{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:35:05Z","timestamp":1752550505887},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1982,10,1]],"date-time":"1982-10-01T00:00:00Z","timestamp":402278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[1982,10]]},"DOI":"10.1007\/bf00441496","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T02:09:12Z","timestamp":1100225352000},"page":"129-134","source":"Crossref","is-referenced-by-count":17,"title":["Development of N-demethylase activity measured with the 13C-aminopyrine breath test"],"prefix":"10.1007","volume":"139","author":[{"given":"E.","family":"J\ufffdger-Roman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Platzek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Helge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","unstructured":"Altman PL, Dittmer DS (eds) (1974) Biological data book, 2nd edn, vol III. Bethesda, Md.: Federation of American Soc. for Experimental Biology, pp 1527"},{"key":"CR2","first-page":"674A","volume":"25","author":"JV Aranda","year":"1977","unstructured":"Aranda JV, Collinger JM, Zurman R, Trippenback T, Jain R (1977) Maturation of caffeine disposition in infancy. Clin Res 25: 674A","journal-title":"Clin Res"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0022-3476(74)80465-8","volume":"85","author":"JV Aranda","year":"1974","unstructured":"Aranda JV, Mac Lead SM, Renton KW, Eacle NR (1974) Hepatic microsomal drug oxidation and electron transport in newborn infants. J Pediatr 85:534?542","journal-title":"J Pediatr"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/cpt1976204484","volume":"20","author":"J Bircher","year":"1976","unstructured":"Bircher J, K\ufffdpfer A, Gikalov I, Preisig R (1976) Aminopyrine demethylation measured by breath analysis in cirrhosis. Clin Pharmacol Ther 20:484?492","journal-title":"Clin Pharmacol Ther"},{"key":"CR5","first-page":"347","volume":"12","author":"J Bircher","year":"1976","unstructured":"Bircher J, Platzer R, Gikalov I, K\ufffdpfer A, Preisig R (1976) Aminopyrine breath test for evaluation of liver function. Radioaktive Isotope in Klinik und Forschung 12:347?355","journal-title":"Radioaktive Isotope in Klinik und Forschung"},{"key":"CR6","first-page":"93","volume-title":"Physiology and biophysics","author":"AC Brown","year":"1973","unstructured":"Brown AC (1973) Energy metabolism. In: Ruch TC, Patton HD (eds) Physiology and biophysics, 20th edn, vol III. Saunders, Philadelphia, pp 93?106","edition":"20th edn"},{"key":"CR7","first-page":"171","volume":"99","author":"BB Brodie","year":"1950","unstructured":"Brodie BB, Axelrod J (1950) The fate of aminopyrine (Pyramidon) in man and methods for estimation of aminopyrine and its metabolites in biological material. J Pharmacol Exp Ther 99:171?184","journal-title":"J Pharmacol Exp Ther"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/gut.19.1.40","volume":"19","author":"J Galizzi","year":"1978","unstructured":"Galizzi J, Long RG, Billing BH, Sherlock S (1978) Assessment of the (14C) aminopyrine breath test in liver disease. Gut 19:40?45","journal-title":"Gut"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0022-3476(77)80360-0","volume":"90","author":"LM Gartner","year":"1977","unstructured":"Gartner LM, Kwang-Sun L, Vaisman S, Lande D, Zarafz I (1977) Development of bilirubin transport and metabolism in the newborn rhesus monkey. J Pediatr 90:513?531","journal-title":"J Pediatr"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0022-3476(76)80818-9","volume":"89","author":"G Giacoia","year":"1976","unstructured":"Giacoia G, Jusko WJ, Menke J, Koup JR (1976) Theophylline pharmacokinetics in premature infants with apnea. J Pediatr 89: 829?832","journal-title":"J Pediatr"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00609866","volume":"12","author":"I Gikalov","year":"1977","unstructured":"Gikalov I, Bircher J (1977) Dose dependence of the 14C-aminopyrine breath test. Eur J Clin Pharmacol 12:229?233","journal-title":"Eur J Clin Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.7326\/0003-4819-83-5-632","volume":"83","author":"GW Hepner","year":"1976","unstructured":"Hepner GW, Vesell ES (1976) Quantitative assessment of hepatic function by breath analysis after oral administration of (14C) aminopyrine. Ann Intern Med 83:632?638","journal-title":"Ann Intern Med"},{"key":"CR13","first-page":"440","volume":"90","author":"GW Hepner","year":"1977","unstructured":"Hepner GW, Vesell ES, Lipton A, Harvey HA, Wilkinson GR, Schenker S (1977) Disposition of aminopyrine, antipyrine, diazepam, and indocyanine green in patients with liver disease or on anticonvulsant drug therapy: diazepam breath test and correlations in drug elimination. J Lab Clin Med 90:440?456","journal-title":"J Lab Clin Med"},{"key":"CR14","first-page":"495","volume-title":"Stable isotopes: Proceedings of the third International Conference","author":"H Helge","year":"1979","unstructured":"Helge H, Gregg B, J\ufffdger E, Knies S, Bochert G, Nigam S (1979) The 13CO2 breath test for the measurement of N-demethylation of 13C-dimethylaminopyrine in children. In: Klein ER, Klein PD (eds) Stable isotopes: Proceedings of the third International Conference. Academic Press, New York, pp 495?505"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0024-3205(75)90343-4","volume":"16","author":"MG Horning","year":"1975","unstructured":"Horning MG, Butler CM, Nowlin J, Hill R (1975) Drug metabolism in the human neonate. Life Sci 16:651?672","journal-title":"Life Sci"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1542\/peds.45.6.945","volume":"45","author":"WJ Jusko","year":"1970","unstructured":"Jusko WJ, Khanna N, Levy G, Stern L, Yaffee SJ (1970) Riboflavin absorption and excretion in the neonate. Pediatrics 45: 945?949","journal-title":"Pediatrics"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.0954-6820.1972.tb04824.x","volume":"192","author":"I Kantero","year":"1972","unstructured":"Kantero I, Mustala OO, Palva IP (1972) Drug-induced agranulocytosis, with special reference to aminophenazone. IV. Children. Acta Med Scand 192:327?330","journal-title":"Acta Med Scand"},{"key":"CR18","first-page":"556","volume":"65","author":"B Lauterburg","year":"1973","unstructured":"Lauterburg B, Bircher J (1973) Hepatic microsomal drug metabolism capacity measured in vivo by breath analysis (abstr). Gastroenterology 65:556","journal-title":"Gastroenterology"},{"key":"CR19","first-page":"501","volume":"196","author":"B Lauterburg","year":"1976","unstructured":"Lauterburg B, Bircher J (1976) Expiratory measurement of maximal aminopyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, portocaval shunt and bile duct ligation in the rat. J Pharmacol Exp Ther 196:501?509","journal-title":"J Pharmacol Exp Ther"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1021\/ja01464a031","volume":"83","author":"JA Montgomery","year":"1961","unstructured":"Montgomery JA, Temple C (1961) Synthesis of potential anti cancer agents. XXVI. Dealkylation of 6-chloropurine. J Am Chem Soc 83:630?635","journal-title":"J Am Chem Soc"},{"key":"CR21","first-page":"89","volume-title":"Clinical pharmacology and therapeutics","author":"PL Morselli","year":"1978","unstructured":"Morselli PL, Baruzzi A (1978) Serum levels and pharmacokinetics of anticonvulsants in the management of seizure disorder. In: Mirkin BL (ed) Clinical pharmacology and therapeutics. Year Book Medical Publishers, Chicago, pp 89?106"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/cpt1973145840","volume":"14","author":"O Pelkonen","year":"1973","unstructured":"Pelkonen O, Kaltiala EH, Larmi TKI, K\ufffdrki NT (1973) Comparison of activities of drug metabolising enzymes in human fetal and adult livers. Clin Pharmacol Ther 14:840?846","journal-title":"Clin Pharmacol Ther"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00420345","volume":"2","author":"C Reinicke","year":"1970","unstructured":"Reinicke C, Rogner G, Frenzel J, Maak B, Klinger W (1970) Die Wirkung von Phenylbutazon und Phenobarbital auf die Aminopyrinelimination, die Bilirubin-Gesamtkonzentration im Serum und einige Blutgerinnungsfaktoren bei neugeborenen Kindern. Pharmacologia Clin 2:167?172","journal-title":"Pharmacologia Clin"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0009-8981(78)90489-8","volume":"84","author":"JF Schneider","year":"1978","unstructured":"Schneider JF, Schoeller DA, Nemchansky B, Boyer JL, Klein PD (1978) Validation of 13CO2 breath analysis as a measurement of demethylation of stable isotope labeled aminopyrine in man. Clin Chim Acta 84:153?162","journal-title":"Clin Chim Acta"},{"key":"CR25","first-page":"412","volume":"90","author":"DA Schoeller","year":"1977","unstructured":"Schoeller DA, Schneider JF, Solomons NW, Watkins JB, Klein PD (1977) Clinical diagnosis with the stable isotope 13C in CO2 breath test: Methodology and fundamental consideration. J Lab Clin Med 90:412?421","journal-title":"J Lab Clin Med"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00368560","volume":"65","author":"HR Schulten","year":"1978","unstructured":"Schulten HR, Schiebel HM (1978) Principle and technique of field-desorption mass spectrometry. Naturwissenschaften 65: 223?230","journal-title":"Naturwissenschaften"},{"key":"CR27","first-page":"716","volume":"12","author":"BH Slanger","year":"1970","unstructured":"Slanger BH, Kusobov N, Winchell HS (1970) Effect of exercise on human CO2?HCO2-kinetics. J Nucl Med 12:716?718","journal-title":"J Nucl Med"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0024-3205(70)90038-X","volume":"9","author":"SJ Yaffee","year":"1970","unstructured":"Yaffee SJ, Rane A, Sj\ufffdqvist F, Bor\ufffdus LO, Orenius S (1970) The presence of a monooxygenase system in human fetal liver microsomes. Life Sci 9:1189?1200","journal-title":"Life Sci"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00441496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00441496\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00441496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T04:59:06Z","timestamp":1682830746000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00441496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,10]]}},"alternative-id":["BF00441496"],"URL":"https:\/\/doi.org\/10.1007\/bf00441496","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10]]}}}