{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:52:37Z","timestamp":1756993957064},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1975,1,1]],"date-time":"1975-01-01T00:00:00Z","timestamp":157766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1975]]},"DOI":"10.1007\/bf00500048","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T23:34:08Z","timestamp":1100561648000},"page":"175-191","source":"Crossref","is-referenced-by-count":62,"title":["Investigation into some imidazoline compounds, with respect to peripheral ?-adrenoceptor stimulation and depression of cardiovascular centers"],"prefix":"10.1007","volume":"291","author":[{"given":"W.","family":"Kobinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-2999(73)90102-7","volume":"23","author":"M. J. Antonaccio","year":"1973","unstructured":"Antonaccio, M. J., Robson, R. D., Kerwin, L.: Evidence for increased vagal tone and enhancement of baroreceptor reflex activity after xylazine (2-(2,6-dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine) in anesthetized dogs. Europ. J. Pharmacol. 23, 311?315 (1973)","journal-title":"Europ. J. Pharmacol."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0014-2999(71)90152-X","volume":"13","author":"A. M. Autret","year":"1971","unstructured":"Autret, A. M., Schmitt, H., F\u00e9nard, S., P\u00e9illot, N.: Comparison of haemodynamic effects of ?-sympathomimetic drugs. Europ. J. Pharmacol. 13, 208?217 (1971)","journal-title":"Europ. J. Pharmacol."},{"key":"CR3","first-page":"1038","volume":"16","author":"W. Hoefke","year":"1966","unstructured":"Hoefke, W., Kobinger, W.: Pharmakologische Wirkungen des 2-(2,6 Dichlorphenyl-amino)-2-imidazolinhydrochlorids, einer neuen antihypertensiven Substanz. Arzneimittel-Forsch. (Drug Res.) 16, 1038?1050 (1966)","journal-title":"Arzneimittel-Forsch. (Drug Res.)"},{"key":"CR4","first-page":"786","volume":"25","author":"W. Hoefke","year":"1975","unstructured":"Hoefke, W., Kobinger, W., Walland, A.: Relationship between activity and structure in derivatives of clonidine. Arzneimittel-Forsch. (Drug Res.) 25, 786?793 (1975)","journal-title":"Arzneimittel-Forsch. (Drug Res.)"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF00535929","volume":"258","author":"W. Kobinger","year":"1967","unstructured":"Kobinger, W.: \u00dcber den Wirkungsmechanismus einer neuen antihypertensiven Substanz mit Imidazolstruktur. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 258, 48?58 (1967)","journal-title":"Naunyn-Schmiedebergs Arch. Pharmak. exp. Path."},{"key":"CR6","first-page":"107","volume-title":"Proc. IV Int. Symp. Med. Chemistry, Main lectures","author":"W. Kobinger","year":"1974","unstructured":"Kobinger, W.: Medicinal chemistry related to the central regulation of blood pressure. II. Pharmacological part. Proc. IV Int. Symp. Med. Chemistry, Main lectures, Ed. J. Maas, pp. 107?120. Amsterdam: Elsevier Scientific Publishing Comp. 1974"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00506651","volume":"286","author":"W. Kobinger","year":"1975","unstructured":"Kobinger, W., Pichler, L.: Localisation in the CNS of adrenoceptors which facilitate a cardioinhibitory reflex. Naunyn-Schmiedeberg's Arch. Pharmacol. 286, 371?377 (1975)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR8","first-page":"202","volume":"17","author":"W. Kobinger","year":"1967","unstructured":"Kobinger, W., Walland, A.: Kreislaufuntersuchungen mit 2-(2,6-Dichlorphenylamino)-2-imidazolinhydrochlorid. Arzneimittel-Forsch. (Drug Res.) 17, 202?300 (1967)","journal-title":"Arzneimittel-Forsch. (Drug Res.)"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0014-2999(71)90066-5","volume":"16","author":"W. Kobinger","year":"1971","unstructured":"Kobinger, W., Walland, A.: Involvement of adrenergic receptors in central vagus activity. Europ. J. Pharmacol. 16, 120?122 (1971)","journal-title":"Europ. J. Pharmacol."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-2999(72)90010-6","volume":"19","author":"W. Kobinger","year":"1972","unstructured":"Kobinger, W., Walland, A.: Evidence for a central activation of a vagal cardiodepressor reflex by clonidine. Europ. J. Pharmacol. 19, 203?209 (1972a)","journal-title":"Europ. J. Pharmacol."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0014-2999(72)90011-8","volume":"19","author":"W. Kobinger","year":"1972","unstructured":"Kobinger, W., Walland, A.: Facilitation of vagal reflex bradycardia by an action of clonidine on central ?-receptors. Europ. J. Pharmacol. 19, 210?217 (1972b)","journal-title":"Europ. J. Pharmacol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00539619","volume":"256","author":"G. Kroneberg","year":"1967","unstructured":"Kroneberg, G., Oberdorf, A., Hoffmeister, F., Wirth, W.: Zur Pharmakologie von 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazin (Bayer 1470), eines Hemmstoffes adrenergischer und cholinergischer Neurone. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 256, 257?288 (1967)","journal-title":"Naunyn-Schmiedebergs Arch. Pharmak. exp. Path."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/cr60274a001","volume":"71","author":"A. Leo","year":"1971","unstructured":"Leo, A., Hansch, C., Elkins, D.: Partition coefficients and their uses. Chem. Rev. 71, 525?616 (1971)","journal-title":"Chem. Rev."},{"key":"CR14","first-page":"432","volume":"155","author":"M. Mujic","year":"1965","unstructured":"Mujic, M., van Rossum, J. M.: Comperative pharmacodynamics of sympathomimetic imidazolines; studies on intestinal smooth muscle of the rabbit and the cardiovascular system of the cat. Arch. int. Pharmacodyn. 155, 432?449 (1965)","journal-title":"Arch. int. Pharmacodyn."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1002\/cber.19741070825","volume":"107","author":"K.-H. Pook","year":"1974","unstructured":"Pook, K.-H., St\u00e4hle, H., Daniel, H.: Strukturuntersuchungen an 2-(Arylamino)-imidazolidinen und 2-(Arylamino)imidazolinen mit Hilfe der Protonen- und Kohlenstoff-13-Resonanz. Chem. Ber. 107, 2644?2657 (1974)","journal-title":"Chem. Ber."},{"key":"CR16","first-page":"229","volume":"190","author":"H. Schmitt","year":"1971","unstructured":"Schmitt, H., F\u00e9nard, S.: Effects des substances sympathomim\u00e9tiques sur les centres vasomoteurs. Arch. int. Pharmacodyn. 190, 229?240 (1971)","journal-title":"Arch. int. Pharmacodyn."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0014-2999(71)90130-0","volume":"14","author":"H. Schmitt","year":"1971","unstructured":"Schmitt, H., Schmitt, H., F\u00e9nard, S.: Evidence for an ?-sympathomimetic component in the effects of catapresan on vasomotor centres: antagonism by piperoxane. Europ. J. Pharmacol. 14, 98?100 (1971)","journal-title":"Europ. J. Pharmacol."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0024-3205(74)90005-8","volume":"15","author":"H. Struyker-Boudier","year":"1974","unstructured":"Struyker-Boudier, H., Smeets, G., Brower, G., van Rossum, J.: Central and peripheral ?-adrenergic activity of imidazoline derivatives. Life Sci. 15, 887?899 (1974)","journal-title":"Life Sci."},{"key":"CR19","first-page":"115","volume":"1","author":"C. G. Wermuth","year":"1973","unstructured":"Wermuth, C. G., Schwartz, J., Leclerc, G., Garnier, J. P., Rouot, B.: Conformation de la clonidine et hypoth\u00e8ses sur son interaction avec un r\u00e9cepteur ?-adr\u00e9nergique. Chim. Th\u00e9r. 1, 115?116 (1973)","journal-title":"Chim. Th\u00e9r."}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00500048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00500048\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00500048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T14:15:14Z","timestamp":1554387314000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00500048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975]]}},"alternative-id":["BF00500048"],"URL":"https:\/\/doi.org\/10.1007\/bf00500048","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975]]}}}