{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:02:56Z","timestamp":1705017776336},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retrospective analysis has been performed on 108 consecutive patients operated for primary hyperparathyroidism (HPT) at 75 to 85 years of age (mean 79 years). The preperative serum calcium value averaged 2.99\u00a0mM, and six patients had hypercalcemic crisis. Psychic disturbances were seen in 60 patients (56%), 40% of whom demonstrated dementia. Skeletal and muscular complaints were registered in 29% and 19%, respectively, and only 6% were overtly asymptomatic. Cardiovascular diseases were presented by 69% of the patients, 13% had diabetes mellitus, and 26% were institutionalized prior to surgery. Bilateral neck exploration disclosed a single adenoma in 69%, which was of the oxyphil cell type in 13%, and water\u2010clear (<jats:italic>n<\/jats:italic>=3) or chief cell hyperplasia in 27%. The total glandular weight averaged 1085\u00a0mg. Altogether 72 patients operated on after 1980 demonstrated a perioperative (30\u2010day) mortality of 1.4%; the corresponding morbidity of 8.7% mainly included infections as well as a vocal cord paralysis in one patient and two incisional hematomas. Analysis for mean 3.1 years postoperatively displayed reversal of hypercalcemia in 95% of the patients; 2.8% of those operated after 1980 had persistent disease. Symptoms seemed to be alleviated in 62%, with a similar rate attained in patients with dementia. Altogether 60 patients died from mainly cardiovascular diseases mean 4.2 years after the operation. Those succumbing the first postoperative year (<jats:italic>n<\/jats:italic>=21) showed overrepresentation of cardiac diseases and diabetes mellitus. The results demonstrate prevalent psychic disturcbances, oxyphil adenomas, and multiglandular parathyroid disease in elderly patients with primary HPT and favor rather liberal application of parathyroid surgery among these individuals.<\/jats:p>","DOI":"10.1007\/bf00353779","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T06:46:34Z","timestamp":1099205194000},"page":"612-618","source":"Crossref","is-referenced-by-count":18,"title":["Surgery for sporadic primary hyperparathyroidism in the elderly"],"prefix":"10.1002","volume":"18","author":[{"given":"Ulf","family":"\u00d6hryall","sequence":"first","affiliation":[{"name":"Department of Surgery Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgery Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverker","family":"Ljunghall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Surgery Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Department of Surgery Uppsala University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1976.tb08208.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001243020402"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1988.tb01163.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90063-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655560"},{"key":"e_1_2_1_7_1","first-page":"1315","article-title":"Primary hyperparathyroidism: changes in the pattern of clinical presentation","volume":"1","author":"Mundy G.R.","year":"1980","journal-title":"Lancet"},{"key":"e_1_2_1_8_1","first-page":"675","article-title":"Primary hyperparathyroidism; changing trends over fifty years","volume":"149","author":"Trigonis C.","year":"1983","journal-title":"Acta Chir. Scand."},{"key":"e_1_2_1_9_1","first-page":"13","article-title":"Clinical characteristics and surgical treatment of sporadic primary hyperparathyroidism with emphasis on chief cell hyperplasia","volume":"107","author":"Wallfelt C.","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_1_10_1","first-page":"175","article-title":"Surgical treatment of primary hyperparathyroidism in elderly patients","volume":"153","author":"Brothers T.E.","year":"1987","journal-title":"Acta Chir. Scand."},{"key":"e_1_2_1_11_1","first-page":"24","article-title":"Primary hyperparathyroidism in the elderly","volume":"14","author":"Kochersberger G.","year":"1988","journal-title":"Compr. Ther."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067389"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90198-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813439209014060"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80043-0"},{"key":"e_1_2_1_16_1","first-page":"305","article-title":"Is the clinical expression of primary hyperparathyroidism a function of the long\u2010term vitamin D status of the patient","volume":"13","author":"Kleeman C.R.","year":"1987","journal-title":"Miner. Electrolyte Metab."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40995-5"},{"key":"e_1_2_1_18_1","first-page":"643","article-title":"Late results of operation for primary hyperparathyroidism in 441 patients","volume":"99","author":"Rudberg C.","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_19_1","first-page":"1123","article-title":"Long\u2010term effects of parathyroid operation on serum calcium and parathyroid hormone values in primary hyperparathyroidism","volume":"112","author":"Lundgren E.","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb03281.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750128"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90085-6"},{"key":"e_1_2_1_23_1","first-page":"72","article-title":"Self\u2010rated psychiatric symptoms in patients operated on because of primary hyperparathyroidism and in patients with long\u2010standing mild hypercalcemia","volume":"105","author":"Joborn C.","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120202"},{"issue":"6","key":"e_1_2_1_25_1","first-page":"149","article-title":"Incidence, type and severity of psychic symptoms in patients with sporadic primary hyperparathyroidism","volume":"15","author":"Rastad J.","year":"1992","journal-title":"J. Endocrinol. Invest."},{"key":"e_1_2_1_26_1","first-page":"375","volume-title":"Functional Endocrine Pathology","author":"Grimelius L.","year":"1991"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81166-0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009738609178493"},{"key":"e_1_2_1_29_1","first-page":"491","article-title":"Indications for surgery in the elderly patient with primary hyperparathyroidism","volume":"142","author":"Alveryd A.","year":"1976","journal-title":"Acta Chir. Scand."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6229.1406"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/36.5.573"},{"key":"e_1_2_1_32_1","first-page":"150","article-title":"Surgical treatment of primary hyperparathyroidism in the elderly patient","volume":"19","author":"Nudelman I.","year":"1983","journal-title":"Isr. J. Med. Sci."},{"key":"e_1_2_1_33_1","first-page":"135","article-title":"Hyperparathyroidism in the old age","volume":"72","author":"Tibblin S.","year":"1983","journal-title":"Ann. Chir. Gynecol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1160457"},{"issue":"2","key":"e_1_2_1_35_1","first-page":"S9","article-title":"NIH Consensus Development Conference Statement","volume":"6","year":"1991","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91906-4"},{"key":"e_1_2_1_37_1","first-page":"1","article-title":"Mortality after surgery for primary hyperparathyroidism: a follow\u2010up of 441 patients operated on from 1956 to 1979","volume":"102","author":"Palm\u00e9r M.","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01670531"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00353779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00353779\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF00353779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:05:37Z","timestamp":1704999937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF00353779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1007\/BF00353779"],"URL":"https:\/\/doi.org\/10.1007\/bf00353779","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}