{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:14:35Z","timestamp":1771625675032,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1981]]},"DOI":"10.1007\/bf00505309","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T10:47:19Z","timestamp":1100602039000},"page":"149-154","source":"Crossref","is-referenced-by-count":10,"title":["Changes in the activity of nigral neurones induced by morphine and other opiates in rats with an intact brain and after prenigral decerebration"],"prefix":"10.1007","volume":"316","author":[{"given":"Ilmar","family":"Jurna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0006-8993(77)90817-4","volume":"134","author":"S Atweh","year":"1977","unstructured":"Atweh S, Kuhar MJ (1977) Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res 134:393?405","journal-title":"Brain Res"},{"key":"CR2","first-page":"425","volume":"57","author":"PB Bradley","year":"1976","unstructured":"Bradley PB, Gayton RJ (1976) Actions and interactions of morphine and dopamine on single neurones in the rat caudate nucleus. Br J Pharmacol 57:425?426P","journal-title":"Br J Pharmacol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(79)90142-0","volume":"55","author":"SR Childers","year":"1979","unstructured":"Childers SR, Creese I, Snowman AM, Snyder SH (1979) Opiate receptor binding affected differentially by opiates and opioid peptides. Eur J Pharmacol 55:11?18","journal-title":"Eur J Pharmacol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0014-4886(79)90016-5","volume":"64","author":"N Dafny","year":"1979","unstructured":"Dafny N, Brown M, Burks TF, Rigor BM (1979a) Unit activity recorded simultaneously from medial thalamus and caudate nucleus in naive and morphine-dependent rats. Exp Neurol 64:216?224","journal-title":"Exp Neurol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-8993(79)90299-3","volume":"162","author":"N Dafny","year":"1979","unstructured":"Dafny N, Brown M, Burks TF, Rigor BM (1979b) Morphine tolerance and dependence: sensitivity of caudate nucleus neurons. Brain Res 162:361?368","journal-title":"Brain Res"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1699-0463.1951.tb05005.x","volume":"28","author":"L Einarson","year":"1951","unstructured":"Einarson L (1951) On the theory of gallocyanin-chromalum staining and its application for quantitative estimation of basophilia. A selective staining of exquisite progressivity. Acta Pathol Microbiol Scand 28:82?102","journal-title":"Acta Pathol Microbiol Scand"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0306-4522(76)90063-4","volume":"1","author":"R Elde","year":"1976","unstructured":"Elde R, H\u00f6kfelt T, Johanson O, Terenius L (1976) Immunohistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat. Neuroscience 1:349?351","journal-title":"Neuroscience"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/B978-0-12-142956-0.50017-5","volume-title":"Electrophysiological methods in biological research","author":"E Fifkov\u00e1","year":"1967","unstructured":"Fifkov\u00e1 E, Mar?ala J (1967) Stereotaxic atlases for the cat, rabbit and rat. In: Bure? J, Petr\u00e1n M, Zachar J (eds) Electrophysiological methods in biological research. Academic Press, New York, pp 653?731"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-2999(79)90296-6","volume":"59","author":"EP Finnerty","year":"1979","unstructured":"Finnerty EP, Chan SHH (1979) Morphine suppression of substantia nigra zona reticulata neurons in the rat: implicated role for a novel striatonigral feedback mechanism. Eur J Pharmacol 59:307?310","journal-title":"Eur J Pharmacol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1126\/science.10625","volume":"194","author":"RCA Fredeickson","year":"1976","unstructured":"Fredeickson RCA, Norris FH (1976) Enkephalin-induced depression of single neurons in brain areas with opiate receptors ? antagonism by naloxone. Science 194:440?442","journal-title":"Science"},{"key":"CR11","first-page":"1","volume-title":"Development in opiate research","author":"V H\u00f6llt","year":"1978","unstructured":"H\u00f6llt V, W\u00fcster M (1978) The opiate receptors. In: Herz A (ed) Development in opiate research. Marcel Dekker Inc, New York Basel, pp 1?65"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0028-3908(77)90089-2","volume":"16","author":"JS Hong","year":"1977","unstructured":"Hong JS, Yang H-YT, Costa E (1977) On the location of methionine enkephalin neurons in rat striatum. Neuropharmacology 16:451?453","journal-title":"Neuropharmacology"},{"key":"CR13","first-page":"429","volume":"202","author":"K Iwatsubo","year":"1977","unstructured":"Iwatsubo K, Clouet DH (1977) Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons. J Pharmacol Exp Ther 202:429?436","journal-title":"J Pharmacol Exp Ther"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.182.4111.490","volume":"182","author":"YF Jacquet","year":"1973","unstructured":"Jacquet YF, Lajtha A (1973) Morphine action at central nervous system sites in the rat: analgesia and hyperalgesia depending on site and dose. Science 182:490?492","journal-title":"Science"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00501222","volume":"309","author":"I Jurna","year":"1979","unstructured":"Jurna I, Heinz G (1979) Anti-nociceptiva effect of morphine, opioid analgesics and haloperidol injected into the caudate nucleus of the rat. Naunyn-Schmiedeberg's Arch Pharmacol 309:145?151","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00508629","volume":"198","author":"I Jurna","year":"1977","unstructured":"Jurna I, Ehrenthal W, Pfleger K (1977) Tolerance to morphine induced by chronic treatment with tilidine. Naunyn-Schmiedeberg's Arch Pharmacol 198:193?195","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-2999(78)90409-0","volume":"51","author":"I Jurna","year":"1978","unstructured":"Jurna I, Heinz G, Blinn G, Nell T (1978) The effect of substantia nigra stimulation and morphine on ?-motoneurones and the tail-flick response. Eur J Pharmacol 51:239?250","journal-title":"Eur J Pharmacol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0364-7722(78)90002-4","volume":"2","author":"WR Klemm","year":"1978","unstructured":"Klemm WR, Mallari CG (1978) Morphine and naloxone effects on spontaneous unit activity in the caudate, central grey, and amygdala. Prog Neuro-Psychopharmacol 2:535?542","journal-title":"Prog Neuro-Psychopharmacol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0028-3908(77)90026-0","volume":"16","author":"CM Lee","year":"1977","unstructured":"Lee CM, Wong PCL, Chan SH (1977) The involvement of dopaminergic neurotransmission in the inhibitory effect of morphine on caudate neurone activities. Neuropharmacology 16:571?575","journal-title":"Neuropharmacology"},{"key":"CR20","first-page":"583","volume":"194","author":"C-Y Lee","year":"1975","unstructured":"Lee C-Y, Akera T, Stolman S, Brody TM (1975) Saturable binding of dihydromorphine and naloxone to rat brain tissue in vitro. J Pharmacol Exp Ther 194:583?592","journal-title":"J Pharmacol Exp Ther"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1073\/pnas.74.6.2584","volume":"74","author":"RA Nicoll","year":"1977","unstructured":"Nicoll RA, Siggins GR, Ling N, Bloom FE, Guillemin R (1977) Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study. Proc Natl Acad Sci USA 74:2584?2588","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00499911","volume":"310","author":"H Osborne","year":"1980","unstructured":"Osborne H, Herz A (1980) K+-evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine. Naunyn-Schmiedeberg's Arch Pharmacol 310:203?209","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(78)90331-X","volume":"48","author":"H Osborne","year":"1978","unstructured":"Osborne H, H\u00f6llt V, Herz A (1978) Potassium-induced release of enkephalins from rat striatal slices. Eur J Pharmacol 48:219?221","journal-title":"Eur J Pharmacol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1126\/science.179.4077.1011","volume":"179","author":"CB Pert","year":"1973","unstructured":"Pert CB, Snyder SH (1973) Opiate receptors: demonstration in nervous tissue. Science 179:1011?1014","journal-title":"Science"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/0024-3205(75)90289-1","volume":"16","author":"CB Pert","year":"1975","unstructured":"Pert CB, Kuhar MJ, Snyder SH (1975) Autoradiographic localization of the opiate receptor in rat brain. Life Sci 16:1849?1854","journal-title":"Life Sci"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0006-8993(78)90895-8","volume":"151","author":"H Pollard","year":"1978","unstructured":"Pollard H, Llorens C, Schwartz JC, Gros C, Dray F (1978) Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies. Brain Res 151:392?398","journal-title":"Brain Res"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-2999(79)90439-4","volume":"56","author":"JA Richter","year":"1979","unstructured":"Richter JA, Wesche DL, Frederickson RCA (1979) K-stimulated release of leu- and met-enkephalin from rat striatal slices: lack of effect of morphine and naloxone. Eur J Pharmacol 56:105?113","journal-title":"Eur J Pharmacol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0006-8993(78)91108-3","volume":"152","author":"DE Sandberg","year":"1978","unstructured":"Sandberg DE, Segal M (1978) Pharmacological analysis of analgesia and self-stimulation elicited by electrical stimulation of catecholamine nuclei in the rat brain. Brain Res 152:529?542","journal-title":"Brain Res"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0006-8993(80)90107-9","volume":"189","author":"J Sawynok","year":"1980","unstructured":"Sawynok J, Labella FS, Pinsky C (1980) Effects of morphine and naloxone on the K+-stimulated release of methioninenkephalin from slices of rat corpus striatum. Brain Res 189:483?493","journal-title":"Brain Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00495543","volume":"304","author":"R Schulz","year":"1978","unstructured":"Schulz R, Bl\u00e4sig J, W\u00fcster M, Herz A (1978) The opiate-like action of tilidine is mediated by metabolites. Naunyn-Schmideberg's Arch Pharmacol 304:89?93","journal-title":"Naunyn-Schmideberg's Arch Pharmacol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(77)90488-7","volume":"123","author":"M Segal","year":"1977","unstructured":"Segal M, Sandberg D (1977) Analgesia produced by electrical stimulation of catecholamine nuclei in the rat brain. Brain Res 123:369?372","journal-title":"Brain Res"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1073\/pnas.74.5.2167","volume":"74","author":"R Simantov","year":"1977","unstructured":"Simantov R, Kuhar MJ, Uhl GR, Snyder SH (1977) Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system. Proc Natl Acad Sci USA 74:2167?2171","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/281227a0","volume":"281","author":"TW Stone","year":"1979","unstructured":"Stone TW, Perkins MN (1979) Is adenosine the mediator of opiate action on neuronal firing rate? Nature 281:227?228","journal-title":"Nature"},{"key":"CR34","volume-title":"Grundri\u00df der biologischen Statistik","author":"E Weber","year":"1972","unstructured":"Weber E (1972) Grundri\u00df der biologischen Statistik. G. Fischer, Stuttgart"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00501267","volume":"301","author":"D Wesche","year":"1977","unstructured":"Wesche D, H\u00f6llt V, Herz A (1977) Radioimmunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophysectomy. Naunyn-Schmiedeberg's Arch Pharmacol 301:79?82","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR36","first-page":"213","volume-title":"Opiates and endogenous opioid peptides","author":"W Zieglg\u00e4nsberger","year":"1976","unstructured":"Zieglg\u00e4nsberger W, Fry JP (1976) Actions of enkephalin on cortical and striatal neurones of naive and morphine tolerant\/dependent rats. In: Kosterlitz HW (ed) Opiates and endogenous opioid peptides. Elsevier\/North-Holland Biomedical Press, Amsterdam, pp 213?238"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00505309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00505309\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00505309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:15:58Z","timestamp":1554401758000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00505309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981]]}},"alternative-id":["BF00505309"],"URL":"https:\/\/doi.org\/10.1007\/bf00505309","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981]]}}}