{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:46:53Z","timestamp":1757544413369},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2-3","license":[{"start":{"date-parts":[[1983,2,1]],"date-time":"1983-02-01T00:00:00Z","timestamp":412905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1983,2]]},"DOI":"10.1007\/bf00427799","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T04:36:23Z","timestamp":1100147783000},"page":"130-136","source":"Crossref","is-referenced-by-count":14,"title":["Chronic elevation of brain GABA by ?-vinyl GABA treatment does not alter the sensitivity of GABAergic or dopaminergic receptors in rat CNS"],"prefix":"10.1007","volume":"79","author":[{"given":"Colin R.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Mallorga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Huot-Olivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Palfreyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"326","volume-title":"GABA-neurotransmitters","author":"G Bartholini","year":"1979","unstructured":"Bartholini G, Scatton B, Zivkovic B, Lloyd KG (1979) On the mode of action of SL 76002, a new GABA receptor agonist. In: Krogsgaard-Larsen P, Scheel-Kr\ufffdger J, Kofod H (eds) GABA-neurotransmitters. Munksgaard, Copenhagen, pp 326?339"},{"key":"CR2","first-page":"138","volume":"1","author":"G Bartholini","year":"1980","unstructured":"Bartholini G (1980) Interaction of striatal dopaminergic, cholinergic and GABA-ergic neurons: Relation to extrapyramidal function. TIPS 1:138?140","journal-title":"TIPS"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0140-6736(73)90398-X","volume":"1","author":"ED Bird","year":"1973","unstructured":"Bird ED, Mackay AVP, Rayner AN, Iversen LL (1973) Reduced glutamic acid decarboxylase activity of postmortem brain in Huntington's chorea. Lancet 1:1090?1092","journal-title":"Lancet"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj1210561","volume":"121","author":"BL Brown","year":"1971","unstructured":"Brown BL, Albano J, Ekins RP, Sherzil A, Tampion W (1971) A simple and sensitive saturation assay method for the measurement of adenosine 3?,5?-cyclic monophosphate. Biochem J 121:561?562","journal-title":"Biochem J"},{"key":"CR5","volume-title":"Long-term effects of neuroleptics","author":"F Cattabeni","year":"1980","unstructured":"Cattabeni F, Racagni G, Spano PF, Costa E (1980) Long-term effects of neuroleptics. Raven, New York"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ddr.430010310","volume":"1","author":"AV Christensen","year":"1981","unstructured":"Christensen AV, Hyttel J (1981) Prolonged treatment with the GABA agonist THIP increases dopamine receptor binding more than it changes dopaminergic behaviour in mice. Drug Dev Res 1:255?263","journal-title":"Drug Dev Res"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/0306-4522(79)90048-4","volume":"4","author":"A Dray","year":"1979","unstructured":"Dray A (1979) The striatum and substantia nigra: A commentary on their relationships. Neuroscience 4:1407?1439","journal-title":"Neuroscience"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S0317167100043894","volume":"9","author":"Y Smet De","year":"1982","unstructured":"De Smet Y, Mear JY, Tell G, Schechter PJ, Lhermitte F, Agid Y (1982) Effect of ?-vinyl GABA in Friedreich's ataxia. Can J Neurol Sci 9:171?173","journal-title":"Can J Neurol Sci"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0024-3205(80)90456-7","volume":"27","author":"JW Ferkany","year":"1980","unstructured":"Ferkany JW, Enna SJ (1980) Interaction between GABA agonists and the cholinergic muscarinic system in the rat corpus striatum. Life Sci 27:143?149","journal-title":"Life Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1471-4159.1980.tb04652.x","volume":"34","author":"JW Ferkany","year":"1980","unstructured":"Ferkany JW, Strong R, Enna SJ (1980) Dopamine receptor super-sensitivity in the corpus striatum following chronic elevation of brain GABA. J Neurochem 34:247?249","journal-title":"J Neurochem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/0028-3908(81)90060-5","volume":"20","author":"JW Ferkany","year":"1981","unstructured":"Ferkany JW, Andree TH, Clarke DE, Enna SJ (1981) Neurochemical effects of kojic amine, a GABA-mimetic and its interaction with benzylamine oxidase. Neuropharmacology 20:1177?1182","journal-title":"Neuropharmacology"},{"key":"CR12","first-page":"74","volume-title":"GABA-neurotransmitters","author":"K Fuxe","year":"1979","unstructured":"Fuxe K, Anderson K, Ogren SO, Perez De La Mora M, Schwarcz R, H\ufffdkfelt T, Energt HP, Gustafsson JA, Skett P (1979) GABA-neurons and their interaction with monoamine neurons. An anatomical, pharmacological and functional analysis. In: Krogsgaard-Larsen P, Scheel-Kr\ufffdger J, Kofod H (eds) GABA-neurotransmitters. Munksgaard, Copenhagen, pp 74?94"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/283569a0","volume":"283","author":"K Gale","year":"1980","unstructured":"Gale K (1980) Chronic blockade of dopamine receptors by anti-schizophrenic drugs enhances GABA binding in substantia nigra. Nature 283:569?570","journal-title":"Nature"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-2999(81)90065-0","volume":"75","author":"CR Gardner","year":"1981","unstructured":"Gardner CR, Klein J, Grove J (1981a) Endogenous GABA determines the characteristics of [3H] GABA binding. Eur J Pharmacol 75:83?92","journal-title":"Eur J Pharmacol"},{"key":"CR15","unstructured":"Gardner CR, Richards MH, Grove J (1981 b) Specific GABA-transaminase inhibition increases the neuronal pool of GABA released by potassium-ion depolarization. Proceedings of the 8th Meeting of the Infernational Society for Neurochemistry, p 176"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/0024-3205(81)90511-7","volume":"28","author":"J Grove","year":"1981","unstructured":"Grove J, Schechter PJ, Tell G, Koch-Weser J, Sjoerdsma A, Waiter JM, Marescant C, Rumbach L (1981) Increased GABA, homocarnosine, and ?-alanine in cerebrospinal fluid of patients treated with ?-vinyl GABA. Life Sci 28:2431?2439","journal-title":"Life Sci"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF00965125","volume":"7","author":"J Grove","year":"1982","unstructured":"Grove J, Gardner CR, Richards MH (1982) Measurement of release of endogeneous GABA and catabolites of [3H] GABA from synaptosomal preparations using ion-exchange chromatography. Neurochem Res 7:583?593","journal-title":"Neurochem Res"},{"key":"CR18","first-page":"479","volume-title":"GABA in nervous system function","author":"O Hornykiewicz","year":"1976","unstructured":"Hornykiewicz O, Lloyd KG, Davidson L (1976) The GABA system, function of the basal ganglia, and Parkinson's disease. In: Roberts E, Chase TN, Tower DB (eds) GABA in nervous system function. Raven, New York, pp 479?485"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0091-3057(82)90269-6","volume":"17","author":"S Huot","year":"1982","unstructured":"Huot S, Palfreyman MG (1982) Effects of ?-vinyl GABA on food intake of rats. Pharmacol Biochem Behav 17:99?106","journal-title":"Pharmacol Biochem Behav"},{"issue":"Suppl 2","key":"CR20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0361-9230(80)90003-9","volume":"5","author":"MJ Iadarola","year":"1980","unstructured":"Iadarola MJ, Gale K (1980) Evaluation of increases in nerve terminal dependent versus nerve terminal-independent compartments of GABA in vivo. Brain Res Bull 5 (Suppl 2):13?19","journal-title":"Brain Res Bull"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-291X(75)90316-2","volume":"67","author":"MJ Jung","year":"1975","unstructured":"Jung MJ, Metcalf BW (1975) Catalytic inhibition of ?-aminobutyric acid ?-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog. Biochem Biophys Res Commun 67:301?306","journal-title":"Biochem Biophys Res Commun"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1471-4159.1977.tb10721.x","volume":"29","author":"MJ Jung","year":"1977","unstructured":"Jung MJ, Lippert B, Metcalf BW, B\ufffdhlen P, Schechter PJ (1977) ?-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: Effects on brain GABA metabolism in mice. J Neurochem 29:797?802","journal-title":"J Neurochem"},{"key":"CR23","first-page":"135","volume-title":"Enzyme-activated irreversible inhibitors","author":"MJ Jung","year":"1978","unstructured":"Jung MJ (1978) In vivo biochemistry of GABA transaminase inhibition. In: Seiler N, Jung MJ, Koch-Weser J (eds) Enzyme-activated irreversible inhibitors. Elsevier, Amsterdam, pp 135?148"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1073\/pnas.69.8.2145","volume":"69","author":"JW Kebabian","year":"1972","unstructured":"Kebabian JW, Petzold GL, Greengard P (1972) Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain and its similarities to the dopamine receptor. Proc Natl Acad Sci USA 69:2145?2150","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1176\/ajp.130.1.82","volume":"130","author":"HL Klawans","year":"1973","unstructured":"Klawans HL (1973) The pharmacology of tardive dyskinesia. Am J Psychiatry 130:82?86","journal-title":"Am J Psychiatry"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0040-4039(00)77904-4","volume":"7","author":"K Kobayashi","year":"1976","unstructured":"Kobayashi K, Miyazawa S, Terahara A, Mishima H, Kurihara H (1976) Gabaculine: ?-Aminobutyrate amino transferase inhibitor of microbial origin. Tetrahedron Lett 7:537?540","journal-title":"Tetrahedron Lett"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1471-4159.1975.tb04411.x","volume":"25","author":"P Krogsgaard-Larsen","year":"1975","unstructured":"Krogsgaard-Larsen P, Johnston GAR, Curtis DR, Game CJA, McCulloch RM (1975) Structure and biological activity of a series of confirmationally restricted analogues of GABA. J Neurochem 25:803?809","journal-title":"J Neurochem"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/268053a0","volume":"268","author":"P Krogsgaard-Larsen","year":"1977","unstructured":"Krogsgaard-Larsen P, Johnston GAR, Lodge D, Curtis DR (1977) A new class of GABA agonists. Nature 268:53?55","journal-title":"Nature"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1471-4159.1981.tb02396.x","volume":"36","author":"JE Leysen","year":"1981","unstructured":"Leysen JE, Gommeren W (1981) Optimal conditions for [3H] apomorphine binding and anomalous equilibrium binding of [3H] apomorphine and [3H] spiperone to rat striatal membranes: Involvement of surface phenomena versus multiple binding sites. J Neurochem 36:201?219","journal-title":"J Neurochem"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1432-1033.1977.tb11410.x","volume":"74","author":"B Lippert","year":"1977","unstructured":"Lippert B, Metcalf BW, Jung MJ, Casara P (1977) 4-Aminohex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric aminotransferase in mammalian brain. Eur J Biochem 74:441?445","journal-title":"Eur J Biochem"},{"key":"CR31","first-page":"253","volume-title":"Long-term effects of neuroleptics","author":"KG Lloyd","year":"1980","unstructured":"Lloyd KG, Worms P (1980) Sustained GABA receptor stimulation and chronic neuroleptic effects. In: Cattabeni F, Racagni G, Spano PF, Costa E (eds) Long-term effects of neuroleptics. Raven, New York pp 253?258"},{"key":"CR32","first-page":"199","volume-title":"GABA and benzodiazepine receptors","author":"KG Lloyd","year":"1981","unstructured":"Lloyd KG, Munari C, Worms P, Bossi L, Bancaud J, Talairach J, Morselli PL (1981) The role of GABA mediated neurotransmission in convulsive states. In: Costa E, DiChiara G, Gessa GL (eds) GABA and benzodiazepine receptors. Raven, New York, pp 199?206"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265?275","journal-title":"J Biol Chem"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0028-3908(80)90193-8","volume":"19","author":"P Mallorga","year":"1980","unstructured":"Mallorga P, Hamburg M, Tallman JF, Gallager DW (1980) Ontogenetic changes in GABA modulation of brain benzodiazepine binding. Neuropharmacology 19:405?408","journal-title":"Neuropharmacology"},{"key":"CR35","first-page":"487","volume-title":"GABA in nervous system function","author":"PL McGeer","year":"1976","unstructured":"McGeer PL, McGeer EG (1976) The GABA system and function of the basal ganglia: Huntington's disease. In: Roberts E, Chase TN, Tower DB (eds) GABA in nervous system function, Raven, New York, pp 487?495"},{"issue":"Suppl 2","key":"CR36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0361-9230(80)90101-X","volume":"5","author":"MG Palfreyman","year":"1980","unstructured":"Palfreyman MG, Robin MM, Zra\ufffdka M, Gardner CR, Schechter PJ (1980) Dyskinesia induced by intracerebral injections of GABA-T inhibitors: A striatal or cortical phenomenon? Brain Res Bull 5 (Suppl 2):613?619","journal-title":"Brain Res Bull"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0006-2952(81)80001-9","volume":"30","author":"MG Palfreyman","year":"1981","unstructured":"Palfreyman MG, Schechter PJ, Buckett WR, Tell GP, Koch-Weser J (1981) The pharmacology of GABA-transaminase inhibitors. Biochem Pharmacol 30:817?824","journal-title":"Biochem Pharmacol"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM197302152880703","volume":"288","author":"TL Perry","year":"1973","unstructured":"Perry TL, Hansen S, Kloster M, (1973) Huntington's chorea, deficiency of gamma-aminobutyric acid in brain. N Engl J Med 288:337?342","journal-title":"N Engl J Med"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/0006-2952(74)90033-1","volume":"23","author":"E Roberts","year":"1974","unstructured":"Roberts E (1974) GABA and nervous system function: A perspective. Biochem Pharmacol 23:2637?2649","journal-title":"Biochem Pharmacol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-2999(77)90270-9","volume":"45","author":"PJ Schechter","year":"1977","unstructured":"Schechter PJ, Tranier Y, Jung MJ, B\ufffdhlen P (1977) Audiogenic seizure protection by elevated brain GABA concentrations in mice: Effects of ?-acetylenic and ?-vinyl GABA, two irreversible GABA-T inhibitors. Eur J Pharmacol 45:319?328","journal-title":"Eur J Pharmacol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0022-510X(80)90103-3","volume":"48","author":"EGS Spokes","year":"1980","unstructured":"Spokes EGS, Garrett NJ, Rossor MN, Iversen LL (1980) Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects. Neurol Sci 48:303?313","journal-title":"Neurol Sci"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/274383a0","volume":"274","author":"JF Tallman","year":"1978","unstructured":"Tallman JF, Thomas JW, Gallager DW (1978) GABAergic modulation of benzodiazepine binding site sensitivity. Nature 274:383?385","journal-title":"Nature"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0028-3908(74)90084-7","volume":"13","author":"D Tarsy","year":"1974","unstructured":"Tarsy D, Baldessarini RJ (1974) Behavioral supersensitivity to apomorphine stereotypy following chronic treatment with drugs which interfere with the synaptic function of catecholamines. Neuropharmacology 13:927?930","journal-title":"Neuropharmacology"},{"key":"CR44","first-page":"581","volume":"305","author":"G Tell","year":"1981","unstructured":"Tell G, Schechter PJ, Koch-Weser J, Cantiniaux P, Chabannes JP, Lambert RA (1981) Effect of ?-vinyl GABA. N Engl J Med 305:581?582","journal-title":"N Engl J Med"},{"key":"CR45","first-page":"461","volume-title":"GABA in nervous system function","author":"DB Tower","year":"1976","unstructured":"Tower DB (1976) GABA and seizures: Clinical correlates in man. In: Roberts E, Chase TN, Tower DB (eds) GABA in nervous system function. Raven, New York, pp 461?478"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1471-4159.1982.tb07897.x","volume":"38","author":"J Wagner","year":"1982","unstructured":"Wagner J, Vitali P, Palfreyman MG, Zra\ufffdka M, Huot S (1982) Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxy phenylalanine, norepinephrine, 3,4-dihydroxy phenylacetic acid, homovanillic acid, serotonin and 5-hydroxy indolacetic acid in rat cerebrospinal fluid and brain by high performance liquid chromatography with electrochemical detection. J Neurochem 38:1241?1254","journal-title":"J Neurochem"},{"key":"CR47","first-page":"266","volume":"241","author":"GG Yarbrough","year":"1979","unstructured":"Yarbrough GG, Williams M, Haubrich DR (1979) The neuropharmacology of a novel ?-aminobutyric acid analog, Kojic amine. Arch Int Pharmacodyn 241:266?279","journal-title":"Arch Int Pharmacodyn"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427799.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00427799\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00427799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T03:55:00Z","timestamp":1624852500000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00427799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":47,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["BF00427799"],"URL":"https:\/\/doi.org\/10.1007\/bf00427799","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}