{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:25Z","timestamp":1790154685366,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1991,10,1]],"date-time":"1991-10-01T00:00:00Z","timestamp":686275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[1991,10]]},"DOI":"10.1007\/bf00371777","type":"journal-article","created":{"date-parts":[[2004,11,3]],"date-time":"2004-11-03T01:01:54Z","timestamp":1099443714000},"page":"421-432","source":"Crossref","is-referenced-by-count":17,"title":["Keratohyalin granules are heterogeneous in ridged and non-ridged human skin: evidence from anti-filaggrin immunogold labelling of normal skin and skin of autosomal dominant ichthyosis vulgaris patients"],"prefix":"10.1007","volume":"283","author":[{"given":"S.","family":"G\ufffdnzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Weidenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hau\\er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Anton-Lamprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"433","volume":"13","author":"MH Allen","year":"1986","unstructured":"Allen MH, Tidman MJ, MacDonald DM (1986) Immunogold-silver staining in the localisation of cutaneous antigens. J Cutan Pathol 13:433","journal-title":"J Cutan Pathol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2133.1988.tb02565.x","volume":"118","author":"MH Allen","year":"1988","unstructured":"Allen MH, Tidman MJ, MacDonald DM (1988) Localization of cutaneous antigens by the immunogold-silver staining technique. Br J Dermatol 118:645?650","journal-title":"Br J Dermatol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00595631","volume":"248","author":"I Anton-Lamprecht","year":"1973","unstructured":"Anton-Lamprecht I (1973) Zur Ultrastruktur heredit\u00c4rer Verhornungsst\u00f6rungen. III. Autosomal-dominante Ichthyosis vulgaris. Arch Dermatol Forsch 248:149?172","journal-title":"Arch Dermatol Forsch"},{"key":"CR4","first-page":"192","volume":"7","author":"I Anton-Lamprecht","year":"1980","unstructured":"Anton-Lamprecht I (1980) Keratinization of the human sweat duct. J Cutan Pathol 7:192?193","journal-title":"J Cutan Pathol"},{"key":"CR5","first-page":"61","volume-title":"The epidermis in disease","author":"I Anton-Lamprecht","year":"1981","unstructured":"Anton-Lamprecht I (1981) Disturbances of tonofilament and keratohyalin structure and arrangement in inborn errors of keratinization. In: Marks R, Christophers E (eds) The epidermis in disease. MTP Press, Lancaster, pp 61?77"},{"key":"CR6","first-page":"430","volume-title":"Proceedings of the XVIth International Congress of Dermatology, 23?28 May, Tokyo","author":"I Anton-Lamprecht","year":"1982","unstructured":"Anton-Lamprecht I (1982) New aspects of inherited ichthyoses and acrokeratoses as obtained from electron microscopy. In: Kukita A, Sciji M (eds) Proceedings of the XVIth International Congress of Dermatology, 23?28 May, Tokyo. University of Tokyo Press, Tokyo, pp 430?434"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"149s","DOI":"10.1111\/1523-1747.ep12540961","volume":"81","author":"I Anton-Lamprecht","year":"1983","unstructured":"Anton-Lamprecht I (1983) Genetically induced abnormalities of epidermal differentiation and ultrastructure in ichthyoses and epidermolyses: pathogenesis, heterogeneity, fetal manifestation, and prenatal diagnosis. J Invest Dermatol 81:149s-156s","journal-title":"J Invest Dermatol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00561188","volume":"250","author":"I Anton-Lamprecht","year":"1974","unstructured":"Anton-Lamprecht I, Schnyder UW (1974) Ultrastructure of inborn errors of keratinization. VI. Inherited ichthyoses ? a model system for heterogeneities in keratinization disturbances. Arch Dermatol Forsch 250:207?227","journal-title":"Arch Dermatol Forsch"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00000372-198502000-00014","volume":"7","author":"BA Dale","year":"1985","unstructured":"Dale BA (1985) Filaggrin, the matrix protein of keratin. Am J Dermatopathol 7:65?68","journal-title":"Am J Dermatopathol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/1523-1747.ep12531715","volume":"72","author":"BA Dale","year":"1979","unstructured":"Dale BA, Ling SY (1979) Immunologie cross-reaction of stratum corneum basic protein and a keratohyalin granule protein. J Invest Dermatol 72:257?261","journal-title":"J Invest Dermatol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/1523-1747.ep12466185","volume":"88","author":"BA Dale","year":"1987","unstructured":"Dale BA, Gown AM, Fleckman P, Kimball JR, Resing KA (1987) Characterization of two monoclonal antibodies to human epidermal keratohyalin: reactivity with filaggrin and related proteins. J Invest Dermatol 88:306?313","journal-title":"J Invest Dermatol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00417327","volume":"279","author":"M Fartasch","year":"1987","unstructured":"Fartasch M, Haneke E, Anton-Lamprecht I (1987) Ultrastructural study of the occurrence of autosomal dominant ichthyosis vulgaris in atopic eczema. Arch Dermatol Res 279:270?272","journal-title":"Arch Dermatol Res"},{"key":"CR13","first-page":"143","volume":"144","author":"M Fartasch","year":"1989","unstructured":"Fartasch M, Diepgen TL, Hornstein OP (1989) Are hyperlinear palms and dry skin signs of a concomitant autosomal dominant ichthyosis vulgaris in atopic dermatitis? Acta Derm Venereol (Stockh) [Suppl] 144:143?145","journal-title":"Acta Derm Venereol (Stockh) [Suppl]"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1083\/jcb.40.3.830","volume":"40","author":"K Fukuyama","year":"1969","unstructured":"Fukuyama K, Epstein WL (1969) Sulfur-containing proteins and epidermal keratinization. J Cell Biol 40:830?838","journal-title":"J Cell Biol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-5320(72)90081-0","volume":"38","author":"K Fukuyama","year":"1972","unstructured":"Fukuyama K, Wier KA, Epstein WL (1972) Dense homogeneous deposits of keratohyaline granules in newborn rat epidermis. J Ultrastruct Res 38:16?26","journal-title":"J Ultrastruct Res"},{"key":"CR16","first-page":"185","volume":"1","author":"LA Goldsmith","year":"1976","unstructured":"Goldsmith LA (1976) The ichthyoses. Prog Med Genet 1:185?210","journal-title":"Prog Med Genet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1016\/S0021-9258(18)67118-2","volume":"261","author":"PV Haydok","year":"1986","unstructured":"Haydok PV, Dale BA (1986) The repetitive structure of the profilaggrin gene as demonstrated using epidermal profilaggrin cDNA. J Biol Chem 261:12520?12525","journal-title":"J Biol Chem"},{"key":"CR18","first-page":"299","volume":"41","author":"D Hohl","year":"1990","unstructured":"Hohl D (1990) Ein neuer Stern am Himmel der epidermalen Proteine: Loricrin ? was ist das? Hautarzt 41:299?301","journal-title":"Hautarzt"},{"key":"CR19","first-page":"445","volume":"92","author":"D Hohl","year":"1989","unstructured":"Hohl D, Mehrel T, Lichti U, Yuspa S, Roop D, Steinert P (1989) Loricrin ? the human glycine-rich cornified envelope precursor ? isolation and characterization of a cDNA clone encoding a major component of the human cornified envelope. J Invest Dermatol 92:445","journal-title":"J Invest Dermatol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/31.7.6189883","volume":"31","author":"CS Holgate","year":"1983","unstructured":"Holgate CS, Jackson P, Cown PN, Bird CC (1983) Immunogold-silver staining: new method of immunostaining with inhanced sensitivity. J Histochem Cytochem 31:938?944","journal-title":"J Histochem Cytochem"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1073\/pnas.56.2.594","volume":"56","author":"JK Hoober","year":"1966","unstructured":"Hoober JK, Bernstein IA (1966) Protein synthesis related to epidermal differentiation. Proc Natl Acad Sci USA 56:594?601","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-5320(70)90120-6","volume":"33","author":"H Jessen","year":"1970","unstructured":"Jessen H (1970) Two types of keratohyaline granules. J Ultrastruct Res 33:95?115","journal-title":"J Ultrastruct Res"},{"key":"CR23","volume-title":"Thesis","author":"I Kastl","year":"1989","unstructured":"Kastl I (1989) Zur normalen und pathologischen Keratinisierung der Leistenhaut (Palmae und Plantae). Charakterisierung und Abgrenzung einer neuen Palmoplantarkeratose mit autosomal-rezessivem Erbgang. Thesis, Faculty of Clinical Medicine, University of Heidelberg, FRG"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00493461","volume":"282","author":"I Kastl","year":"1990","unstructured":"Kastl I, Anton-Lamprecht I (1990) Bicomponent keratohyalin in normal kuman ridged skin. Arch Dermatol Res 282:71?75","journal-title":"Arch Dermatol Res"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF00509238","volume":"277","author":"R Laurent","year":"1985","unstructured":"Laurent R, Prost O, Nicollier M, Coumes Marquet S, Balzer MM, Adessi G (1985) Composite keratohyaline granules in palmoplantar keratoderma: an ultrastructural study. Arch Dermatol Res 277:384?394","journal-title":"Arch Dermatol Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1021\/bi00266a033","volume":"21","author":"JD Lonsdale-Eccles","year":"1982","unstructured":"Lonsdale-Eccles JD, Teller DC, Dale BA (1982) Characterization of a phosphorylated form of the intermediate filament-aggregating protein filaggrin. Biochemistry 21:5940?5948","journal-title":"Biochemistry"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1021\/bi00301a034","volume":"23","author":"JD Lonsdale-Eccles","year":"1984","unstructured":"Lonsdale-Eccles JD, Resing KA, Meek RL, Dale BA (1984) High-molecular-weight precursor of epidermal filaggrin and hypothesis for its tandem repeating structure. Biochemistry 23:1239?1245","journal-title":"Biochemistry"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0167-4838(83)90336-9","volume":"744","author":"AM Lynley","year":"1983","unstructured":"Lynley AM, Dale BA (1983) The characterization of human epidermal filaggrin, a histidine-rich, keratin filament-aggregating protein. Biochim Biophys Acta 744:28?35","journal-title":"Biochim Biophys Acta"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/jid.1966.19","volume":"46","author":"AG Matoltsy","year":"1966","unstructured":"Matoltsy AG, Matoltsy MN (1966) The membrane protein of horny cells. J Invest Dermatol 46:127?129","journal-title":"J Invest Dermatol"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.47.3.593","volume":"47","author":"AG Matoltsy","year":"1970","unstructured":"Matoltsy AG, Matoltsy MN (1970) The chemical nature of keratohyaline granules of the epidermis. J Cell Biol 47:593?603","journal-title":"J Cell Biol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/1523-1747.ep12701661","volume":"62","author":"AG Matoltsy","year":"1974","unstructured":"Matoltsy AG, Lavker RM, Matoltsy MN (1974) Demonstration of cystine-containing protein in keratohyalin granules of the epidermis. J Invest Dermatol 62:406?410","journal-title":"J Invest Dermatol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1073\/pnas.86.13.4848","volume":"86","author":"LJ McKinley Grant","year":"1989","unstructured":"McKinley Grant LJ, Idler WW, Bernstein IA, Parry DA, Cannizzaro L, Croce CM, Huebner K, Lessin SR, Steinert PM (1989) Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. Proc Natl Acad Sci USA 86:4848?4852","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1021\/bi00290a001","volume":"22","author":"RL Meek","year":"1983","unstructured":"Meek RL, Lonsdale-Eccles JD, Dale BA (1983) Epidermal filaggrin is synthesized on a large messenger ribonucleic acid as a high molecular weight precursor. Biochemistry 22:4867?4871","journal-title":"Biochemistry"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0092-8674(90)90073-N","volume":"61","author":"T Mehrel","year":"1990","unstructured":"Mehrel T, Hohl D, Rothnagel JA, Longley MA, Bundman D, Cheng C, Lichti U, Bisher ME, Steven AC, Steinert PM, Yuspa SH, Roop DR (1990) Identification of a major keratinocyte cell envelope protein, loricrin. Cell 61:1103?1112","journal-title":"Cell"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/37.5.2539408","volume":"37","author":"J Ohno","year":"1989","unstructured":"Ohno J, Fukuyama K, Hara A, Epstein WL (1989) Immuno- and enzyme-histochemical detection of phosphqprotein phosphatase in rat epidermis. J Histochem Cytochem 37:629?634","journal-title":"J Histochem Cytochem"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1083\/jcb.53.1.234","volume":"53","author":"C Peracchia","year":"1972","unstructured":"Peracchia C, Mittler BS (1972) Fixation by means of glutaraldehyde-hydrogen peroxide reaction products. J Cell Biol 53:234?238","journal-title":"J Cell Biol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1083\/jcb.99.4.1372","volume":"99","author":"KA Resing","year":"1984","unstructured":"Resing KA, Walsh KA, Dale BA (1984) Identification of two intermediates during processing of profilaggrin in neonatal mouse epidermis. J Cell Biol 99:1372?1378","journal-title":"J Cell Biol"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/S0021-9258(18)94264-X","volume":"264","author":"KA Resing","year":"1989","unstructured":"Resing KA, Walsh KA, Haugen-Schofield J, Dale BA (1989) Identification of proteolytic cleavage sites in the conversion of profilaggrin in mammalian epidermis. J Biol Chem 264:1837?1845","journal-title":"J Biol Chem"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","volume":"17","author":"ES Reynolds","year":"1963","unstructured":"Reynolds ES (1963) The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J Cell Biol 17:208?212","journal-title":"J Cell Biol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"15643","DOI":"10.1016\/S0021-9258(18)47775-7","volume":"262","author":"JA Rothnagel","year":"1987","unstructured":"Rothnagel JA, Mehrel T, Idler WW, Roop DR, Steinert PM (1987) The gene for mouse epidermal filaggrin precursor. J Biol Chem 262:15643?15648","journal-title":"J Biol Chem"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0012-1606(86)90230-7","volume":"115","author":"IR Scott","year":"1986","unstructured":"Scott IR, Harding CR (1986) Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 115:84?92","journal-title":"Dev Biol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0304-4165(82)90314-2","volume":"719","author":"IR Scott","year":"1982","unstructured":"Scott IR, Harding CR, Barrett JG (1982) Histidine-rich protein of the keratohyaline granules ? source of the free amino acids, urocanic acid and pyrrolidone carboxylic acid in the stratum corneum. Biochim Biophys Acta 719:110?117","journal-title":"Biochim Biophys Acta"},{"key":"CR43","unstructured":"Steven AC, Bisher ME, Roop DR, Steinert PM (1989) Biosynthetic pathways of filaggrin and loricrin elucidated by immunolabelling of newborn mouse epidermis. J Cell Biol 109:258a"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/1523-1747.ep12264813","volume":"84","author":"VP Sybert","year":"1985","unstructured":"Sybert VP, Dale BA, Holbrook KA (1985) Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules. J Invest Dermatol 84:191?194","journal-title":"J Invest Dermatol"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1346-8138.1986.tb02969.x","volume":"13","author":"T Tezuka","year":"1986","unstructured":"Tezuka T, Takahashi M (1986) A novel protein of rat epidermis ? haematoxylin stain-positive protein of keratohyaline granules as the membrane lining protein of the stratum corneum. J Dermatol (Tokyo) 13:417?425","journal-title":"J Dermatol (Tokyo)"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1126\/science.166.3902.250","volume":"166","author":"AR Ugel","year":"1969","unstructured":"Ugel AR (1969) Keratohyalin: extraction and in vitro aggregation. Science 166:250?251","journal-title":"Science"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/33.2.2578499","volume":"33","author":"MJ Warhol","year":"1985","unstructured":"Warhol MJ, Roth J, Lucocq JM, Pinkus GS, Rice RH (1985) Immuno-ultrastructural localization of involucrin in squamous epithelium and cultured keratinocytes. J Histochem Cytochem 33:141?149","journal-title":"J Histochem Cytochem"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archderm.1965.01600130007001","volume":"92","author":"RS Wells","year":"1965","unstructured":"Wells RS, Kerr CB (1965) Genetic classification of ichthyosis. Arch Dermatol 92:1?6","journal-title":"Arch Dermatol"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1525-1470.1983.tb01087.x","volume":"1","author":"ML Williams","year":"1983","unstructured":"Williams ML (1983) The ichthyoses ? pathogenesis and prenatal diagnosis: a review of recent advances. Pediatr Dermatol 1:1?24","journal-title":"Pediatr Dermatol"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1073\/pnas.81.1.238","volume":"81","author":"JG Zettergren","year":"1984","unstructured":"Zettergren JG, Peterson LL, Wuepper KD (1984) Keratolinin: the soluble substrate of epidermal transglutaminase from human and bovine tissue. Proc Natl Acad Sci USA 81:238?242","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00371777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00371777\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00371777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T13:19:19Z","timestamp":1624799959000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00371777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["BF00371777"],"URL":"https:\/\/doi.org\/10.1007\/bf00371777","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}