{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:51:22Z","timestamp":1757587882648},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[1979]]},"DOI":"10.1007\/bf00422494","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T07:05:08Z","timestamp":1100070308000},"page":"139-147","source":"Crossref","is-referenced-by-count":30,"title":["Vinyl chloride and trichloroethylene: Comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver"],"prefix":"10.1007","volume":"94","author":[{"given":"R. J.","family":"Laib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"St\ufffdckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Bolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0006-291X(75)90854-2","volume":"67","author":"A. Barbin","year":"1975","unstructured":"Barbin, A., Br\u00e9sil, H., Croisy, A., Jacquignon, P., Malaveille, C., Montesano, R., Bartsch, H.: Liver microsome mediated formation of alkylating agents from vinyl bromide and vinyl chloride. Biochem. Biophys. Res. Commun. 67, 596?603 (1975)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR2","first-page":"1085","volume":"236","author":"P. B\u00f6rner","year":"1961","unstructured":"B\u00f6rner, P., G\u00f6ssner, W.: Enzymhistochemische Untersuchungen der Adenosintriphosphatase, der Succinodehydrogenase sowie der alkalischen und sauren Phosphatase im Leberparenchym der Ratte w\u00e4hrend der Einwirkung des Carcinogens Di\u00e4thylnitrosamin. Z. Naturforsch. 236, 1085?1091 (1961)","journal-title":"Z. Naturforsch."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00380890","volume":"39","author":"H.M. Bolt","year":"1977","unstructured":"Bolt, H.M., Buchter, A., Wolowski, L., Gil, D.L., Bolt, W.: Incubation of 14C-trichloroethylene vapor with rat liver microsomes: Uptake of radioactivity and covalent protein binding of metabolites. Int. Arch. Occup. Environ. Health 39, 103?111 (1977)","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/10408447609164019","volume":"5","author":"G. Bonse","year":"1976","unstructured":"Bonse, G., Henschler, D.: Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds. CRC Crit. Rev. Toxicol. 5, 395?409 (1976)","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF00524337","volume":"72","author":"H. Friedrich-Freksa","year":"1969","unstructured":"Friedrich-Freksa, H., G\u00f6ssner, W., B\u00f6rner, P.: Histochemische Untersuchungen der Cancerogenese der Rattenleber nach Dauergaben von Di\u00e4thylnitrosamin. Z. Krebsforsch. 72, 226?239 (1969a)","journal-title":"Z. Krebsforsch."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00524338","volume":"72","author":"H. Friedrich-Freksa","year":"1969","unstructured":"Friedrich-Freksa, H., Papadopulu, G., G\u00f6ssner, W.: Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach zeitlich begrenzter Verabfolgung von Di\u00e4thylnitrosamin. Z. Krebsforsch. 72, 240?253 (1969b)","journal-title":"Z. Krebsforsch."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/0006-2952(75)90396-2","volume":"24","author":"H. Greim","year":"1975","unstructured":"Greim, H., Bonse, G., Radwan, Z., Reichert, D., Henschler, D.: Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation. Biochem. Pharmacol. 24, 2013?2017 (1975)","journal-title":"Biochem. Pharmacol."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00355492","volume":"37","author":"D. Henschler","year":"1977","unstructured":"Henschler, D., Eder, E., Neudecker, T., Metzler, M.: Carcinogenicity of trichloroethylene: Fact or artifact? Arch. Toxicol. 37, 233?236 (1977)","journal-title":"Arch. Toxicol."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0006-2952(79)90251-X","volume":"28","author":"D. Henschler","year":"1979","unstructured":"Henschler, D., Hoos, W. R., Fetz, H., Dallmeier, E., Metzler, M.: Reactions of trichloroethylene epoxide in aqueous systems. Biochem. Pharmacol. 28, 543?548 (1979)","journal-title":"Biochem. Pharmacol."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/257134a0","volume":"257","author":"H. Kappus","year":"1975","unstructured":"Kappus, H., Bolt, H.M., Buchter, A., Bolt, W.: Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules. Nature 257, 134?135 (1975)","journal-title":"Nature"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0041-008X(76)90208-8","volume":"37","author":"H. Kappus","year":"1976","unstructured":"Kappus, H., Bolt, H.M., Buchter, A., Bolt, W.: Liver microsomal uptake of 14C-vinyl chloride and transformation to protein alkylating metabolites in vitro. Toxicol. Appl. Pharmacol. 37, 461?471 (1976)","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"CR12","unstructured":"Kunz, W., St\u00f6ckle, G., Appel, K.: Quantitative analyses of enzyme-deficient cell areas to assess early precancerous alterations of hepatocarcenogenic substances. Naunyn-Schmiedeberg's Arch. Pharmacol. (Suppl.) 293, R65 (1976)"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0300-483X(77)90007-5","volume":"8","author":"R.J. Laib","year":"1977","unstructured":"Laib, R.J., Bolt, H.M.: Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1,N6-ethenoadenosine. Toxicology 8, 185?195 (1977)","journal-title":"Toxicology"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00368232","volume":"39","author":"R.J. Laib","year":"1978","unstructured":"Laib, R.J., Bolt, H.M.: Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolites in vitro and in vivo. Arch. Toxicol. 39, 235?240 (1978)","journal-title":"Arch. Toxicol."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.77211","volume":"21","author":"C. Maltoni","year":"1977","unstructured":"Maltoni, C.: Recent findings on carcinogenicity of chlorinated olefins. Presented at the Conference on Comparative Metabolism and Toxicity of Vinyl Chloride Related Compounds, May 2?4, 1977, Bethesda, Md. Env. Hlth. Perspect. 21, 1?5 (1977)","journal-title":"Env. Hlth. Perspect."},{"key":"CR16","series-title":"Carcinogenesis Technical Report Series","volume-title":"Carcinogenesis bioassay of trichloroethylene","author":"NCI, National Institutes of Health, US Dept. of Health, Education and Welfare","year":"1976","unstructured":"NCI, National Institutes of Health, US Dept. of Health, Education and Welfare: Carcinogenesis bioassay of trichloroethylene. Carcinogenesis Technical Report Series, No.2. Washington, D.C.: US Government Printing Office 1976"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0076-6879(67)10117-1","volume":"10","author":"H. Remmer","year":"1967","unstructured":"Remmer, H., Greim, H., Schenkman, J.B., Estabrook, R.W.: Methods for the elevation of hepatic microsomal mixed function oxidase levels and cytochrome P-450. Methods Enzym. 10, 703?708 (1967)","journal-title":"Methods Enzym."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF00537000","volume":"70","author":"A. Schauer","year":"1968","unstructured":"Schauer, A., Kunze, E.: Enzymhistochemische und autoradiographische Untersuchungen w\u00e4hrend der Cancerisierung der Rattenleber mit Di\u00e4thylnitrosamin. Z. Krebsforsch. 70, 252?266 (1968)","journal-title":"Z. Krebsforsch."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00330820","volume":"37","author":"H. Uehleke","year":"1977","unstructured":"Uehleke, H., Tabarelli-Poplawski, S.: Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro. Arch. Toxicol. 37, 289?294 (1977)","journal-title":"Arch. Toxicol."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00293858","volume":"37","author":"H. Uehleke","year":"1977","unstructured":"Uehleke, H., Tabarelli-Poplawski, S., Bonse, G., Henschler, D.: Spectral evidence for 2,2,3-trichlorooxirane formation during microsomal trichloroethylene oxidation. Arch. Toxicol. 37, 95?105 (1977)","journal-title":"Arch. Toxicol."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1749-6632.1975.tb51101.x","volume":"246","author":"B.L. Duuren Van","year":"1975","unstructured":"Van Duuren, B.L.: On the possible mechanism of carcinogenic action of vinyl chloride. Ann. N.Y. Acad. Sci. 246, 258?267 (1975)","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"CR22","first-page":"2419","volume":"36","author":"B.L. Duuren Van","year":"1976","unstructured":"Van Duuren, B.L., Banerjee, S.: Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes. Cancer Res. 36, 2419?2422 (1976)","journal-title":"Cancer Res."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/4.6.592","volume":"4","author":"M. Wachstein","year":"1956","unstructured":"Wachstein, M., Meisel, E.: On the histochemical demonstration of glucose-6-phosphatase. J. Histochem. Cytochem. 4, 592 (1956)","journal-title":"J. Histochem. Cytochem."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajcp\/27.1.13","volume":"27","author":"M. Wachstein","year":"1957","unstructured":"Wachstein, M., Meisel, E.: Histochemistry of hepatic phosphatases at a physiological pH with special reference to the demonstration of bile canaliculi. Am. J. Clin. Pathol. 27, 13?23 (1957)","journal-title":"Am. J. Clin. Pathol."}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00422494.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00422494\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00422494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T23:31:13Z","timestamp":1554852673000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00422494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979]]}},"alternative-id":["BF00422494"],"URL":"https:\/\/doi.org\/10.1007\/bf00422494","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979]]}}}