemistry","author":"LA Sternberger","year":"1986","unstructured":"Sternberger LA (1986) Immunocytochemistry, 3rd edn. Wiley, New York Chichester Brisbane","edition":"3rd edn."},{"key":"CR46","first-page":"119","volume":"8","author":"E Tapp","year":"1970","unstructured":"Tapp E, Blumfield M (1970) The parenchymal cells of the rat pineal gland. Acta Morphol Neerl-Scand 8:119?131","journal-title":"Acta Morphol Neerl-Scand"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-8993(81)90215-8","volume":"220","author":"B Trapp","year":"1981","unstructured":"Trapp B, Marangos P, Webster H (1981) Immunocytochemical localization and developmental profile of neuron-specific enolase during differentiation. Brain Res 220:121?130","journal-title":"Brain Res"},{"key":"CR48","volume-title":"Handbuch der Mikroskopischen Anatomie des Menschen VI\/7","author":"L Vollrath","year":"1981","unstructured":"Vollrath L (1981) The pineal organ. In: Oksche A, Vollrath L (eds) Handbuch der Mikroskopischen Anatomie des Menschen VI\/7. Springer, Berlin Heidelberg New York"},{"key":"CR49","first-page":"13","volume-title":"Fundamentals and clinics in pineal research, vol 44","author":"L Vollrath","year":"1987","unstructured":"Vollrath L, Schr\u00f6der H (1987) Neuronal properties of mammalian pinealocytes? In: Trentini GP, De Gaetani C, P\u00e9vet P (eds) Fundamentals and clinics in pineal research, vol 44. Raven Press, New York, pp 13?23"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/aja.1001680107","volume":"168","author":"L Vollrath","year":"1983","unstructured":"Vollrath L, Schultz R, McMillan P (1983) ?Synaptic? ribbons and spherules of the guinea pig pineal gland: inverse day\/night differences in number. Am J Anat 168:67?74","journal-title":"Am J Anat"},{"key":"CR51","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1210\/endo-94-5-1422","volume":"94","author":"WF White","year":"1974","unstructured":"White WF, Hedlund MT, Weber GF, Rippel RH, Johnson ES, Wilber JF (1974) The pineal gland: a supplemental source of hypothalamic-releasing hormones. Endocrinology 94:1422?1426","journal-title":"Endocrinology"},{"key":"CR52","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0092-8674(85)80082-9","volume":"41","author":"B Wiedenmann","year":"1985","unstructured":"Wiedenmann B, Franke WW (1985) Identification and localization of synaptophysin, an integral membrane glycoprotein of M 38000 characteristic of presynaptic vesicles. Cell 41:1017?1028","journal-title":"Cell"},{"key":"CR53","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1073\/pnas.83.10.3500","volume":"83","author":"B Wiedenmann","year":"1986","unstructured":"Wiedenmann B, Franke WW, Kuhn C, Moll R, Gould VE (1986) Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci USA 83:3500?3504","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR54","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0079-6123(08)63460-3","volume-title":"Structure and function of the epiphysis cerebri (Progress in Brain Research, vol 10)","author":"DE Wolfe","year":"1965","unstructured":"Wolfe DE (1965) The epiphyseal cell: an electron-microscopic study of its intercellular relationships and intracellular morphology in the pineal body of the albino rat. In: Ari\u00ebns Kappers J, Schad\u00e9 JP (eds) Structure and function of the epiphysis cerebri (Progress in Brain Research, vol 10). Elsevier, Amsterdam, pp 332?386"},{"key":"CR55","volume-title":"The pineal","author":"RJ Wurtman","year":"1968","unstructured":"Wurtman RJ, Axelrod J, Kelly DE (1968) The pineal. Academic Press, New York"}],"container-title":["Cell & Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00327768.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00327768\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00327768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T20:25:05Z","timestamp":1624739105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00327768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["BF00327768"],"URL":"https:\/\/doi.org\/10.1007\/bf00327768","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}