{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:30:40Z","timestamp":1789983040200,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1976,3,1]],"date-time":"1976-03-01T00:00:00Z","timestamp":194486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch. A Path. Anat. and Histol."],"published-print":{"date-parts":[[1976,3]]},"DOI":"10.1007\/bf00427310","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T18:32:01Z","timestamp":1100111521000},"page":"55-68","source":"Crossref","is-referenced-by-count":35,"title":["The influence of immobilization on osteocyte morphology"],"prefix":"10.1007","volume":"370","author":[{"given":"B.","family":"Krempien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ch.","family":"Manegold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1976,3,1]]},"reference":[{"key":"BF00427310_CR1","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1210\/jcem-1-9-711","volume":"1","author":"F. Albright","year":"1941","unstructured":"Albright, F., Burnett, Ch. H., Copp, O., Parson, W.: Acute atrophy of bone (Osteoporosis) Simulating Hyperparathyroidism. J. clin. Endoor. 1, 711\u2013716 (1941)","journal-title":"J. clin. Endoor."},{"key":"BF00427310_CR2","first-page":"253","volume-title":"Clinical aspects of metabolic bone disease","author":"A. R. Arnstein","year":"1973","unstructured":"Arnstein, A. R., McCann, D. S., Blumenthal, F. S., Prunty, J.: Serum immunoreactive parathyroid hormone in patients with paralysis due to spinal cord trauma. In: Clinical aspects of metabolic bone disease (B. Frame, A. M. Parfitt, H. Duncan eds.), p. 253\u2013256. Amsterdam: Excerpta Medica 1973"},{"key":"BF00427310_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/BF02008098","volume":"1","author":"C. A. Bassett","year":"1968","unstructured":"Bassett, C. A.: Biologic significance of piezoelectricity. Calcif. Tiss. Res. 1, 252\u2013272 (1968)","journal-title":"Calcif. Tiss. Res."},{"key":"BF00427310_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/00003086-196801000-00025","volume":"56","author":"C. A. Baud","year":"1968","unstructured":"Baud, C. A.: Submicrosoopic Structure and Functional Aspects of the Osteocyte. Clin. Orthop. 56, 227\u2013236 (1968)","journal-title":"Clin. Orthop."},{"key":"BF00427310_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000143597","volume":"78","author":"C. A. Baud","year":"1971","unstructured":"Baud, C. A., Auil, E.: Osteocyte differential count in normal human alveolar hone. Acta anat. (Basel) 78, 321\u2013328 (1971)","journal-title":"Acta anat. (Basel)"},{"key":"BF00427310_CR6","unstructured":"B\u00e9langer, L. F., Rasmussen, H.: Inhibition of osteocytic osteolysis by thyrocalcitonin and some antigrowth factors. In: Parathyroid hormone and thyrocalcitonin (Calcitonin). Edited by R. V. Talmage and L. F. B\u00e9langer. Excerpta Medica Int. Congr. Ser. 159, 156\u2013168 (1968)"},{"key":"BF00427310_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02279101","volume":"4","author":"L. F. B\u00e9langer","year":"1969","unstructured":"B\u00e9langer, L. F.: Osteocytic Osteolysis. Calcif. Tiss. Res. 4, 1\u201312 (1969)","journal-title":"Calcif. Tiss. Res."},{"key":"BF00427310_CR8","first-page":"8","volume":"Suppl.","author":"A. Boerbooms","year":"1975","unstructured":"Boerbooms, A., Buys, W.: Rapid assessment of 99 mTc-Pertechnetate uptake in the knee joint as parameter of inflammatory activity. Scand. J. Rheumatol., Suppl. 8 (1975)","journal-title":"Scand. J. Rheumatol."},{"key":"BF00427310_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-642-80875-3_6","volume-title":"Calcium metabolism bone and metabolic bone disease","author":"H. Bohr","year":"1975","unstructured":"Bohr, H.: On calcium metabolism during immobilization. In: Calcium metabolism bone and metabolic bone disease. (Kuhlencordt and H. P. Kruse, eds.), p. 39\u201342. Berlin-Heidelberg-New York: Springer 1975"},{"key":"BF00427310_CR10","unstructured":"Bommer, J.: Der Einflu\u00df von Thyroxin auf den Phosphatstoffwechsel und das Knochenwachstum. Habil. Schrift, Heidelberg, 1975"},{"key":"BF00427310_CR11","first-page":"222","volume-title":"Clinical aspects of metabolic bone diseases","author":"P. Bordier","year":"1973","unstructured":"Bordier, P., Arnaud, C., Hawker, C., Tun-Chot, S., Hioco, D.: Relationship between Serum I. PTH, osteoclastic and osteocytic Bone resorptions and serum calcium in Primary hyperparathyroidism and osteomalacia. In: Clinical aspects of metabolic bone diseases. (B. Frame, A. M. Parfitt, and H. Duncan eds.), p. 222\u2013228. Amsterdam: Excerpta Medica Foundation 1973"},{"key":"BF00427310_CR12","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1210\/endo-81-5-1053","volume":"81","author":"J. M. Burkhart","year":"1967","unstructured":"Burkhart, J. M., Jowsey, J.: Parathyroid and thyroid hormones in the development of immobilization osteoporosis. Endocrinology 81, 1053\u20131082 (1967)","journal-title":"Endocrinology"},{"key":"BF00427310_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF02547231","volume":"11","author":"H. H. Conaway","year":"1973","unstructured":"Conaway, H. H., Waite, C. C., Kenny, A. D.: Immobilization and bone mass in rats. Effects of parathyroidectomy and acetazolamide. Caleif. Tiss. Res. 11, 323\u2013330 (1973)","journal-title":"Caleif. Tiss. Res."},{"key":"BF00427310_CR14","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000245472","volume":"15","author":"M. J. Denham","year":"1973","unstructured":"Denham, M. J.: Progressive osteoporosis in hemiplegia. Geront clin. (Basel) 15, 361\u2013365 (1973)","journal-title":"Geront clin. (Basel)"},{"key":"BF00427310_CR15","unstructured":"Eichler, J.: Inaktivit\u00e4tsosteoporose. Akt. Orthop. Heft 3, 1970"},{"key":"BF00427310_CR16","first-page":"119","volume":"4","author":"H. M. Frost","year":"1963","unstructured":"Frost, H. M.: The osteocyte as a water pump. Bone remodelling, skeletal modelling errors. Orthop. Lect. 4, 119 (1963)","journal-title":"Orthop. Lect."},{"key":"BF00427310_CR17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1302\/0301-620X.40B2.282","volume":"40 B","author":"M. Geiser","year":"1958","unstructured":"Geiser, M., Trueta, J.: Muscle action, bone rarefication and bone formation. An experimental study. J. Bone, Jt Surg. 40 B, 282\u2013311 (1958)","journal-title":"J. Bone, Jt Surg."},{"key":"BF00427310_CR18","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/0002-9343(62)90017-7","volume":"33","author":"R. P. Heaney","year":"1962","unstructured":"Heaney, R. P.: Radiocalcium metabolism in disuse osteoporosis in man. Amer. J. Med. 33, 188\u2013200 (1962)","journal-title":"Amer. J. Med."},{"key":"BF00427310_CR19","first-page":"257","volume-title":"Clinical aspects of metabolic bone disease","author":"H. Heath","year":"1973","unstructured":"Heath, H., Schaaf, M., Wray, H. L., Monchik, J. M., Earll, J. M.: Parathyroid activity and Immobilization-induced changes in calcium metabolism. In: Clinical aspects of metabolic bone disease. (B. Frame, A. M. Parfitt, H. Duncan, eds.), p. 257\u2013260. Amsterdam: Excerpta Medica 1973"},{"key":"BF00427310_CR20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1210\/endo-82-2-384","volume":"82","author":"J. Jowsey","year":"1968","unstructured":"Jowsey, J., Raisz, L. G.: Experimental osteoporosis and parathyroid activity. Endocrinology 82, 348\u2013396 (1968)","journal-title":"Endocrinology"},{"key":"BF00427310_CR21","first-page":"411","volume":"58","author":"U. Kreinsen","year":"1974","unstructured":"Kreinsen, U., Krempien, B.: Aktivit\u00e4t und Richtung der Umbau- und Wachstunisvorg\u00e4nge an den Oberfl\u00e4chen der Knochen unter experimenteller Immobilisation. Verh. dtsch. Ges. Path. 58, 411\u2013414 (1974)","journal-title":"Verh. dtsch. Ges. Path."},{"key":"BF00427310_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00548653","volume":"360","author":"B. Krempien","year":"1973","unstructured":"Krempien, B., Geiger, G., Ritz, E., B\u00fcttner, S.: Osteocytes in chronic uremia. Differential count of osteocytes in human femoral bone. Virchows Arch. Abt. A 360, 1\u20139 (1973)","journal-title":"Virchows Arch. Abt. A"},{"key":"BF00427310_CR23","first-page":"156","volume-title":"Vitamin D and problems related to uremic bone disease","author":"B. Krempien","year":"1975","unstructured":"Krempien, B., Geiger, G., Ritz, E.: Alteration of bone tissue structure in secondary hyperparathyroidism. A scanning electron microscopical study. In: Vitamin D and problems related to uremic bone disease. (A. W. Normann, K. Schaefer, H. G. Grigoleit, D. v. Herrath, E. Ritz, eds.), p. 156\u2013165. Berlin-New York: W. DeGruyter 1975"},{"key":"BF00427310_CR24","doi-asserted-by":"crossref","unstructured":"Krempien, B., Geiger, G., Ritz, E.: Effects of acute and chronic Parathyroid hormone stimulation on osteoblasts and the underlying bone matrix. Experimental studies in rats with scanning and transmission electron-microscopy. XIth Europ. Symp. Calcif. Tiss. 1975, in the press","DOI":"10.1007\/BF02546459"},{"key":"BF00427310_CR25","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1302\/0301-620X.46B4.764","volume":"46 B","author":"M. Landry","year":"1964","unstructured":"Landry, M., Fleisch, H.: The influence of immobilisation on bone formation as evaluated by osseous incorporation of tetracycline. J. bone, Jt Surg. 46 B, 764\u2013771 (1964)","journal-title":"J. bone, Jt Surg."},{"key":"BF00427310_CR26","unstructured":"Lindgren, U.: Disuse osteoporosis and parathyroid function. XIth Europ. Symp. Calcif. Tiss. 1975 (in press)"},{"key":"BF00427310_CR27","first-page":"261","volume-title":"Clinical aspects of metabolic bone disease","author":"D. R. Lockwood","year":"1973","unstructured":"Lockwood, D. R., Lammert, J. E., Vogel, M. J., Hulley, S. B.: Bone mineral loss during bedrest. In: Clinical aspects of metabolic bone disease. (B. Frame, A. M. Parfitt, H. Duncan, eds.), p. 261\u2013265. Amsterdam: Excerpta Medica 1973"},{"key":"BF00427310_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00958673","volume":"321","author":"G. Majno","year":"1951","unstructured":"Majno, G., Rouiller, C.: Die alkalische Phosphatase in der Biologie des Knochengewebes. Virchows Arch. Path. Anat. 321, 1\u201361 (1951)","journal-title":"Virchows Arch. Path. Anat."},{"key":"BF00427310_CR29","unstructured":"Manegold, Ch.: Morphologische Untersuchungen an Osteocyten bei experimenteller Immobilisation. Inaugural Dissertation, Heidelberg, 1975"},{"key":"BF00427310_CR30","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0014-4827(69)90524-2","volume":"58","author":"D. C. Mears","year":"1969","unstructured":"Mears, D. C.: Relationship between membrane potential and metabolic activity of osteoclasts. Exp. Cell Res. 58, 427\u2013429 (1969)","journal-title":"Exp. Cell Res."},{"key":"BF00427310_CR31","first-page":"263","volume-title":"Hard tissue, growth, repair and remineralization","author":"M. Owen","year":"1973","unstructured":"Owen, M., Triffit, J. T., Melick, R. A.: Albumin in bone. In: Hard tissue, growth, repair and remineralization. Ciba Foundation Symposium 11 (new series), p. 263\u2013287. Amsterdam-London-New York: Elsevier, Exeerpta Medica, North Holland 1973"},{"key":"BF00427310_CR32","volume-title":"The physiological and cellular basis of metabolic bone disease","author":"H. Rasmussen","year":"1974","unstructured":"Rasmussen, H., Bordier, Ph.: The physiological and cellular basis of metabolic bone disease. Baltimore: Williams and Wilkins Comp. 1974"},{"key":"BF00427310_CR33","volume-title":"Untersuchungen \u00fcber Rachitis und Osteomalacie","author":"F. v. Recklinghausen","year":"1910","unstructured":"Recklinghausen, F. v.: Untersuchungen \u00fcber Rachitis und Osteomalacie. Jena: Fischer 1910"},{"key":"BF00427310_CR34","volume-title":"Calciumkinetik und Knochenmorphologie","author":"W. Remagen","year":"1970","unstructured":"Remagen, W.: Calciumkinetik und Knochenmorphologie. Stuttgart: G. Thieme 1970"},{"key":"BF00427310_CR35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/BF00959552","volume":"328","author":"E. Rutishauser","year":"1960","unstructured":"Rutishauser, E., Rohner, A., Held, D.: Experimentelle Untersuchungen \u00fcber die Wirkung der Isch\u00e4mie auf den Knochen und das Mark. Virchows Arch. Path. Anat. 328, 101\u2013118 (1960)","journal-title":"Virchows Arch. Path. Anat."},{"key":"BF00427310_CR36","first-page":"346","volume":"7","author":"J. A. Sevastik","year":"1971","unstructured":"Sevastik, J. A., Mattsson, S.: Osteoporosis and Parathyroid Glands. Israel J. med. Sci. 7, 346\u2013349 (1971)","journal-title":"Israel J. med. Sci."},{"key":"BF00427310_CR37","first-page":"69","volume":"47","author":"E. Uehlinger","year":"1963","unstructured":"Uehlinger, E.: Die Kinetik des Calciumstoffwechsels. Verh. dtsch. Ges. Path. 47, 69\u201391 (1963)","journal-title":"Verh. dtsch. Ges. Path."},{"key":"BF00427310_CR38","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/00003086-196801000-00024","volume":"56","author":"P. Vittali","year":"1968","unstructured":"Vittali, P.: Osteocyte activity Clin. Orthop. 56, 213\u2013226 (1968)","journal-title":"Clin. Orthop."},{"key":"BF00427310_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF02060280","volume":"14","author":"J. M. Weininger","year":"1974","unstructured":"Weininger, J. M., Holtrop, M. E.: An ultrastructural study of bone cells: The occurrence of microtubules, microfilaments and tight junctions. Calcif. Tiss. Res. 14, 15\u201329 (1974)","journal-title":"Calcif. Tiss. Res."},{"key":"BF00427310_CR40","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/00003086-197407000-00023","volume":"102","author":"N. Westlin","year":"1974","unstructured":"Westlin, N.: Loss of bone mineral after Colles' fracture. Clin. Orthop. 102, 194\u2013199 (1974)","journal-title":"Clin. Orthop."},{"key":"BF00427310_CR41","doi-asserted-by":"crossref","unstructured":"Whalen, J. P., Krook, L., Nunez, E. A.: A radiographic and histologic study of bone in the active and hibernating bat (Myotis Lucifugus). Anat. Rec. 172, 97\u2013108","DOI":"10.1002\/ar.1091720109"},{"key":"BF00427310_CR42","doi-asserted-by":"crossref","unstructured":"Whedon, G. D., Lutwak, L., Rambaut, P., Whittle, M., Leach, C., Reid, J., Smith, M.: Effect of weightlessness on mineral metabolism, metabolic studies on skylab orbital space flights. XIth Europ. Symp. Calcif. Tiss. 1975 (in press)","DOI":"10.1007\/BF02546488"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00427310\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:36Z","timestamp":1585958436000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00427310"}},"subtitle":["Osteocyte differential count and electron microscopical studies"],"short-title":[],"issued":{"date-parts":[[1976,3]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,3]]}},"alternative-id":["BF00427310"],"URL":"https:\/\/doi.org\/10.1007\/bf00427310","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,3]]}}}