{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:17:43Z","timestamp":1760782663987},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pfl\ufffdgers Arch"],"published-print":{"date-parts":[[1991,7]]},"DOI":"10.1007\/bf00370568","type":"journal-article","created":{"date-parts":[[2004,11,3]],"date-time":"2004-11-03T00:02:20Z","timestamp":1099440140000},"page":"538-543","source":"Crossref","is-referenced-by-count":39,"title":["Bile acids and their amidates inhibit 11?-hydroxysteroid dehydrogenase obtained from rat kidney"],"prefix":"10.1007","volume":"418","author":[{"given":"F. H.","family":"Perschel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"B\ufffdhler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hierholzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/cs0630065","volume":"63","author":"TC Bartholomew","year":"1982","unstructured":"Bartholomew TC, Summerfield JA, Billing BH, Lawson AM, Setchell KDR (1982) Bile acid profiles of human serum and skin interstitial fluid and their relationship to pruritus studies by gas chromatography-mass spectrometry. Clin Sci 63:65?73","journal-title":"Clin Sci"},{"key":"CR2","first-page":"374","volume":"19","author":"H B\u00fchler","year":"1990","unstructured":"B\u00fchler H, Kobayashi N, Lichtenstein I, Perschel FH, Siebe H, Hierholzer K (1990) Reversible inhibition of renal 11?-hydroxysteroid dehydrogenase (11?-HSD) by steroids, structure-function-relationship. Nieren-Hochdruckkr 19:374","journal-title":"Nieren-Hochdruckkr"},{"key":"CR3","unstructured":"Reference deleted"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0167-7306(08)60689-4","volume-title":"Sterols and bile acids","author":"MC Carey","year":"1985","unstructured":"Carey MC (1985) Physicochemical properties of bile acids and their salts. In: Danielsson H, Sj\u00f6vall J (eds) Sterols and bile acids. Elsevier, Amsterdam, pp 345?403"},{"key":"CR5","unstructured":"Edwards CRW, Stewart PM, Burt D, Brett L, McIntyre MA, Sutano WS, De Kloet ER, Monder C (1988) Localisation of 11?-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet:986?989"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1530\/acta.0.072S0010","volume":"173","author":"H Gerdes","year":"1973","unstructured":"Gerdes H, Riemenschneider H, Littmann KP (1973) Effect of bile acids and some biliary excreted drugs on the metabolism of cortisol. Acta Endocrinol [Suppl] 173:10","journal-title":"Acta Endocrinol [Suppl]"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/cs0600065","volume":"60","author":"IT Gilmore","year":"1981","unstructured":"Gilmore IT, Thompson RPH (1981) Direct measurement of hepatic extraction of bile acids in subjects with and without liver disease. Clin Sci 60:65?72","journal-title":"Clin Sci"},{"key":"CR8","first-page":"277","volume-title":"Liver and biliary disease: pathophysiology, diagnosis, management","author":"KW Heaton","year":"1985","unstructured":"Heaton KW (1985) Bile salts. In: Wright R, Millward-Sadler GH, Alberti KGMM, Karren S (eds) Liver and biliary disease: pathophysiology, diagnosis, management, 2nd edn. Bailliere Tindall, London, pp 277?299","edition":"2nd edn."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/978-3-642-68147-9_19","volume-title":"Renal transport of organic substances","author":"K Hierholzer","year":"1981","unstructured":"Hierholzer K, Tsiakiras D, Sch\u00f6nesh\u00f6fer M, Siebe H, Weskamp P (1981) Renal handling of hormones. In: Greger R, Lang F, Silbernagel S (eds) Renal transport of organic substances. Springer, Berlin Heidelberg New York, pp 278?289"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF01715842","volume":"60","author":"K Hierholzer","year":"1982","unstructured":"Hierholzer K, Lichtenstein I, Siebe H, Tsiakiras D, Witt T (1982) Renal metabolism of corticosteroid hormones. Klin Wochenschr 60:1127?1135","journal-title":"Klin Wochenschr"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF00587533","volume":"400","author":"K Hierholzer","year":"1984","unstructured":"Hierholzer K, Sch\u00f6nesh\u00f6fer M, Siebe H, Tsiakiras D, Weskamp P (1984) Corticosteroid metabolism in isolated rat kidney in vitro: I. Formation of lipid soluble metabolites from corticosterone in renal tissue. Pfl\u00fcgers Arch 400:363?371","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ki.1990.258","volume":"38","author":"K Hierholzer","year":"1990","unstructured":"Hierholzer K, Siebe H, Fromm M (1990) Inhibition of 11?-hydroxysteroid dehydrogenase and its effect on epithelial sodium transport. Kidney Int 38:673?678","journal-title":"Kidney Int"},{"key":"CR13","first-page":"67","volume-title":"The frontiers of nephrology","author":"K Hierholzer","year":"1990","unstructured":"Hierholzer K, Castello R, Kobayashi N, Fromm M (1990) Sites and significance of renal corticosteroid metabolism. In: Berliner RW, Honda N, Ullrich KJ (eds) The frontiers of nephrology. Excerpta Medica, Elsevier, Amsterdam New York Oxford, pp 67?76"},{"key":"CR14","first-page":"553","volume-title":"The liver: biology and pathobiology","author":"AF Hofmann","year":"1988","unstructured":"Hofmann AF (1988) Bile acids. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shafritz DA (eds) The liver: biology and pathobiology, 2nd edn. Raven, New York, pp 553?572","edition":"2nd edn."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0022-2275(20)34421-7","volume":"25","author":"AF Hofmann","year":"1984","unstructured":"Hofmann AF, Roda A (1984) Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem. J Lipid Res 25:1477?1489","journal-title":"J Lipid Res"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF00587535","volume":"400","author":"G-A Hoyer","year":"1984","unstructured":"Hoyer G-A, Tsiakiras D, Siebe H, Hierholzer K (1984) Corticosteroid metabolism in isolated rat kidney in vitro. III. Structure analysis of lipid soluble metabolites of corticosterone. Pfl\u00fcgers Arch 400:377?380","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0300-5089(21)00394-1","volume":"6","author":"NB Javitt","year":"1977","unstructured":"Javitt NB (1977) Diagnostic value of serum bile acids. Clin Gastroenterol 6:219?226","journal-title":"Clin Gastroenterol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00581839","volume":"408","author":"N Kobayashi","year":"1987","unstructured":"Kobayashi N, Schulz W, Hierholzer K (1987) Corticosteroid metabolism in rat kidney in vitro. IV. Subcellular sites of 11?-hydroxysteroid dehydrogenase activity. Pfl\u00fcgers Arch 408:45?63","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/endo-116-2-552","volume":"116","author":"V Lakshmi","year":"1985","unstructured":"Lakshmi V, Monder C (1985) Evidence for independent 11-oxidase and 11-reductase activities of 11?-hydroxysteroid dehydrogenase: enzyme latency, phase transitions, and lipid requirements. Endocrinology 116:552?560","journal-title":"Endocrinology"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF00582374","volume":"411","author":"D l'Allemand","year":"1988","unstructured":"l'Allemand D, Siebe H, Tsiakiras D, Hoyer G-A, Vecsei P, Hierholzer K (1988) Aldosterone metabolism in rat renal tissue in vitro. Formation of lipid soluble metabolites. Pfl\u00fcgers Arch 411:529?539","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1210\/endo-125-2-1046","volume":"125","author":"C Monder","year":"1989","unstructured":"Monder C, Stewart PM, Lakshmi V, Valentine R, Burt D, Edwards CRW (1989) Licorice inhibits corticosteroid 11?-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 125:1046?1053","journal-title":"Endocrinology"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.12.2.145","volume":"12","author":"G Neale","year":"1971","unstructured":"Neale G, Lewis B, Weaver V, Panveliwalla D (1971) Serum bile acids in liver disease. Gut 12:145?152","journal-title":"Gut"},{"key":"CR23","first-page":"406","volume":"19","author":"FH Perschel","year":"1990","unstructured":"Perschel FH, B\u00fchler H, Siebe H, Lichtenstein I, Hierholzer K (1990) Bile acids as endogenous inhibitors of 11?-hydroxysteroid dehydrogenase (11?-HSD). Nieren-Hochdruckkr 19:406","journal-title":"Nieren-Hochdruckkr"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF00587534","volume":"400","author":"H Siebe","year":"1984","unstructured":"Siebe H, Tsiakiras D, Hierholzer K (1984) Corticosteroid metabolism in isolated rat kidney in vitro. II. Sex dependancy and formation of 11-dehydro-corticosterone. Pfl\u00fcgers Arch 400:372?376","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0300-5089(21)00385-0","volume":"6","author":"A Stiehl","year":"1977","unstructured":"Stiehl A (1977) Disturbances of bile acid metabolism in cholestasis. Clin Gastroenterol 6:45?68","journal-title":"Clin Gastroenterol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1210\/jcem-49-5-757","volume":"49","author":"S Ulick","year":"1979","unstructured":"Ulick S, Levine LS, Gunczler P, Zanconato G, Ramirez LC, Rauh W, R\u00f6sler A, Bradlow HL, New MI (1979) A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 49:757?765","journal-title":"J Clin Endocrinol Metab"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0021-9673(01)87090-4","volume":"353","author":"HJ Wildgrube","year":"1986","unstructured":"Wildgrube HJ, Stockhausen H, Petri J, F\u00fcssel U, Lauer H (1986) Naturally occurring conjugated bile acids, measured by high-performance liquid chromatography, in human, dog, and rabbit bile. J Chromatogr 353:207?213","journal-title":"J Chromatogr"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1172\/JCI105664","volume":"46","author":"B Zumoff","year":"1967","unstructured":"Zumoff B, Bradlow HL, Gallagher TF, Hellman L (1967) Cortisol metabolism in cirrhosis. J Clin Invest 46:1735?1742","journal-title":"J Clin Invest"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/jcem-32-1-36","volume":"32","author":"B Zumoff","year":"1971","unstructured":"Zumoff B, Bradlow HL, Gallagher TF, Hellman L (1971) Cortisol metabolism in total extrahepatic biliary obstruction. J Clin Endocrinol 32:36?41","journal-title":"J Clin Endocrinol"}],"container-title":["Pfl\ufffdgers Archiv European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00370568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00370568\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00370568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T13:01:07Z","timestamp":1624798867000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00370568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["BF00370568"],"URL":"https:\/\/doi.org\/10.1007\/bf00370568","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}