{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:13:55Z","timestamp":1789852435846,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to examine the frequency of the pheochromocytoma (pheo), defined as a \u201cbenign, intra\u2010adrenal, hypertensive, sporadic, unilateral tumor.\u201d Three large series amounting to 310 subphrenic chromaffin tumors operated over periods of 17, 23, and 41 years, respectively, have been reviewed. Among those combined 310\u00a0pheos, 48 (15.5%) were malignant (i.e., metastatic) and 262 (84.5%) were benign; 42 (13.5%) were ectopic (35% of malignant tumors versus 9.5% of benign tumors); 230 (74.2%) were hypertensive (74% of benign tumors versus 73% of malignant tumors); 29 (9.4%) were bilateral, including 23 patients with a family history; 41 (13.2%) of patients had MEN II type A or B syndrome; and 20 (6.5%) occurred in a phacomatosis setting. Some of the patients had a non\u2010MEN family history of pheo (<jats:italic>n<\/jats:italic>=5), seemingly sporadic hyperparathyroidism (<jats:italic>n<\/jats:italic>=4), or other associated neuroendocrine tumor (<jats:italic>n<\/jats:italic>=9). Sometimes several of these features were combined. Finally 125 (40.3%) cases fitted the classic description of the tumor, 47.0% at the time of initial presentation and 40.3% at the end of follow\u2010up. Late occurrence of metastases or metachronous diagnosis of familial disease make lifelong follow\u2010up mandatory. Genetic studies may be indicated in pheochromocytoma patients.<\/jats:p>","DOI":"10.1007\/bf00353738","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T06:46:34Z","timestamp":1099205194000},"page":"467-472","source":"Crossref","is-referenced-by-count":53,"title":["\u201cThe\u201d pheochromocytoma: A benign, intra\u2010adrenal, hypertensive, sporadic unilateral tumor. Does it exist?"],"prefix":"10.1002","volume":"18","author":[{"given":"Charles A. G.","family":"Proye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R. C. S.","family":"Edbg","sequence":"additional","affiliation":[{"name":"Clinique Chirurgicale Adultes Est, Service de Chirurgie G\u00e9n\u00e9rale et Endocrinienne CHU de Lille H\u00f4pital Huriez Place de Verdun 59037 Lille C\u00e9dex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vix","sequence":"additional","affiliation":[{"name":"Clinique Chirurgicale Adultes Est, Service de Chirurgie G\u00e9n\u00e9rale et Endocrinienne CHU de Lille H\u00f4pital Huriez Place de Verdun 59037 Lille C\u00e9dex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska Sjukhuset S\u2010413 45 G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010E.","family":"Tisell","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska Sjukhuset S\u2010413 45 G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hennig","family":"Dralle","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal und Transplantationchirurgie Medizinische Hochschule Hannover D\u20103000 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hiller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal und Transplantationchirurgie Medizinische Hochschule Hannover D\u20103000 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1994,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55898-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345808"},{"key":"e_1_2_1_4_1","first-page":"98","article-title":"La malignit\u00e9 d'un ph\u00e9ochromocytome est\u2010elle pr\u00e9visible? A propos de 50 patients op\u00e9r\u00e9s","volume":"83","author":"Proye C.","year":"1987","journal-title":"Lyon Chir."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345810"},{"key":"e_1_2_1_6_1","first-page":"1154","article-title":"Dopamine secreting pheochromocytoma. An unrecognized entity? Classification of pheochromocytomas according to their type of secretion","volume":"100","author":"Proye C.","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_7_1","first-page":"1024","article-title":"Un cas de ph\u00e9ochromocytome \u00e0 localisation cardiaque. Revue de la litt\u00e9rature","volume":"14","author":"Geisler F.","year":"1985","journal-title":"Presse Med."},{"key":"e_1_2_1_8_1","first-page":"611","article-title":"Pheochromocytome r\u00e9trocardiaque associ\u00e9 \u00e0 une double localisation carotidienne","volume":"44","author":"Peiffert B.","year":"1990","journal-title":"Ann. Chir. Thor. Cardio. Vasc."},{"key":"e_1_2_1_9_1","first-page":"480","article-title":"Une localisation exceptionnelle de ph\u00e9ochromocytome de la prostate: Int\u00e9r\u00eat de l'\u00e9chographie","volume":"29","author":"Pichat L.","year":"1986","journal-title":"Ann. Radiol."},{"key":"e_1_2_1_10_1","unstructured":"Aelbrecht S.:Le paragangliome de l'organe de Zuckerkandl. A propos d'un cas non s\u00e9cr\u00e9tant chez un enfant de 10 ans et revue de la litt\u00e9rature. M\u00e9dical Thesis Lille University France 1990."},{"key":"e_1_2_1_11_1","first-page":"677","article-title":"Pheochromocytoma of the urinary bladder","volume":"109","author":"Sweetser P.M.","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655896"},{"key":"e_1_2_1_13_1","first-page":"108","article-title":"Operative therapie des sporadischen und familiaren ph\u00e4ochromozytoms","volume":"4","author":"Dralle H.","year":"1988","journal-title":"Acta. Med. 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