{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:58:09Z","timestamp":1769176689914,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[1991,2]]},"DOI":"10.1007\/bf00393876","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T12:25:19Z","timestamp":1099916719000},"page":"61-74","source":"Crossref","is-referenced-by-count":111,"title":["Systemic effects of implanted prostheses made of cobalt-chromium alloys"],"prefix":"10.1007","volume":"110","author":[{"given":"R.","family":"Michel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"L\ufffder3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","unstructured":"Abeln M (1977) Spurenelemente im Serum nach Implantation von Kobalt-Chrom-Totalendoprothesen der H\ufffdfte: Untersuchungen mit Hilfe der Neutronenaktivierungsanalyse. Thesis, University of Cologne"},{"key":"CR2","first-page":"200","volume-title":"Grenzschichtprobleme der Verankerung von Implantaten unter besonderer Ber\ufffdcksichtigung von Endoprothesen","author":"M Abeln","year":"1980","unstructured":"Abeln M, Ohnsorge J, Kasparek K (1980) Biochemische Untersuchungen der legierungsspezifischen Spurenelemente von Kobalt-Chrom-H\ufffdftgelenktotalendoprothesen und AO-Winkelplatten im implantatnahen und implantatfernen Gewebe Bowie im Serum mit Hilfe der Neutronenaktivierungsanalyse. In: Jaeger M, Hackenbroch MH, Refior HJ (eds) Grenzschichtprobleme der Verankerung von Implantaten unter besonderer Ber\ufffdcksichtigung von Endoprothesen. Thieme, Stuttgart, pp 200?209"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1302\/0301-620X.70B4.3403590","volume":"70","author":"J Black","year":"1988","unstructured":"Black J (1988) Does corrosion matter? (Editorial). J Bone Joint Surg [Br] 70:517?520","journal-title":"J Bone Joint Surg [Br]"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-9244(08)70218-X","volume-title":"Nuclear analytical techniques in medicine","author":"HJM Bowen","year":"1988","unstructured":"Bowen HJM (1988) Trace elements in biological samples. In: Cesaro R (ed) Nuclear analytical techniques in medicine. Elsevier, Amsterdam, pp 1?17"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0536.1975.tb05385.x","volume":"1","author":"R Brun","year":"1975","unstructured":"Brun R (1975) Epidemiology of contact dermatitis in Geneve (1000 cases). Contact Dermatitis 1:214?217","journal-title":"Contact Dermatitis"},{"key":"CR6","first-page":"422","volume":"55","author":"RF Coleman","year":"1973","unstructured":"Coleman RF (1973) Concentration of implant products in the body. J Bone Joint Surg [Br] 55:422","journal-title":"J Bone Joint Surg [Br]"},{"key":"CR7","first-page":"587","volume-title":"Trace element analytical chemistry in medicine and biology","author":"R Cornelis","year":"1980","unstructured":"Cornelis R, Versieck J (1980) Critical evaluation of the literature values of eighteen trace elements in human serum or plasma. In: Braetter P, Schramel P (eds) Trace element analytical chemistry in medicine and biology. De Grumer, Berlin, pp 587?600"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/ac60259a007","volume":"40","author":"LA Currie","year":"1968","unstructured":"Currie LA (1968) Limits for qualitative detection and quantitative determination. Anal Chem 40:586?593","journal-title":"Anal Chem"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0142-9612(80)90016-2","volume":"1","author":"HS Dobbs","year":"1980","unstructured":"Dobbs HS, Minski MJ (1980) Metal ion release after total hip replacement. Biomaterials 1:193?198","journal-title":"Biomaterials"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02821712","volume":"1","author":"A Furst","year":"1979","unstructured":"Furst A, Radding SB (1979) Unusual metals as carcinogens. Biol Trace Elem Res 1:169?181","journal-title":"Biol Trace Elem Res"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1302\/0301-620X.70B4.3403594","volume":"70","author":"WI Gillespie","year":"1988","unstructured":"Gillespie WI, Frampton CMA, Henderson RI, Ryan PM (1988) The incidence of cancer following total hip replacement. J Bone Joint Surg [Br] 70:539?542","journal-title":"J Bone Joint Surg [Br]"},{"key":"CR12","series-title":"NATO-ASI series","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4613-0757-0_12","volume-title":"Biocompatibility of Co-Cr-Ni alloys","author":"HF Hildebrand","year":"1988","unstructured":"Hildebrand HF, Ostapczuk P, Mercier JF, Stoeppler M, Roumazeille B, Decozlx J (1988) Orthopaedic implants and corrosion products: ultrastructural and analytical studies of 65 patients. In: Hildebrand HF, Champy M (eds) Biocompatibility of Co-Cr-Ni alloys. Plenum, NewYork (NATO-ASI series), pp 133?153"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/sia.740030304","volume":"3","author":"J Hofmann","year":"1981","unstructured":"Hofmann J, Michel R, Holm R, Zilkens J (1981) Corrosion behaviour of stainless steel implants in biological media. Surf Interf Anal 3:110?117","journal-title":"Surf Interf Anal"},{"key":"CR14","first-page":"85","volume":"70","author":"J Hofmann","year":"1982","unstructured":"Hofmann J, Wiehl N, Michel R, L\ufffder F, Zilkens J (1982) Neutron activation studies of the in-body corrosion of hip-joint prostheses made of Co-Cr alloys. J Radional Chem 70:85?107","journal-title":"J Radional Chem"},{"key":"CR15","series-title":"ICRP publication","volume-title":"Report of the task group on reference man","author":"ICRP (International Commision on Radiological Protection)","year":"1975","unstructured":"ICRP (International Commision on Radiological Protection) (1975) Report of the task group on reference man. Pergamon, Oxford (ICRP publication no. 23)"},{"key":"CR16","first-page":"183","volume-title":"Geographical variations in the trace element concentrations of human milk","author":"GV Iyengar","year":"1985","unstructured":"Iyengar GV (1985) Geographical variations in the trace element concentrations of human milk. In: Gladtke E, Heiman G, Lombeek I, Eckert I (eds) Thieme, Stuttgart, pp 183?188"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF02796686","volume":"12","author":"GV Iyengar","year":"1987","unstructured":"Iyengar GV (1987) Reference values for the concentrations of As, Cd, Co, Cr, Cu, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn in selected human tissues and body fluids. Biol Trace Elem Res 12:263?295","journal-title":"Biol Trace Elem Res"},{"key":"CR18","volume-title":"The elemental composition of human tissues and body fluids","author":"GV Iyengar","year":"1978","unstructured":"Iyengar GV, Kollmer WE, Bowen HJM (1978) The elemental composition of human tissues and body fluids. Verlag Chemie, Weinheim"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1302\/0301-620X.57B3.289","volume":"57","author":"DA Jones","year":"1975","unstructured":"Jones DA, Lucas HK, O'Driscoll M, Price CHG, Wibberley B (1975) Cobalt toxicity after McKee hip arthroplasty. J Bone Joint Surg [Br] 57:289?296","journal-title":"J Bone Joint Surg [Br]"},{"key":"CR20","first-page":"468","volume":"143","author":"K Kasparek","year":"1972","unstructured":"Kasparek K, Schicha H, Siller V, Feinendegen LE (1972) Normalwerte von Spurenelementen im menschlichen Serum und Korrelation zum Lebensalter und zur Serum-Eiwei\ufffd-Konzentration. Strahlentherapie 143:468?472","journal-title":"Strahlentherapie"},{"key":"CR21","first-page":"255","volume":"121","author":"F L\ufffder","year":"1983","unstructured":"L\ufffder F, Zilkens J, Michel R, Freisem-Broda G, Bigalke KH (1983) Gewebebelastung mit k\ufffdrperfremden Spurenelementen durch Roentgenkontrastmittel der Knochenzemente. Z Orthop 121:255?259","journal-title":"Z Orthop"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.7022654","volume":"213","author":"W Mertz","year":"1981","unstructured":"Mertz W (1981) The essential trace elements. Science 213:1332?1338","journal-title":"Science"},{"key":"CR23","first-page":"235","volume":"3","author":"R Michel","year":"1987","unstructured":"Michel R (1987) Trace metal analysis in biocompatibility testing. Crit Rev Biocompat 3:235?317","journal-title":"Crit Rev Biocompat"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00389578","volume":"103","author":"R Michel","year":"1984","unstructured":"Michel R, Hofmann J, L\ufffder F, Zilkens J (1984) Trace element burdening of human tissues due to the corrosion of hip-joint prostheses made of cobalt-chromium alloys. Arch Orthop Trauma Surg 103:85?95","journal-title":"Arch Orthop Trauma Surg"},{"key":"CR25","first-page":"607","volume-title":"Instrumentelle Multielementanalyse","author":"R Michel","year":"1985","unstructured":"Michel R, Iyengar GV, Zeisler R (1985) Current aspects of multielement analysis in the life science. In: Sansoni B (ed) Instrumentelle Multielementanalyse. VCH, Weinheim, pp 607?619"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02036050","volume":"113","author":"R Michel","year":"1987","unstructured":"Michel R, Loer, F, Nolte M, Reich M, Zilkens J (1987) Neutron activation analysis of human tissues, organs and body fluids to describe the interaction of orthopaedic implants made of cobalt-chromium alloys with the patient's organism. J Radioanal Nucl Chem 113:83?95","journal-title":"J Radioanal Nucl Chem"},{"key":"CR27","series-title":"NATO-ASI series","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4613-0757-0_6","volume-title":"Biocompatibility of Co-Cr-Ni alloys","author":"R Michel","year":"1988","unstructured":"Michel R, L\ufffder F, Nolte M, Reich M, Zilkens J (1988) Phenomenology of the trace element burdening of the human organism by the in-body corrosion of Co-Cr-Ni alloys as revealed by neutron activation analysis. In: Hildebrand HF, Champy M (eds) Biocompatibility of Co-Cr-Ni alloys. Plenum, New York, pp 59?75 (NATO-ASI series)"},{"key":"CR28","first-page":"767","volume":"119","author":"R Miehlke","year":"1981","unstructured":"Miehlke R, Henke G, Ehrenbrink H (1981) Kobalt- und Chromkonzentrationen in der Synovialfl\ufffdssigkeit und im Blutserum nach Implantation von Kniegelenksendoprothesen mit Hilfe der Neutronenaktivierungsanalyse. Z Orthop 119:767?768","journal-title":"Z Orthop"},{"key":"CR29","first-page":"339","volume-title":"Trace element analytical chemistry in medicine and biology","author":"MJ Minski","year":"1980","unstructured":"Minski MJ, Dobbs HS (1980) Neutron activation techniques applied to biomedical samples in particular tissues contaminated by stainless steel implants. In: Braetter P, Schramel P (eds) Trace element analytical chemistry in medicine and biology. De Gruyter, Berlin, pp 339?350"},{"key":"CR30","unstructured":"Nolte M (1986) Ver\ufffdnderungen des menschlichen Spurenelementhaushaltes durch H\ufffdftgelenkstotalendoprothesen aus Co-Basis Legierungen. Thesis, University of Cologne"},{"key":"CR31","first-page":"607","volume":"116","author":"J Ohnsorge","year":"1978","unstructured":"Ohnsorge J, Abeln M, Zilkens J (1978) Spurenelementkonzentration verschiedener Gewebe, nachgewiesen mit Hilfe der Neutronenaktivierungsanalyse. Z Orthop 116:607?608","journal-title":"Z Orthop"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/archderm.1973.01620250025006","volume":"108","author":"EJ Rudner","year":"1973","unstructured":"Rudner EJ, Clendenning WE, Epstein E, Fisher AA, Jillson OF, Jordan WP, Larsen W, Meibach H, Mitchell JC, Quinn SE, Schorr WF, Sulzberger MB (1973) Epidemiology of contact dermatitis in North America. Arch Dermatol 108:537?540","journal-title":"Arch Dermatol"},{"key":"CR33","first-page":"1","volume":"2","author":"GN Schrauzer","year":"1979","unstructured":"Schrauzer GN (1979) Trace elements in carcinogenesis. Adv Nutr Res 2:1","journal-title":"Adv Nutr Res"},{"key":"CR34","unstructured":"Schleupner KH (1986) Untersuchungen zur Frage der Sensibilisierung des Organismus durch die implantatspezifischen Materialien bei Patienten mit H\ufffdftgelenkstotalendoprothesen. Thesis, University of Aachen"},{"key":"CR35","series-title":"CRC series in biocompatibility","first-page":"1","volume-title":"Systemic aspects of biocompatibility, vol 2","author":"GK Smith","year":"1981","unstructured":"Smith GK (1981) Systemic biocompatibility of metallic surgical implants. In: Williams DF (ed) Systemic aspects of biocompatibility, vol 2. CRC Press, Boca Raton, pp 1?22 (CRC series in biocompatibility)"},{"key":"CR36","series-title":"NBS special publication","first-page":"23","volume-title":"Retrieval and analysis of orthopedic implants","author":"GK Smith","year":"1977","unstructured":"Smith GK, Black J (1977) Models for systemic effects of metallic implants. In: Weinstein A, Horowitz E, Ruff AW (eds) Retrieval and analysis of orthopedic implants. US Dept. Comm., Washington, pp 23?30 (NBS special publication 472)"},{"key":"CR37","first-page":"63","volume-title":"Titanlegierungen fur Implantate ? Physikochemische Prinzipien, in Entwicklungstendenzen bei Implantatwerkstoffen","author":"SG Steinemann","year":"1984","unstructured":"Steinemann SG, Perren SM (1984) Titanlegierungen fur Implantate ? Physikochemische Prinzipien, in Entwicklungstendenzen bei Implantatwerkstoffen. Deutscher Verband f\ufffdr Materialpr\ufffdfung, Berlin, pp 63?73"},{"key":"CR38","first-page":"237","volume-title":"Toxicology of the trace elements","author":"FW Sundermann Jr","year":"1977","unstructured":"Sundermann FW Jr (1977) Metal carcinogenesis. In: Goyer RA, Mchlman MA (eds) Toxicology of the trace elements. Wiley, New York, pp 237?295"},{"key":"CR39","first-page":"422","volume":"55","author":"DM Taylor","year":"1973","unstructured":"Taylor DM (1973) Trace metal patterns and disease. J Bone Joint Surg [Br] 55:422?423","journal-title":"J Bone Joint Surg [Br]"},{"key":"CR40","volume-title":"Human hair, vol 1: Fundamentals and methods for measurement of elemental composition","author":"V Valkovic","year":"1988","unstructured":"Valkovic V (1988) Human hair, vol 1: Fundamentals and methods for measurement of elemental composition. CRC Press, Boca Raton"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/10408368509165788","volume":"22","author":"J Versieck","year":"1985","unstructured":"Versieck J (1985) Trace elements in human body fluids and tissues. Crit Rev Clin Lab Sci 22:97?184","journal-title":"Crit Rev Clin Lab Sci"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0003-2670(00)86346-1","volume":"204","author":"J Versieck","year":"1988","unstructured":"Versieck J, Vanballenberghe L, De Kesel A, Hoste J, Wallaeys B, Vandenhaute J, Baeck N, Steyaert H, Byrne AR, Sundermann FW (1988) Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determination. Anal Chim Acta 204:63?75","journal-title":"Anal Chim Acta"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0003-2670(01)95205-5","volume":"116","author":"J Versieck","year":"1980","unstructured":"Versieck J, Cornelis R (1980) Normal levels of trace elements in human blood, plasma or serum. Anal Chim Acta 116:217?254","journal-title":"Anal Chim Acta"},{"key":"CR44","volume-title":"Trace elements in human plasma or serum","author":"J Versieck","year":"1989","unstructured":"Versieck J, Cornelis R (1989) Trace elements in human plasma or serum. CRC Press, Boca Raton"},{"key":"CR45","series-title":"Environmental Health Criteria","first-page":"19","volume-title":"Principles and methods for evaluating the toxicity or chemicals, part 1","author":"World Health Organisation","year":"1978","unstructured":"World Health Organisation (1978) Principles and methods for evaluating the toxicity or chemicals, part 1 WHO geneva pp 19?61 (Environmental Health Criteria 6)"},{"key":"CR46","series-title":"NBS special publication","volume-title":"The pilot national environmental specimen bank ? analysis of human liver specimens","author":"R Zeisler","year":"1983","unstructured":"Zeisler R, Harrison SH, Wise SA (1983) The pilot national environmental specimen bank ? analysis of human liver specimens. US Dept. Comm., Washington (NBS special publication 656)"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02918319","volume":"6","author":"R Zeisler","year":"1984","unstructured":"Zeisler R, Harrison SH, Wise SA (1984) Trace elements in human livers using quality control in the complete analytical process. Biol Trace Elem Res 6:31?49","journal-title":"Biol Trace Elem Res"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00393876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00393876\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00393876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T21:35:41Z","timestamp":1554327341000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00393876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["BF00393876"],"URL":"https:\/\/doi.org\/10.1007\/bf00393876","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]}}}