{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:06:06Z","timestamp":1760979966207},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1984]]},"DOI":"10.1007\/bf00505327","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T11:26:44Z","timestamp":1100604404000},"page":"254-261","source":"Crossref","is-referenced-by-count":41,"title":["Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants"],"prefix":"10.1007","volume":"326","author":[{"given":"Lars","family":"Lundblad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan M.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\ufffdngg\ufffdrd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/003591576906201238","volume":"62","author":"JE Angell-James","year":"1969","unstructured":"Angell-James JE, de Burgh Daly M (1969) Nasal reflexes. Proc Roy Soc Med 62:1287?1293","journal-title":"Proc Roy Soc Med"},{"key":"CR2","first-page":"423","volume-title":"The nose upper airway physiology and the atmospheric environment","author":"J Andersen","year":"1982","unstructured":"Andersen J, Proctor DF (1982) The fate and effects of inhaled materials. In: Procter DF, Andersen IB (eds) The nose upper airway physiology and the atmospheric environment. Elsevier Biomedical, Amsterdam, pp 423?455"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/1523-1747.ep12520912","volume":"76","author":"JE Bernstein","year":"1981","unstructured":"Bernstein JE, Swifft RM, Soltani K, Lorincz AL (1981) Inhibition of acon reflex vasodilation by topically applied capsaicin. J Invest Dermatol 76:394?395","journal-title":"J Invest Dermatol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1113\/jphysiol.1965.sp007660","volume":"179","author":"EM Coleridge","year":"1965","unstructured":"Coleridge EM, Coleridge JCG, Luck JC (1965) Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol 179:248?262","journal-title":"J Physiol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1476-5381.1980.tb10898.x","volume":"70","author":"M Dixon","year":"1980","unstructured":"Dixon M, Jackson DM, Richards JM (1980) The action of sodium cromoglycate on ?c?-fibre endings in the dog lung. Br J Pharmacol 70:11?13","journal-title":"Br J Pharmacol"},{"key":"CR6","first-page":"191","volume-title":"The nose upper airway physiology and the atmospheric environment","author":"R Eccles","year":"1982","unstructured":"Eccles R (1982) Neurological and pharmacological considerations. In: Proctor DF, Andersen I (eds) The nose upper airway physiology and the atmospheric environment. Elsevier Biomedical, Amsterdam, pp 191?208"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0024-3205(79)90558-7","volume":"25","author":"R Gamse","year":"1979","unstructured":"Gamse R, Molnar A, Lembeck F (1979) Substance P release from spinal cord slices by capsaicin. Life Sci 25:629?636","journal-title":"Life Sci"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4522(81)90136-6","volume":"6","author":"R Gamse","year":"1981","unstructured":"Gamse R, Wax A, Zigmond RE, Leeman SA (1981) Immunoreactive substance P in sympathetic ganglia: Distribution and sensitivity towards capsaicin. Neurosci 6:437?441","journal-title":"Neurosci"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0006-8993(82)90521-2","volume":"239","author":"R Gamse","year":"1982","unstructured":"Gamse R, Petsche U, Lembeck F, Jancs\ufffd-G\ufffdbor A (1982) Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin. Brain Res 239:447?462","journal-title":"Brain Res"},{"key":"CR10","first-page":"561","volume":"61","author":"AJ Gissen","year":"1982","unstructured":"Gissen AJ, Covino BC, Gregus J (1982) Differential sensitivity of fast and slow fibres in mammalian nerve. II. Margin of safety for nerve transmission. Anaest Anal 61:561?569","journal-title":"Anaest Anal"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3940(82)90029-5","volume":"31","author":"P Holzer","year":"1982","unstructured":"Holzer P, Bucsics A, Lembeck F (1982) Distribution of capsaicin sensitive nerve fibres containing immunoreactive substance P in cutancous and visceral tissues of the rat. Neurosci Lett 31:253?257","journal-title":"Neurosci Lett"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(75)90481-3","volume":"100","author":"T H\ufffdkfelt","year":"1975","unstructured":"H\ufffdkfelt T, Kellerth JO, Nilsson G, Pernow B (1975) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100:235?252","journal-title":"Brain Res"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/BF01258524","volume":"10","author":"G Jancs\ufffd","year":"1981","unstructured":"Jancs\ufffd G, H\ufffdkfelt T, Lundberg JM, Kir\ufffdley E, Hal\ufffdsz N, Nilsson G, Terenius L, Rehfeld J, Steinbusch H, Verhofstad A, Elde R, Said S, Brown M (1981) Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin\/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine. J Neurocytol 10:963?980","journal-title":"J Neurocytol"},{"key":"CR14","first-page":"53","volume":"7","author":"N Jancs\ufffd","year":"1960","unstructured":"Jancs\ufffd N (1960) Role of the nerve terminals in the mechanism of inflammatory reactions. Bull Millard Filmore Hosp 7:53?77","journal-title":"Bull Millard Filmore Hosp"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/00220345720510020901","volume":"51","author":"A Jancs\ufffd-G\ufffdbor","year":"1972","unstructured":"Jancs\ufffd-G\ufffdbor A, Szolcs\ufffdnyi I (1972) Neurogenic inflammation responses. J Dent Res 51:264?266","journal-title":"J Dent Res"},{"key":"CR16","first-page":"113","volume":"19\/1?4","author":"N Jancs\ufffd","year":"1961","unstructured":"Jancs\ufffd N, Jancs\ufffd-G\ufffdbor A, Tak\ufffdta J (1961) Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizing agents. Acta Physiol Acad Sci Hung 19\/1?4:113?132","journal-title":"Acta Physiol Acad Sci Hung"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1476-5381.1967.tb01984.x","volume":"31","author":"N Jancs\ufffd","year":"1967","unstructured":"Jancs\ufffd N, Jancs\ufffd-G\ufffdbor A, Scolcs\ufffdnyi I (1967) Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol Chemother 31:138?151","journal-title":"Br J Pharmacol Chemother"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1476-5381.1968.tb00471.x","volume":"32","author":"N Jancs\ufffd","year":"1968","unstructured":"Jancs\ufffd N, Jancs\ufffd-G\ufffdbor A, Szolcs\ufffdnyi I (1968) The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol Chemother 32:32?41","journal-title":"Br J Pharmacol Chemother"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-8993(78)90146-4","volume":"152","author":"TM Jessell","year":"1978","unstructured":"Jessell TM, Iversen LL, Cuello AC (1978) Capsaicin induced depletion of substance P from primary sensory neurons. Brain Res 152:183?188","journal-title":"Brain Res"},{"key":"CR20","first-page":"R383","volume":"243","author":"MR Kaufman","year":"1982","unstructured":"Kaufman MR, Ordway GA, Longhurst JC, Mitchell JH (1982) Reflex relaxation of tracheal smooth muscle by thin-fibre muscle afferents in dogs. Am J Physiol 243:R383?388","journal-title":"Am J Physiol"},{"key":"CR21","first-page":"12","volume":"303","author":"SN Lawson","year":"1980","unstructured":"Lawson SN, Nickels SM (1980) The use of morphometric techniques to analyse the effect of neonatal capsaicin treatment on rat dorsal root ganglia and dorsal roots. J Physiol (Lond) 303:12","journal-title":"J Physiol (Lond)"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00505656","volume":"316","author":"F Lembeck","year":"1981","unstructured":"Lembeck F, Donnerer I (1981) Time course of capsaicin-induced functional impairments in comparison with changes in neuronal substance P content. Naunyn-Schmiedeberg's Arch Pharmacol 316:240?243","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF00508344","volume":"322","author":"F Lembeck","year":"1983","unstructured":"Lembeck F, Donnerer I (1983) Reflex fall in blood pressure mediated by capsaicin-sensitive afferent fibres of the rat splanchnic nerve. Naunyn-Schmiedeberg's Arch Pharmacol 322:286?289","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00500282","volume":"310","author":"F Lembeck","year":"1979","unstructured":"Lembeck F, Holzer P (1979) Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Arch Pharmacol 310:175?183","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0014-2999(82)90462-9","volume":"85","author":"F Lembeck","year":"1982","unstructured":"Lembeck F, Donnerer I, Barth\ufffd L (1982) Inhibition of neurogenic vasodilation and plasma extravasation by substance P-antagonists, somatostatin and (D-Met,Pho5)-enkephalinamide. Eur J Pharmacol 85:171?179","journal-title":"Eur J Pharmacol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/302251a0","volume":"302","author":"JM Lundberg","year":"1983","unstructured":"Lundberg JM, Saria A (1983) Capsaicin-induced desensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature (Lond) 302:251?252","journal-title":"Nature (Lond)"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1748-1716.1983.tb07334.x","volume":"119","author":"JM Lundberg","year":"1983","unstructured":"Lundberg JM, Brodin E, Saria A (1983a) Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs. Acta Physiol Scand 119:243?252","journal-title":"Acta Physiol Scand"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1073\/pnas.80.4.1120","volume":"80","author":"JM Lundberg","year":"1983","unstructured":"Lundberg JM, Saria A, Brodin E, Rosell S, Folkers K (1983b) A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contractions in the guinea pig. Proc Natl Acad Sci USA 80:1120?1124","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1748-1716.1983.tb07304.x","volume":"119","author":"JM Lundberg","year":"1983","unstructured":"Lundberg JM, Martling CR, Saria A (1983c) Substance P and capsaicin induced bronchial smooth muscle contraction in human airways. Acta Physiol Scand 119:49?53","journal-title":"Acta Physiol Scand"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00517317","volume":"326","author":"JM Lundberg","year":"1984","unstructured":"Lundberg JM, Lundblad L, Saria A, \ufffdngg\ufffdrd A (1984a) Inhibition of cigarette smoke-induced oedema in the nasal mucosa by capsaicin pretreatment and a substance P antagonist. Naunyn-Schmiedeberg's Arch Pharmacol 326:181?185","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1748-1716.1984.tb00127.x","volume":"120","author":"JM Lundberg","year":"1984","unstructured":"Lundberg JM, Brodin E, Hua X-Y, Saria A (1984b) Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig. Acta Physiol Scand 120:217?227","journal-title":"Acta Physiol Scand"},{"key":"CR32","first-page":"378","volume":"77","author":"L Lundblad","year":"1982","unstructured":"Lundblad L, \ufffdngg\ufffdrd A, Lundberg JM (1982) Capsaicin-sensitive substance P nerves: Antidromic vasodilation and increased vascular permeability in the cat nasal mucosa. Br J Pharmacol 77:378","journal-title":"Br J Pharmacol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/00016488309132735","volume":"96","author":"L Lundblad","year":"1983","unstructured":"Lundblad L, Lundberg JM, Brodin E, \ufffdngg\ufffdrd A (1983a) Origin and distribution of capsaicin-sensitive substance P-immunoreactive nerves in the mucosa. Acta Otolaryngol 96:485?493","journal-title":"Acta Otolaryngol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/00016488309132734","volume":"96","author":"L Lundblad","year":"1983","unstructured":"Lundblad L, Saria A, Lundberg JM, \ufffdngg\ufffdrd A (1983b) Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons. Acta Otolaryngol 96:479?484","journal-title":"Acta Otolaryngol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1748-1716.1983.tb07299.x","volume":"119","author":"L Lundblad","year":"1983","unstructured":"Lundblad L, \ufffdngg\ufffdrd A, Lundberg JM (1983c) Effects of antidromic trigeminal nerve stimulation in relation to parasympathetic vasodilation in cat nasal mucosa. Acta Physiol Scand 119:7?13","journal-title":"Acta Physiol Scand"},{"key":"CR36","doi-asserted-by":"crossref","unstructured":"Lundblad L, Lundberg JM (1984) Cigarette smoke-induced nasal irritation by vapour-phase activation of capsaicin-sensitive sensory neurons. Toxicology (Submitted)","DOI":"10.1016\/0300-483X(84)90011-8"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0014-2999(67)90043-X","volume":"1","author":"J Molnar","year":"1967","unstructured":"Molnar J, Gy\ufffdrgy L (1967) Pulmonary hypertensive and other haemodynamic effects of capsaicin in the cat. Eur J Pharmacol 1:86?92","journal-title":"Eur J Pharmacol"},{"key":"CR38","first-page":"377","volume-title":"The nose upper airway physiology and the atmospheric environment","author":"N Mygind","year":"1982","unstructured":"Mygind N, L\ufffdwenstein H (1982) Allergy and other environmental factors. In: Proctor DF, Andersen I (eds) The nose upper airway physiology and the atmospheric environment. Elsevier Biomedical, Amsterdam, pp 377?397"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1523\/JNEUROSCI.03-02-00399.1983","volume":"3","author":"JI Nagy","year":"1983","unstructured":"Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP (1983) Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 3:399?406","journal-title":"J Neurosci"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-0270(83)90050-X","volume":"8","author":"A Saria","year":"1983","unstructured":"Saria A, Lundberg JM (1983) Evans blue fluorescence: Quantitative and morphological evaluation of vascular permeability in animal tissues. Neurosci Methods 8:41?49","journal-title":"Neurosci Methods"},{"key":"CR41","first-page":"251","volume":"73","author":"I Szolcs\ufffdnyi","year":"1977","unstructured":"Szolcs\ufffdnyi I (1977) A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J Physiol (Paris) 73:251?259","journal-title":"J Physiol (Paris)"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0304-3959(81)90636-9","volume":"11","author":"PD Wall","year":"1981","unstructured":"Wall PD, Fitzgerald M (1981) Effects of capsaicin applied locally to adult peripheral nerve. I. Physiology of peripheral nerve and spinal cord. Pain 11:363?377","journal-title":"Pain"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/ajplegacy.1972.222.1.189","volume":"22","author":"MM Webb-Peploe","year":"1972","unstructured":"Webb-Peploe MM, Brender D, Shepar JT (1972) Vascular response to stimulation of receptors in muscle by capsaicin. Am J Physiol 22:189?195","journal-title":"Am J Physiol"},{"key":"CR44","unstructured":"Widdicombe J (1981) Nervous receptors in the respiratory tract and lungs. In: Lung biology in health and disease, vol 17, part I, Regulations of breathing. Hornbein T (ed), pp 429?471"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(82)90679-5","volume":"253","author":"JT Williams","year":"1982","unstructured":"Williams JT, Zieglg\ufffdnsberger W (1982) The acute effects of capsaicin on rat primary afferents and spinal neurons. Brain Res 253:125?131","journal-title":"Brain Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00505327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00505327\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00505327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T03:33:03Z","timestamp":1585971183000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00505327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984]]}},"alternative-id":["BF00505327"],"URL":"https:\/\/doi.org\/10.1007\/bf00505327","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984]]}}}