{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:33:14Z","timestamp":1760099594893},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1982]]},"DOI":"10.1007\/bf00500485","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T04:49:03Z","timestamp":1100666943000},"page":"234-240","source":"Crossref","is-referenced-by-count":130,"title":["Assessment of ?Ca2+-antagonist? effects of drugs in K+-depolarized smooth muscle"],"prefix":"10.1007","volume":"318","author":[{"given":"M.","family":"Spedding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1476-5381.1959.tb00928.x","volume":"14","author":"O Arunlakshana","year":"1959","unstructured":"Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 14:48?58","journal-title":"Br J Pharmacol Chemother"},{"key":"CR2","first-page":"226","volume":"29","author":"VF Bossert","year":"1979","unstructured":"Bossert VF, Horstmann H, Meyer H, Vater W (1979) Einflu\u00df der Esterfunktion auf die vasodilatierenden Eigenschaften von 1,4-dihydro-2,6-dimethyl-4-nitrophenyl-pyridin-3,5-dicarbons\u00e4ureestern. Arzneim Forsch 29:226?229","journal-title":"Arzneim Forsch"},{"key":"CR3","first-page":"31","volume":"2","author":"R Bayer","year":"1977","unstructured":"Bayer R, Ehara T (1977) Comparative studies on calcium antagonists. Prog Pharmacol 2:31?37","journal-title":"Prog Pharmacol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1476-5381.1980.tb07928.x","volume":"70","author":"AF Brading","year":"1980","unstructured":"Brading AF, Sneddon P (1980) Evidence for multiple sources of calcium for activation of the contractile mechanism of guinea-pig taenia coli on stimulation with carbachol. Br J Pharmacol 70:229?240","journal-title":"Br J Pharmacol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1139\/y80-044","volume":"58","author":"J Church","year":"1980","unstructured":"Church J, Zsot\u00e9r TT (1980) Calcium antagonist drugs. Mechanism of action. Can J Physiol Pharmacol 58:254?264","journal-title":"Can J Physiol Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1113\/jphysiol.1961.sp006707","volume":"157","author":"RP Durbin","year":"1961","unstructured":"Durbin RP, Jenkinson DH (1961) The calcium dependence of tension development in depolarized smooth muscle. J Physiol Lond 157:90?96","journal-title":"J Physiol Lond"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.2042-7158.1970.tb08394.x","volume":"22","author":"M Ferrari","year":"1970","unstructured":"Ferrari M (1970) Interactions between calcium and some myolytic agents on depolarized vascular smooth muscle. J Pharm Pharmacol 22:71?72","journal-title":"J Pharm Pharmacol"},{"key":"CR8","first-page":"223","volume":"174","author":"M Ferrari","year":"1968","unstructured":"Ferrari M, Carpenedo F (1968) On the mechanism of action of some myolytic agents on depolarized guinea, pig taenia coli. Arch Int Pharmacodyn 174:223?232","journal-title":"Arch Int Pharmacodyn"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.pa.17.040177.001053","volume":"17","author":"A Fleckenstein","year":"1977","unstructured":"Fleckenstein A (1977) Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann Rev Pharmacol Toxicol 17:149?166","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"CR10","first-page":"562","volume":"27","author":"A Fleckenstein","year":"1977","unstructured":"Fleckenstein A, Fleckenstein-Gr\u00fcn G, Byon YK (1977) Cardiovascular effects of the Ca2+-antagonistic coronary drug Fendiline (Sensit). Arzneim Forsch 27:562?571","journal-title":"Arzneim Forsch"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/01.RES.41.5.702","volume":"41","author":"JS Frank","year":"1977","unstructured":"Frank JS, Langer GA, Nudd LM, Seraynoudarian K (1977) The myocardial cell surface, its histochemistry, and the effects of sialic acid and calcium removal on its structure and cellular ionic exchange. Circ Res 41:702?714","journal-title":"Circ Res"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1476-5381.1969.tb08010.x","volume":"36","author":"T Godfraind","year":"1969","unstructured":"Godfraind T, Kaba A (1969) Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle. Br J Pharmacol 36:549?560","journal-title":"Br J Pharmacol"},{"key":"CR13","first-page":"131","volume-title":"Excitation-contraction coupling in smooth muscle","author":"K Golenhofen","year":"1977","unstructured":"Golenhofen K, Wagner B, Weston AH (1977) Calcium systems of smooth muscle and their selective inhibition. In: Casteels R, Godfraind T, R\u00fcegg JC (eds) Excitation-contraction coupling in smooth muscle. Elsevier, Amsterdam, pp 131?136"},{"key":"CR14","first-page":"672","volume":"180","author":"G Haeusler","year":"1972","unstructured":"Haeusler G (1972) Differential effects of verapamil on excitation-contraction coupling in smooth muscle and on excitation-secretion coupling in adrenergic nerve terminals. J Pharmacol Exp Ther 180:672?682","journal-title":"J Pharmacol Exp Ther"},{"key":"CR15","first-page":"212","volume":"231","author":"K Hashimoto","year":"1978","unstructured":"Hashimoto K, Nakagawa Y, Nabata H, Imai S (1978) In vitro analysis of Ca-antagonistic effects of prenylamine as mechanisms for its cardiac actions. Arch Int Pharmacodyn 231:212?221","journal-title":"Arch Int Pharmacodyn"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0002-9149(80)90366-5","volume":"46","author":"PD Henry","year":"1980","unstructured":"Henry PD (1980) Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am J Cardiol 46:1047?1058","journal-title":"Am J Cardiol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","volume":"69","author":"B Hille","year":"1977","unstructured":"Hille B (1977) Local anaesthetics: hydrophilic and hydrophobic pathways for the drug receptor reaction. J Gen Physiol 69:497?515","journal-title":"J Gen Physiol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-6147(79)90033-6","volume":"1","author":"S Imai","year":"1979","unstructured":"Imai S (1979) Antiangial drugs-revival of interest in vasodilators. Trends Pharmacol Sci 1:87?89","journal-title":"Trends Pharmacol Sci"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1476-5381.1980.tb10420.x","volume":"68","author":"M Jetley","year":"1980","unstructured":"Jetley M, Weston AH (1980) Some effects of sodium nitroprusside, methoxyverapamil (D600) and nifedipine on rat portal vein. Br J Pharmacol 68:311?319","journal-title":"Br J Pharmacol"},{"key":"CR20","first-page":"454","volume":"208","author":"RM Levin","year":"1979","unstructured":"Levin RM, Weiss B (1979) Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J Pharmacol Exp Ther 208:454?459","journal-title":"J Pharmacol Exp Ther"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1021\/jm00255a010","volume":"17","author":"B Loev","year":"1974","unstructured":"Loev B, Goodman MM, Snader KM, Tedeschi R, Macko E (1974) ?Hantzsch-type? dihydropyridine hypotensive agents. J Med Chem 17:956?965","journal-title":"J Med Chem"},{"key":"CR22","first-page":"315","volume":"236","author":"N Morel","year":"1978","unstructured":"Morel N, Godfraind T (1978) Action of calcium antagonists on microsomal calcium activated ATPase of rat aorta. Arch Int Pharmacodyn 236:315?316","journal-title":"Arch Int Pharmacodyn"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1254\/jjp.27.239","volume":"27","author":"H Nabata","year":"1977","unstructured":"Nabata H (1977) Effects of calcium-antagonistic coronary vasodilators on myocardial contractility and membrane potentials. Jpn J Pharmacol 27:239?249","journal-title":"Jpn J Pharmacol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1254\/jjp.30.731","volume":"30","author":"K Nakayama","year":"1980","unstructured":"Nakayama K, Kasuya Y (1980) Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine. Jpn J Pharmacol 30:731?742","journal-title":"Jpn J Pharmacol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0140-6736(80)91303-3","volume":"I","author":"LH Opie","year":"1980","unstructured":"Opie LH (1980) Calcium antagonists. Lancet I:806?810","journal-title":"Lancet"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-2999(78)90274-1","volume":"53","author":"A Quintana","year":"1978","unstructured":"Quintana A (1978) Effects of pimozide on the response of smooth muscle to non-dopamine agonists and calcium. Eur J Pharmacol 53:113?116","journal-title":"Eur J Pharmacol"},{"key":"CR27","first-page":"2422","volume":"39","author":"E Racker","year":"1980","unstructured":"Racker E (1980) Fluxes of Ca2+ and concepts. Fed Proc 39:2422?2426","journal-title":"Fed Proc"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1139\/y79-069","volume":"57","author":"RG Rahwan","year":"1979","unstructured":"Rahwan RG, Piascik MF, Witiak DT (1979) The role of calcium antagonism in the therapeutic action of drugs. Can J Physiol Pharmacol 57:443?460","journal-title":"Can J Physiol Pharmacol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/0024-3205(80)90540-8","volume":"27","author":"JH Sanner","year":"1980","unstructured":"Sanner JH, Prusa CM (1980) Inhibition by verapamil of contractions produced by calcium on depolarized rabbit aortic strips. Life Sci 27:2565?2570","journal-title":"Life Sci"},{"key":"CR30","unstructured":"Spedding M (1981) Marked differences in the effects of ?Ca2+-antagonists? on CaCl2-induced contractions in K+-depolarized smooth muscle Br J Pharmacol 72: 144P"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1476-5381.1978.tb17279.x","volume":"63","author":"M Spedding","year":"1978","unstructured":"Spedding M, Weetman DF (1978) The mechanism of the relaxant effect of 2-2?-pyridylisatogen on the isolated taenia of the guinea-pig caecum. Br J Pharmacol 63:659?664","journal-title":"Br J Pharmacol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1476-5381.1956.tb00006.x","volume":"11","author":"RP Stephenson","year":"1956","unstructured":"Stephenson RP (1956) A modification of receptor theory. Br J Pharmacol Chemother 11:379?393","journal-title":"Br J Pharmacol Chemother"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-2999(79)90410-2","volume":"54","author":"S Thorens","year":"1979","unstructured":"Thorens S, Haeusler G (1979) Effects of some vasodilators on calcium translocation in intact and fractionated vascular smooth muscle. Eur J Pharmacol 54:79?91","journal-title":"Eur J Pharmacol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.2042-7158.1973.tb09117.x","volume":"25","author":"A Tomiyama","year":"1973","unstructured":"Tomiyama A, Takayanagi I, Takagi K (1973) Relaxation of intestinal smooth muscle and calcium movements. J Pharm Pharmacol 25:65?68","journal-title":"J Pharm Pharmacol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1113\/jphysiol.1977.sp012046","volume":"272","author":"C Breemen Van","year":"1977","unstructured":"Van Breemen C (1977) Calcium requirement for activation of intact aortic smooth muscle. J Physiol Lond 272:317?329","journal-title":"J Physiol Lond"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-2952(80)90365-2","volume":"29","author":"JM Nueten Van","year":"1980","unstructured":"Van Nueten JM, Vanhoutte PM (1980) Improvement of tissue perfusion with inhibitors of calcium ion influx. Biochem Pharmacol 29:479?481","journal-title":"Biochem Pharmacol"},{"key":"CR37","first-page":"42","volume":"232","author":"JM Nueten Van","year":"1978","unstructured":"Van Nueten JM, Van Beck J, Janssen PAJ (1978) Effect of flunarizine on calcium-induced responses of peripheral vascular smooth muscle. Arch Int Pharmacodyn 232:42?52","journal-title":"Arch Int Pharmacodyn"},{"key":"CR38","first-page":"299","volume":"143","author":"JM Rossum Van","year":"1963","unstructured":"Van Rossum JM (1963) Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn 143:299?330","journal-title":"Arch Int Pharmacodyn"},{"key":"CR39","first-page":"15","volume-title":"Recent advances in the pharmacology of adrenoceptors","author":"AH Weston","year":"1978","unstructured":"Weston AH (1978) The effect of noradrenaline on electrical activity and calcium fluxes in rat portal vein. In: Szabadi E, Bradshaw CM, Bevan P (eds) Recent advances in the pharmacology of adrenoceptors. Elsevier, Amsterdam, pp 15?22"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00500485.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00500485\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00500485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:15:25Z","timestamp":1554401725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00500485"}},"subtitle":["Differentiation of antagonist subgroups"],"short-title":[],"issued":{"date-parts":[[1982]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982]]}},"alternative-id":["BF00500485"],"URL":"https:\/\/doi.org\/10.1007\/bf00500485","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982]]}}}