{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:19:41Z","timestamp":1771643981413,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have demonstrated the presence of epidermal growth factor receptors in human parathyroid tumors. However, there is little information on the effect of other peptide growth factors on parathyroid cell growth. We therefore studied the interaction of insulin\u2010like growth factor I (IGF\u2010I) with human parathyroid tumor cells. Parathyroid tissues were obtained from 24 patients with primary or secondary hyperparathyroidism. There were 15 solitary adenomas, 5 carcinomas, and 4 hyperplastic tissues. First, the binding of [<jats:sup>125<\/jats:sup>I]IGF\u2010I to the crude membrane fractions was studied by competitive inhibition with unlabeled IGF\u2010I. Second, isolated parathyroid cells were cultured with IGF\u2010I and examined for DNA synthesis. The IGF\u2010binding protein (IGFBP) content of tissue homogenates was determined by ligand blot analysis. The binding of [<jats:sup>125<\/jats:sup>I]IGF\u2010I to parathyroid membranes was dependent on time, temperature, and pH of the medium. Maximum binding was obtained after incubation for 18 hours at 4\u00b0C. Specific binding to parathyroid cancer membranes (mean\u00b1SE, 10.75\u00b110.55%\/mg protein) was significantly (<jats:italic>p<\/jats:italic>&lt;0.05) greater than that in adenoma tissues 3.71\u00b12.11%\/mg. The value in hyperplastic tissues (4.78\u00b12.97%\/mg) was not different from that in adenomas. Affinity cross\u2010linking and autoradiography demonstrated the type I IGF receptors. Cultured parathyroid cells responded to IGF\u2010I with increased DNA synthesis. The parathyroid tumor tissues expressed IGFBPs. These results suggest that IGF\u2010I and IGFBPs are involved in the growth regulation of parathyroid tumor cells.<\/jats:p>","DOI":"10.1007\/bf00353784","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T06:46:34Z","timestamp":1099205194000},"page":"635-641","source":"Crossref","is-referenced-by-count":16,"title":["Insulin\u2010like growth factor I receptors and insulin\u2010like growth factor\u2010binding proteins in human parathyroid tumors"],"prefix":"10.1002","volume":"18","author":[{"given":"Reiko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku 162 Tokyo Japan"},{"name":"Department of Surgery c\/oDr. Edwin Kaplan University of Chicago Medical Center MC 5031, 5841 South Maryland Avenue 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Department of Medicine Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Institute for Growth Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Shizume","sequence":"additional","affiliation":[{"name":"Institute for Growth Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women's Medical College 8\u20101\u00a0Kawada\u2010cho, Shinjuku 162 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605153142004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-1-149"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-8-4-391"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(86)90099-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199109000267"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90296-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-122-2-395"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-2-940"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-2-749"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90033-X"},{"key":"e_1_2_1_12_1","first-page":"2122","article-title":"Somatomedin\u2010C receptors and growth effects in human breast cells maintained in long\u2010term tissue culture","volume":"44","author":"Frulanetto R.W.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","first-page":"3716","article-title":"Evidence for autocrine mitogenic stimulation by somatomedin\u2010C\/insulin\u2010like growth factor\u2010I on an established human lung cancer cell line","volume":"48","author":"Minuto F.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-1-388"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-5-1175"},{"key":"e_1_2_1_16_1","first-page":"112","article-title":"Expression of insulin\u2010like growth factors in primary human thyroid neoplasms","volume":"121","author":"Yashiro T.","year":"1989","journal-title":"Acta Endocrinol. 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