{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:09:23Z","timestamp":1768687763056,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1983,3,1]],"date-time":"1983-03-01T00:00:00Z","timestamp":415324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1983,3]]},"DOI":"10.1007\/bf00433407","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T05:18:43Z","timestamp":1100150323000},"page":"308-312","source":"Crossref","is-referenced-by-count":58,"title":["3H-Rauwolscine binding in platelets from depressed patients and healthy volunteers"],"prefix":"10.1007","volume":"79","author":[{"given":"Carmen","family":"Pimoule","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Briley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Loo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Zarifian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Raisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salomon Z.","family":"Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"425","volume":"4","author":"B Asarch","year":"1981","unstructured":"Asarch B, Shih J, Kulcsar A (1981) Decreased 3H-imipramine binding in depressed males and females. Comm Psychopharmacol 4:425?432","journal-title":"Comm Psychopharmacol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-2999(79)90489-8","volume":"58","author":"MS Briley","year":"1979","unstructured":"Briley MS, Raisman R, Langer SZ (1979) Human platelets possess high-affinity binding sites for 3H-imipramine. Eur J Pharmacol 58:347?348","journal-title":"Eur J Pharmacol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.7384806","volume":"209","author":"MS Briley","year":"1980","unstructured":"Briley MS, Langer SZ, Raisman R, Sechter D, Zarifian E (1980) 3H-Imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209:303?305","journal-title":"Science"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/0024-3205(81)90171-5","volume":"28","author":"M Daiguji","year":"1981","unstructured":"Daiguji M, Meltzer HY, U'Prichard DC (1981a) Human platelet ?2-adrenergic receptors: labeling, with 3H-yohimbine, a selective antagonist ligand. Life Sci 28:2705?2717","journal-title":"Life Sci"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/0024-3205(81)90662-7","volume":"29","author":"M Daiguji","year":"1981","unstructured":"Daiguji M, Meltzer HY, Tong C, U'Prichard DC, Young M, Kravitz H (1981b) 311-2 receptors in platelet membranes of depressed patients: no change in number or 3H-yohimbine affinity. Life Sci 29:2059?2064","journal-title":"Life Sci"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1476-5381.1982.tb09197.x","volume":"76","author":"JM Elliott","year":"1982","unstructured":"Elliott JM, Grahame-Smith DG (1982) The binding characteristics of [3H]-dihydroergocryptine on intact human platelets. Br J Pharmacol 76:121?130","journal-title":"Br J Pharmacol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0014-2999(81)90612-9","volume":"69","author":"JA Garcia-Sevilla","year":"1981","unstructured":"Garcia-Sevilla JA, Athanasios PZ, Thomas CZ, Smith CB (1981a) Tricyclic antidepressant drug treatment decreases ?2-adrenoceptors on human platelet membranes. Eur J Pharmacol 69:121?123","journal-title":"Eur J Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0014-2999(81)90052-2","volume":"74","author":"JA Garcia-Sevilla","year":"1981","unstructured":"Garcia-Sevilla JA, Hollingsworth PJ, Smith CB (1981b) 311-4 on human platelets: selective labelling by 3H-clonidine and 3H-yohimbine and competitive inhibition by antidepressants drugs. Eur J Pharmacol 74:329?341","journal-title":"Eur J Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1210\/endo-110-3-926","volume":"110","author":"BB Hoffman","year":"1982","unstructured":"Hoffman BB, Michel T, Brenneman TB, Lefkowitz RJ (1982) Interactions of agonists with platelet ?2-adrenergic receptors. Endocrinology 110:926?932","journal-title":"Endocrinology"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/274819a0","volume":"24","author":"KH Jakobs","year":"1978","unstructured":"Jakobs KH (1978) Synthetic alpha-adrenergic agonists are potent alpha-adrenergic antagonists in human platelets. Nature 24:819?820","journal-title":"Nature"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/0024-3205(77)90197-7","volume":"1","author":"MS Kafka","year":"1977","unstructured":"Kafka MS, Tallman JF, Smith CC (1977) Alpha-adrenergic receptors on human platelets. Life Sci 1:1429?1438","journal-title":"Life Sci"},{"key":"CR12","first-page":"337","volume":"32","author":"SZ Langer","year":"1980","unstructured":"Langer SZ (1980) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32:337?362","journal-title":"Pharmacol Rev"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0166-2236(81)90011-4","volume":"4","author":"SZ Langer","year":"1981","unstructured":"Langer SZ, Briley M (1981) High-affinity 3H-imipramine binding: A new biological tool for studies in depression. Trends Neuro Sci 4:28?31","journal-title":"Trends Neuro Sci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00505732","volume":"313","author":"SZ Langer","year":"1980","unstructured":"Langer SZ, Briley MS, Raisman R, Henry J-F, Morselli PL (1980) Specific 3H-imipramine binding in human platelets: Influence of age and sex. Naunyn-Schmiedeberg's Arch Pharmacol 313:189?194","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1471-4159.1981.tb00450.x","volume":"37","author":"SZ Langer","year":"1981","unstructured":"Langer SZ, Javoy-Agid F, Raisman R, Briley M, Agid Y (1981) Distribution of specific high-affinity binding sites for 3H-imipramine in human brain. J Neurochem 37:267?271","journal-title":"J Neurochem"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265?275","journal-title":"J Biol Chem"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/S0006-291X(80)80044-1","volume":"97","author":"HJ Motulsky","year":"1980","unstructured":"Motulsky HJ, Shattil SJ, Insel PA (1980) Characterization of ?2-adrenergic receptorson human platelets using 3H-yohimbine. Biochem Biophys Res Commun 97:1562?1570","journal-title":"Biochem Biophys Res Commun"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0304-4165(81)90182-3","volume":"676","author":"A Mukherjee","year":"1981","unstructured":"Mukherjee A (1981) Characterization of ?2 receptors in human platelets by binding of a radioactive ligand 3H-yohimbine. Biochem Biophys Acta 676:148?154","journal-title":"Biochem Biophys Acta"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1172\/JCI108950","volume":"61","author":"KD Newman","year":"1978","unstructured":"Newman KD, Williams LT, Bishopric NH, Lefkowitz RJ (1978) Identification of ?-adrenergic receptors by 3H-dihydroergocryptine binding. J Clin Invest 61:395?402","journal-title":"J Clin Invest"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/archpsyc.1981.01780370017001","volume":"38","author":"SM Paul","year":"1981","unstructured":"Paul SM, Rehavi P, Ballenger JC, Goodwin FK (1981) Depressed patients have decreased binding of [3H]-imipramine to the platelet serotonin ?transporter?. Arch Gen Psychiatry 38:1315?1317","journal-title":"Arch Gen Psychiatry"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0014-2999(81)90123-0","volume":"76","author":"BD Perry","year":"1981","unstructured":"Perry BD, U'Prichard DC (1981) 3H-Rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha2-adrenergic receptors. Eur J Pharmacol 76:461?470","journal-title":"Eur J Pharmacol"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF00435855","volume":"75","author":"R Raisman","year":"1981","unstructured":"Raisman R, Sechter D, Briley MS, Zarifian E, Langer SZ (1981) High-affinity 3H-imipramine binding in platelets from untreated depressed patients compared to healthy volunteers. Psychopharmacology 75:368?371","journal-title":"Psychopharmacology"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/BF00432765","volume":"77","author":"R Raisman","year":"1982","unstructured":"Raisman R, Briley MS, Bouchami F, Sechter D, Zarifian E, Langer SZ (1982) 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers. Psychopharmacology 77:332?335","journal-title":"Psychopharmacology"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/0024-3205(80)90213-1","volume":"26","author":"M Rehavi","year":"1980","unstructured":"Rehavi M, Paul SM, Skolnick P, Goodwin FK (1980) Demonstration of specific high-affinity binding sites for 3H-imipramine in human brain. Life Sci 26:2273?2279","journal-title":"Life Sci"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/224609a0","volume":"224","author":"EW Salzman","year":"1969","unstructured":"Salzman EW, Neir LL (1969) Cyclic 3?,5?-adenosine monophosphate in human blood platelets. Nature 224:609?610","journal-title":"Nature"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/ajp.122.5.509","volume":"32","author":"JJ Schildkraut","year":"1965","unstructured":"Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: A review of the supporting evidence. Am J Psychiatry 32:509?522","journal-title":"Am J Psychiatry"},{"key":"CR27","first-page":"179","volume":"19","author":"SJ Shattil","year":"1981","unstructured":"Shattil SJ, McDonough M, Turnbull J, Insel PA (1981) Characterization of alpha-adrenergic receptors in human platelets using 3H-clonidine. Mol Pharmacol 19:179?183","journal-title":"Mol Pharmacol"},{"key":"CR28","first-page":"99","volume-title":"New vistas in depression","author":"CB Smith","year":"1982","unstructured":"Smith CB, Garcia-Sevilla JA (1982) Alpha2-adrenoceptors in endogenous depression. In: Langer SZ, Takahashi R, Segawa T, Briley M (eds) New vistas in depression. Pergamon, Oxford, pp 99?106"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0301-0082(73)90019-1","volume":"1","author":"JM Sneddon","year":"1973","unstructured":"Sneddon JM (1973) Blood platelets as a model for monoamine containing neurones. Prog Neurobiol 1:153?198","journal-title":"Prog Neurobiol"},{"key":"CR30","first-page":"47","volume":"16","author":"DC U'Prichard","year":"1979","unstructured":"U'Prichard DC, Bechtel WD, Rouot BM, Snyder SH (1979) Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: Effect of 6-hydroxydopamine. Mol Pharmacol 16:47?60","journal-title":"Mol Pharmacol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0006-291X(82)80038-7","volume":"105","author":"EA Woodstock","year":"1982","unstructured":"Woodstock EA, Murley B (1982) Increased central alpha2-adrenergic receptors measured with 3H-yohimbine in the presence of sodium ion and guanyl nucleotides. Biochem Biophys Res Commun 105:252?258","journal-title":"Biochem Biophys Res Commun"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/B978-1-4831-3140-5.50021-1","volume-title":"Handbook of studies in depression","author":"HM Praag Van","year":"1977","unstructured":"Van Praag HM (1977) Indoleamines in depression. In: Burrows GH (ed) Handbook of studies in depression. Excerpta Medica, Amsterdam, pp 303?323"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00433407.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00433407\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00433407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T04:01:42Z","timestamp":1624852902000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00433407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,3]]}},"alternative-id":["BF00433407"],"URL":"https:\/\/doi.org\/10.1007\/bf00433407","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3]]}}}