{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:36:26Z","timestamp":1761662186699},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1995,8]]},"DOI":"10.1007\/bf00400576","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T14:06:41Z","timestamp":1098281201000},"page":"889-898","source":"Crossref","is-referenced-by-count":24,"title":["Haemodynamic and metabolic effects in diabetic ketoacidosis in rats of treatment with sodium bicarbonate or a mixture of sodium bicarbonate and sodium carbonate"],"prefix":"10.1007","volume":"38","author":[{"given":"J. S.","family":"Beech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C. R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Iles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J. W.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C. D.","family":"Going","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0002-9343(83)91203-2","volume":"75","author":"E Lever","year":"1983","unstructured":"Lever E, Jaspan JB (1983) Sodium bicarbonate therapy in severe diabetic ketoacidosis. Am J Med 75: 263?268","journal-title":"Am J Med"},{"key":"CR2","first-page":"209","volume":"2","author":"RA Fronzo De","year":"1994","unstructured":"De Fronzo RA, Matsuda M, Barrett EJ (1994) Diabetic ketoacidosis: a combined metabolic-nephrologic approach to therapy. Diabetes Reviews 2: 209?238","journal-title":"Diabetes Reviews"},{"key":"CR3","first-page":"F630","volume":"249","author":"H Graf","year":"1985","unstructured":"Graf H, Leach W, Arieff AI (1985) Metabolic effects of sodium bicarbonate in hypoxic dogs. Am J Physiol 249: F630-F635","journal-title":"Am J Physiol"},{"key":"CR4","first-page":"F586","volume":"242","author":"AI Arieff","year":"1982","unstructured":"Arieff AI, Leach W, Park R, Lazarowitz VC (1982) Systemic effects of NaHCO3 in experimental lactic acidosis in dogs. Am J Physiol 242: F586-F591","journal-title":"Am J Physiol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7326\/0003-4819-105-2-276","volume":"105","author":"PW Stacpoole","year":"1986","unstructured":"Stacpoole PW (1986) Lactic acidosis: the case against bicarbonate therapy. Ann Intern Med 105: 276?279","journal-title":"Ann Intern Med"},{"key":"CR6","first-page":"141","volume":"96","author":"GF Filley","year":"1984","unstructured":"Filley GF, Kindig N (1984) ?Carbicarb?, an alkalinizing iongenerating agent of possible clinical usefulness. Trans Am Clin Climatol Assoc 96: 141?153","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0140-6736(90)91305-T","volume":"335","author":"JM Ritter","year":"1990","unstructured":"Ritter JM, Doktor HS, Benjamin N (1990) Paradoxical effect of bicarbonate on cytoplasmic pH. Lancet 335: 1243?1246","journal-title":"Lancet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1056\/NEJM198607173150303","volume":"315","author":"MH Weil","year":"1986","unstructured":"Weil MH, Rackow EC, Trevino R et al. (1986) Difference in acid-base state between venous and arterial blood during cardiopulmonary resuscitation. New Eng J Med 315: 153?156","journal-title":"New Eng J Med"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.77.1.227","volume":"77","author":"RM Bersin","year":"1988","unstructured":"Bersin RM, Arieff AI (1988) Improved hemodynamic function during hypoxia with ?Carbicarb?, a new agent for the management of acidosis. Circulation 77: 227?233","journal-title":"Circulation"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00003246-198808000-00009","volume":"16","author":"TJ Iberti","year":"1988","unstructured":"Iberti TJ, Kelly KM, Gentili DR et al. (1988) Effects of sodium bicarbonate in canine hemorrhagic shock. Crit Care Med 16: 779?782","journal-title":"Crit Care Med"},{"key":"CR11","first-page":"H1835","volume":"258","author":"JI Shapiro","year":"1990","unstructured":"Shapiro JI (1990) Functional and metabolic responses of isolated hearts to acidosis: effects of sodium bicarbonate and ?Carbicarb?. Am J Physiol 258: H1835-H1839","journal-title":"Am J Physiol"},{"key":"CR12","first-page":"H1316","volume":"256","author":"JI Shapiro","year":"1989","unstructured":"Shapiro JI, Whalen M, Kucera R et al. (1989) Brain responses to sodium bicarbonate and ?Carbicarb? during systemic acidosis. Am J Physiol 256: H1316-H1321","journal-title":"Am J Physiol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.RES.41.6.849","volume":"41","author":"C Steenbergen","year":"1977","unstructured":"Steenbergen C, Deleeuw G, Rich T, Williamson JR (1977) Effects of acidosis and ischemia on contractility and intracellular pH of rat heart. Circ Res 41: 849?858","journal-title":"Circ Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"C99","DOI":"10.1152\/ajpcell.1977.233.3.C99","volume":"233","author":"S Vogel","year":"1977","unstructured":"Vogel S, Sperelakis N (1977) Blockade of myocardial slow calcium channels at low pH. Am J Physiol 233: C99-C103","journal-title":"Am J Physiol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/bj1640185","volume":"164","author":"RA Iles","year":"1977","unstructured":"Iles RA, Cohen RD, Rist AH, Baron PG (1977) The mechanism of inhibition by acidosis of gluconeogenesis from lactate in rat liver. Biochem J 164: 185?191","journal-title":"Biochem J"},{"key":"CR16","first-page":"175","volume":"55","author":"RA Iles","year":"1978","unstructured":"Iles RA, Cohen RD, Baron PG (1978) Effect of varying PCO2 on intracellular pH and lactate consumption in the isolated perfused rat liver. Clin Sci Mol Med 55: 175?181","journal-title":"Clin Sci Mol Med"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj2630737","volume":"263","author":"JS Beech","year":"1989","unstructured":"Beech JS, Williams SR, Cohen RD, Iles RA, (1989) Gluconeogenesis and the protection of hepatic intracellular pH during diabetic ketoacidosis in rats. Biochem J 263: 737?744","journal-title":"Biochem J"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/mrm.1910170209","volume":"17","author":"R Zahler","year":"1991","unstructured":"Zahler R, Majumdar S, Frederick B et al. (1991) NMR determination of myocardial pH in vivo: separation of tissue inorganic phosphate from blood 2,3-DPG. Magn Res Med 17: 368?378","journal-title":"Magn Res Med"},{"key":"CR19","first-page":"H1572","volume":"262","author":"R Zahler","year":"1992","unstructured":"Zahler R, Barrett E, Majumdar A et al. (1992) Lactic acidosis: effect of treatment on intracellular pH and energetics in living rat heart. Am J Physiol 262: H1572-H1578","journal-title":"Am J Physiol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0026-0495(94)90087-6","volume":"43","author":"JS Beech","year":"1994","unstructured":"Beech JS, Nolan KM, Iles RA et al. (1994) The effects of sodium bicarbonate and a mixture of sodium bicarbonate and carbonate (?Carbicarb?) on skeletal muscle pH and haemodynamic status in rats with hypovolemic shock. Metabolism 43: 1?7","journal-title":"Metabolism"},{"key":"CR21","first-page":"266","volume-title":"Methods of enzymatic analysis","author":"HJ Hohorst","year":"1962","unstructured":"Hohorst HJ (1962) L(+)lactate determination with lactate dehydrogenase and NAD. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York NY. pp 266?270"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1042\/bj0820090","volume":"82","author":"DH Williamson","year":"1962","unstructured":"Williamson DH, Mellanby J, Krebs HA (1962) Enzymatic determination of D(?)-?-hydroxybutyric and acetoacetic acid in blood. Biochem J 82: 90?98","journal-title":"Biochem J"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","volume":"300","author":"JNS Matthews","year":"1989","unstructured":"Matthews JNS, Altman DG, Campbell MJ, Royston JP (1989) Analysis of serial measurements in medical research. BMJ 300: 230?235","journal-title":"BMJ"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/sim.4780111304","volume":"11","author":"L Frison","year":"1992","unstructured":"Frison L, Pocock SJ (1992) Repeated measures in clinical trials: analysis using mean summary statistics and its implications for design. Statistics Medicine 11: 1685?1704","journal-title":"Statistics Medicine"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1378\/chest.104.3.913","volume":"104","author":"KH Rhee","year":"1993","unstructured":"Rhee KH, Toro LO, McDonald GG et al. (1993) Carbicarb, sodium bicarbonate and sodium chloride in hypoxic lactic acidosis. Chest 104: 913?918","journal-title":"Chest"},{"key":"CR26","first-page":"835","volume":"102","author":"JH Sun","year":"1987","unstructured":"Sun JH, Filley GF, Hord K et al. (1987) Carbicarb: an effective substitute for NaHCO3 for the treatment of acidosis. Surgery 102: 835?839","journal-title":"Surgery"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1172\/JCI106540","volume":"50","author":"A Bellingham","year":"1971","unstructured":"Bellingham A, Detter JC, Lenfant C (1971) Regulatory mechanisms of hemoglobin-oxygen affinity in acidosis and alkalosis. J Clin Invest 50: 700?706","journal-title":"J Clin Invest"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0026-0495(93)90084-2","volume":"42","author":"JS Beech","year":"1993","unstructured":"Beech JS, Iles RA, Cohen RD (1993) Bicarbonate in the treatment of metabolic acidosis: effects on hepatic intracellular pH and lactate disposal in rats. Metabolism 42: 341?346","journal-title":"Metabolism"},{"key":"CR29","first-page":"202","volume-title":"Debates in medicine","author":"RD Cohen","year":"1990","unstructured":"Cohen RD (1990) When is bicarbonate appropriate in treating metabolic acidosis, including diabetic ketoacidosis? In: Gitnick G (ed) Debates in medicine. (3rd edn) Year Book Medical Publishers, Inc., Chicago pp 202?210","edition":"3rd edn"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/00000542-199006000-00018","volume":"72","author":"BJ Hindman","year":"1990","unstructured":"Hindman BJ (1990) Sodium bicarbonate in the treatment of subtypes of acute lactic acidosis: physiologic considerations. Anesthesiol 72: 1064?1076","journal-title":"Anesthesiol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bj1840635","volume":"184","author":"RA Iles","year":"1979","unstructured":"Iles RA, Baron PG, Cohen RD (1979) The effect of reduction of perfusion rate on lactate and oxygen uptake, glucose output and energy supply in the isolated perfused liver of starved rats. Biochem J 184: 635?642","journal-title":"Biochem J"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0304-4165(66)90194-2","volume":"124","author":"M Ui","year":"1966","unstructured":"Ui M (1966) A role of phosphofructokinase in pH-dependant regulation of glycolysis. Biochim Biophys Acta 124: 310?322","journal-title":"Biochim Biophys Acta"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1016\/S0021-9258(18)99819-4","volume":"241","author":"B Trivedi","year":"1966","unstructured":"Trivedi B, Danforth WH (1966) Effect of pH on the kinetics of frog muscle phosphofructokinase. J Biol Chem 241: 4110?4112","journal-title":"J Biol Chem"},{"key":"CR34","first-page":"177","volume":"2","author":"VL Hood","year":"1994","unstructured":"Hood VL, Tannen RL (1994) Maintenance of acid-base homeostasis during ketoacidosis and lactic acidosis. Diabetes Reviews 2: 177?194","journal-title":"Diabetes Reviews"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0140-6736(72)91793-X","volume":"3","author":"KGMM Alberti","year":"1972","unstructured":"Alberti KGMM, Darley JH, Emerson PM, Hockaday TDR (1972) 2,3-bisphosphoglycerate and tissue oxygenation in uncontrolled diabetes mellitus. Lancet 3: 391?395","journal-title":"Lancet"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7326\/0003-4819-112-7-492","volume":"112","author":"DJ Cooper","year":"1990","unstructured":"Cooper DJ, Walley KR, Wiggs BR, Russell JA (1990) Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. Ann Intern Med 112: 492?498","journal-title":"Ann Intern Med"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00400576.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00400576\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00400576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T18:16:14Z","timestamp":1624731374000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00400576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["BF00400576"],"URL":"https:\/\/doi.org\/10.1007\/bf00400576","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8]]}}}