{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:10:20Z","timestamp":1759482620038},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1991,10,1]],"date-time":"1991-10-01T00:00:00Z","timestamp":686275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1991,10]]},"DOI":"10.1007\/bf00401513","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T15:17:01Z","timestamp":1098285421000},"page":"695-701","source":"Crossref","is-referenced-by-count":36,"title":["Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats"],"prefix":"10.1007","volume":"34","author":[{"given":"M. L.","family":"McCaleb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"McKean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Hohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Laver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"W. G.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00401513_CR1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/dmr.5610040205","volume":"4","author":"GC Viberti","year":"1988","unstructured":"Viberti GC, Walker JD (1988) Diabetic nephropathy: etiology and prevention. Diab Metab Rev 4: 147\u2013162","journal-title":"Diab Metab Rev"},{"key":"BF00401513_CR2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJM198407123110204","volume":"311","author":"CE Mogensen","year":"1984","unstructured":"Mogensen CE, Christensen CK (1984) Predicting diabetic nephropathy in insulin-dependent patients. N Eng J Med 311: 89\u201393","journal-title":"N Eng J Med"},{"key":"BF00401513_CR3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2337\/diab.27.9.959","volume":"27","author":"SM Mauer","year":"1978","unstructured":"Mauer SM, Brown DM, Matas AJ, Steffes MW (1978) Effects of pancreatic islet transplantation on the increased urinary excretion rates in intact and uninephrectomized rats with diabetes mellitus. Diabetes 27: 959\u2013964","journal-title":"Diabetes"},{"key":"BF00401513_CR4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1530\/acta.0.0950376","volume":"95","author":"R Rasch","year":"1980","unstructured":"Rasch R, Mogensen CE (1980) Urinary excretion of albumin and total protein in normal and streptozotocin diabetic rats. Acta Endocrinol 95: 376\u2013381","journal-title":"Acta Endocrinol"},{"key":"BF00401513_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/0891-6632(88)90020-7","volume":"2","author":"ML McCaleb","year":"1988","unstructured":"McCaleb ML, Sredy J, Millen J, Ackerman DM, Dvornik D (1988) Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat. J Diabetic Comp 2: 16\u201318","journal-title":"J Diabetic Comp"},{"key":"BF00401513_CR6","unstructured":"Report of the National Commission on Diabetes to the Congress of the United States (1976) Vol. 1, The long-range plan to combat diabetes. Bethesda, MD: Department of Health, Education, and Welfare (DHEW publication no. (NIH) 76-1018)"},{"key":"BF00401513_CR7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/bjo.58.4.344","volume":"58","author":"N Ashton","year":"1974","unstructured":"Ashton N (1974) Vascular basement membrane changes in diabetic retinopathy. Br J Ophthalmol 58: 344\u2013366","journal-title":"Br J Ophthalmol"},{"key":"BF00401513_CR8","first-page":"279","volume":"1","author":"JMB Bloodworth Jr","year":"1970","unstructured":"Bloodworth Jr JMB, Engerman RL, Camerini-Davalos RA, Powers KL (1970) Variations in capillary basement membrane width produced by aging and diabetes mellitus. Adv Metab Disord 1 [Suppl]: 279\u2013295","journal-title":"Adv Metab Disord"},{"key":"BF00401513_CR9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2337\/diab.26.1.65","volume":"26","author":"JR Williamson","year":"1977","unstructured":"Williamson JR, Kilo C (1977) Current status of capillary basement-membrane disease in diabetes mellitus. Diabetes 26: 65\u201373","journal-title":"Diabetes"},{"key":"BF00401513_CR10","first-page":"437","volume":"27","author":"M Nagata","year":"1986","unstructured":"Nagata M, Katz ML, Robison Jr WG (1986) Age-related thickening of retinal capillary basement membranes. Invest Ophthalmol Vis Sci 27: 437\u2013440","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF00401513_CR11","first-page":"365","volume-title":"Prediabetes, advances in experimental medicine and biology, Vol 246","author":"WG Robison Jr","year":"1988","unstructured":"Robison Jr WG (1988) Prevention of diabetes-related retinal microangiopathy with aldose reductase inhibitors. In: Camerini-Davalos RA, Cole HS (eds) Prediabetes, advances in experimental medicine and biology, Vol 246. Plenum Publishing, New York, pp 365\u2013372"},{"key":"BF00401513_CR12","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1126\/science.6612330","volume":"221","author":"WG Robison Jr","year":"1983","unstructured":"Robison Jr WG, Kador PF, Kinoshita JH (1983) Retinal capillaries: Basement membrane thickening by galactosemia prevented with an aldose reductase inhibitor. Science 221: 1177\u20131179","journal-title":"Science"},{"key":"BF00401513_CR13","first-page":"1519","volume":"24","author":"RN Frank","year":"1983","unstructured":"Frank RN, Keirn RJ, Kennedy A, Frank KW (1983) Galactose-induced retinal capillary basement membrane thickening: prevention by sorbinil. Invest Ophthalmol Vis Sci 24: 1519\u20131524","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF00401513_CR14","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2337\/diab.38.9.1181","volume":"38","author":"S Chakrabarti","year":"1989","unstructured":"Chakrabarti S, Sima AAF (1989) Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats. Diabetes 38: 1181\u20131186","journal-title":"Diabetes"},{"key":"BF00401513_CR15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198408093110604","volume":"311","author":"Kroc Collaborative Study Group","year":"1984","unstructured":"Kroc Collaborative Study Group (1984) Blood glucose control and the evaluation of diabetic retinopathy and albuminuria. N Eng J Med 311: 365\u2013372","journal-title":"N Eng J Med"},{"key":"BF00401513_CR16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/acta.0.1170019","volume":"117","author":"K Dahl-Jorgensen","year":"1988","unstructured":"Dahl-Jorgensen K, Hanssen KF, Kierulf P, Bjoro T, Sandrik L, Aagenaes O (1988) Reduction of urinary albumin excretion after 4 years of continuous subcutaneous insulin infusion in insulin-dependent diabetes mellitus, The Oslo Study. Acta Endocrinol 117: 19\u201325","journal-title":"Acta Endocrinol"},{"key":"BF00401513_CR17","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2337\/diab.36.8.944","volume":"36","author":"AJ Cohen","year":"1987","unstructured":"Cohen AJ, McGill PD, Rossetti RG, Gugerski DL, Like AA (1987) Glomerulopathy in spontaneously diabetic rat. Impact of glycemic control. Diabetes 36: 944\u2013951","journal-title":"Diabetes"},{"key":"BF00401513_CR18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2337\/diab.35.3.295","volume":"35","author":"WG Robison Jr","year":"1986","unstructured":"Robison Jr WG, Kador PF, Akagi Y, Kinoshita JH, Gonzalez R, Dvornik D (1986) Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat. Diabetes 35: 295\u2013299","journal-title":"Diabetes"},{"key":"BF00401513_CR19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/ac00268a010","volume":"56","author":"GO Guerrant","year":"1984","unstructured":"Guerrant GO, Moss CW (1984) Determination of monosaccharides as aldonitrile, o-methyloxime, alditol, and cyclitol acetate derivatives by gas chromatography. Anal Chem 56: 633\u2013638","journal-title":"Anal Chem"},{"key":"BF00401513_CR20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000138152","volume":"32","author":"A Beyer-Mears","year":"1986","unstructured":"Beyer-Mears A, Cruz E, Edelist T, Varagiannis E (1986) Diminished proteinuria in diabetes mellitus by sorbinil, an aldose reductase inhibitor. Pharmacol 32: 52\u201360","journal-title":"Pharmacol"},{"key":"BF00401513_CR21","first-page":"595","volume-title":"Recent trends in management of diabetes mellitus","author":"S Kawazu","year":"1987","unstructured":"Kawazu S, Watanabe T, Hokama A et al. (1987) Diabetic nephropathy and sorbitol pathway in BB\/W rat. In: Sakamoto N, Alberti KGMM, Hotta N (eds) Recent trends in management of diabetes mellitus. Elsevier, Amsterdam, pp 595\u2013597"},{"key":"BF00401513_CR22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2337\/diab.38.10.1258","volume":"38","author":"RG Tilton","year":"1989","unstructured":"Tilton RG, Chang K, Pugliese G et al. (1989) Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes 38: 1258\u20131270","journal-title":"Diabetes"},{"key":"BF00401513_CR23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2337\/diab.38.8.981","volume":"38","author":"BS Daniels","year":"1989","unstructured":"Daniels BS, Hostetter TH (1989) Aldose reductase inhibition and glomerular abnormalities in diabetic rats. Diabetes 38: 981\u2013986","journal-title":"Diabetes"},{"key":"BF00401513_CR24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2337\/diab.38.7.839","volume":"38","author":"SM Mauer","year":"1989","unstructured":"Mauer SM, Steffes MW, Azar S, Brown DM (1989) Effects of sorbinil on glomerular structure and function in long-termdiabetic rats. Diabetes 38: 839\u2013846","journal-title":"Diabetes"},{"key":"BF00401513_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0891-6632(89)90015-9","volume":"3","author":"D Stribling","year":"1989","unstructured":"Stribling D, Armstrong FM, Harrison HE (1989) Aldose reductase in the etiology of diabetic complications: 2. Nephropathy. J Diab Comp 3: 70\u201376","journal-title":"J Diab Comp"},{"key":"BF00401513_CR26","first-page":"306","volume-title":"The diabetes annual, 13","author":"CE Mogensen","year":"1987","unstructured":"Mogensen CE (1987) Early diabetic renal involvement and nephropathy. In: Alberti KGMM, Krall LP (eds) The diabetes annual, 13. Elsevier, Amsterdam, pp 306\u2013324"},{"key":"BF00401513_CR27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1056\/NEJM198909143211112","volume":"321","author":"S Goldfarb","year":"1989","unstructured":"Goldfarb S, Ziyadeh FN (1989) Glomerular lesions and microalbuminuria in diabetes. N Engl J Med 321: 759","journal-title":"N Engl J Med"},{"key":"BF00401513_CR28","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1096\/fasebj.2.7.3280378","volume":"2","author":"RS Goldstein","year":"1988","unstructured":"Goldstein RS, Tarloff JB, Hook JB (1988) Age-related nephropathy in laboratory rats. FASEB J 2: 2241\u20132251","journal-title":"FASEB J"},{"key":"BF00401513_CR29","unstructured":"McCaleb ML, Sredy J (1989) Metabolic abnormalities of the hyperglycemic obese Zucker rat. J Cell Biochem [Suppl. 13E]: 238"},{"key":"BF00401513_CR30","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ki.1988.51","volume":"33","author":"BL Kasiske","year":"1988","unstructured":"Kasiske BL, O'Donnell MP, Cleary MP, Keane WF (1988) Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats. Kid Int 33: 667\u2013672","journal-title":"Kid Int"},{"key":"BF00401513_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00404802","volume":"33","author":"L Niskanen","year":"1990","unstructured":"Niskanen L, Uusitupa M, Sarlund H et al. (1990) Microalbuminuria predicts the development of serum lipoprotein abnormalities favouring atherogenesis in newly diagnosed Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 33: 237\u2013243","journal-title":"Diabetologia"},{"key":"BF00401513_CR32","first-page":"A741","volume":"2","author":"DN Granger","year":"1988","unstructured":"Granger DN, Korthuis RJ, Kvietys PR, Tso P (1988) Intestinal microvascular fluid exchange during lipid absorption. FASEB J 2: A741","journal-title":"FASEB J"},{"key":"BF00401513_CR33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0014-4835(83)90149-5","volume":"37","author":"F Fischer","year":"1983","unstructured":"Fischer F, Gaertner J (1983) Morphometic analysis of basal laminae in rats with long-term streptozotocin diabetes. II. Retinal capillaries. Exp Eye Res 37: 55\u201364","journal-title":"Exp Eye Res"},{"key":"BF00401513_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02892551","volume":"37","author":"S Waber","year":"1981","unstructured":"Waber S, Meister V, Rossi GL, Mordasini R-C, Riesen WF (1981) Studies on retinal microangiopathy and coronary microangiopathy in rats with streptozotocin-induced diabetes. Virch Arch [Cell Pathol] 37: 1\u201310","journal-title":"Virch Arch [Cell Pathol]"},{"key":"BF00401513_CR35","first-page":"99","volume":"29","author":"K Kojima","year":"1985","unstructured":"Kojima K, Matsubara H, Harada T et al. (1985) Effects of aldose reductase inhibitor on retinal microangiopathy in streptozocin-diabetic rats. Jpn J Ophthalmol 29: 99\u2013109","journal-title":"Jpn J Ophthalmol"},{"key":"BF00401513_CR36","first-page":"159","volume":"25","author":"ML Chandler","year":"1984","unstructured":"Chandler ML, Shannon WA, DeSantis L (1984) Prevention of retinal capillary basement membrane thickening in diabetic rats by aldose reductase inhibitors. Invest Ophthamol Vis Sci 25 [Suppl.]: 159","journal-title":"Invest Ophthamol Vis Sci"},{"key":"BF00401513_CR37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/dmr.5610040403","volume":"4","author":"JH Kinoshita","year":"1988","unstructured":"Kinoshita JH, Nishimura C (1988) The involvement of aldose reductase in diabetic complications. Diab Metab Rev 4: 323\u2013337","journal-title":"Diab Metab Rev"},{"key":"BF00401513_CR38","first-page":"264","volume-title":"Ellenberg and Rifkin's diabetes mellitus, theory and practice","author":"JH Kinoshita","year":"1990","unstructured":"Kinoshita JH, Datiles MB, Kador PF, Robison Jr WG (1990) Aldose reductase and diabetic eye complications. In: Rifkin H, Porte Jr D (eds) Ellenberg and Rifkin's diabetes mellitus, theory and practice, 4th edn. Elsevier, New York, pp 264\u2013278","edition":"4th edn"},{"key":"BF00401513_CR39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1001\/archopht.1990.01070110117035","volume":"108","author":"PF Kador","year":"1990","unstructured":"Kador PF, Akagi Y, Takahaski Y, Ikebe H, Wyman M, Kinoshita JH (1990) Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors. Arch Ophthalmol 108: 1301\u20131309","journal-title":"Arch Ophthalmol"},{"key":"BF00401513_CR40","first-page":"2285","volume":"30","author":"WG Robison Jr","year":"1989","unstructured":"Robison Jr WG, Nagata M, Laver N, Hohman TC, Kinoshita JH (1989) Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor. Invest Ophthalmol Vis Sci 30: 2285\u20132292","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF00401513_CR41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00404095","volume":"33","author":"AJM Boulton","year":"1990","unstructured":"Boulton AJM, Levin S, Comstock J (1990) A multicentre trial of the aldose reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia 33: 431\u2013437","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00401513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00401513\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00401513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00401513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T17:56:46Z","timestamp":1581962206000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00401513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["BF00401513"],"URL":"https:\/\/doi.org\/10.1007\/bf00401513","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}