{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:04:11Z","timestamp":1760979851083},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1975,1,1]],"date-time":"1975-01-01T00:00:00Z","timestamp":157766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1975]]},"DOI":"10.1007\/bf00501471","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T06:15:32Z","timestamp":1100585732000},"page":"243-259","source":"Crossref","is-referenced-by-count":38,"title":["Prejunctional effects of a purified toxin from the scorpion Tityus serrulatus"],"prefix":"10.1007","volume":"287","author":[{"given":"S. Z.","family":"Langer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Adler-Graschinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","unstructured":"Adler-Graschinsky, E., Langer, S. Z.: Possible role of a ?-adrenoceptor in the regulation of noradrenaline release by nerve stimulation through a positive feedback mechanism. Brit. J. Pharmacol. (in press, 1975)","DOI":"10.1111\/j.1476-5381.1975.tb07328.x"},{"key":"CR2","first-page":"286","volume":"180","author":"E. Adler-Graschinsky","year":"1972","unstructured":"Adler-Graschinsky, E., Langer, S. Z., Rubio, M. C.: Metabolism of norepinephrine released by phenoxybenzamine in isolated guinea-pig atria. J. Pharmacol. exp. Ther. 180, 286?301 (1972)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR3","first-page":"431","volume":"190","author":"L. X. Cubeddu","year":"1974","unstructured":"Cubeddu, L. X., Barnes, E. M., Langer, S. Z., Weiner, N.: Release of norepinephrine and dopamine-?-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of ?-presynaptic receptors. J. Pharmacol. exp. Ther. 190, 431?450 (1974a)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR4","first-page":"368","volume":"188","author":"L. X. Cubeddu","year":"1974","unstructured":"Cubeddu, L. X., Langer, S. Z., Weiner, N.: The relationships between ?-receptor block, inhibition of norepinephrine uptake and the release and metabolism of 3H-norepinephrine. J. Pharmacol. exp. Ther. 188, 368?385 (1974b)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR5","first-page":"253","volume":"164","author":"A. P. Corrado","year":"1968","unstructured":"Corrado, A. P., Antonio, A., Diniz, C. R.: Brazilian scorpion venom (Tityus serrulatus), an unusual sympathetic postganglionic stimulant. J. Pharmacol. exp. Ther. 164, 253?258 (1968)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0041-0101(68)90119-0","volume":"5","author":"C. R. Diniz","year":"1968","unstructured":"Diniz, C. R., Torres, J. M.: Release of an acetylcholine-like substance from guineapig ileum by scorpion venom. Toxicon 5, 277?281 (1968)","journal-title":"Toxicon"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00500649","volume":"278","author":"M. Dubocovich","year":"1973","unstructured":"Dubocovich, M., Langer, S. Z.: Effects of flow-stop on the metabolism of noradrenaline released by nerve stimulation in the perfused spleen. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 179?194 (1973)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.1974.sp010495","volume":"237","author":"M. L. Dubocovich","year":"1974","unstructured":"Dubocovich, M. L., Langer, S. Z.: Negative feed-back regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and postsynaptic adrenergic receptors. J. Physiol. (Lond.) 237, 505?519 (1974)","journal-title":"J. Physiol. (Lond.)"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1476-5381.1973.tb08367.x","volume":"49","author":"Ma. A. Enero","year":"1973","unstructured":"Enero, Ma. A., Langer, S. Z.: Influence of reserpine-induced depletion of noradrenaline on the negative feed-back mechanism for transmitter release during nerve stimulation. Brit. J. Pharmacol. 49, 214?225 (1973)","journal-title":"Brit. J. Pharmacol."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1476-5381.1972.tb07306.x","volume":"44","author":"Ma. A. Enero","year":"1972","unstructured":"Enero, Ma. A., Langer, S. Z., Rothlin, R. P., Stefano, F. J. E.: Role of the ?-adrenoceptor in regulating noradrenaline overflow by nerve stimulation. Brit. J. Pharmacol. 44, 672?688 (1972)","journal-title":"Brit. J. Pharmacol."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1476-5381.1974.tb09723.x","volume":"52","author":"M. B. Farah","year":"1974","unstructured":"Farah, M. B., Langer, S. Z.: Protection by phentolamine against the effects of phenoxybenzamine on transmitter release elicited by nerve stimulation in the perfused cat heart. Brit. J. Pharmacol. 52, 549?558 (1974)","journal-title":"Brit. J. Pharmacol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1476-5381.1971.tb07160.x","volume":"43","author":"L.-O. Farnebo","year":"1971","unstructured":"Farnebo, L.-O., Hamberger, B.: Drug-induced changes in the release of [3H]-noradrenaline from field stimulated rat iris. Brit. J. Pharmacol. 43, 97?106 (1971)","journal-title":"Brit. J. Pharmacol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1471-4159.1973.tb00076.x","volume":"20","author":"M. V. Gomez","year":"1973","unstructured":"Gomez, M. V., Dai, M. E. M., Diniz, C. R.: Effect of scorpion venom, tityustoxin, on the release of acetylcholine from incubated slices of rat brain. J. Neurochem. 20, 1051?1061 (1973)","journal-title":"J. Neurochem."},{"key":"CR14","first-page":"899","volume":"33","author":"M. V. Gomez","year":"1966","unstructured":"Gomez, M. V., Diniz, C. R.: Separation of toxic components from Brazilian scorpion-Tityus serrulatus-venom. Mem. Inst. Butantan 33, 899 (1966)","journal-title":"Mem. Inst. Butantan"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0006-2952(73)90231-1","volume":"22","author":"K. H. Graefe","year":"1973","unstructured":"Graefe, K. H., Stefano, F. J. E., Langer, S. Z.: Preferential metabolism of (-)-3H-norepinephrine through the deaminated glycol in the rat vas deferens. Biochem. Pharmacol. 22, 1147?1160 (1973)","journal-title":"Biochem. Pharmacol."},{"key":"CR16","first-page":"529","volume":"187","author":"S. M. Kirpekar","year":"1973","unstructured":"Kirpekar, S. M., Furchgott, R. F., Wakade, A. R., Prat, J. C.: Inhibition by sympathomimetic amines of the release of norepinephrine evoked by nerve stimulation in the cat spleen. J. Pharmacol. exp. Ther. 187, 529?538 (1973)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1476-5381.1971.tb07159.x","volume":"43","author":"S. M. Kirpekar","year":"1971","unstructured":"Kirpekar, S. M., Puig, M.: Effect of flow-stop on noradrenaline release from normal spleens and spleens treated with cocaine, phentolamine or phenoxybenzamine. Brit. J. Pharmacol. 43, 359?369 (1971)","journal-title":"Brit. J. Pharmacol."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/B978-0-08-017922-3.50099-X","volume-title":"Frontiers in Catecholamine Research","author":"S. Z. Langer","year":"1973","unstructured":"Langer, S. Z.: The regulation of transmitter release elicited by nerve stimulation through a presynaptic feed-back mechanism. Frontiers in Catecholamine Research, pp. 543?549. Oxford-London: Pergamon Press 1973"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/0006-2952(74)90187-7","volume":"23","author":"S. Z. Langer","year":"1974","unstructured":"Langer, S. Z.: Presynaptic regulation of catecholamine release. Biochem. Pharmacol. 23, 1793?1800 (1974)","journal-title":"Biochem. Pharmacol."},{"key":"CR20","unstructured":"Langer, S. Z., Adler, E., Enero, M. A., Stefano, F. J. E.: The role of the alpha receptor in regulating noradrenaline overflow by nerve stimulation. XXVth. Int. Congr. Physiol. Sciences, p. 335 (1971)"},{"key":"CR21","first-page":"431","volume":"191","author":"S. Z. Langer","year":"1974","unstructured":"Langer, S. Z., Enero, M. A.: The potentiation of responses to adrenergic nerve stimulation in the presence of cocaine: its relationship to the metabolic fate of released norepinephrine. J. Pharmacol. exp. Ther. 191, 431?443 (1974)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0003-2697(68)90316-3","volume":"22","author":"R. Laverty","year":"1968","unstructured":"Laverty, R., Taylor, K. M.: The fluorometric assay of catecholamines and related compounds: Improvements and extensions to the hydroxyindole technique. Analyt. Biochem. 22, 269?279 (1968)","journal-title":"Analyt. Biochem."},{"key":"CR23","first-page":"210","volume":"190","author":"J. A. Levin","year":"1974","unstructured":"Levin, J. A.: The uptake and metabolism of 3H-l-and 3H-dl-norepinephrine by intact rabbit aorta and by isolated adventitia and media. J. Pharmacol. exp. Ther. 190, 210?226 (1974)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01417206","volume":"265","author":"K. L\u00f6ffelholz","year":"1969","unstructured":"L\u00f6ffelholz, K., Muscholl, E.: A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation. Naunyn-Schmiedebergs Arch. Pharmak. 265, 1?15 (1969)","journal-title":"Naunyn-Schmiedebergs Arch. Pharmak."},{"key":"CR25","first-page":"640","volume":"188","author":"M. A. Luchelli-Fortis","year":"1974","unstructured":"Luchelli-Fortis, M. A., Langer, S. Z.: Reserpine-induced depletion of norepinephrine stores: Is it a reliable criterion for the classification of the mechanism of action of sympathomimetic amines? J. Pharmacol. exp. Ther. 188, 640?653 (1974)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1471-4159.1974.tb11582.x","volume":"22","author":"J. Moss","year":"1974","unstructured":"Moss, J., Colburn, R. W., Kopin, I. J.: Scorpion toxin-induced catecholamine release from synaptosomes. J. Neurochem. 22, 217?221 (1974a)","journal-title":"J. Neurochem."},{"key":"CR27","first-page":"39","volume":"190","author":"J. Moss","year":"1974","unstructured":"Moss, J., Thoa, N. B., Kopin, I. J.: On the mechanism of scorpion toxin-induced release of norepinephrine from peripheral adrenergic neurons. J. Pharmacol. exp. Ther. 190, 39?48 (1974b)","journal-title":"J. Pharmacol. exp. Ther."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1152\/ajplegacy.1972.222.4.850","volume":"222","author":"T. Narahashi","year":"1972","unstructured":"Narahashi, T., Shapiro, B. I., Deguchi, T., Scuka, M., Wang, Ch. M.: Effects of scorpion venom on squid axon membranes. Amer. J. Physiol. 222, 850?857 (1972)","journal-title":"Amer. J. Physiol."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/B978-0-08-017922-3.50105-2","volume-title":"Frontiers in Catecholamine Research","author":"M. J. Rand","year":"1973","unstructured":"Rand, M. J., Story, D. F., Allen, G. S., Glover, A. B., McCulloch, M. W.: Pulse-topulse modulation of noradrenaline release through a prejunctional ?-receptor auto-inhibitory mechanism. Frontiers in Catecholamine Research, pp. 579?581. Oxford-London: Pergamon Press 1973"},{"key":"CR30","volume-title":"Statistical methods","author":"G. W. Snedecor","year":"1967","unstructured":"Snedecor, G. W., Cochran, W. G.: Statistical methods, 6th. ed. Ames: The Iowa State University Press 1967","edition":"6th. ed."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00505064","volume":"275","author":"K. Starke","year":"1972","unstructured":"Starke, K.: Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: evidence for an ?-receptor-mediated feed-back inhibition of noradrenaline release. Naunyn-Schmiedeberg's Arch. Pharmacol. 275, 11?23 (1972)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00501149","volume":"285","author":"K. Starke","year":"1974","unstructured":"Starke, K., Montel, H., Gayk, W., Merker, R.: Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 285, 133?150 (1974)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00501471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00501471\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00501471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T03:24:01Z","timestamp":1585970641000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00501471"}},"subtitle":["Release of 3H-noradrenaline and enhancement of transmitter overflow elicited by nerve stimulation"],"short-title":[],"issued":{"date-parts":[[1975]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975]]}},"alternative-id":["BF00501471"],"URL":"https:\/\/doi.org\/10.1007\/bf00501471","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975]]}}}