{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:28:55Z","timestamp":1777296535272,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1982,8,1]],"date-time":"1982-08-01T00:00:00Z","timestamp":397008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1982,8]]},"DOI":"10.1007\/bf00506317","type":"journal-article","created":{"date-parts":[[2004,11,22]],"date-time":"2004-11-22T09:53:34Z","timestamp":1101117214000},"page":"170-174","source":"Crossref","is-referenced-by-count":14,"title":["Inhibitory ?2-Adrenergic mechanism regulating gastric secretion in pylorus-ligated rats"],"prefix":"10.1007","volume":"320","author":[{"given":"Teruo","family":"Nakadate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Nakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamura","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00569726","volume":"312","author":"K Aktories","year":"1980","unstructured":"Aktories K, Schultz G, Jakobs KH (1980) Regulation of adenylate cyclase activity in hamster adipocytes. Naunyn-Schmiedeberg's Arch Pharmacol 312:167?173","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0024-3205(77)90066-2","volume":"21","author":"S Berthelsen","year":"1977","unstructured":"Berthelsen S, Pettinger WA (1977) A functional basis for classification of ?-adrenergic receptors. Life Sci 21:595?606","journal-title":"Life Sci"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02235639","volume":"15","author":"DA Brodie","year":"1970","unstructured":"Brodie DA, Lotti VJ, Bauer BG (1970) Drug effects on gastric secretion and stress gastric hemorrhage in the rat. Digestive Dis 15:111?120","journal-title":"Digestive Dis"},{"key":"CR4","first-page":"121","volume":"217","author":"HC Cheng","year":"1981","unstructured":"Cheng HC, Gleason EM, Nathan BA, Lachmann PJ, Woodward JK (1981) Effects of clonidine on gastric secretion in the rat. J Pharmacol Exp Ther 217:121?126","journal-title":"J Pharmacol Exp Ther"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00499027","volume":"282","author":"A Csongrady","year":"1974","unstructured":"Csongrady A, Kobinger W (1974) Investigations into the positive inotropic effect of clonidine in isolated hearts. Naunyn-Schmiedeberg's Arch Pharmacol 282:123?128","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1476-5381.1972.tb06867.x","volume":"46","author":"BP Curwain","year":"1972","unstructured":"Curwain BP, Holton P (1972) The effects of isoprenaline on pentagastrinstimulated gastric acid secretion and mucosal blood flow in the dog. Br J Pharmacol 46:225?233","journal-title":"Br J Pharmacol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1476-5381.1977.tb16752.x","volume":"60","author":"JC Doxey","year":"1977","unstructured":"Doxey JC, Smith CFC, Walker JM (1977) Selectivity of blocking agents for pre- and post-synaptic ?-adrenoceptors. Br J Pharmacol 60:91?96","journal-title":"Br J Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(76)90084-4","volume":"36","author":"GM Drew","year":"1976","unstructured":"Drew GM (1976) Effects of ?-adrenoceptor agonists and antagonists on pre- and post-synaptically located ?-adrenoceptors. Eur J Pharmacol 36:313?320","journal-title":"Eur J Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0024-3205(81)90085-0","volume":"28","author":"JA Garcia-Sainz","year":"1980","unstructured":"Garcia-Sainz JA, Li S, Fain JN (1980a) Alpha 2 adrenergic amines, adenosine and prostaglandins inhibit lipolysis and cyclic AMP accumulation in hamster adipocytes in the absence of extracellular sodium. Life Sci 28:401?406","journal-title":"Life Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0024-3205(80)90105-8","volume":"27","author":"JA Garcia-Sainz","year":"1980","unstructured":"Garcia-Sainz JA, Hoffman BB, Li S, Lefkowitz RJ, Fain JN (1980b) Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. Life Sci 27:953?961","journal-title":"Life Sci"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/277659a0","volume":"277","author":"JA Grant","year":"1979","unstructured":"Grant JA, Scrutton MC (1979) Novel ?2-adrenoceptor primarily responsible for inducing human platelet aggregation. Nature 277:659?661","journal-title":"Nature"},{"key":"CR12","first-page":"1038","volume":"16","author":"W Hoefke","year":"1966","unstructured":"Hoefke W, Kobinger W (1966) Pharmakologische Wirkungen des 2-(2,6-Dichlorophenylamino)-2-imidazolin-hydrochlorids, einer neuen, antihypertensiven Substanz. Arzneimittel Forsch 16:1038?1050","journal-title":"Arzneimittel Forsch"},{"key":"CR13","first-page":"366","volume":"208","author":"CY Hsu","year":"1979","unstructured":"Hsu CY, Knapp DR, Halushka PV (1979) The effect of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther 208:366?370","journal-title":"J Pharmacol Exp Ther"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00502070","volume":"279","author":"HO Karppanen","year":"1973","unstructured":"Karppanen HO, Westermann E (1973) Increased production of cyclic AMP in gastric tissue by stimulation of H2-receptors. Naunyn-Schmiedeberg's Arch Pharmacol 279:83?87","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0024-3205(76)90290-3","volume":"19","author":"R Keller","year":"1976","unstructured":"Keller R, Oke A, Mefford I, Adams RN (1976) Liquid chromatographic analysis of catecholamines. Routine assay for regional brain mapping. Life Sci 19:995?1004","journal-title":"Life Sci"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","volume":"16","author":"PE Lacy","year":"1967","unstructured":"Lacy PE, Kostianovsky M (1967) Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35?39","journal-title":"Diabetes"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-2999(80)90298-8","volume":"66","author":"M Lafontan","year":"1980","unstructured":"Lafontan M, Berlan M (1980) Evidence for the ?2 nature of the ?-adrenergic receptor inhibiting lipolysis in human fat cells. Eur J Pharmacol 66:87?93","journal-title":"Eur J Pharmacol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/0006-2952(74)90187-7","volume":"23","author":"SZ Langer","year":"1974","unstructured":"Langer SZ (1974) Presynaptic regulation of catecholamine release. Biochem Pharmacol 23:1793?1800","journal-title":"Biochem Pharmacol"},{"key":"CR19","first-page":"337","volume":"32","author":"SZ Langer","year":"1980","unstructured":"Langer SZ (1980) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32:337?362","journal-title":"Pharmacol Rev"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00498981","volume":"306","author":"P Lasch","year":"1979","unstructured":"Lasch P, Jakobs KH (1979) Agonistic and antagonistic effects of various ?-adrenergic agonists in human platelets. Naunyn-Schmiedeberg's Arch Pharmacol 306:119?125","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1476-5381.1974.tb09688.x","volume":"52","author":"L Lundell","year":"1974","unstructured":"Lundell L, Svensson SE (1974) Implication of gastric mucosal histamine in inhibition by isoprenaline of pentagastrin-induced gastric secretion. Br J Pharmacol Chemother 52:69?75","journal-title":"Br J Pharmacol Chemother"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3181\/00379727-151-39280","volume":"151","author":"DF Magee","year":"1976","unstructured":"Magee DF (1976) Adrenergic activity and gastric secretion. Proc Soc Exp Biol Med 151:659?662","journal-title":"Proc Soc Exp Biol Med"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0014-2999(80)90347-7","volume":"65","author":"T Nakadate","year":"1980","unstructured":"Nakadate T, Nakaki T, Muraki T, Kato R (1980a) Regulation of plasma insulin level by ?2-adrenergic receptors. Eur J Pharmacol 65:421?424","journal-title":"Eur J Pharmacol"},{"key":"CR24","first-page":"226","volume":"215","author":"T Nakadate","year":"1980","unstructured":"Nakadate T, Nakaki T, Muraki T, Kato R (1980b) Adrenergic regulation of blood glucose levels: Possible involvement of postsynaptic alpha-2 type adrenergic receptors regulating insulin release. J Pharmacol Exp Ther 215:226?230","journal-title":"J Pharmacol Exp Ther"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00498572","volume":"313","author":"T Nakaki","year":"1980","unstructured":"Nakaki T, Nakadate T, Kato R (1980) 174-4 modulating insulin release from isolated pancreatic islets. Naunyn-Schmiedeberg's Arch Pharmacol 313:151?153","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR26","first-page":"607","volume":"216","author":"T Nakaki","year":"1981","unstructured":"Nakaki T, Nakadate T, Ishii K, Kato R (1981) Postsynaptic alpha-2 adrenergic receptors in isolated rat islets of Langerhans: Inhibition of insulin release and cyclic 3?:5?-adenosine monophosphate accumulation. J Pharmacol Exp Ther 216:607?612","journal-title":"J Pharmacol Exp Ther"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/0024-3205(77)90369-1","volume":"20","author":"Y Osumi","year":"1977","unstructured":"Osumi Y, Aibara S, Sakae K, Fujiwara M (1977) Central noradrenergic inhibition of gastric mucosal blood flow and acid secretion in rats. Life Sci 20:1407?1416","journal-title":"Life Sci"},{"key":"CR28","first-page":"152","volume":"Suppl 440","author":"I Paakkari","year":"1976","unstructured":"Paakkari I, Paakkari P, Karppanen H (1976) Antagonism of the central hypotensive effect of clonidine by the histamine H2-blocking agent, metiamide. Acta Physiol Scand Suppl 440:152","journal-title":"Acta Physiol Scand"},{"key":"CR29","first-page":"429","volume":"209","author":"RR Ruffolo Jr","year":"1979","unstructured":"Ruffolo RR Jr, Rosing EL, Waddell JE (1979) Receptor interactions of imidazolines. I. Affinity and efficacy for alpha adrenergic receptors in rat aorta. J Pharmacol Exp Ther 209:429?436","journal-title":"J Pharmacol Exp Ther"},{"key":"CR30","first-page":"43","volume":"5","author":"H Shay","year":"1945","unstructured":"Shay H, Komarov SA, Fels SS, Merange D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43?61","journal-title":"Gastroenterology"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.ph.41.030179.000343","volume":"41","author":"AH Soll","year":"1979","unstructured":"Soll AH, Walsh JH (1979) Regulation of gastric secretion. Ann. Rev Physiol 41:35?53","journal-title":"Ann. Rev Physiol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0050157","volume":"77","author":"K Starke","year":"1977","unstructured":"Starke K (1977) Regulation of noradrenaline release by presynaptic receptor system. Rev Physiol Biochem Pharmacol 77:1?124","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00510821","volume":"291","author":"K Starke","year":"1975","unstructured":"Starke K, Endo T, Taube HD (1975a) Relative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch Pharmacol 291:55?78","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0014-2999(75)90268-X","volume":"34","author":"K Starke","year":"1975","unstructured":"Starke K, Borowski E, Endo T (1975b) Preferential blockade of presynaptic ?-adrenoceptors by yohimbine. Eur J Pharmacol 34:385?388","journal-title":"Eur J Pharmacol"},{"key":"CR35","first-page":"1","volume-title":"Presynaptic receptors","author":"K Starke","year":"1979","unstructured":"Starke K, Langer SZ (1979) A note on terminology for presynaptic receptors. In: Langer SZ, Starke K, Dobocovich ML (eds) Presynaptic receptors. Pergamon Press, Oxford, pp 1?3"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1073\/pnas.77.9.5515","volume":"77","author":"Y Tache","year":"1980","unstructured":"Tache Y, Vale W, River J, Brown M (1980a) Brain regulation of gastric secretion: Influence of neuropeptides. Proc Natl Acad Sci USA 77:5515?5519","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/287149a0","volume":"287","author":"Y Tache","year":"1980","unstructured":"Tache Y, Vale W, Brown M (1980b) Thyrotropin-releasing hormone ?CNS action to stimulate gastric secretion. Nature 287:149?151","journal-title":"Nature"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/0006-2952(79)90155-2","volume":"28","author":"S Tani","year":"1979","unstructured":"Tani S, Mutoh N (1979) Effects of adrenergic agonists on gastric secretion in the rat. Biochem Pharmacol 28:678?683","journal-title":"Biochem Pharmacol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1113\/jphysiol.1953.sp004956","volume":"121","author":"JE Thompson","year":"1953","unstructured":"Thompson JE, Vane JR (1953) Gastric secretion induced by histamine and its relationship to the rate of blood flow. J Physiol 121:433?444","journal-title":"J Physiol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0006-2952(79)90424-6","volume":"28","author":"CL Wood","year":"1979","unstructured":"Wood CL, Arnett CD, Clarke WR, Tsai BS, Lefkowitz RJ (1979) Subclassification of alpha-adrenergic receptors by direct binding studies. Biochem Pharmacol 28:1277?1282","journal-title":"Biochem Pharmacol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00499054","volume":"308","author":"R Weitzell","year":"1979","unstructured":"Weitzell R, Tanaka T, Starke K (1979) Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 308:127?136","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"CR42","first-page":"125","volume":"203","author":"I Yamaguchi","year":"1977","unstructured":"Yamaguchi I, Hiroi J, Kumada S (1977) Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther 203:125?131","journal-title":"J Pharmacol Exp Ther"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00509265","volume":"297","author":"I Zebrowska-Lupina","year":"1977","unstructured":"Zebrowska-Lupina I, Przegalinski E, Sloniec M, Kleinrok Z (1977) Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic ?-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol 297:227?231","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00506317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00506317\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00506317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T14:16:21Z","timestamp":1554387381000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00506317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["BF00506317"],"URL":"https:\/\/doi.org\/10.1007\/bf00506317","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}