{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:35:36Z","timestamp":1782423336999,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochemistry"],"published-print":{"date-parts":[[1982]]},"DOI":"10.1007\/bf00495054","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T21:25:09Z","timestamp":1100553909000},"page":"85-93","source":"Crossref","is-referenced-by-count":11,"title":["Copper accumulation in primary biliary cirrhosis"],"prefix":"10.1007","volume":"74","author":[{"given":"W.","family":"Humbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aprahamian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","unstructured":"Ballan-Dufran\u00e7ais C, Jeantet AY, Ruste J (1980) Quantitative X-Ray micro-analysis and toxicology of mercury. In: Brederro P, Cosslett VE (eds) Electron microscopy, vol 3: Analysis, pp 118?119"},{"key":"CR2","unstructured":"Berry JP, Hourdry J, Galle P, Lagrue G (1980) Chromium concentration by proximal renal tubular cells: an ultrastructural, microanalytical and cytochemical study. DR Beaman, RE Ogilvie, DB Wittry (eds) X-Ray Optics and Microanalysis. pp 476?482"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-5320(80)90051-9","volume":"72","author":"DN Crighton","year":"1980","unstructured":"Crighton DN, Busuttil A, Ross A (1980) An ultrastructural study of murine splenic lipofuscinosis. J Ultrastruct Res 72:130?140","journal-title":"J Ultrastruct Res"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0022-5320(60)90016-2","volume":"3","author":"E Essner","year":"1960","unstructured":"Essner E, Novikoff AB (1960) Human hepatocellular pigments and lysosomes. J Ultrastruct Res 3:375?391","journal-title":"J Ultrastruct Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0016-5085(78)90473-0","volume":"75","author":"J Evans","year":"1978","unstructured":"Evans J, Newman S, Sherlock S (1978) Liver copper levels in intrahepatic cholestasis of childhood. Gastroenterology 75:875?878","journal-title":"Gastroenterology"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0016-5085(19)32704-0","volume":"67","author":"CR Fleming","year":"1974","unstructured":"Fleming CR, Dickson ER, Baggenstoss AH, McGall JT (1974) Copper and primary biliary cirrhosis. Gastroenterology 67:1182?1187","journal-title":"Gastroenterology"},{"key":"CR7","first-page":"17","volume":"19","author":"P Galle","year":"1974","unstructured":"Galle P (1974) R\u00f4le des lysosomes et des mitochondries dans les ph\u00e9nom\u00e8nes de concentration et d'\u00e9limination d'\u00e9lements min\u00e9raux (uranium et or) par le rein. J Microsc (Paris) 19:17?24","journal-title":"J Microsc (Paris)"},{"key":"CR8","unstructured":"Galle P, Berry JP (1980) The role of acid phosphatases in the concentration of some mineral elements in lysosomes. In: Brederro P, Cosslett VE (eds) Electron microscopy, vol 3: Analysis, pp 92?93"},{"key":"CR9","volume-title":"Ultrastructural pathology of the cell","author":"FN Ghadially","year":"1975","unstructured":"Ghadially FN (1975) Ultrastructural pathology of the cell. Butterworths, London Boston"},{"key":"CR10","volume-title":"Progress in liver diseases, vol 4","author":"S Goldfisher","year":"1972","unstructured":"Goldfisher S, Biempica L (1972) Morphology of the normal liver cell. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 4, Grune and Statton, New York London"},{"key":"CR11","first-page":"305","volume":"48","author":"S Goldfisher","year":"1966","unstructured":"Goldfisher S, Moskal J (1966) Electron probe microanalysis of liver in Wilson's disease. Am J Pathol 48:305?315","journal-title":"Am J Pathol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/14.9.641","volume":"14","author":"S Goldfisher","year":"1966","unstructured":"Goldfisher S, Villaverde H, Forschirm R (1966) The demonstration of acid hydrolase, thermostable reduced diphosphopyridine nucleotide tetrazolium reductase and peroxydase activity in lysosomes. J Histochem Cytochem 14:641?652","journal-title":"J Histochem Cytochem"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/228172a0","volume":"228","author":"S Goldfisher","year":"1970","unstructured":"Goldfisher S, Schiller B, Sternlieb I (1970) Copper in Hepatocyte lysosomes of the toad (Bufo marinus L). Nature 228:172?173","journal-title":"Nature"},{"key":"CR14","unstructured":"Goldfisher S, Popper H, Sternlieb I (1980) The distribution of lysosomal and cytosol copper in liver disease. VIth Int Histochem and Cytochem Congress Brighton G.B. Abstract p 143"},{"key":"CR15","doi-asserted-by":"crossref","unstructured":"Humbert W (1980) Intracellular accumulation of uranium and lead in Collembolan (Insect). In: Bailey GW (ed) Proceedings EMSA, 38th Annual meeting San Francisco (California). Baton Rouge Claitor's publishing division, pp 564?566","DOI":"10.1017\/S1431927600002506"},{"key":"CR16","unstructured":"Jeanguillaume C (1979) R\u00f4le des h\u00e9patocytes dans la captation des collo\u00efdes par le foie. Th\u00e8se M\u00e9decine, Universit\u00e9 Paris Val de Marne"},{"key":"CR17","first-page":"82","volume":"43","author":"J Ludwig","year":"1979","unstructured":"Ludwig J, Owen CA, Barham SS, Call JT, Hardy RM (1979) The liver in the inherited copper diseases of Bedlington Terriers. Lab Invest 43:82?87","journal-title":"Lab Invest"},{"key":"CR18","first-page":"88","volume":"43","author":"E Mezey","year":"1980","unstructured":"Mezey E, Potter JJ, Slusser RJ, Brandes D, Romero J, Tamura T, Halsted CH (1980) Effect of ethanol feeding on hepatic lysosomes in the monkey. Lab Invest 43:88?93","journal-title":"Lab Invest"},{"key":"CR19","first-page":"697","volume":"5","author":"A Monneron","year":"1966","unstructured":"Monneron A Berhardt W (1966) Action de certains enzymes sur des tissus inclus en Epon. J Microsc (Paris) 5:697?714","journal-title":"J Microsc (Paris)"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0002-9343(60)90011-5","volume":"29","author":"AA Novikoff","year":"1960","unstructured":"Novikoff AA, Essner E (1960) The liver cell. Some new approaches to its study. Am J Med 29:102?131","journal-title":"Am J Med"},{"key":"CR21","first-page":"1338","volume":"1","author":"M Portman","year":"1970","unstructured":"Portman M, Tanner MS, Mowatt AP, Williams R (1970) Orcein positive liver deposits in Indian Childhood cirrhosis. Lancet 1:1338?1340","journal-title":"Lancet"},{"key":"CR22","first-page":"315","volume":"41","author":"F Schaffner","year":"1962","unstructured":"Schaffner F, Sternlieb I, Barka T, Popper H (1962) Hepatocellular changes in Wilson's disease. Histochemical and electron microscopic studies. Am J Pathol 41:315?327","journal-title":"Am J Pathol"},{"key":"CR23","first-page":"203","volume":"24","author":"P Sipponen","year":"1980","unstructured":"Sipponen P, Pikkarainen P, Vvori E, Salaspuro M (1980) Copper deposits in fine needle aspiratio biopsies in primary biliary cirrhosis. Acta Cytol 24:203?207","journal-title":"Acta Cytol"},{"key":"CR24","unstructured":"Sternlieb I, Evolution of the hepatic lesion in Wilson's disease (Hepatolenticular degeneration). In: Popper H, Schaffner F (eds) Progress in liver diseases Vol. 4. Grune and Stratton, New York and London"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-5320(77)90012-0","volume":"61","author":"B Vivien-Roels","year":"1977","unstructured":"Vivien-Roels B, Humbert W (1977) The lipopigments of the pineal gland of Testudo hermani (Reptile, Chelonian): Microprobe Analysis and physiological significance. J Ultrastruct Res 61:134?139","journal-title":"J Ultrastruct Res"}],"container-title":["Histochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00495054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00495054\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00495054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T07:29:46Z","timestamp":1682839786000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00495054"}},"subtitle":["An electron and X-ray microanalytical study"],"short-title":[],"issued":{"date-parts":[[1982]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982]]}},"alternative-id":["BF00495054"],"URL":"https:\/\/doi.org\/10.1007\/bf00495054","relation":{},"ISSN":["0301-5564","1432-119X"],"issn-type":[{"value":"0301-5564","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982]]}}}