{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:05:32Z","timestamp":1782705932517,"version":"3.54.5"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1995,11]]},"DOI":"10.1007\/bf00401757","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T06:49:58Z","timestamp":1098254998000},"page":"1262-1270","source":"Crossref","is-referenced-by-count":133,"title":["Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats"],"prefix":"10.1007","volume":"38","author":[{"given":"A.","family":"Su\ufffdrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Casla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Arrieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0005-2736(73)90417-3","volume":"291","author":"AJ Lostroh","year":"1973","unstructured":"Lostroh AJ, Krahl ME (1973) Accumulation in vitro of Mg2+ and K+ in rat uterus: ion pump activity. Bioch Biophys Acta 291: 260?268","journal-title":"Bioch Biophys Acta"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/BF00869264","volume":"29","author":"G Paolisso","year":"1986","unstructured":"Paolisso G, Sgambato S, Passariello N et al. (1986) Insulin induces opposite changes in plasma and erythrocyte magnesium concentrations in normal man. Diabetologia 29: 644?647","journal-title":"Diabetologia"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/BF00265376","volume":"31","author":"G Paolisso","year":"1988","unstructured":"Paolisso G, Sgambato S, Giugliano D et al. (1988) Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 31: 910?915","journal-title":"Diabetologia"},{"key":"CR4","first-page":"328","volume":"16","author":"G Paolisso","year":"1990","unstructured":"Paolisso G, Pizza G, Riu S et al. (1990) Impaired insulin-mediated erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose diposal in aged non-diabetic obese patients. Diabetes Metab 16: 328?333","journal-title":"Diabetes Metab"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/cs0730535","volume":"73","author":"G Paolisso","year":"1987","unstructured":"Paolisso G, Passariello N, Sgambato S et al. (1987) Impaired insulin-mediated erythrocyte magnesium accumulation in essential hypertension. Clin Sci 73: 535?539","journal-title":"Clin Sci"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/physrev.1950.30.3.393","volume":"30","author":"AS Lehninger","year":"1950","unstructured":"Lehninger AS (1950 Role of metal ions in enzyme systems. Physiol Rev 30: 393?429","journal-title":"Physiol Rev"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0065-2571(74)90007-7","volume":"12","author":"AJ Lostroh","year":"1974","unstructured":"Lostroh AJ, Krahl ME (1974) Magnesium a second messenger for insulin: ion translocation coupled to transport activity. Adv Enzyme Regul 12: 73?81","journal-title":"Adv Enzyme Regul"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bmj.285.6337.262","volume":"285","author":"KW Moles","year":"1982","unstructured":"Moles KW, McMullen JK (1982) Insulin resistance and hypomagnesaemia: case report. BMJ 285: 262","journal-title":"BMJ"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/bmj.288.6423.1032","volume":"288","author":"CS Yajnik","year":"1984","unstructured":"Yajnik CS, Smith RF, Hockaday TDK, Ward NI (1984) Fasting plasma magnesium concentrations and glucose disposal in diabetes. BMJ 288: 1032?1034","journal-title":"BMJ"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2337\/diacare.12.4.265","volume":"12","author":"G Paolisso","year":"1989","unstructured":"Paolisso G, Sgambato S, Pizza G, Passariello N, Varricchio M, D'Onofrio F (1989) Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Diabetes Care 12: 265?269","journal-title":"Diabetes Care"},{"key":"CR11","first-page":"56","volume":"3","author":"A Rapado","year":"1990","unstructured":"Rapado A, Rovira A, Grant C, Casla A (1990) Insulin resistance in patients with hypomagnesemia. Magnesium Res 3: 56 (Abstract)","journal-title":"Magnesium Res"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"14208","DOI":"10.1016\/S0021-9258(18)89879-9","volume":"259","author":"T Kadowaki","year":"1984","unstructured":"Kadowaki T, Kasuga M, Akanuma Y, Ezaki O, Takaku F (1984) Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. J Biol Chem 259: 14208?14216","journal-title":"J Biol Chem"},{"key":"CR13","first-page":"E542","volume":"251","author":"M Okamoto","year":"1986","unstructured":"Okamoto M, White MF, Maron R, Kahn R (1986) Autophosphorylation and kinase activity of insulin receptor in diabetic rats. Am J Physiol 251: E542-E550","journal-title":"Am J Physiol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/315676a0","volume":"315","author":"Y Marchand-Brustel Le","year":"1985","unstructured":"Le Marchand-Brustel Y, Gr\u00e9meaux T, Ballotti R, van Obberghen E (1985) Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Nature 315: 676?679","journal-title":"Nature"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1172\/JCI112558","volume":"78","author":"FJ Caro","year":"1986","unstructured":"Caro FJ, Ittoop O, Pories WJ et al. (1986) Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. J Clin Invest 78: 249?258","journal-title":"J Clin Invest"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"17081","DOI":"10.1016\/S0021-9258(19)76002-5","volume":"261","author":"J Simon","year":"1986","unstructured":"Simon J, Rosebrough RW, McMurtry JP et al. (1986) Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors. J Biol Chem 261: 17081?17088","journal-title":"J Biol Chem"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1042\/bj0890114","volume":"89","author":"FC Greenwood","year":"1963","unstructured":"Greenwood FC, Hunter WM, Glover JS (1963) The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochem J 89: 114?123","journal-title":"Biochem J"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-25-10-1375","volume":"25","author":"V Herbert","year":"1965","unstructured":"Herbert V, Lau KS, Gottlieb CW, Bleicher SJ (1965) Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25: 1375?1384","journal-title":"J Clin Endocrinol Metab"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1055\/s-2007-1013553","volume":"17","author":"B Varnum","year":"1985","unstructured":"Varnum B, Davidson MB, Venkatesan N (1985) Insulin secretion and action in the hyperthyroid rat. Horm Metab Res 17: 383?386","journal-title":"Horm Metab Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/bj1240639","volume":"124","author":"NB Ruderman","year":"1971","unstructured":"Ruderman NB, Houghton CRS, Hems R (1971) Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 124: 639?651","journal-title":"Biochem J"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/bj1880255","volume":"188","author":"GL Dohm","year":"1980","unstructured":"Dohm GL, Kasperek GJ, Tapscott EB, Beecher GR (1980) Effect of exercise on synthesis and degradation of muscle protein. Biochem J 188: 255?262","journal-title":"Biochem J"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/bi00515a013","volume":"20","author":"JA Hedo","year":"1981","unstructured":"Hedo JA, Harrison LC, Roth J (1981) Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochemistry 20: 3385?3393","journal-title":"Biochemistry"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248?254","journal-title":"Anal Biochem"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","volume":"51","author":"G Scatchard","year":"1949","unstructured":"Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51: 660?672","journal-title":"Ann NY Acad Sci"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0006-291X(83)80181-8","volume":"115","author":"G Grunberger","year":"1983","unstructured":"Grunberger G, Zick Y, Roth J, Gorden P (1983) Protein kinase activity of the insulin receptor in human circulating and cultured mononuclear cells. Biochem Biophys Res Commun 115: 560?566","journal-title":"Biochem Biophys Res Commun"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680?685","journal-title":"Nature"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0021-9258(19)86092-1","volume":"255","author":"PF Pilch","year":"1980","unstructured":"Pilch PF, Czech MP (1980) The subunit structure of the high affinity insuin receptor: evidence for a disulfide linked receptor complex in fat cell and liver plasma membranes. J Biol Chem 255: 1722?1731","journal-title":"J Biol Chem"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/338083a0","volume":"338","author":"DE James","year":"1989","unstructured":"James DE, Strube M, Mueckler M (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338: 83?87","journal-title":"Nature"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0026-0495(87)90011-4","volume":"36","author":"C Legrand","year":"1987","unstructured":"Legrand C, Okitolonda W, Pottier AM, Lederer J, Henquin JC (1987) Glucose homeostasis in magnesium-deficient rats. Metabolism 36: 160?164","journal-title":"Metabolism"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1055\/s-2007-1018801","volume":"15","author":"E Gueux","year":"1983","unstructured":"Gueux E, Rayssiguier Y (1983) The effect of magnesium deficiency on glucose stimulated insulin secretion in rats. Horm Metab Res 15: 594?597","journal-title":"Horm Metab Res"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/jn\/112.4.736","volume":"112","author":"DA McNeill","year":"1982","unstructured":"McNeill DA, Herbein JH, Ritchey SJ (1982) Hepatic gluconeogenic enzymes, plasma insulin and glucagon response to magnesium deficiency and fasting. J Nutr 112: 736?743","journal-title":"J Nutr"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/endo-101-1-203","volume":"101","author":"DL Curry","year":"1977","unstructured":"Curry DL, Joy RM, Holley DC, Bennett LL (1977) Magnesium modulation of glucose-induced insulin secretion by the perfused rat pancreas. Endocrinology 101: 203?208","journal-title":"Endocrinology"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1210\/endo-92-3-735","volume":"92","author":"BJ Lin","year":"1973","unstructured":"Lin BJ, Haist RE (1973) Effects of some modifiers of insulin secretion on insulin biosynthesis. Endocrinology 92: 735?742","journal-title":"Endocrinology"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01269910","volume":"3","author":"RDG Milner","year":"1967","unstructured":"Milner RDG, Hales CN (1967) The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3: 47?49","journal-title":"Diabetologia"},{"key":"CR35","first-page":"895","volume":"76","author":"WJ Malaisse","year":"1970","unstructured":"Malaisse WJ, Brisson G, Malaisse-Lagae F (1970) The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations. J Lab Clin Med 76: 895?902","journal-title":"J Lab Clin Med"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2337\/diab.15.12.910","volume":"15","author":"GM Grodsky","year":"1966","unstructured":"Grodsky GM, Bennett LL (1966) Cation requirements for insulin secretion in the isolated perfused pancreas. Diabetes 15: 910?913","journal-title":"Diabetes"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0304-4165(69)90268-2","volume":"184","author":"AE Lambert","year":"1969","unstructured":"Lambert AE, Jeanrenaud B, Junod A, Renold AE (1969) Organ culture of fetal rat pancreas. II. Insulin release induced by amino and organic acids, by hormonal peptides, by cationic alterations of the medium and by other agents. Biochim Biophys Acta 184: 540?553","journal-title":"Biochim Biophys Acta"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1210\/endo-93-6-1360","volume":"93","author":"V Leclercq-Meyer","year":"1973","unstructured":"Leclercq-Meyer V, Marchand J, Malaisse WJ (1973) The effect of calcium and magnesium on glucagon secretion. Endocrinology 93: 1360?1370","journal-title":"Endocrinology"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1210\/endo-85-3-594","volume":"85","author":"LL Bennett","year":"1969","unstructured":"Bennett LL, Curry DL, Grodsky GM (1969) Calcium-magnesium antagonism in insulin secretion by the perfused rat pancreas. Endocrinology 85: 594?596","journal-title":"Endocrinology"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/BF01219542","volume":"10","author":"JC Henquin","year":"1974","unstructured":"Henquin JC, Lambert AE (1974) Cationic environment and dynamics of insulin secretion III. Effect of the absence of potassium. Diabetologia 10: 789?794","journal-title":"Diabetologia"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI104717","volume":"42","author":"R Whang","year":"1963","unstructured":"Whang R, Welt LG (1963) Observations in experimental magnesium depletion. J Clin Invest 42: 305?313","journal-title":"J Clin Invest"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1042\/bj0700456","volume":"70","author":"I MacIntyre","year":"1958","unstructured":"MacIntyre I, Davidsson D (1958) The production of secondary potassium depletion, sodium retention, nephrocalcinosis and hypercalcaemia by magnesium deficiency. Biochem J 70: 456?462","journal-title":"Biochem J"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj1520609","volume":"152","author":"GA George","year":"1975","unstructured":"George GA, Heaton FW (1975) Changes in cellular composition during magnesium deficiency. Biochem J 152: 609?615","journal-title":"Biochem J"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2337\/diab.17.11.673","volume":"17","author":"ME Kahil","year":"1968","unstructured":"Kahil ME, Simons EL, Brown H (1968) Magnesium deficiency and sugar transport in muscle. Diabetes 17: 673?678","journal-title":"Diabetes"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1161\/01.HYP.23.6.1036","volume":"23","author":"TW Balon","year":"1994","unstructured":"Balon TW, Jasman A, Scott S, Meehan WP, Rude RK, Nadler JL (1994) Dietary magnesium prevents fructose-induced insulin insensitivity in rats. Hypertension 23 (part 2): 1036?1039","journal-title":"Hypertension"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0304-4165(70)90022-X","volume":"215","author":"MK Gould","year":"1970","unstructured":"Gould MK, Chaudry IH (1970) The action of insulin on glucose uptake by isolated rat soleus muscle. I. Effects of cations. Biochim Biophys Acta 215: 249?257","journal-title":"Biochim Biophys Acta"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.85.15.5434","volume":"85","author":"H Fukumoto","year":"1988","unstructured":"Fukumoto H, Seino S, Imura H et al. (1988) Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci USA 85: 5434?5438","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/333183a0","volume":"333","author":"DE James","year":"1988","unstructured":"James DE, Brown R, Navarro J, Pilch PF (1988) Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 333: 183?185","journal-title":"Nature"},{"key":"CR49","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1016\/S0021-9258(19)37577-5","volume":"263","author":"T Kayano","year":"1988","unstructured":"Kayano T, Fukumoto H, Eddy RL et al. (1988) Evidence for a family of human glucose transporter-like proteins. J Biol Chem 263: 15245?15248","journal-title":"J Biol Chem"},{"key":"CR50","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/ajcn\/55.5.1018","volume":"55","author":"GA Colditz","year":"1992","unstructured":"Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE (1992) Diet and risk of clinical diabetes in women. Am J Clin Nutr 55: 1018?1023","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 1","key":"CR51","first-page":"88","volume":"43","author":"T Balon","year":"1994","unstructured":"Balon T, Jasman A, Scott S, Gu JL, Nadler J (1994) Evidence that dietary magnesium supplementation prevents the development of diabetes in a rat model of spontaneous NIDDM. Diabetes 43 [Suppl 1]: 88 (Abstract)","journal-title":"Diabetes"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00401757.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00401757\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00401757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T17:46:25Z","timestamp":1624729585000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00401757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["BF00401757"],"URL":"https:\/\/doi.org\/10.1007\/bf00401757","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}