{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:50:37Z","timestamp":1784224237518,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 1976 the National Surgical Adjuvant Breast and Bowel Project (NSABP) initiated a randomized trial (B\u201006) to evaluate the worth of lumpectomy in the treatment of patients with stages I and II breast cancer. This report presents, for the first time, findings from that trial through 10 years of follow\u2010up relative to ipsilateral breast tumor recurrence (IBTR), distant disease\u2010free survival, and survival of patients who were treated by modified radical mastectomy, lumpectomy, or lumpectomy followed by breast irradiation. The report indicates that the incidence of IBTR observed in the B\u201006 trial is decreased by effective systemic therapy as well. Also commented on are a number of issues regarding the use of lumpectomy that are of concern to clinicians. They relate to the need for tumor specimen margins, the size of tumors amenable to lumpectomy, treatment of breast tumor recurrence, lumpectomy in older women, and other concerns. No patient or tumor characteristics have been identified that preclude the use of lumpectomy and radiation therapy. All evidence continues to justify the use of lumpectomy and breast irradiation for the treatment of invasive breast cancer. In addition, we have noted findings that indicate the propriety of lumpectomy and breast irradiation for treatment of localized ductal carcinoma in situ.<\/jats:p>","DOI":"10.1007\/bf00348193","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T07:37:32Z","timestamp":1102664252000},"page":"63-69","source":"Crossref","is-referenced-by-count":218,"title":["Conservative surgery for the management of invasive and noninvasive carcinoma of the breast: NSABP trials"],"prefix":"10.1002","volume":"18","author":[{"given":"Bernard","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Surgery University of Pittsburgh Medical School 15261 Pittsburgh Pennsylvania USA"},{"name":"National Surgical Adjuvant Breast and Bowel Project (NSABP) Headquarters Room 914, Scaife Hall, 3550 Terrace Street 15261 Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh Medical School 15261 Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1994,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121101"},{"key":"e_1_2_1_3_1","first-page":"14","volume-title":"Debates in Clinical Surgery","author":"Fisher B.","year":"1990"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903303201302"},{"key":"e_1_2_1_5_1","first-page":"7","article-title":"Lumpectomy for breast cancer: an update of the NSABP experience","volume":"11","author":"Fisher B.","year":"1992","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"e_1_2_1_6_1","first-page":"153","article-title":"Breast tumor recurrence following lumpectomy with and without breast irradiation: an overview of recent NSABP findings","volume":"8","author":"Fisher B.","year":"1992","journal-title":"Semin. Surg. Oncol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655182"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860501)57:9<1717::AID-CNCR2820570902>3.0.CO;2-H"},{"key":"e_1_2_1_9_1","first-page":"828","article-title":"The technique of segmental mastectomy (lumpectomy) and axillary dissection: a syllabus from the National Surgical Adjuvant Breast Project workshops","volume":"102","author":"Margolese R.","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_1_10_1","first-page":"425","article-title":"Conservative surgery: the American experience","volume":"13","author":"Fisher B.","year":"1986","journal-title":"Semin. 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Assoc."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058444"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655181"},{"key":"e_1_2_1_18_1","first-page":"2371","article-title":"The evolution of paradigms for the management of breast cancer: a personal perspective","volume":"52","author":"Fisher B.","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_1","first-page":"173","article-title":"Changing patterns of surgical treatment for breast cancer: the status of lumpectomy","volume":"21","author":"Fisher B.","year":"1992","journal-title":"J. Irish Coll. 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