{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:14:42Z","timestamp":1789751682702,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1995,5]]},"DOI":"10.1007\/bf00400722","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T22:45:28Z","timestamp":1098571528000},"page":"543-549","source":"Crossref","is-referenced-by-count":78,"title":["Rapid deposition of amyloid in human islets transplanted into nude mice"],"prefix":"10.1007","volume":"38","author":[{"given":"P.","family":"Westermark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Eizirik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G.","family":"Pipeleers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hellerstr\ufffdm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0006-291X(86)90708-4","volume":"140","author":"P Westermark","year":"1986","unstructured":"Westermark P, Wernstedt C, Wilander E, Sletten K (1986) A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827?831","journal-title":"Biochem Biophys Res Commun"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","volume":"84","author":"P Westermark","year":"1987","unstructured":"Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84: 3881?3885","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","volume":"84","author":"GJ Cooper","year":"1987","unstructured":"Cooper GJ, Willis AC, Clark A, Turner AC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84: 8628?8632","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00401195","volume":"35","author":"P Westermark","year":"1992","unstructured":"Westermark P, Johnson KH, O'Brien TD, Betsholtz C (1992) Islet amyloid polypeptide ? a novel controversy in diabetes research. Diabetologia 35: 297?303","journal-title":"Diabetologia"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00549079","volume":"359","author":"P Westermark","year":"1973","unstructured":"Westermark P (1973) Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch. A 359: 1?18","journal-title":"Virchows Arch. A"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/dmr.5610080204","volume":"8","author":"A Clark","year":"1992","unstructured":"Clark A (1992) Islet amyloid ? an enigma of type-2 diabetes. Diab Metabol Rev 8: 117?132","journal-title":"Diab Metabol Rev"},{"key":"CR7","first-page":"1","volume":"101","author":"N Gellerstedt","year":"1938","unstructured":"Gellerstedt N (1938) Die elektive, insul\ufffdre (Para-)Amyloidose der Bauchspeicheldr\ufffdse. Zugleich ein Beitrag zur Kenntnis der ?senilen Amyloidose?. Beitr Path Anat 101: 1?13","journal-title":"Beitr Path Anat"},{"key":"CR8","first-page":"801","volume":"35","author":"ET Bell","year":"1959","unstructured":"Bell ET (1959) Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Path 35: 801?805","journal-title":"Am J Path"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1517\/03009734000000014","volume":"77","author":"P Westermark","year":"1972","unstructured":"Westermark P (1972) Quantitative studies of amyloid in the islets of Langerhans. Upsala J Med Sci 77: 91?94","journal-title":"Upsala J Med Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF01219652","volume":"15","author":"P Westermark","year":"1978","unstructured":"Westermark P, Wilander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15: 417?421","journal-title":"Diabetologia"},{"key":"CR11","first-page":"189","volume-title":"Diabetes: clinical science in practice","author":"P Westermark","year":"1995","unstructured":"Westermark P. (1995) Islet amyloid polypeptide and amyloid in the islets of Langerhans. In: Leslie RDG, Robbins DC, (eds) Diabetes: clinical science in practice. University Cambridge Press, Cambridge, pp. 189?199"},{"key":"CR12","first-page":"291","volume":"81","author":"P Westermark","year":"1973","unstructured":"Westermark P, Grimelius L (1973) The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Path Microbiol Scand [A] 81: 291?300","journal-title":"Acta Path Microbiol Scand [A]"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI115989","volume":"90","author":"DL Eizirik","year":"1992","unstructured":"Eizirik DL, Korbutt GS, Hellerstr\ufffdm C (1992) Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the ?-cell function. J Clin Invest 90: 1263?1268","journal-title":"J Clin Invest"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1073\/pnas.91.20.9253","volume":"91","author":"DL Eizirik","year":"1994","unstructured":"Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerstr\ufffdm C, Andersson A (1994) Major species differences between man and rodents in the susceptibility to pancreatic ?-cell injury. Proc Natl Acad Sci USA 91: 9253?9256","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00399947","volume":"36","author":"L Christmanson","year":"1993","unstructured":"Christmanson L, Betsholtz C, Leckstr\ufffdm A et al. (1993) Islet amyloid polypeptide in the rabbit and European hare: studies on its relationship to amyloidogenesis. Diabetologia 36: 183?188","journal-title":"Diabetologia"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00400235","volume":"36","author":"GT Westermark","year":"1993","unstructured":"Westermark GT, Christmanson L, Terenghi G et al. (1993) Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits. Diabetologia 36: 323?328","journal-title":"Diabetologia"},{"key":"CR17","volume-title":"Immunocytochemistry","author":"LA Sternberger","year":"1979","unstructured":"Sternberger LA (1979) Immunocytochemistry, 2nd edn. John Wiley, New York","edition":"2nd edn"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-2249.1991.tb05788.x","volume":"86","author":"GT Westermark","year":"1991","unstructured":"Westermark GT, Norling B, Westermark P (1991) Fibronectin and basement membrane components in renal amyloid deposits in patients with primary and secondary amyloidosis. Clin Exp Immunol 86: 150?156","journal-title":"Clin Exp Immunol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00285291","volume":"32","author":"A Lukinius","year":"1989","unstructured":"Lukinius A, Wilander E, Westermark GT, Engstr\ufffdm U, Westermark P (1989) Co-localization of islet amyloid polypeptide and insulin in the beta-cell secretory granules of the human pancreatic islets. Diabetologia 32: 240?244","journal-title":"Diabetologia"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2337\/diab.42.10.1514","volume":"42","author":"A Novials","year":"1993","unstructured":"Novials A, Sarri Y, Casamitjana R, Rivera F, Gomis R (1993) Regulation of islet amyloid polypeptide in human pancreatic islets. Diabetes 42: 1514?1519","journal-title":"Diabetes"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0092-8674(93)90635-4","volume":"73","author":"JT Jarrett","year":"1993","unstructured":"Jarrett JT, Lansbury PT (1993) Seeding ?one-dimensional crystallization? of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73: 1055?1058","journal-title":"Cell"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/13506129409148624","volume":"1","author":"P Westermark","year":"1994","unstructured":"Westermark P (1994) Amyloid and polypeptide hormones: what is their inter-relationship? Amyloid 1: 47?60","journal-title":"Amyloid"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"11012","DOI":"10.1021\/ja00076a078","volume":"115","author":"TT Ashburn","year":"1993","unstructured":"Ashburn TT, Lansbury PT (1993) Interspecies sequence variations affect the kinetics and thermodynamics of amyloid formation: peptide models of pancreatic amyloid. J Am Chem Soc 115: 11012?11013","journal-title":"J Am Chem Soc"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368: 756?760","journal-title":"Nature"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2337\/diab.27.4.357","volume":"27","author":"CFJ Howard","year":"1978","unstructured":"Howard CFJ (1978) Insular amyloidosis and diabetes mellitus in Macaca nigra. Diabetes 27: 357?364","journal-title":"Diabetes"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2337\/diab.22.2.81","volume":"22","author":"KH Johnson","year":"1973","unstructured":"Johnson KH, Stevens JB (1973) Light and electron microscopic studies of islet amyloid in diabetic cats. Diabetes 22: 81?90","journal-title":"Diabetes"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0014-5793(93)81444-5","volume":"323","author":"N Fox","year":"1993","unstructured":"Fox N, Schrementi J, Nishi M et al. (1993) Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM). FEBS Lett 323: 40?44","journal-title":"FEBS Lett"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/BF00400803","volume":"36","author":"JWM H\ufffdppener","year":"1993","unstructured":"H\ufffdppener JWM, Verbeek JS, de Koning EJP et al. (1993) Chronic overproduction of islet amyloid polypeptide\/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia. Diabetologia 36: 1258?1265","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00400722.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00400722\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00400722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T22:17:19Z","timestamp":1554329839000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00400722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":28,"aliases":["10.1007\/s001250050317"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["BF00400722"],"URL":"https:\/\/doi.org\/10.1007\/bf00400722","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}