{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:10:02Z","timestamp":1773277802327,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,8,1]],"date-time":"1991-08-01T00:00:00Z","timestamp":681004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res."],"published-print":{"date-parts":[[1991,8]]},"DOI":"10.1007\/bf00398075","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T22:36:17Z","timestamp":1098570977000},"page":"275-285","source":"Crossref","is-referenced-by-count":10,"title":["Age-related accumulation of lysosomes and other cytological features in active thyroid follicles of the CBA mouse"],"prefix":"10.1007","volume":"265","author":[{"given":"P.","family":"N\ufffdve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rondeaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1530\/acta.0.1080511","volume":"108","author":"N Bagchi","year":"1985","unstructured":"Bagchi N, Shivers B, Brown TR (1985) Studies on the mechanism of acute inhibition of thyroglobulin hydrolysis by iodine. Acta Endocrinol 108:511?517","journal-title":"Acta Endocrinol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1768-322X.1985.tb00390.x","volume":"54","author":"A Beaumont","year":"1985","unstructured":"Beaumont A, Fragu P (1985) Ultrastructural changes in the rat thyroid gland during iodine deficiency. Biol Cell 54:177?180","journal-title":"Biol Cell"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00644538","volume":"63","author":"JF Denef","year":"1979","unstructured":"Denef JF, Cordier AC, Mesquita M, Haumont S (1979) The influence of fixation procedure, embedding medium and section thickness on morphometric data in the thyroid. Histochemistry 63:163?171","journal-title":"Histochemistry"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.ph.28.030166.002251","volume":"28","author":"C Duve de","year":"1966","unstructured":"Duve C de, Wattiaux R (1966) Functions of lysosomes. Ann Rev Physiol 28:435?492","journal-title":"Ann Rev Physiol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1210\/endo-115-4-1558","volume":"115","author":"R Ekholm","year":"1984","unstructured":"Ekholm R, Bj\u00f6rkman U (1984) Localization of iodine binding in the thyroid gland in vitro. Endocrinology 115:1558?1567","journal-title":"Endocrinology"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0074-7696(08)60954-7","volume":"40","author":"H Fujita","year":"1975","unstructured":"Fujita H (1975) Fine structure of the thyroid gland. Int Rev Cytol 40:197?280","journal-title":"Int Rev Cytol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1210\/endo-120-5-1758","volume":"120","author":"H Gerber","year":"1987","unstructured":"Gerber H, Peter HJ, Studer H (1987) Age-related failure of endocytosis may be the pathogenic mechanism responsible for ?cold? follicle formation in the aging mouse thyroid. Endocrinology 120:1758?1764","journal-title":"Endocrinology"},{"key":"CR8","first-page":"1","volume":"110","author":"P Heimann","year":"1966","unstructured":"Heimann P (1966) Ultrastructure of human thyroid. Acta Endocrinol [Suppl] 110:1?102","journal-title":"Acta Endocrinol [Suppl]"},{"key":"CR9","first-page":"2","volume":"22","author":"GH Klinck","year":"1970","unstructured":"Klinck GH, Oertel JE, Winship T (1970) Ultrastructure of normal human thyroid. Lab Invest 22:2?22","journal-title":"Lab Invest"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/geronj\/34.4.502","volume":"34","author":"DN Mc Martin","year":"1979","unstructured":"Mc Martin DN (1979) Morphologic lesions in aging Syrian hamsters. J Gerontol 34:502?511","journal-title":"J Gerontol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1210\/endo-104-4-1136","volume":"104","author":"TL Klug","year":"1979","unstructured":"Klug TL, Adelman RC (1979) Altered hypothalamic-pituitary regulation of thyrotropin in male rats during aging. Endocrinology 104:1136?1142","journal-title":"Endocrinology"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00306855","volume":"37","author":"BM Kopriwa","year":"1973","unstructured":"Kopriwa BM (1973) A reliable standardized method for ultrastructural electron microscopic radioautography. Histochemistry 37:1?17","journal-title":"Histochemistry"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0014-4827(68)90554-5","volume":"52","author":"M Kosanovic","year":"1968","unstructured":"Kosanovic M, Ekholm R, Strandberg U, Smeds S (1968) The effect of TSH on the acid phosphatase and thyroglobulin hydrolyzing activities in the guinea pig thyroid. Exp Cell Res 52:147?160","journal-title":"Exp Cell Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/aja.1001660106","volume":"166","author":"PP Krupp","year":"1983","unstructured":"Krupp PP, Kavolius JP, Golstein J, N\u00e8ve P (1983) Ultrastructural and functional effects of chronic endogeneous stimulation of thyroid cells by thyrotropin. Am J Anat 166:73?82","journal-title":"Am J Anat"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1210\/endo-115-5-1905","volume":"115","author":"PP Krupp","year":"1984","unstructured":"Krupp PP, Starling JRS, Golstein J, N\u00e8ve P (1984) Thyroid lysosomal enzyme activity and ultrastructure after subtotal thyroidectomy. Endocrinology 115:1905?1912","journal-title":"Endocrinology"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01621459.1952.10483441","volume":"47","author":"WH Kruskal","year":"1952","unstructured":"Kruskal WH, Wallis WA (1952) Use of ranks on one-criterion variance analysis. J Am Stat Assoc 47:583?621","journal-title":"J Am Stat Assoc"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/endo-102-1-188","volume":"102","author":"L Lamas","year":"1978","unstructured":"Lamas L, Ingbar SH (1978) The effect of varying iodine content on the susceptibility of thyroglobulin to hydrolysis by thyroid protease. Endocrinology 102:175?182","journal-title":"Endocrinology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.9.2.409","volume":"9","author":"JH Luft","year":"1961","unstructured":"Luft JH (1961) Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol 9:409?414","journal-title":"J Biophys Biochem Cytol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00297224","volume":"260","author":"C Mestdagh","year":"1990","unstructured":"Mestdagh C, Many MC, Halpern S, Briancon C, Fragu P, Denef JF (1990) Correlated autoradiographic and ion-microscopic study of the role of iodine in the formation of ?cold? follicles in young and old mice. Cell Tissue Res 260:449?457","journal-title":"Cell Tissue Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00501403","volume":"82","author":"Y Mizukami","year":"1985","unstructured":"Mizukami Y, Matsubara F, Matsukawa S (1985) Cytochemical localization of peroxidase and hydrogen-peroxidase-producing NAD(P)H-oxidase in thyroid follicular cells of propylthiouracyl-treated rats. Histochemistry 82:263?268","journal-title":"Histochemistry"},{"key":"CR21","first-page":"811","volume":"4","author":"P N\u00e8ve","year":"1965","unstructured":"N\u00e8ve P (1965) Ultrastructure des cellules folliculaires d'une thyro\u00efde humaine normale. J Microsc 4:811?814","journal-title":"J Microsc"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0014-4827(68)90159-6","volume":"51","author":"P N\u00e8ve","year":"1968","unstructured":"N\u00e8ve P, Rodesch FR, Dumont JE (1968) Electron microscopy of isolated sheep thyroid cells. Ex Cell Res 51:68?78","journal-title":"Ex Cell Res"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/jcem-31-1-38","volume":"31","author":"P N\u00e8ve","year":"1970","unstructured":"N\u00e8ve P, Eagleton GB, Wollman SH (1970) Structure of colloid cells in the thyroid gland. J Clin Endocrinol 31:38?42","journal-title":"J Clin Endocrinol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/BF00216753","volume":"220","author":"P N\u00e8ve","year":"1981","unstructured":"N\u00e8ve P, Authelet M, Golstein J (1981) Effect of aging on the morphology and function of the thyroid gland of the cream hamster. Further evidence for two different mechanisms of hormone secretion. Cell Tissue Res 220:499?509","journal-title":"Cell Tissue Res"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1210\/endo-123-1-478","volume":"123","author":"P N\u00e8ve","year":"1988","unstructured":"N\u00e8ve P, Starling JR, Golstein J, Krupp PP (1988) Effects of iodine intake on thyroid secondary lysosomes after subtotal thyroidectomy. Endocrinology 123:478?486","journal-title":"Endocrinology"},{"key":"CR26","first-page":"349","volume-title":"Advances in Cytopharmacology","author":"AB Novikoff","year":"1974","unstructured":"Novikoff AB, Novikoff PM, Ma M, Shin W, Quintana N (1974) Cytochemical studies of secretory and other granules associated with the endoplasmic reticulum in rat thyroid epithelial cells. In: Ceccarelli B, Clementi F, Melodosi J (eds) Advances in Cytopharmacology. Raven Press, New York, pp 349?369"},{"key":"CR27","first-page":"193","volume":"4","author":"JB Rognoni","year":"1989","unstructured":"Rognoni JB, Penel C, Bastiani P, Roccabianca M, Lemarchand-B\u00e9raud T (1989) Down regulation of hypertrophied follicular cell volume in thyroid hyperplastic gland. Histol Histopathol 4:193?200","journal-title":"Histol Histopathol"},{"key":"CR28","first-page":"432","volume":"39","author":"B Rousset","year":"1985","unstructured":"Rousset B, Authelet M, Munari-Silem Y, Dumont JE, N\u00e8ve P (1985) Formation of intracellular lumina in dispersed pig thyroid cells. Eur J Cell Biol 39:432?442","journal-title":"Eur J Cell Biol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0022-4804(80)90083-9","volume":"28","author":"J Starling","year":"1980","unstructured":"Starling J, Hopps BA (1980) Effects of excess iodine on thyroid and liver lysosomal enzymes. J Surg Res 28:57?64","journal-title":"J Surg Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1159\/000125160","volume":"49","author":"SA Stein","year":"1989","unstructured":"Stein SA, Shanklin DR, Krulich L, Roth MG, Chubb CM, Adams PM (1989) Evaluation and characterization of the hyt\/hyt hypothyroid mouse. II Abnormalities of TSH and the thyroid gland. Neuroendocrinology 49:509?519","journal-title":"Neuroendocrinology"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1210\/endo-102-5-1576","volume":"102","author":"H Studer","year":"1978","unstructured":"Studer H, Forster R, Conti A, Kohler H, Haeberli A, Engler H (1978) Transformation of normal follicles into thyrotropin-refractory ?cold? follicles in the aging mouse thyroid gland. Endocrinology 102:1576?1586","journal-title":"Endocrinology"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1679\/aohc1950.44.177","volume":"44","author":"S Tamura","year":"1981","unstructured":"Tamura S, Fujita H (1981) Fine structural aspects on the cold follicles in the aged mouse thyroid. Arch Histol Jpn 44:177?188","journal-title":"Arch Histol Jpn"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0003-9861(70)90063-9","volume":"139","author":"A Taurog","year":"1970","unstructured":"Taurog A (1970) Thyroid peroxidase-catalyzed iodination of thyroglobulin: inhibition by excess iodide. Arch Biochem Biophys 139:212?220","journal-title":"Arch Biochem Biophys"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1210\/endo-103-5-1597","volume":"103","author":"J Unger","year":"1978","unstructured":"Unger J, Boeynams JM, Ketelbant-Balasse P, Dumont JE, Mockel J (1978) Kinetics of dog thyroid secretion in vitro. Endocrinology 103:1597?1605","journal-title":"Endocrinology"},{"key":"CR35","first-page":"61","volume-title":"The thyroid gland","author":"MF Hove-Vandenbroucke Van den","year":"1980","unstructured":"Van den Hove-Vandenbroucke MF (1980) Secretion of thyroid hormones. In: Visscher M de (ed) The thyroid gland. Raven Press, New York, pp 61?79"},{"key":"CR36","first-page":"162","volume-title":"Stereological methods, vol 1","author":"ER Weibel","year":"1979","unstructured":"Weibel ER (1979) Stereological methods, vol 1. Academic Press, London, pp 162?204"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.25.3.593","volume":"25","author":"BK Wetzel","year":"1965","unstructured":"Wetzel BK, Spicer SS, Wollman SH (1965) Changes in fine structure and acid phosphatase localization in rat thyroid cells following thyrotropin administration. J Cell Biol 25:593?618","journal-title":"J Cell Biol"},{"key":"CR38","first-page":"401","volume-title":"Lysosomes in biology and pathology, vol 7","author":"SA Wharton","year":"1984","unstructured":"Wharton SA, Riley PA (1984) Lysosomes and aging. In: Dingle JT, Dean RT, Sly W (eds) Lysosomes in biology and pathology, vol 7. Elsevier Science Publishers, Amsterdam, pp 401?419"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","volume":"1","author":"F Wilcoxon","year":"1945","unstructured":"Wilcoxon F (1945) Individual comparisons by ranking methods. Biometrics 1:80?83","journal-title":"Biometrics"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1210\/endo-93-1-248","volume":"93","author":"SH Wollman","year":"1973","unstructured":"Wollman SH, Loewenstein JE (1973) Rates of colloid droplet and apical vesicle production and membrane turnover during thyroglobulin secretion and resorption. Endocrinology 93:248?252","journal-title":"Endocrinology"},{"key":"CR41","first-page":"213","volume":"27","author":"SH Wollman","year":"1971","unstructured":"Wollman SH, N\u00e8ve P (1971) Ultimobranchial follicles in the thyroid glands of rats and mice. Rec Prog Horm Res 27:213?212","journal-title":"Rec Prog Horm Res"}],"container-title":["Cell & Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00398075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00398075\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00398075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T18:30:02Z","timestamp":1554316202000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00398075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["BF00398075"],"URL":"https:\/\/doi.org\/10.1007\/bf00398075","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}