{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:01:40Z","timestamp":1760644900933},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[1992,7]]},"DOI":"10.1007\/bf00384730","type":"journal-article","created":{"date-parts":[[2004,11,7]],"date-time":"2004-11-07T13:54:39Z","timestamp":1099835679000},"page":"99-106","source":"Crossref","is-referenced-by-count":33,"title":["Immunocytochemical localization of muscarinic acetylcholine receptors in the rat endocrine pancreas"],"prefix":"10.1007","volume":"269","author":[{"given":"E. A.","family":"Van der Zee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Buwalda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Strubbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Strosberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G. M.","family":"Luiten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/BF00870137","volume":"29","author":"B Ahren","year":"1986","unstructured":"Ahren B, Taborsky GJ Jr, Porte D Jr (1986) Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion. Diabetologia 29: 827?836","journal-title":"Diabetologia"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/j.1460-2075.1983.tb01453.x","volume":"2","author":"C Andr\u00e9","year":"1983","unstructured":"Andr\u00e9 C, De Backer JP, Guillet JC, Vanderheyden P, Vauquelin G, Strosberg AD (1983) Purification of muscarinic acetylcholine receptors by affinity chromatography. EMBO J 2: 499?504","journal-title":"EMBO J"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/j.1460-2075.1984.tb01755.x","volume":"3","author":"C Andr\u00e9","year":"1984","unstructured":"Andr\u00e9 C, Guillet JG, De Backer JP, Vanderheyden P, Hoebeke J, Strosberg AD (1984) Monoclonal antibodies against the native or denatured forms of muscarinic acetylcholine receptors. EMBO J 3: 17?21","journal-title":"EMBO J"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/10799898709054981","volume":"7","author":"C Andr\u00e9","year":"1987","unstructured":"Andr\u00e9 C, Marullo S, Guillet JG, Convents A, Lauwereys M, Kaveri S, Hoebeke J, Strosberg AD (1987) Immunochemical studies of the muscarinic acetylcholine receptor. J Recept Res 7: 89?103","journal-title":"J Recept Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/BF00210454","volume":"220","author":"HE Appert","year":"1981","unstructured":"Appert HE, Chiu TH, Budd GC, Leonardi AJ, Howard JM (1981) Tritium-labeled methylscopolamine binding to dispersed pancreatic acini. Cell Tissue Res 220: 673?684","journal-title":"Cell Tissue Res"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000123239","volume":"33","author":"A Arimura","year":"1981","unstructured":"Arimura A, Fishback JB (1981) Somatostatin: regulation of secretion. Prog Neuroendocrinol 33: 246?256","journal-title":"Prog Neuroendocrinol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.3037705","volume":"237","author":"TI Bonner","year":"1987","unstructured":"Bonner TI, Buckley NJ, Young AC, Brann MR (1987) Identification of a family of muscarinic acetylcholine receptor genes. Science 237: 527?532","journal-title":"Science"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/diab.37.5.616","volume":"37","author":"S Bonner-Weir","year":"1988","unstructured":"Bonner-Weir S (1988) Morphological evidence for pancreatic polarity of B cell within the islets of Langerhans. Diabetes 37: 616?621","journal-title":"Diabetes"},{"key":"CR9","first-page":"15","volume-title":"The endocrine pancreas","author":"S Bonner-Weir","year":"1991","unstructured":"Bonner-Weir S (1991) Anatomy of the islet of Langerhans. In: Samois E (ed) The endocrine pancreas. Raven Press, New York, pp 15?27"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-4159.1985.tb04030.x","volume":"45","author":"G Bruce","year":"1985","unstructured":"Bruce G, Wainer BH, Hersh LB (1985) Immunoaffinity purification of human choline acetyltransferase: comparison of the brain and placental enzymes. J Neurochem 45: 611?620","journal-title":"J Neurochem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1523\/JNEUROSCI.08-12-04646.1988","volume":"8","author":"NJ Buckley","year":"1988","unstructured":"Buckley NJ, Bonner TI, Brann MR (1988) Localization of a family of muscarinic receptor mRNAs in rat brain. J Neurosci 8: 4646?4652","journal-title":"J Neurosci"},{"key":"CR12","first-page":"143","volume":"92","author":"RE Coupland","year":"1958","unstructured":"Coupland RE (1958) The innervation of pancreas of the rat, cat and rabbit as revealed by the cholinesterase technique. J Anat 92: 143?149","journal-title":"J Anat"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1523\/JNEUROSCI.03-11-02286.1983","volume":"3","author":"F Eckenstein","year":"1983","unstructured":"Eckenstein F, Sofroniew MV (1983) Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase. J Neurosci 3: 2286?2291","journal-title":"J Neurosci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF01235634","volume":"8","author":"U Fischer","year":"1972","unstructured":"Fischer U, Hommel H, Ziegler M, Michael R (1972) The mechanism of insulin secretion after oral glucose administration. Diabetologia 8: 104?110","journal-title":"Diabetologia"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/BF00400270","volume":"34","author":"WM Fritschy","year":"1991","unstructured":"Fritschy WM, Strubbe JH, Wolters GHJ, Schilfgaarde R van (1991) Glucose tolerance and plasma insulin response to intravenous glucose infusion and test meal in rats with microencapsulated islet allografts. Diabetologia 34: 542?547","journal-title":"Diabetologia"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2337\/diab.16.7.443","volume":"16","author":"LA Frohman","year":"1967","unstructured":"Frohman LA, Ezdinli EZ, Javid R (1967) Effect of vagotomy and vagal stimulation on insulin release. Diabetes 16: 443?448","journal-title":"Diabetes"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/23.9.126256","volume":"23","author":"DA Godfrey","year":"1975","unstructured":"Godfrey DA, Matschinsky FM (1975) Enzymes of the cholinergic system in islets of Langerhans. J Histochem Cytochem 23: 645?651","journal-title":"J Histochem Cytochem"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0304-4165(83)90087-9","volume":"756","author":"V Grill","year":"1983","unstructured":"Grill V, \u00d6stenson C-G (1983) Muscarinic receptors in pancreatic islets of the rat. Demonstration and dependence on long-term glucose environment. Biochim Biophys Acta 756: 159?162","journal-title":"Biochim Biophys Acta"},{"key":"CR19","first-page":"59","volume-title":"Neurotransmitter interactions in the basal ganglia","author":"E Hamel","year":"1987","unstructured":"Hamel E, Beaudet A (1987) Ulrastructural distribution of muopioid receptors in rat neostriatum. In: Sandler M (ed) Neurotransmitter interactions in the basal ganglia. Raven Press, New York, pp 59?69"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/33.2.2578498","volume":"33","author":"JC Hedreen","year":"1985","unstructured":"Hedreen JC, Bacon SJ, Price DL (1985) A modified histochemical technique to visualize acetylcholinesterase-containing axons. J Histochem Cytochem 33: 134?140","journal-title":"J Histochem Cytochem"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-5793(88)80290-4","volume":"236","author":"J-C Henquin","year":"1988","unstructured":"Henquin J-C, Nenquin M (1988) The muscarinic receptor subtype in mouse pancreatic B cells. FEBS Lett 236: 89?92","journal-title":"FEBS Lett"},{"key":"CR22","first-page":"492","volume":"19","author":"K Hermansen","year":"1980","unstructured":"Hermansen K (1980) Secretion of somatostatin from the normal and diabetic pancreas. Studies in vitro. Diabetologia 19: 492?497","journal-title":"Diabetologia"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1210\/endo-107-4-1065","volume":"107","author":"RN Honey","year":"1980","unstructured":"Honey RN, Weir GC (1980) Acetylcholine stimulates insulin, glucagon, and somatostatin release in the perfused chicken pancreas. Endocrinology 107: 1065?1068","journal-title":"Endocrinology"},{"key":"CR24","first-page":"118","volume":"240","author":"M Korc","year":"1987","unstructured":"Korc M, Ackerman MS, Roeske WRA (1987) Cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini. J Pharmacol Exp Ther 240: 118?122","journal-title":"J Pharmacol Exp Ther"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(81)91274-9","volume":"216","author":"MJ Kuhar","year":"1981","unstructured":"Kuhar MJ, Taylor N, Wamsley JK, Hulme EC, Birdsall NJM (1981) Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography. Brain Res 216: 1?9","journal-title":"Brain Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1073\/pnas.81.14.4331","volume":"81","author":"D Leiber","year":"1984","unstructured":"Leiber D, Harbon S, Guillet JG, Andr\u00e9 C, Strosberg AD (1984) Monoclonal antibodies to purified muscarinic receptor display agonist-like activity. Proc Natl Acad Sci USA 81: 4331?4334","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0306-4522(84)90234-3","volume":"2","author":"AI Levey","year":"1984","unstructured":"Levey AI, Wainer BH, Rye DB, Mufson EJ, Mesulam M-M (1984) Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons. Neurosci 2: 341?353","journal-title":"Neurosci"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-1838(86)90077-9","volume":"15","author":"PGM Luiten","year":"1986","unstructured":"Luiten PGM, Ter Horst GJ, Buijs RM, Steffens AB (1986) Autonomic innervation of the pancreas in diabetic and non-diabetic rats. A new view on intramural sympathetic structural organization. J Auton Nerv Systems 15: 33?44","journal-title":"J Auton Nerv Systems"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1210\/edrv-2-4-471","volume":"2","author":"RE Miller","year":"1981","unstructured":"Miller RE (1981) Pancreatic neuroendocrinology: peripheral neuroal mechanisms in the regulation of the islets of Langerhans. Endocr Rev 2: 471?494","journal-title":"Endocr Rev"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-187820-7.50007-3","volume-title":"The islets of Langerhans","author":"BL Munger","year":"1981","unstructured":"Munger BL (1981) Morphological characterization of islet cell diversity. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 3?34"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000137262","volume":"18","author":"KH Ng","year":"1979","unstructured":"Ng KH, Morrisset J, Poireir GG (1979) Muscarinic receptors of the pancreas: a correlation between displacement of 3H quinuclinidyl benzilate binding and amylase secretion. Pharmacology 18: 263?270","journal-title":"Pharmacology"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1210\/endo-116-5-1741","volume":"116","author":"C-G \u00d6stenson","year":"1985","unstructured":"\u00d6stenson C-G, Grill V (1985) Glucose exerts opposite effects on muscarinic receptor binding to A and B cells of the endocrine pancreas. Endocrinology 116: 1741?1744","journal-title":"Endocrinology"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1210\/endo-121-5-1705","volume":"121","author":"C-G \u00d6stenson","year":"1987","unstructured":"\u00d6stenson C-G, Grill V (1987) Evidence that hyperglycemia increases muscarinic binding in pancreatic islets of the rat. Endocrinology 121: 1705?1710","journal-title":"Endocrinology"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(75)92078-4","volume":"II","author":"L Orci","year":"1975","unstructured":"Orci L, Unger RH (1975) Functional subdivision of islets of Langerhans and possible role of D cells. Lancet II: 1243?1247","journal-title":"Lancet"},{"key":"CR35","first-page":"115","volume":"55","author":"AGE Pearse","year":"1977","unstructured":"Pearse AGE (1977) The diffuse neuroendocrine system and the APUD concept: related ?endocrine? peptides in brain, intestine, pituitary, placenta, and cutaneous glands. Med Biol 55: 115?125","journal-title":"Med Biol"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"229s","DOI":"10.1111\/j.1365-2265.1976.tb03832.x","volume":"5","author":"AGE Pearse","year":"1976","unstructured":"Pearse AGE, Takor Takor T (1976) Neuroendocrine embryology and the APUD concept. Clin Endocrinol [Suppl] 5: 229s-244s","journal-title":"Clin Endocrinol [Suppl]"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1002\/j.1460-2075.1987.tb02733.x","volume":"6","author":"EG Peralta","year":"1987","unstructured":"Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ (1987) Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J 6: 3923?3929","journal-title":"EMBO J"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00299019","volume":"30","author":"DG Pipeleers","year":"1987","unstructured":"Pipeleers DG (1987) The biosociology of pancreatic B cells. Diabetologia 30: 277?291","journal-title":"Diabetologia"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1073\/pnas.85.11.3865","volume":"85","author":"FC Schuit","year":"1988","unstructured":"Schuit FC, In't Veld PA, Pipeleers DG (1988) Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci USA 85: 3865?3869","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1210\/endo-104-6-1705","volume":"104","author":"V Schusdziarra","year":"1979","unstructured":"Schusdziarra V, Harris V, Arimura A, Unger RH (1979) Evidence for a role of splanchnic somatostatin in the homeostasis of ingested nutrients. Endocrinol 104: 1705?1708","journal-title":"Endocrinol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1172\/JCI108992","volume":"61","author":"TW Schwartz","year":"1978","unstructured":"Schwartz TW, Holst JJ, Fahrenkrug J (1978) Vagal, cholinergic regulation of pancreatic polypeptide secretion. J Clin Invest 61: 781?789","journal-title":"J Clin Invest"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0026-0495(78)90114-2","volume":"27","author":"JH Strubbe","year":"1978","unstructured":"Strubbe JH, Bouman PR (1978) Plasma insulin patterns in the unanesthetized rat during intracardial infusion and spontaneous ingestion of graded loads of glucose. Metabolism 27: 341?351","journal-title":"Metabolism"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/ajplegacy.1975.229.4.1019","volume":"229","author":"JH Strubbe","year":"1975","unstructured":"Strubbe JH, Steffens AB (1975) Rapid insulin release after ingestion of a meal in the unanesthetized rat. Am J Physiol 229: 1019?1022","journal-title":"Am J Physiol"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00524759","volume":"92","author":"EA Zee Van der","year":"1989","unstructured":"Van der Zee EA, Matsuyama T, Strosberg AD, Traber J, Luiten PGM (1989) Demonstration of muscarinic acetylcholine receptor-like immunoreactivity in rat forebrain and upper brainstem. Histochemistry 92: 475?485","journal-title":"Histochemistry"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0361-9230(91)90005-5","volume":"26","author":"EA Zee Van der","year":"1991","unstructured":"Van der Zee EA, Benoit R, Strosberg AD, Luiten PGM (1991a) Coexistence of muscarinic acetylcholine receptors and somatostatin in nonpyramidal neurons of the rat dorsal hippocampus. Brain Res Bull 26: 343?351","journal-title":"Brain Res Bull"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0361-9230(91)90048-O","volume":"27","author":"EA Zee Van der","year":"1991","unstructured":"Van der Zee EA, Jong GI de, Strosberg AD, Luiten PGM (1991b) Parvalbumin-positive neurons in rat dorsal hippocampus contain muscarinic acetylcholine receptors. Brain Res Bull 27: 697?700","journal-title":"Brain Res Bull"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0014-5793(91)80551-D","volume":"283","author":"S Vasudevan","year":"1991","unstructured":"Vasudevan S, Reil\u00e4nder H, Maul G, Michel H (1991) Expression and cell membrane localization of rat M3 muscarinic acetylcholine receptor produced in Sf9 insect cells using baculovirus system. FEBS Lett 283: 52?56","journal-title":"FEBS Lett"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-2999(90)90109-J","volume":"178","author":"EJ Verspohl","year":"1990","unstructured":"Verspohl EJ, Tacke R, Mutschler E, Lambrecht G (1990) Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies. Eur J Pharmacol 178: 303?311","journal-title":"Eur J Pharmacol"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/0024-3205(87)90521-2","volume":"41","author":"M Waelbroeck","year":"1987","unstructured":"Waelbroeck M, Camus J, Winand J, Christophe J (1987) Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors. Life Sci 41: 2235?2240","journal-title":"Life Sci"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/B978-0-12-027310-2.50021-9","volume-title":"CNS regulation of carbohydrate metabolism","author":"SM Wood","year":"1983","unstructured":"Wood SM, Polak JM, Bloom SR (1983) Neuropeptides in the control of the islets of Langerhans. In: Szabo AJ (ed) CNS regulation of carbohydrate metabolism. Academic Press, New York, pp 401?420"},{"key":"CR51","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1210\/endo-125-5-2400","volume":"125","author":"WS Zawilich","year":"1989","unstructured":"Zawilich WS, Zawalich KC, Rasmussen H (1989) Cholinergic agonists prime the B-cell to glucose. Endocrinology 125: 2400?2406","journal-title":"Endocrinology"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00384730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00384730\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00384730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T21:36:39Z","timestamp":1585949799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00384730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["BF00384730"],"URL":"https:\/\/doi.org\/10.1007\/bf00384730","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}