{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:56:31Z","timestamp":1790031391085,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1982,5,1]],"date-time":"1982-05-01T00:00:00Z","timestamp":389059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[1982,5]]},"DOI":"10.1007\/bf00441205","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T01:59:22Z","timestamp":1100224762000},"page":"216-220","source":"Crossref","is-referenced-by-count":18,"title":["Hypergonadotropic hypogonadism, SHBG deficiency and hyperprolactinaemia: A transient phenomenon during induction chemotherapy in leukemic children"],"prefix":"10.1007","volume":"138","author":[{"given":"W.","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H.","family":"Heidemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stubbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"K\ufffdnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2265.1974.tb03298.x","volume":"3","author":"DC Anderson","year":"1974","unstructured":"Anderson DC (1974) Sex-hormone-binding globulin. Clin Endocrinology 3:69?96","journal-title":"Clin Endocrinology"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1210\/jcem-50-4-635","volume":"50","author":"W Beck","year":"1980","unstructured":"Beck W, Wuttke W (1980) Diurnal variations of plasma LH, FSH and prolactin in boys and girls from birth to puberty. J Clin Endocrinol Metab 50:635?639","journal-title":"J Clin Endocrinol Metab"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJM198105073041901","volume":"304","author":"J Blatt","year":"1981","unstructured":"Blatt J, Poplack DG, Sherins RJ (1981) Testicular function in boys after chemotherapy for acute lymphoblastic leukemia. New Engl J Med 304:1121?1124","journal-title":"New Engl J Med"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1210\/jcem-41-6-1161","volume":"41","author":"KD Burman","year":"1975","unstructured":"Burman KD, Dimond RC, N\u00f6el GL, Earll JM, Frantz AG, Wartofsky L (1975) Klinefelter's syndrome: examination of thyroid function, and the TSH and PRL response to thyrotropin-releasing hormone prior to and after testosterone adminsitration. J Clin Endocrinol Metab 41:1161?1166","journal-title":"J Clin Endocrinol Metab"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1210\/jcem-40-3-442","volume":"40","author":"G Copinschi","year":"1975","unstructured":"Copinschi G, L'Hermite M, Leder R, Goldstein J, Vantaelst L, Virasoro E, Robyn C (1975) Effects of glucocorticoids on pituitary hormonal responses to hypoglycemia: Inhibition of prolactin release. J Clin Endocrinol Metab 40:442?449","journal-title":"J Clin Endocrinol Metab"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1530\/acta.0.0910511","volume":"91","author":"KW Faulborn","year":"1979","unstructured":"Faulborn KW, Fenske M, Pitzel L, K\u00f6nig A (1979) Effects of an i.v. injection of tetracosactid on plasma corticosteroid and testosterone levels in unstressed male rabbits. Acta Endocrinologica 91:511?518","journal-title":"Acta Endocrinologica"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1530\/acta.0.0630499","volume":"63","author":"JC Gabrilove","year":"1970","unstructured":"Gabrilove JC, Nicolis GL, Hausknecht RU (1970) Urinary testosterone oestrogen production rate and urinary oestrogen in chromatin positive Klinefelter's syndrome. Acta Endocrinologica (Kbh) 63:499?504","journal-title":"Acta Endocrinologica (Kbh)"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(74)91401-9","volume":"2","author":"C Hagen","year":"1974","unstructured":"Hagen C, McNeilly AS, Arroe M, Emmertsen K, Froland A (1974) Prolactin levels in gynaecomastia related to Klinefelter's syndrome. Lancet 2:57","journal-title":"Lancet"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00442997","volume":"136","author":"PH Heidemann","year":"1981","unstructured":"Heidemann PH, Stubbe P, Beck W (1981) Transient secondary hypothyroidism and transient thyroxine binding globulin deficiency in leukemic children during polychemotherapy: an effect of l-asparaginase. Eur J Pediatr 136:291?295","journal-title":"Eur J Pediatr"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1210\/jcem-50-2-298","volume":"50","author":"RA Lantigua","year":"1980","unstructured":"Lantigua RA, Streck WF, Lockwood DH, Jacobs LS (1980) Glucocorticoid suppression of pancreatic and pituitary hormones: pancreatic polypeptide, growth hormone, and prolactin. J Clin Endocrinol Metab 50:298?303","journal-title":"J Clin Endocrinol Metab"},{"key":"CR11","first-page":"313","volume":"34","author":"LT Mashburn","year":"1974","unstructured":"Mashburn LT, Landin LM (1974) Inhibition of thymidine and basic amminoacid metabolism in P 1798 lymphosarcoma by l-asparaginase. Cancer Res 34:313?318","journal-title":"Cancer Res"},{"key":"CR12","first-page":"463","volume":"31","author":"KE M\u00fchlendahl von","year":"1976","unstructured":"M\u00fchlendahl KE von, Gadner H, Riehm H, Helge H, Weber B, M\u00fcller-Hess R (1976) Endocrine function after antineoplastic therapy in 22 children with acute lymphoblastic leukemia. Helv Paediat Acta 31:463?471","journal-title":"Helv Paediat Acta"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1172\/JCI106402","volume":"49","author":"R Penny","year":"1970","unstructured":"Penny R, Huyda HJ, Baghdassarian A, Johanson AJ, Blizzard RM (1970) Correlation of serum follicular stimulating hormone (FSH) and luteinizing hormone (LH) as measured by radioimmunoassay in disorders of sexual development. J Clin Invest 49:1847?1852","journal-title":"J Clin Invest"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0022-3476(74)80758-4","volume":"84","author":"J Penso","year":"1974","unstructured":"Penso J, Lippe B, Ehrlich R, Smith FG Jr, DeLita VT Jr (1974) Testicular function in prepubertal and pubertal male patients treated with cyclophosphamide for nephrotic syndrome. J Pediatr 84:831?836","journal-title":"J Pediatr"},{"key":"CR15","first-page":"89","volume":"189","author":"H Riehm","year":"1977","unstructured":"Riehm H, Gadner H, Welte K (1977) Die West-Berliner Studie zur Behandlung der akuten lymphoblastischen Leuk\u00e4mie des Kindes ?Ein Erfahrungsbericht nach 6 Jahren. Klin P\u00e4diat 189:89?102","journal-title":"Klin P\u00e4diat"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0022-4731(75)90055-2","volume":"6","author":"RL Rosenfield","year":"1975","unstructured":"Rosenfield RL (1975) Studies of the relation of plasma androgen levels to androgen action in women. J Steroid Biochem 6:695?702","journal-title":"J Steroid Biochem"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jcem-40-6-1027","volume":"40","author":"RT Rubin","year":"1975","unstructured":"Rubin RT, Gouin PR, Lubin A, Poland RE, Pirke KM (1975) Nocturnal increase of plasma testosterone in men: relation to gonadotropins and prolactin. J Clin Endocrinol Metab 40:1027?1033","journal-title":"J Clin Endocrinol Metab"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1210\/jcem-42-1-112","volume":"42","author":"RT Rubin","year":"1976","unstructured":"Rubin RT, Poland RE, Tower BB (1976) Prolactin-related testosterone secretion in normal adult men. J Clin Endocrinol Metab 42:112?116","journal-title":"J Clin Endocrinol Metab"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1210\/jcem-46-5-830","volume":"46","author":"RT Rubin","year":"1978","unstructured":"Rubin RT, Poland RE, Sowers JR, Hershman JM (1978) Influence of methyl-TRH induced prolactin increase on serum testosterone levels in normal adult men. J Clin Endocrinol Metab 46:830?833","journal-title":"J Clin Endocrinol Metab"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2265.1981.tb02966.x","volume":"14","author":"S Schwarz","year":"1981","unstructured":"Schwarz S, Toppeiner G, Hinter H (1981) Hormone binding globulin levels in patients with hereditary angiooedema during treatment with Danazol. Clin Endocrinol 14:563?570","journal-title":"Clin Endocrinol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(76)90881-3","volume":"2","author":"G Schiliro","year":"1976","unstructured":"Schiliro G, Rusoo A, Sciotto A, Distefano G, Vigo R (1976) Radiotherapy, chemotherapy, and growth hormone deficiency. Lancet 2:1031?1032","journal-title":"Lancet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1651-2227.1977.tb07846.x","volume":"66","author":"G Schiliro","year":"1977","unstructured":"Schiliro G, Rusoo A, Sciotto A, Vigo R (1977) Insulin and growth hormone secretion in a leukaemic girl with hypothalamic syndrome. Acta Paediatr Scand 66:261?263","journal-title":"Acta Paediatr Scand"},{"key":"CR23","first-page":"652","volume":"225","author":"S Seller","year":"1969","unstructured":"Seller S, Weser U (1969) Inhibition of 3H-thymidine incorporation into rat liver nuclei by E. coli l-asparaginase. Nature 225:652?653","journal-title":"Nature"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/adc.51.7.489","volume":"51","author":"SM Shalet","year":"1976","unstructured":"Shalet SM, Beardwell CG, Morris-Jones PH, Pearson D (1976) Growth-hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child 51:489?493","journal-title":"Arch Dis Child"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0022-3476(77)80559-3","volume":"90","author":"SM Shalet","year":"1977","unstructured":"Shalet SM, Beardwell CG, Twomey JA, Jones PHM, Pearson D (1977) Endocrine function following the treatment of acute leukemia in children. J Pediatr 90:920?923","journal-title":"J Pediatr"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-3476(79)80137-7","volume":"94","author":"SM Shalet","year":"1979","unstructured":"Shalet SM, Price DA, Beardwell CG, Morris Jones PH, Pearson D (1979) Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. J Pediatr 94:719?722","journal-title":"J Pediatr"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/adc.56.4.275","volume":"56","author":"SM Shalet","year":"1981","unstructured":"Shalet SM, Hann IM, Lendon M, Morris Jones PH, Beardwell CG (1981) Testicular function after combination chemotherapy in childhood for acute lymphoblastic leukaemia. Arch Dis Child 56:275?278","journal-title":"Arch Dis Child"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-79-2-216","volume":"79","author":"RJ Sherins","year":"1973","unstructured":"Sherins RJ, DeVita VT Jr (1973) Effects of drug treatment of lymphoma on male reproductive capacity: studies of men in remission after therapy. Ann Intern Med 79:216?220","journal-title":"Ann Intern Med"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1056\/NEJM197807062990103","volume":"229","author":"RJ Sherins","year":"1978","unstructured":"Sherins RJ, Olwanny CLM, Ziegler JL (1978) Gynecomastia and gonadal dysfunction in adolescent boys treated with chemotherapy for Hodgkin's disease. New Engl J Med 229:12?16","journal-title":"New Engl J Med"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1056\/NEJM197605202942102","volume":"294","author":"ES Siris","year":"1975","unstructured":"Siris ES, Leventhal BG, Vaitukaitis JL (1975) Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls. New Engl J Med 294:1143?1146","journal-title":"New Engl J Med"},{"key":"CR31","first-page":"442","volume":"44","author":"JR Sowers","year":"1975","unstructured":"Sowers JR, Carlson HE, Brautbar N, Hershman JM (1975) Effect of dexamethasone on prolactin and TSH responses to TRH and metodopramide in man. J Clin Endocrinol Metab 44:442?449","journal-title":"J Clin Endocrinol Metab"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jcem-48-6-941","volume":"48","author":"IM Spitz","year":"1979","unstructured":"Spitz IM, Zyllner E, Cohen H, Almaliach U, Peroith D (1979) Impaired prolactin response to thyrotropin-releasing hormone in isolated gonadotropin deficiency and exaggerated response in primary testicular failure. J Clin Endocrinol Metab 48:941?945","journal-title":"J Clin Endocrinol Metab"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/adc.53.11.890","volume":"53","author":"PGF Swift","year":"1978","unstructured":"Swift PGF, Kearny PJ, Dalton RG, Bullimore JH, Mott MG, Savage DCL (1978) Growth and hormonal status of children treated for acute lymphoblastic leukaemia. Arch Dis Child 53:890?894","journal-title":"Arch Dis Child"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/adc.51.3.170","volume":"51","author":"JM Tanner","year":"1976","unstructured":"Tanner JM, Whitehouse RH (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51:170?179","journal-title":"Arch Dis Child"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI106861","volume":"51","author":"DH Thiel van","year":"1972","unstructured":"Thiel DH van, Sherins RJ, Meyers GH Jr, DeVita Jr (1972) Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man. J Clin Invest 51:1009?1019","journal-title":"J Clin Invest"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00441205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00441205\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00441205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:38:01Z","timestamp":1554338281000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00441205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,5]]}},"alternative-id":["BF00441205"],"URL":"https:\/\/doi.org\/10.1007\/bf00441205","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,5]]}}}