{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:50:35Z","timestamp":1791035435659,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pfl\ufffdgers Arch"],"published-print":{"date-parts":[[1995,7]]},"DOI":"10.1007\/bf00373908","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T11:20:59Z","timestamp":1099653659000},"page":"340-347","source":"Crossref","is-referenced-by-count":74,"title":["On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation"],"prefix":"10.1007","volume":"430","author":[{"given":"Xiangang","family":"Zong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\ufffdrgen","family":"Schreieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Mehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andera","family":"Welling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Flockerzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0014-5793(90)81205-3","volume":"269","author":"M Biel","year":"1990","unstructured":"Biel M, Ruth P, Bosse E, Hullin R, St\u00fchmer W, Flockerzi V, Hofmann F (1990) Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett 269:409?412","journal-title":"FEBS Lett"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1432-1033.1991.tb21051.x","volume":"200","author":"M Biel","year":"1991","unstructured":"Biel M, Hullin R, Freundner S, Singer D, Dascal N, Flockerzi V, Hofmann F (1991) Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels. Eur J Biochem 200:81?88","journal-title":"Eur J Biochem"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/j.1460-2075.1992.tb05260.x","volume":"11","author":"E Bosse","year":"1992","unstructured":"Bosse E, Bottlender R, Kleppisch T, Hescheler J, Welling A, Hofmann F, Flockerzi V (1992) Stable and functional expression of the calcium channel ?1 subunit from smooth muscle in somatic cell lines. EMBO J 11:2033?2038","journal-title":"EMBO J"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00370785","volume":"419","author":"A Cavali\u00e9","year":"1991","unstructured":"Cavali\u00e9 A, Allen TJA, Trautwein W (1991) Role of the GTP-binding protein Gs in the ?-adrenergic modulation of cardiac Ca channels. Pfl\u00fcgers Arch 419:433?443","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"18929","DOI":"10.1016\/S0021-9258(18)37371-X","volume":"263","author":"CF Chang","year":"1988","unstructured":"Chang CF, Hosey MM (1988) Dihydropyridine and phenyl-alkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different. J Biol Chem 263:18929?18937","journal-title":"J Biol Chem"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0014-4827(91)90398-E","volume":"195","author":"A Fernandez","year":"1991","unstructured":"Fernandez A, Mery J, Vandromme M, Basset M, Cavadore J-C, Lamb NJC (1991) Effective intracellular inhibition of the cAMP-dependent protein kinase by microinjection of a modified form of the specific inhibitor peptide PKI in living fibroblasts. Exp Cell Res 195:468?477","journal-title":"Exp Cell Res"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1113\/jphysiol.1993.sp019948","volume":"472","author":"AM Frace","year":"1993","unstructured":"Frace AM, Hartzell HC (1993) Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytes. J Physiol (Lond) 472:305?326","journal-title":"J Physiol (Lond)"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(93)80733-B","volume":"335","author":"H Haase","year":"1993","unstructured":"Haase H, Karczewski P, Beckert R, Krause EG (1993) Phosphorylation of the L-type calcium channel ? subunit is involved in ?-adrenergic signal transduction in canine myocardium. FEBS Lett 335:217?222","journal-title":"FEBS Lett"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0165-6147(92)90117-O","volume":"13","author":"HC Hartzell","year":"1992","unstructured":"Hartzell HC, Fischmeister R (1992) Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary ? Trends Pharmacol Sci 13:380?385","journal-title":"Trends Pharmacol Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"19451","DOI":"10.1016\/S0021-9258(19)36536-6","volume":"268","author":"JW Hell","year":"1993","unstructured":"Hell JW, Yokoyama CT, Wong ST, Warner C, Snutch TP, Catterall WA (1993) Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel ?1, subunit. J Biol Chem 268:19451?19457","journal-title":"J Biol Chem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.ne.17.030194.002151","volume":"17","author":"F Hofmann","year":"1994","unstructured":"Hofmann F, Biel M, Flockerzi V (1994) Molecular basis for Ca2+channel diversity. Annu Rev Neurosci 17: 399?418","journal-title":"Annu Rev Neurosci"},{"key":"CR12","first-page":"369","volume-title":"Ion channels in the cardiovascular system","author":"F Hofmann","year":"1994","unstructured":"Hofmann F, Biel M, Bosse E, Flockerzi V, Ruth P, Welling A (1994) Functional expression of cardiac and smooth muscle calcium channels. In: Sponer PM, Brown AM, Catterall WA, Kaczorowski GJ, Strauss HC (eds) Ion channels in the cardiovascular system. Futura, Armonk, New York, pp 369?381"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/j.1460-2075.1992.tb05126.x","volume":"11","author":"R Hullin","year":"1992","unstructured":"Hullin R, Singer-Lahat D, Freichel M, Biel M, Dascal N, Hofmann F, Flockerzi V (1992) Calcium channel ? subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J 11:885?890","journal-title":"EMBO J"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/1050-1738(93)90036-6","volume":"3","author":"R Hullin","year":"1993","unstructured":"Hullin R, Biel M, Flockerzi V, Hofmann F (1993) Tissue-specific expression of calcium channels. Trends Cardiovasc Med 3: 48?53","journal-title":"Trends Cardiovasc Med"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF00582573","volume":"405","author":"M Kameyama","year":"1985","unstructured":"Kameyama M, Hofmann F, Trautwein W (1985) On the mechanism of ?-adrenergic regulation of the Ca channel on the guinea-pig heart. Pfl\u00fcgers Arch 405:285?293","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR16","first-page":"9.0.5","volume-title":"Current protocols in molecular biology, vol 1","author":"RE Kingston","year":"1994","unstructured":"Kingston RE (1994) Introduction of DNA in to mammalian cells. In: Ausubel FM, Brent R, Kingston R, Moore DD, Seidmann JG, Smith JA, Struhl K (eds) Current protocols in molecular biology, vol 1. Greene and Wiley Interscience, New York, pp 9.0.5?9.1.9"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/j.1460-2075.1994.tb06538.x","volume":"13","author":"T Kleppisch","year":"1994","unstructured":"Kleppisch T, Pedersen K, Str\u00fcbing C, Bosse-Doenecke E, Flockerzi V, Hofmann F, Hescheler J (1994) Double-pulse facilitation of smooth muscle ?1-subunit Ca2+ channels expressed in CHO cells. EMBO J 13:2502?2507","journal-title":"EMBO J"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00374479","volume":"420","author":"U Kl\u00f6ckner","year":"1992","unstructured":"Kl\u00f6ckner U, Itagaki K, Bodi I, Schwartz A (1992) ?-Subunit expression is required for cAMP-dependent increase of cloned cardiac and vascular calcium channel currents. Pfl\u00fcgers Arch 420:413?415","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR19","first-page":"R40","volume":"349","author":"A Ludwig","year":"1994","unstructured":"Ludwig A, Bosse E, Brandt W, Flockerzi V, Hofmann F (1994) Production of specific antibodies against the ?2 and ?3 subunit of the high voltage activated calcium channel. Naunyn-Schmiedebergs Arch Pharmacol 349:R40","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/340230a0","volume":"340","author":"A Mikami","year":"1989","unstructured":"Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S (1989) Primary struture and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340:230?233","journal-title":"Nature"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.1992.sp019286","volume":"454","author":"K Ono","year":"1992","unstructured":"Ono K, Fozzard HA (1992) Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells. J Physiol (Lond) 454:673?688","journal-title":"J Physiol (Lond)"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/jphysiol.1993.sp019848","volume":"470","author":"K Ono","year":"1993","unstructured":"Ono K, Fozzard HA (1993) Two phosphatase sites on the Ca2+ channel affecting different kinetic functions. J Physiol (Lond) 470:73?84","journal-title":"J Physiol (Lond)"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/298576a0","volume":"298","author":"W Osterrieder","year":"1982","unstructured":"Osterrieder W, Brum G, Hescheler J, Trautwein W, Flockerzi V, Hofmann F (1982) Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current. Nature 298:576?578","journal-title":"Nature"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-5793(94)80484-2","volume":"342","author":"E Perez-Reyes","year":"1994","unstructured":"Perez-Reyes E, Yuan W, Wei X, Bers DM (1994) Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase. FEBS Lett 342:119?123","journal-title":"FEBS Lett"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.1974.sp010716","volume":"242","author":"H Reuter","year":"1974","unstructured":"Reuter H (1974) Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle. J Physiol (Lond) 242:429?451","journal-title":"J Physiol (Lond)"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1432-1033.1988.tb14107.x","volume":"174","author":"T Schneider","year":"1988","unstructured":"Schneider T, Hofmann F (1988) The bovine cardiac receptor for calcium channel blockers is a 195-kDa protein. Eur J Biochem 174:369?375","journal-title":"Eur J Biochem"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1073\/pnas.90.21.10135","volume":"90","author":"A Sculptoreanu","year":"1993","unstructured":"Sculptoreanu A, Rotman E, Takahashi M, Scheuer T, Catterall WA (1993) Voltage-dependent potentiation of the activity of cardiac L-type calcium channel ?1, subunits due to phosphorylation by cAMP-dependent protein kinse. Proc Natl Acad Sci USA 90:10135?10139","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1716787","volume":"253","author":"D Singer","year":"1991","unstructured":"Singer D, Biel M, Lotan I, Flockerzi V, Hofmann F, Dascal N (1991) The roles of the subunits in the function of the calcium channel. Science 253:1553?1557","journal-title":"Science"},{"key":"CR29","first-page":"215","volume":"2","author":"D Singer-Lahat","year":"1994","unstructured":"Singer-Lahat D, Lotan I, Biel M, Flockerzi V, Hofmann F, Dascal N (1994) Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation. Receptors Channels 2:215?226","journal-title":"Receptors Channels"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.ph.52.030190.001353","volume":"52","author":"W Trautwein","year":"1990","unstructured":"Trautwein W, Hescheler J (1990) Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annu Rev Physiol 52:257?274","journal-title":"Annu Rev Physiol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1113\/jphysiol.1993.sp019926","volume":"471","author":"A Welling","year":"1993","unstructured":"Welling A, Bosse E, Cavali\u00e8 A, Bottlender R, Ludwig A, Nastainczyk W, Flockerzi V, Hofmann F (1993) Stable co-expression of calcium channel ?1, ? and ?2\/? subunits in a somatic cell line. J Physiol (Lond) 471:749?765","journal-title":"J Physiol (Lond)"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.RES.73.5.974","volume":"73","author":"A Welling","year":"1993","unstructured":"Welling A, Kwan YW, Bosse E, Flockerzi V, Hofmann F, Kass RS (1993) Subunit-dependent modulation of recombinant L-type calcium channels: molecular basis for dihydropyridine tissue selectivity. Circ Res 73:974?980","journal-title":"Circ Res"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/01.RES.66.1.241","volume":"66","author":"DJ Williford","year":"1990","unstructured":"Williford DJ, Sharma VK, Korth M, Sheu SS (1990) Spatial heterogeneity of intracellular Ca2+ concentration in nonbeating guinea pig ventricular myocytes. Circ Res 66:234?241","journal-title":"Circ Res"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.2544999","volume":"245","author":"A Yatani","year":"1989","unstructured":"Yatani A, Brown AM (1989) Rapid ?-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. Science 245:71?74","journal-title":"Science"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0014-5793(92)80804-P","volume":"309","author":"A Yoshida","year":"1992","unstructured":"Yoshida A, Takahashi M, Nishimura S, Takeshima H, Kokubun S (1992) Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel. FEBS Lett 309:343?349","journal-title":"FEBS Lett"}],"container-title":["Pfl\ufffdgers Archiv European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00373908.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00373908\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00373908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T17:53:30Z","timestamp":1624816410000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00373908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["BF00373908"],"URL":"https:\/\/doi.org\/10.1007\/bf00373908","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}