{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:47:10Z","timestamp":1770752830102,"version":"3.50.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1978,1,1]],"date-time":"1978-01-01T00:00:00Z","timestamp":252460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch. A Path. Anat. and Histol."],"published-print":{"date-parts":[[1978]]},"DOI":"10.1007\/bf00427003","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T18:27:30Z","timestamp":1100111250000},"page":"157-174","source":"Crossref","is-referenced-by-count":113,"title":["The endocrine pancreas in chronic pancreatitis"],"prefix":"10.1007","volume":"377","author":[{"given":"G.","family":"Kl\ufffdppel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Commandeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ph.","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/gut.11.6.524","volume":"11","author":"M.F. Anderson","year":"1970","unstructured":"Anderson, M.F., Davison, S.H.H., Dick, A.P., Hales, C.N., Owens, J.: Plasma insulin in pancreatic disease. Gut 11, 524?531 (1970)","journal-title":"Gut"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/pgmj.44.509.214","volume":"44","author":"S. Bank","year":"1968","unstructured":"Bank, S., Jackson, W.P.U., Keller, P., Marks, I.N.: Serum-insulin response to glucose in pancreatic diabetes. Postgrad. Med. J. 44, 214?217 (1968)","journal-title":"Postgrad. Med. J."},{"key":"CR3","first-page":"13","volume":"64","author":"S. Bank","year":"1975","unstructured":"Bank, S., Marks, I.N., Vinic, A.I.: Clinical and hormonal aspects of pancreatic diabetes. Amer. J. Gastroenterol. 64, 13?22 (1975)","journal-title":"Amer. J. Gastroenterol."},{"key":"CR4","volume-title":"Spezielle pathologische Anatomie, Bd. 6","author":"V. Becker","year":"1973","unstructured":"Becker, V.: Bauchspeicheldr\u00fcse (Inselapparat ausgenommen). In: Spezielle pathologische Anatomie, Bd. 6. Ed. W. Doerr, G. Seifert, E. Uehlinger. Berlin-Heidelberg-New York: Springer 1973"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1055\/s-0028-1107445","volume":"97","author":"W. B\u00f6cker","year":"1972","unstructured":"B\u00f6cker, W., Seifert, G.: Zur Pathologie der Alkoholpankreatitis. H\u00c4ufigkeit, Klassifikation und Pathogenese. Dtsch. med. Wschr. 97, 803?808 (1972)","journal-title":"Dtsch. med. Wschr."},{"key":"CR6","first-page":"485","volume":"60","author":"G. Bommer","year":"1976","unstructured":"Bommer, G., Heitz, P.U., Kl\u00f6ppel, G.: Immunhistologische und ultrastrukturelle Untersuchungen des endokrinen Pankreas bei chronischer Pankreatitis. Verh. Dtsch. Ges. Path. 60, 485 (1976)","journal-title":"Verh. Dtsch. Ges. Path."},{"key":"CR7","first-page":"327","volume":"373","author":"C. Capella","year":"1977","unstructured":"Capella, C., Solcia, E., Frigerio, B., Buffa, R., Usellini, L., Fontana, P.: The endocrine cells of the pancreas related tumours. Ultrastructural study and classification. Virchoes Arch. A Path. Anat. and Histol. 373, 327?352 (1977)","journal-title":"Virchoes Arch. A Path. Anat. and Histol."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF01211879","volume":"7","author":"J.F. Deconinck","year":"1971","unstructured":"Deconinck, J.F., Potvliege, P.R., Gepts, W.: The ultrastructure of the human pancreatic islets. I. The islets of adults. Diabetologia 7, 266?282 (1971)","journal-title":"Diabetologia"},{"key":"CR9","first-page":"718","volume":"70","author":"W. Doerr","year":"1964","unstructured":"Doerr, W.: Pathogenese der akuten und chronischen Pankreatitis. Verh. dtsch. Ges. inn. Med. 70, 718?758 (1964)","journal-title":"Verh. dtsch. Ges. inn. Med."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF01220638","volume":"12","author":"R. Ebert","year":"1976","unstructured":"Ebert, R., Creutzfeldt, W., Brown, J.C., Frerichs, H., Arnold, R.: Response of gastric inhibitory polypeptide (GIP) to test meal in chronic pancreatitis-relationship to endocrine and exocrine insufficiency. Diabetologia 12, 609?612 (1976)","journal-title":"Diabetologia"},{"key":"CR11","first-page":"157","volume":"115","author":"M. Eder","year":"1955","unstructured":"Eder, M.: Regressive and progressive Ver\u00c4nderungen der Langerhansschen Inseln. Untersuchungen an Bauchspeicheldr\u00fcsen bei Gangverschlu\\ durch Pankreaskopfcarcinom. Beitr. path. Anat. 115, 157?177 (1955)","journal-title":"Beitr. path. Anat."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00996324","volume":"13","author":"W. Gepts","year":"1977","unstructured":"Gepts, W., Mey, J. De, Marichal-Pipeleers, M.: Hyperplasia of pancreatic polypeptide-cells in the pancreas of juvenile diabetics. Diabetologia 13, 27?34 (1977)","journal-title":"Diabetologia"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-0028-1107779","volume":"99","author":"W. Grabner","year":"1974","unstructured":"Grabner, W., Phillip, J., Mayer, A., Daniel, U., Matz-Kies, F.: Nachweis inkretorischer Funktionsst\u00f6rungen bei chronischer Pankreatitis. Dtsch. med. Wschr. 99, 445?448 (1974)","journal-title":"Dtsch. med. Wschr."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/14.4.291","volume":"14","author":"R.C. Graham","year":"1966","unstructured":"Graham, R.C., Karnovsky, M.J.: The early stages of absorption of injected horse-radish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem. 14, 291?302 (1966)","journal-title":"J. Histochem. Cytochem."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02890341","volume":"20","author":"L. Grimelius","year":"1976","unstructured":"Grimelius, L., Capella, C., Buffa, R., Polak, J.M., Pearse, A.G.E., Solcia, E.: Cytochemical and ultrastructural differentiation of enteroglucagon and pancreatic-type glucagon cells of the gastrointestinal tract. Virchows Arch. B Cell Path. 20, 217?228 (1976)","journal-title":"Virchows Arch. B Cell Path."},{"key":"CR16","unstructured":"H\u00c4cki, W.H., Kayasseh, L., Gyr, K.: Impaired release of pancreatic polypeptide in patients with chronic pancreatitis. European Pancreatic Club, X Symposium, Dublin, 1977"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0002-9610(69)90282-7","volume":"117","author":"Y. Idezuki","year":"1969","unstructured":"Idezuki, Y., Goetz, F.C., Lillehei, R.C.: Late effect of pancreatic duct ligation on beta cell function. Amer. J. Surg. 117, 33?39 (1969)","journal-title":"Amer. J. Surg."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(68)91055-6","volume":"11","author":"B.I. Joffe","year":"1968","unstructured":"Joffe, B.I., Bank, S., Jackson, W.P.U., Keller, P., O'Reilly, I.G., Vinik, A.I.: Insulin reserve in patients with chronic pancreatitis. Lancet 11, 890?892 (1968)","journal-title":"Lancet"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diab.23.4.257","volume":"23","author":"W.J. Kalk","year":"1974","unstructured":"Kalk, W.J., Vinik, A.I., Bank, S., Buchanan, K.D., Keller, P., Jackson, W.P.U.: Glucagon responses to arginine in chronic pancreatitis. Possible pathogenetic significance in diabetes. Diabetes 23, 257?267 (1974)","journal-title":"Diabetes"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2337\/diab.24.9.851","volume":"24","author":"W.J. Kalk","year":"1975","unstructured":"Kalk, W.J., Vinik, A.I., Paul, M., Keller, P., Jackson, W.P.U.: Immunoreactive glucagon response to intravenous tolbutamide in chronic pancreatitis. Diabetes 24, 851?855 (1975)","journal-title":"Diabetes"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(76)92879-8","volume":"11","author":"L.-I. Larsson","year":"1976","unstructured":"Larsson, L.-I.: Human pancreatic polypeptide, vasoactive intestinal polypeptide, and watery diarrhoea syndrome. Lancet 11, 149 (1976)","journal-title":"Lancet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00422088","volume":"12","author":"L.J. Larsson","year":"1976","unstructured":"Larsson, L.J., Sundler, F., Hakanson, R.: Pancreatic polypeptide. A postulated new hormone: identification of its cellular storage site by light and electron immunochemistry. Diabetologia 12, 211?226 (1976)","journal-title":"Diabetologia"},{"key":"CR23","first-page":"1093","volume":"19","author":"J.N. Marks","year":"1963","unstructured":"Marks, J.N., Bank, M.B.: The aetiology, clinical features and diagnosis of pancreatitis in the south western cape. S. Afr. Med. I. 19, 1093 (1963)","journal-title":"S. Afr. Med. I"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2337\/diab.12.3.238","volume":"12","author":"J.M. Martin","year":"1963","unstructured":"Martin, J.M., Lacy, P.E.: The prediabetic period in partially pancreatectomised rats. Diabetes 12, 238?242 (1963)","journal-title":"Diabetes"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1172\/JCI106691","volume":"50","author":"W.A. M\u00fcller","year":"1971","unstructured":"M\u00fcller, W.A., Faloona, G.F., Unger, R.: The effect of experimental insulin deficiency on glucagon secretion. J. Clin. Invest. 50, 1992?1999 (1971)","journal-title":"J. Clin. Invest."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1055\/s-0028-1108345","volume":"96","author":"E. Nieschlag","year":"1971","unstructured":"Nieschlag, E., Gilfrich, H.J., Nagel, M.: Insulinsekretion nach Pankreasresektion. Dtsch. med. Wschr. 96, 859?862 (1971)","journal-title":"Dtsch. med. Wschr."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1073\/pnas.73.4.1338","volume":"73","author":"L. Orci","year":"1976","unstructured":"Orci, L., Baetens, D., Rufener, C., Amherdt, M., Ravazzola, M., Studer, P., Malaisse-Lagae, F., Unger, R.: Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc. Natl. Acad. Sci. US 73, 1338?1342 (1976)","journal-title":"Proc. Natl. Acad. Sci. US"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jama.1967.03120220059009","volume":"200","author":"E. Paloyan","year":"1967","unstructured":"Paloyan, E., Lawrence, A., Strauss II, F.H., Paloyan, D., Harper, P.V., Cummings, D.: Alpha cell hyperplasia in calcific pancreatitis associated with hyperparathyreoidism. JAMA 200, 97?101 (1967)","journal-title":"JAMA"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/gut.7.3.277","volume":"7","author":"N. Peters","year":"1966","unstructured":"Peters, N., Dick, A.P., Hales, C.N., Orrel, D.H., Sarner, M.: Exocrine and endocrine pancreatic function in diabetes mellitus and chronic pancreatitis. Gut 7, 277?281 (1966)","journal-title":"Gut"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0140-6736(76)90084-2","volume":"1","author":"J.M. Polak","year":"1976","unstructured":"Polak, J.M., Bloom, S.R., Adrian, T.E., Heitz, Ph., Bryant, M.G., Pearse, A.G.E.: Pancreatic polypeptide (PP) in insulinomas, gastrinomas, vipomas and glucagonomas. Lancet 1, 328?330 (1976)","journal-title":"Lancet"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0140-6736(75)92198-4","volume":"1","author":"J.M. Polak","year":"1975","unstructured":"Polak, J.M., Pearse, A.G.E., Grimelius, L., Bloom, S.R., Arimura, A.: Growth hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet 1, 1220?1222 (1975)","journal-title":"Lancet"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/BF01212548","volume":"7","author":"S. Raptis","year":"1971","unstructured":"Raptis, S., Rau, R.M., Schr\u00f6der, K.E., Hartman, W., Faulhaber, J.D., Clodi, P.H., Pfeiffer, E.F.: The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones. III. Insulin response to secretin and pancreozymin and to oral and intravenous glucose in patients suffering from chronic insufficiency of the excrine pancreas. Diabetologia 7, 160?167 (1971)","journal-title":"Diabetologia"},{"key":"CR33","first-page":"191","volume-title":"Europ. Pancreas-Symposium, Erlangen 1963","author":"H. Sarles","year":"1964","unstructured":"Sarles, H., Sarles, J.S.: \u00c4tiologie und Pathogenese der akuten und chronischen Pankreatitis. Europ. Pancreas-Symposium, Erlangen 1963, p. 191. Stuttgart: Schattauer 1964"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF02433627","volume":"316","author":"G. Seifert","year":"1966","unstructured":"Seifert, G.: Das morphologische Bild der chronischen Pankreatitis. Langenbecks Arch. klin. Chir. 316, 264?276 (1966)","journal-title":"Langenbecks Arch. klin. Chir."},{"key":"CR35","first-page":"119","volume-title":"Gastroenterologie und Stoffwechsel. Aktionen und Interaktionen","author":"G. Seifert","year":"1974","unstructured":"Seifert, G., Kl\u00f6ppel, G.: Korrelationen zwischen exokrinem Pankreas und Inselsystem. In: Gastroenterologie und Stoffwechsel. Aktionen und Interaktionen, pp. 119?142, Ed. V. Becker. Baden-Baden-Br\u00fcssel: Witzstrock 1974"},{"key":"CR36","volume-title":"Die Untersuchung der Bauchspeicheldr\u00fcse","author":"G. Seifert","year":"1977","unstructured":"Seifert, G., Bommer, G., Kl\u00f6ppel, G.: Die Wertigkeit der pr\u00c4operativen Diagnostik f\u00fcr die chirurgische Taktik. In: Die Untersuchung der Bauchspeicheldr\u00fcse. Ed. H. Bartelheimer, M. Classen, F.-W. Ossenberg. Stuttgart: Thieme 1977"},{"key":"CR37","volume-title":"Gastrointestinal hormones","author":"E. Solcia","year":"1977","unstructured":"Solcia, E., Polak, J.M., Pearse, A.G.E., Forssmann, W.G., Larsson, L.-I., Sundler, F., Lechago, J., Grimelius, L., Fujita, T., Creutzfeldt, W., Gepts, W., Falkmer, S., Lefranc, G., Heitz, Ph., Hage, E., Buchan, A.M.J., Bloom, S.R., Grossman, M.I.: Lausanne 1977 classification of gastroenteropancreatic endocrine cells. In: Gastrointestinal hormones. Ed. S.R. Bloom, Livingstone, Edinburgh: Churchill 1977 (in press)"},{"key":"CR38","first-page":"129","volume-title":"Immunocytochemistry","author":"L. Sternberger","year":"1974","unstructured":"Sternberger, L.: The unlabeled antibody enzyme method. In: Immunocytochemistry, pp. 129?171. Englewood Cliffs, New Jersey: Prentice-Hall 1974"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/diab.25.2.136","volume":"25","author":"R.H. Unger","year":"1975","unstructured":"Unger, R.H.: Diabetes and the alpha cell. Diabetes 25, 136?151 (1975)","journal-title":"Diabetes"},{"key":"CR40","first-page":"179","volume":"7","author":"G. Wacjner","year":"1965","unstructured":"Wacjner, G.: Adenomatous hyperplasia of the islets of Langerhans in chronic pancreatitis. Bibl. Gastroent. 7, 179?188 (1965)","journal-title":"Bibl. Gastroent."},{"key":"CR41","first-page":"246","volume":"25","author":"B. Weber","year":"1974","unstructured":"Weber, B.: Kohlenhydratstoffwechsel bei der Mukoviszidose. Med. Welt 25, 246?248 (1974)","journal-title":"Med. Welt"}],"container-title":["Virchows Archiv A Pathological Anatomy and Histology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00427003\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T03:53:20Z","timestamp":1682826800000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00427003"}},"subtitle":["Immunocytochemical and ultrastructural studies"],"short-title":[],"issued":{"date-parts":[[1978]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978]]}},"alternative-id":["BF00427003"],"URL":"https:\/\/doi.org\/10.1007\/bf00427003","relation":{},"ISSN":["0340-1227","1432-2307"],"issn-type":[{"value":"0340-1227","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978]]}}}