{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:38:17Z","timestamp":1761154697596},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Comparing patients with primary hyperparathyroidism (PHP) to a normocalcemic control population, those with PHP have a higher incidence of cardiovascular disease and cardiac abnormalities. This study aimed at correlating cardiac findings (valvular and myocardial calcification, myocardial hypertrophy) with clinical data (age, sex, clinical manifestation, nephrolithiasis, nephrocalcinosis, hypertension, skeletal abnormalities, hypercalcemic syndrome) and biochemical data (serum calcium, serum phosphate, serum iPTH level, serum creatinine). A group of 132 consecutive patients with surgically verified PHP (94 women, 38\u00a0men; ages 15\u201386, mean age 57\u00b116 years) were included in this study. Blood chemistry, clinical presentation, radiography, and echocardiography were carried out in all patients for univariate and multivariate analyses of all parameters. There was no statistical correlation between clinical symptoms, biochemical data, and cardiac calcific alterations. Typical skeletal manifestations (osteolysis\/subperiostal resorption) and valvular calcifications were significantly correlated to left ventricular hypertrophy (<jats:italic>p<\/jats:italic>=0.005). Cardiac abnormalities such as calcific myocardial deposits or mitral and aortic valvular calcifications do not correlate with laboratory findings and clinical presentation at the time of diagnosis. There was no biochemical or clinical variable that could predict the frequency or severity of valvular sclerosis or calcific deposits in the myocardium. However, PHP\u2010related skeletal abnormalities and valvular calcification were predicting factors for left ventricular hypertrophy, a reversible cardiac manifestation of PHP. Myocardial hypertrophy is more often found with classic symptomatic PHP with osseous abnormalities.<\/jats:p>","DOI":"10.1007\/bf00353780","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T06:46:34Z","timestamp":1099205194000},"page":"619-624","source":"Crossref","is-referenced-by-count":26,"title":["Primary hyperparathyroidism and the heart: Cardiac abnormalities correlated to clinical and biochemical data"],"prefix":"10.1002","volume":"18","author":[{"given":"Friedrich","family":"L\u00e4ngle","sequence":"first","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Vienna Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudette","family":"Abela","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Vienna Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janette","family":"Koller\u2010Strametz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Division of Cardiology) Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Mittelb\u00f6ck","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Vienna Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Bergler\u2010Klein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Division of Cardiology) Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stefenelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Division of Cardiology) Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Woloszczuk","sequence":"additional","affiliation":[{"name":"Luawig Boltzmann Institute for Clinical Endocrinology University of Vienna Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Niederle","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Vienna Medical School W\u00e4hringer G\u00fcrtel 18\u201020 A\u20101090 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"60","article-title":"The state of health of patients previously operated on for primary hyperparathyroidism compared with randomized controls","volume":"74","author":"Ronni\u2010Sivula H.","year":"1985","journal-title":"Ann. 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