{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:39:08Z","timestamp":1760384348668},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1989,3]]},"DOI":"10.1007\/bf00439443","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T10:43:26Z","timestamp":1100169806000},"page":"309-318","source":"Crossref","is-referenced-by-count":46,"title":["Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography"],"prefix":"10.1007","volume":"97","author":[{"given":"G.","family":"Wik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. -A.","family":"Wiesel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Sj\ufffdgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Blomqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Greitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stone-Elander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00423250","volume":"48","author":"G Alfredsson","year":"1976","unstructured":"Alfredsson G, Wode-Helgodt B, Sedvall G (1976) A mass fragmentographic method for the determination of chlorpromazine and two of its active metabolites in human plasma and CSF. Psychopharmacology 48:123?131.","journal-title":"Psychopharmacology"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-4347(00)81187-1","volume":"164","author":"G Alfredsson","year":"1979","unstructured":"Alfredsson G, Sedvall G, Wiesel F-A (1979) Quantitative analysis of sulpiride in body fluids by high performance liquid chromatography with fluorescence detection. J Chromatogr 164:187?193.","journal-title":"J Chromatogr"},{"issue":"Suppl 1","key":"CR3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0447.1984.tb06859.x","volume":"69","author":"G Alfredsson","year":"1984","unstructured":"Alfredsson G, Bjerkenstedt L, Edman G, H\u00e4rnryd C, Oxenstierna G, Sedvall G, Wiesel F-A (1984) Relationships between drug concentrations in serum and CSF, clinical effects and monoaminergic variables in schizophrenic patients treated with sulpiride or chlorpromazine. Acta Psychiatr Scand [Suppl 1] 69:49?74.","journal-title":"Acta Psychiatr Scand"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00427315","volume":"85","author":"G Alfredsson","year":"1985","unstructured":"Alfredsson G, H\u00e4rnryd C, Wiesel F-A (1985) Effects of sulpiride and chlorpromazine on autistic and positive psychotic symptoms in schizophrenic patients ? relationship to drug concentrations. Psychopharmacology 85:8?13.","journal-title":"Psychopharmacology"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0447.1978.tb02357.x","volume":"271","author":"M \u00c5sberg","year":"1978","unstructured":"\u00c5sberg M, Montgomery S, Perris C, Schalling D, Sedvall G (1978) CPRS ? the psychopathological rating scale. Acta Psychiatr Scand [Suppl] 271:5?27.","journal-title":"Acta Psychiatr Scand [Suppl]"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00004728-198102000-00027","volume":"5","author":"M Bergstr\u00f6m","year":"1981","unstructured":"Bergstr\u00f6m M, Boethius J, Eriksson L, Greitz T, Ribbe T, Wid\u00e9n L (1981) Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr 5:136?141.","journal-title":"J Comput Assist Tomogr"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00341708","volume":"226","author":"L Bjerkenstedt","year":"1978","unstructured":"Bjerkenstedt L, H\u00e4rnryd C, Grimm V, Gullberg B, Sedvall G (1978) A double-blind comparison of melperone and thiothixene in psychotic women using a new rating scale, the CPRS. Arch Psychiatr Nervenkr 226:157?172.","journal-title":"Arch Psychiatr Nervenkr"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/jcbfm.1984.89","volume":"4","author":"G Blomqvist","year":"1984","unstructured":"Blomqvist G (1984) On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 4:629?632.","journal-title":"J Cereb Blood Flow Metab"},{"key":"CR9","first-page":"185","volume-title":"Metabolism of the human brain studied with positron emission tomography","author":"G Blomqvist","year":"1985","unstructured":"Blomqvist G, Bergstr\u00f6m K, Bergstr\u00f6m M, Ehrin E, Eriksson L, Garmelius B, Lindberg B, Lilja A, Litton J-E, Lundmark L, Lundqvist H, Malmborg P, Mostr\u00f6m U, Nielsson L, Stone-Elander S, Wid\u00e9n L (1985) Models for 11C-glucose. In: Greitz T, Ingvar D, Wid\u00e9n L (eds) Metabolism of the human brain studied with positron emission tomography. Raven Press, New York, pp 185?194."},{"key":"CR10","first-page":"53","volume":"28","author":"RA Brooks","year":"1987","unstructured":"Brooks RA, Di Chiro G, Zukerberg BW, Bairamian D, Larson SM (1987) Test-retest studies of cerebral glucose metabolism using fluorine-18 deoxyglucose: validation of method. J Nucl Med 28:53?59.","journal-title":"J Nucl Med"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-3223(87)90170-3","volume":"22","author":"MS Buchsbaum","year":"1987","unstructured":"Buchsbaum MS, Wu JC, DeLisi LE, Holcomb HH, Hazlett E, Cooper-Langston K, Kessler R (1987) Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenic patients. Biol Psychiatry 22:479?494.","journal-title":"Biol Psychiatry"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1176\/ajp.135.2.164","volume":"135","author":"A Carlsson","year":"1978","unstructured":"Carlsson A (1978) Antipsychotic drugs, neurotransmitters and schizophrenia. Am J Psychiatry 135:164?173.","journal-title":"Am J Psychiatry"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/jcbfm.1985.26","volume":"5","author":"LE DeLisi","year":"1985","unstructured":"DeLisi LE, Holcomb HH, Cohen RM, Pickar D, Carpenter W, Morihisa JM, King AC, Kessler R, Buchsbaum M (1985) Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J Cereb Blood Flow Metab 5:201?206.","journal-title":"J Cereb Blood Flow Metab"},{"key":"CR14","first-page":"326","volume":"24","author":"E Ehrin","year":"1983","unstructured":"Ehrin E, Stone-Elander S, Nilsson JLG, Bergstr\u00f6m M, Blomqvist G, Brismar T, Eriksson L, Greitz T, Jansson PE, Litton J-E, Malmborg P, af Ugglas M, Wid\u00e9n L (1983) 11C-labelled glucose and its utilization in positron emission tomography. J Nucl Med 24:326?331.","journal-title":"J Nucl Med"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF00212840","volume":"94","author":"L Farde","year":"1988","unstructured":"Farde L, Pauli S, Hall H, Stone-Elander S, Eriksson L, Halldin C, H\u00f6gberg T, Nilsson T, Sj\u00f6gren I (1988a) Stereoselectivity of 11C-raclopride binding ? a search for extrastriatal D2-dopamine receptors in man by PET. Psychopharmacology 94:471?478.","journal-title":"Psychopharmacology"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archpsyc.1988.01800250087012","volume":"45","author":"L Farde","year":"1988","unstructured":"Farde L, Wiesel F-A, Halldin C, Sedvall G (1988b) Central D2-dopamine receptor occupaney in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45:71?78.","journal-title":"Arch Gen Psychiatry"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1001\/archpsyc.1987.01800140021003","volume":"44","author":"RE Gur","year":"1987","unstructured":"Gur RE, Resnick SM, Alavi A, Gur RC, Caroff S, Dann R, Silver FL, Saykin AJ, Chawluk JB, Kushner M, Reivich M (1987a) Regional brain function in schizophrenia. Arch Gen Psychiatry 44:119?125.","journal-title":"Arch Gen Psychiatry"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1001\/archpsyc.1987.01800140028004","volume":"44","author":"RE Gur","year":"1987","unstructured":"Gur RE, Resnick SM, Gur RC, Alavi A, Caroff S, Kushner M, Reivich M (1987b) Regional brain function in schizophrenia. Arch Gen Psychiatry 44:126?129.","journal-title":"Arch Gen Psychiatry"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00004728-198402000-00016","volume":"8","author":"J-E Litton","year":"1984","unstructured":"Litton J-E, Bergstr\u00f6m M, Eriksson L, Bohm C, Blomqvist G, Kesselberg M (1984) Performance study of the PC-384 positron camera system for emission tomography of the brain. J Comput Assist Tomogr 8:74?87.","journal-title":"J Comput Assist Tomogr"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0006-8993(82)91122-2","volume":"243","author":"J McCulloch","year":"1982","unstructured":"McCulloch J, Savaki HE, Sokoloff L (1982) Distribution of effects of haloperidol on energy metabolism in the rat brain. Brain Res 243:81?90.","journal-title":"Brain Res"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","volume":"134","author":"SA Montgomery","year":"1979","unstructured":"Montgomery SA, \u00c5sberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382?389.","journal-title":"Br J Psychiatry"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0006-8993(85)91543-4","volume":"327","author":"JM Palacios","year":"1984","unstructured":"Palacios JM, Wiederhold K-H (1984) Dopamine D2 receptor agents, but not dopamine D1, modify brain glucose metabolism. Brain Res 327:390?394.","journal-title":"Brain Res"},{"key":"CR23","volume-title":"Atlas der topographischen und angewandten Anatomie des Menschen. Erster Band: Kopf und Hals. 106","author":"E Pernkopf","year":"1963","unstructured":"Pernkopf E (1963) Atlas der topographischen und angewandten Anatomie des Menschen. Erster Band: Kopf und Hals. 106. Urban und Schwarzenberg, Munich"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1176\/ajp.137.12.1518","volume":"137","author":"SJ Peroutka","year":"1980","unstructured":"Peroutka SJ, Snyder SH (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, adrenergic and histamine receptors to clinical potency. Am J Psychiatry 137:1518?1522.","journal-title":"Am J Psychiatry"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1471-4159.1984.tb12792.x","volume":"43","author":"G Pizzolato","year":"1984","unstructured":"Pizzolato G, Soncrant TT, Rapoport SI (1984) Haloperidol and cerebral metabolism in the conscious rat: relation to pharmacokinetics. J Neurochem 43:631?638.","journal-title":"J Neurochem"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(85)91604-X","volume":"337","author":"G Pizzolato","year":"1985","unstructured":"Pizzolato G, Soncrant TT, Larson DM, Rapoport SI (1985) Reduced metabolic response of the rat brain to haloperidol after chronic treatment. Brain Res 337:1?9.","journal-title":"Brain Res"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1471-4159.1987.tb02910.x","volume":"49","author":"G Pizzolato","year":"1987","unstructured":"Pizzolato G, Soncrant TT, Larson DM, Rapoport SI (1987) Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain. J Neurochem 49:631?638.","journal-title":"J Neurochem"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/jcbfm.1985.24","volume":"5","author":"M Reivich","year":"1985","unstructured":"Reivich M, Alavi A, Wolf A, Fowler J, Russel J, Arnett C, MacGregor RR, Shiue CY, Atkins H, Dann R, Greenberg JH (1985) Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for (18F)fluorodeoxyglucose and (11C)deoxyglucose. J Cereb Blood Flow Metab 5:179?192.","journal-title":"J Cereb Blood Flow Metab"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1523\/JNEUROSCI.05-03-00776.1985","volume":"5","author":"LD Selemon","year":"1985","unstructured":"Selemon LD, Goldman-Rakic PS (1985) Longitudinal topography and interdigita of corticostriatal projections in the rhesus monkey. J Neurosci 5:776?794.","journal-title":"J Neurosci"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0140-6736(83)90798-5","volume":"II","author":"G Sheppard","year":"1983","unstructured":"Sheppard G, Gruzelier J, Machanda R, Hirsch SR (1983) 15O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet II:1448?1452.","journal-title":"Lancet"},{"key":"CR31","doi-asserted-by":"crossref","unstructured":"Simpson EN, Angus JWF (1970) A rating scale for extrapyramidal side-effects. Acta Psychiatr Scand [Suppl] 212","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"CR32","volume-title":"Schedule for affective disorders and schizophrenia (SADS)","author":"RL Spitzer","year":"1977","unstructured":"Spitzer RL, Endicott J (1977) Schedule for affective disorders and schizophrenia (SADS), 3rd edn. New York State Psychiatric Institute of Biometrics Research, New York","edition":"3rd edn."},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1136\/jnnp.49.10.1199","volume":"49","author":"ND Volkow","year":"1986","unstructured":"Volkow ND, Brodie JD, Wolf AP, Angrist B, Russell J, Cancro R (1986) Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. J Neurol Neurosurg Psychiatry 49:1199?1202.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1600-0447.1987.tb02933.x","volume":"76","author":"F-A Wiesel","year":"1987","unstructured":"Wiesel F-A, Wik G, Sj\u00f6gren I, Blomqvist G, Greitz T, Stone-Elander S (1987) Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 76:628?641.","journal-title":"Acta Psychiatr Scand"},{"key":"CR35","doi-asserted-by":"crossref","DOI":"10.1037\/11774-000","volume-title":"Statistical principles in experimental design","author":"BJ Winer","year":"1962","unstructured":"Winer BJ (1962) Statistical principles in experimental design. McGraw-Hill, New York"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/ajp.142.5.564","volume":"142","author":"A Wolkin","year":"1985","unstructured":"Wolkin A, Jaeger J, Brodie JD, Wolf AP, Fowler J, Rotrosen J, Gomez-Mont F, Cancro R (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 142:564?571.","journal-title":"Am J Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00439443.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00439443\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00439443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:37:24Z","timestamp":1554338244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00439443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["BF00439443"],"URL":"https:\/\/doi.org\/10.1007\/bf00439443","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]}}}