{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:28:35Z","timestamp":1762003715936},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[1980,6,1]],"date-time":"1980-06-01T00:00:00Z","timestamp":328665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[1980,6]]},"DOI":"10.1007\/bf00484403","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T07:54:34Z","timestamp":1100505274000},"page":"577-590","source":"Crossref","is-referenced-by-count":37,"title":["Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts"],"prefix":"10.1007","volume":"18","author":[{"given":"Maria R. Castro","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan B.","family":"Edelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela M.","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xandra O.","family":"Breakefield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-72-17313","volume":"72","author":"W. W. Ackerman","year":"1949","unstructured":"Ackerman, W. W., and Potter, J. R. (1949). Enzyme inhibition in relation to chemotherapy. Proc. Soc. Exp. Biol. Med. 721.","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1176\/ajp.134.7.805","volume":"134","author":"W. D. Berretini","year":"1977","unstructured":"Berretini, W. D., Vogel, W. H., and Clouse, R. (1977). Platelet monoamine oxidase in chronic schizophrenia. Am. J. Psychiat. 134805.","journal-title":"Am. J. Psychiat."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1126\/science.1273584","volume":"192","author":"X. O. Breakefield","year":"1976","unstructured":"Breakefield, X. O., Castiglione, C. M., and Edelstein, S. B. (1976). Monoamine oxidase decreased in cells lacking hypoxanthine phosphoriboslyltransferase activity. Science 1921018.","journal-title":"Science"},{"key":"CR4","volume-title":"Neurogenetics: Genetic Approaches to the Nervous System","author":"X. O. Breakefield","year":"1979","unstructured":"Breakefield, X. O., Edelstein, S. B., and Costa, M. R. C. (1979a). Genetic analysis of neurotransmitter metabolism in cell culture: Studies on the Lesch-Nyhan syndrome. In Breakfield, X. O. (ed.), Neurogenetics: Genetic Approaches to the Nervous System, Elsevier-North Holland, New York."},{"key":"CR5","volume-title":"Society for Neuroscience Symposium, Vol. IV","author":"X. O. Breakefield","year":"1979","unstructured":"Breakefield, X. O., Cawthon, R. M., Costa, M. R. C., Edelstein, S. B., and Hawkins, M. Jr. (1979b). A genetic view of monoamine oxidase. In Society for Neuroscience Symposium, Vol. IV, Society for Neuroscience, Bethesda, Md."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.2042-7158.1978.tb13326.x","volume":"30","author":"B. J. Browne","year":"1978","unstructured":"Browne, B. J., Fowler, C. J., and Callingham, B. A. (1978). The effects of homogenization of rat liver in different buffer solutions on the yield and kinetic properties of monoamine oxidase. J. Pharm. Pharmacol. 30573.","journal-title":"J. Pharm. Pharmacol."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1055\/s-0028-1114586","volume":"84","author":"V. W. Catel","year":"1959","unstructured":"Catel, V. W., and Schmidt, J. (1959). \u00dcber famili\u00e4re gichtische Diathese in Verbindung mit zerebralen und renalen Symptomen bei einem Kleinkind. Deutsch. Med. Wschr. 842145.","journal-title":"Deutsch. Med. Wschr."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/281692a0","volume":"281","author":"R. M. Cawthon","year":"1979","unstructured":"Cawthon, R. M., and Breakefield, X. O. (1979). Differences in A and B forms of monoamine oxidase revealed by limited proteolysis and peptide mapping. Nature 281692.","journal-title":"Nature"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0006-2952(75)90246-4","volume":"24","author":"C. G. S. Collins","year":"1975","unstructured":"Collins, C. G. S., and Youdim, M. B. H. (1975). The binding of [14C]phenethylhydrazine to rat liver monoamine oxidase. Biochem. Pharmacol. 24703.","journal-title":"Biochem. Pharmacol."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1073\/pnas.73.8.2838","volume":"73","author":"G. E. Degnen","year":"1976","unstructured":"Degnen, G. E., Miller, I. L., Eisenstadt, J. M., and Adelberg, E. A. (1976). Chromosome-mediated gene transfer between closely related strains of cultured mouse cells. Proc. Natl. Acad. Sci. USA 732838.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0006-2952(77)90398-7","volume":"26","author":"C. H. Donnelly","year":"1977","unstructured":"Donnelly, C. H., and Murphy, D. L. (1977) Substrate and inhibitor-related characteristics of human platelet monoamine oxidase. Biochem. Pharmacol. 26853.","journal-title":"Biochem. Pharmacol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/0006-2952(76)90476-7","volume":"25","author":"C. H. Donnelly","year":"1976","unstructured":"Donnelly, C. H., Richelson, E., and Murphy, D. L. (1976). Properties of monoamine oxidase in mouse neuroblastoma N1E-115 cells. Biochem. Pharmacol. 251639.","journal-title":"Biochem. Pharmacol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1471-4159.1978.tb06249.x","volume":"31","author":"S. B. Edelstein","year":"1978","unstructured":"Edelstein, S. B., Castiglione, C. M., and Breakefield, X. O. (1978). Monoamine oxidase activity in normal and Lesch-Nyhan fibroblasts. J. Neurochem. 311247.","journal-title":"J. Neurochem."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/0006-2952(76)90512-8","volume":"25","author":"T. Egashira","year":"1976","unstructured":"Egashira, T., Ekstedt, B., and Oreland, L. (1976a). Inhibition by clorgyline and deprenyl of the different forms of monoamine oxidase in rat liver mitochondria. Biochem. Pharmacol. 252583.","journal-title":"Biochem. Pharmacol."},{"key":"CR15","first-page":"272","volume":"54","author":"T. Egashira","year":"1976","unstructured":"Egashira, T., Ekstedt, B., and Kinemuchi, H., et al. 1976b). Molecular turnover numbers of different forms of mitochondrial monoamine oxidase in rat. Med. Biol. 54272.","journal-title":"Med. Biol."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.2042-7158.1978.tb13235.x","volume":"30","author":"C. J. Fowler","year":"1978","unstructured":"Fowler, C. J., and Callingham, B. A. (1978). The inhibition of clorgyline of 5-hydroxytryptamine deamination by the rat liver. J. Pharm. Pharmacol. 30304.","journal-title":"J. Pharm. Pharmacol."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0009-8981(77)90270-4","volume":"80","author":"R. Groshong","year":"1977","unstructured":"Groshong, R., Gibson, D. A., and Baldessarini, R. J. (1977). Monoamine oxidase activity in cultured human skin fibroblasts. Clin. Chim. Acta 80113.","journal-title":"Clin. Chim. Acta"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1126\/science.432659","volume":"204","author":"R. A. Harper","year":"1979","unstructured":"Harper, R. A., and Grove G. (1979). Human skin fibroblasts derived from papillary and reticular dermis: Differences in growth potential in vitro. Science 204526.","journal-title":"Science"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1471-4159.1978.tb10471.x","volume":"30","author":"M. Hawkins Jr.","year":"1978","unstructured":"Hawkins, M. Jr., and Breakefield, X. O. (1978). Monoamine oxidase A and B in cultured cells. J. Neurochem. 301391.","journal-title":"J. Neurochem."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1016\/S0021-9258(18)91942-3","volume":"243","author":"L. Hellerman","year":"1968","unstructured":"Hellerman, L., and Erwin, V. G. (1968). Mitochondrial monoamine oxidase. II. Action of various inhibitors for the bovine kidney enzyme. catalytic mechanism. J. Biol. Chem. 2435234.","journal-title":"J. Biol. Chem."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0024-3205(76)90224-1","volume":"19","author":"M. D. Houslay","year":"1976","unstructured":"Houslay, M. D., Tipton, K. F., and Youdim, M. B. H. (1976). Multiple forms of monoamine oxidase: Fact and artefact. Life Sci. 19467.","journal-title":"Life Sci."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0006-2952(68)90066-X","volume":"17","author":"J. P. Johnston","year":"1968","unstructured":"Johnston, J. P. (1968). Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmacol. 171285.","journal-title":"Biochem. Pharmacol."},{"key":"CR23","first-page":"393","volume":"5","author":"J. Knoll","year":"1972","unstructured":"Knoll, J., and Magyar, K. (1972). Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv. Biochem. Psychopharmacol. 5393.","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0002-9343(64)90104-4","volume":"36","author":"M. Lesch","year":"1964","unstructured":"Lesch, M., and Nyhan, W. L. (1964). A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 36561.","journal-title":"Am. J. Med."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/ja01318a036","volume":"56","author":"H. Lineweaver","year":"1934","unstructured":"Lineweaver, H., and Burk, D. (1934). The determination of enzyme dissociation constants. J. Am. Chem. Soc. 56658.","journal-title":"J. Am. Chem. Soc."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"O. H. Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. J., and Farr, A. L. et al. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193265.","journal-title":"J. Biol. Chem."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/0006-2952(78)90001-1","volume":"27","author":"D. L. Murphy","year":"1978","unstructured":"Murphy, D. L. (1978). Substrate-selective monoamine oxidases?Inhibitor, tissue, species and functional differences. Biochem. Pharmacol. 271889.","journal-title":"Biochem. Pharmacol."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0006-2944(76)90031-4","volume":"16","author":"D. L. Murphy","year":"1976","unstructured":"Murphy, D. L., Wright, C., and Buchsbaum, M., et al. (1976). Platelet and plasma amine oxidase activity in 680 normals: Sex and age differences and stability over time. Biochem. Med. 16254.","journal-title":"Biochem. Med."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1001\/archpsyc.1973.01750360060008","volume":"28","author":"A. Nies","year":"1973","unstructured":"Nies, A., Robinson, D. S., and Lamborn, K. R., et al. (1973). Genetic control of platelet and plasma monoamine oxidase activity. Arch. Gen. Psychiat. 28834.","journal-title":"Arch. Gen. Psychiat."},{"key":"CR30","first-page":"59","volume":"12","author":"A. Nies","year":"1974","unstructured":"Nies, A., Robinson, D. S., and Harris, L. S., et al. (1974). Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives and controls. Adv. Biochem. Psychopharmacol. 1259.","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/0003-9861(73)90527-4","volume":"159","author":"L. Oreland","year":"1973","unstructured":"Oreland, L., Kinemushi, H., and Stigbrand, T. (1973). Pig liver monoamine oxidase: studies on the subunit structure. Arch. Biochem. Biophys. 159854.","journal-title":"Arch. Biochem. Biophys."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1126\/science.185.4148.320","volume":"185","author":"R. R. Rando","year":"1974","unstructured":"Rando, R. R. (1974). Chemistry and enzymology of K cat inhibitors. Science 185320.","journal-title":"Science"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/0024-3205(76)90077-1","volume":"19","author":"J. A. Roth","year":"1976","unstructured":"Roth, J. A., Breakefield, X. O., and Castiglione, C. M. (1976). Monoamine oxidase and catechol-O-methyltransferase activities in cultured human skin fibroblasts. Life Sci. 191705.","journal-title":"Life Sci."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1126\/science.155.3770.1682","volume":"155","author":"J. E. Seegmiller","year":"1967","unstructured":"Seegmiller, J. E., Rosenbloom, F. M. and Kelley, W. N. (1967). Enzyme defect associated with sex-linked human neurological disorder and excessive purine synthesis. Science 1551682.","journal-title":"Science"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1399-0004.1979.tb01754.x","volume":"15","author":"S. Singh","year":"1979","unstructured":"Singh, S., Williers, I., Kluss, E.-M., and Goedde, H. W. (1979). Monoamine oxidase and catechol-O-methyltransferase activity in cultured fibroblasts from patients with maple syrup urine disease, Lesch-Nyhan syndrome and healthy controls. Clin. Genet. 15153.","journal-title":"Clin. Genet."},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/BF00484533","volume":"16","author":"S. D. Skaper","year":"1978","unstructured":"Skaper, S. D., and Schafer, I. A. (1978). Monoamine oxidase activity reduced in cultured human fetal cells deficient in hypoxanthine-guanine phosphoribosyltransferase activity. Biochem. Genet. 161135.","journal-title":"Biochem. Genet."},{"key":"CR37","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.996547","volume":"194","author":"S. D. Skaper","year":"1976","unstructured":"Skaper, S. D., and Seegmiller, J. E. (1976). Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: Diminished monamine oxidase activity. Science 1941171.","journal-title":"Science"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.32.2.415","volume":"32","author":"G. L. Sottocasa","year":"1967","unstructured":"Sottocasa, G. L., Kuylenstierna, B., and Ernster, L. et al. (1967). An electrontransport system associated with the outer membrane of liver mitochondria: A biochemical and morphologic study. J. Cell Biol. 32415.","journal-title":"J. Cell Biol."},{"key":"CR39","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1432-1033.1971.tb19690.x","volume":"24","author":"W. H. Walker","year":"1971","unstructured":"Walker, W. H., Kearney, E. B., and Seng, R. L. et al. (1971). The covalently-bound flavin of hepatic monoamine oxidase. Identification and properties of cisteinyl riboflavin. Eur. J. Biochem. 24328.","journal-title":"Eur. J. Biochem."},{"key":"CR40","volume-title":"Neurogenetics: Genetic Approaches to the Nervous System","author":"R. M. Weinshilboum","year":"1979","unstructured":"Weinshilboum, R. M. (1979). Catecholamine biochemical genetics in human population. In Breakefield, X. O. (ed.), Neurogenetics: Genetic Approaches to the Nervous System. Elsevier-North Holland, New York."},{"key":"CR41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1042\/bj0800324","volume":"80","author":"G. N. Wilkinson","year":"1961","unstructured":"Wilkinson, G. N. (1961). Statistical estimations in enzyme kinetics. Biochem. J. 80324.","journal-title":"Biochem. J."},{"key":"CR42","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0006-2952(63)90215-6","volume":"12","author":"R. J. Wurtman","year":"1963","unstructured":"Wurtman, R. J., and Axelrod, J. (1963). A specific and sensitive assay for monoamine oxidase. Biochem. Pharmacol. 121439.","journal-title":"Biochem. Pharmacol."},{"key":"CR43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/schbul\/2.1.77","volume":"2","author":"R. J. Wyatt","year":"1976","unstructured":"Wyatt, R. J., and Murphy, D. L. (1976). Low platelet monoamine oxidase activity and schizophrenia. Schiz. Bull. 277.","journal-title":"Schiz. Bull."}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00484403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00484403\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00484403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T14:07:24Z","timestamp":1624889244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00484403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,6]]},"references-count":43,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[1980,6]]}},"alternative-id":["BF00484403"],"URL":"https:\/\/doi.org\/10.1007\/bf00484403","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,6]]}}}