{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:30:59Z","timestamp":1783366259024,"version":"3.54.6"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[1985,1,1]],"date-time":"1985-01-01T00:00:00Z","timestamp":473385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1985]]},"DOI":"10.1007\/bf00543714","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T03:09:50Z","timestamp":1100833790000},"page":"73-76","source":"Crossref","is-referenced-by-count":74,"title":["Central nervous system side-effects with hydrophilic and lipophilic ?-Blockers"],"prefix":"10.1007","volume":"28","author":[{"given":"A.","family":"Westerlund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","unstructured":"Abel MJ, Longshaw S, Reeves P (1978) Imperial Chemical Industries Limited, Pharmaceuticals Division, Safety of Medicines Department."},{"key":"CR2","unstructured":"Betts T (1982) VIIIth Scientific Meeting of the International Society of Hypertension. Mexico City"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1476-5381.1982.tb09216.x","volume":"76","author":"PJ Cowen","year":"1982","unstructured":"Cowen PJ, Graham-Smith DG, Green AR, Green DJ (1982) Beta-adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses. Br J Pharmacol 76: 265?270","journal-title":"Br J Pharmacol"},{"issue":"Suppl 3","key":"CR4","first-page":"161","volume":"59","author":"R Cove-Smith","year":"1983","unstructured":"Cove-Smith R, Kirk CA (1983) Letter to the editor. Postgrad Med J 59 (Suppl 3): 161?163","journal-title":"Postgrad Med J"},{"key":"CR5","unstructured":"Cruickshank JM, Neil-Dwyer G, Cameron MM, McAinsh J (1979) VIth Scientific Meeting of the International Society of Hypertension. Gothenburg"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-8703(80)90112-X","volume":"100","author":"JM Cruickshank","year":"1980","unstructured":"Cruickshank JM (1980) The clinical importance of cardioselectivity and lipophilicity in beta-blockers. Am Heart J 100: 160?178","journal-title":"Am Heart J"},{"key":"CR7","doi-asserted-by":"crossref","unstructured":"Fraser HS, Carr AC (1976) Propranolol psychosis. Br J Psychiatry 129?508","DOI":"10.1192\/bjp.129.5.508b"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/BF00435263","volume":"76","author":"H Hallberg","year":"1982","unstructured":"Hallberg H, Almgren O, Svensson TS (1982) Reduced brain serotonergic activity after repeated treatment with beta-adrenoceptor antagonists. Psychopharmacology 76: 114?117","journal-title":"Psychopharmacology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/bmj.2.5967.367","volume":"17","author":"L Hansson","year":"1975","unstructured":"Hansson L, \u00c5berg H, Karlberg BE, Westerlund A (1975) Controlled study of atenolol in treatment of hypertension. Br Med J 17: 367?370","journal-title":"Br Med J"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0954-6820.1976.tb06729.x","volume":"199","author":"L Hansson","year":"1976","unstructured":"Hansson L, Karlberg BE, \u00c5berg H, Westerlund A, Jameson S, Henningsen NC (1976) Long-term hypotensive effect of atenolol (ICI 66 082) a new beta-adrenergic blocking agent. Acta Med Scand 199: 257?261","journal-title":"Acta Med Scand"},{"key":"CR11","unstructured":"Mattiasson I, Henningsen NC (1978) VIIIth World Congress of Cardiology. Tokyo"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/267289a0","volume":"267","author":"DN Middlemiss","year":"1977","unstructured":"Middlemiss DN, Blakeborough L, Leather SR (1977) Direct evidence for an interaction of beta-adrenergic blockers with the 5-HT receptor. Nature 267: 289?290","journal-title":"Nature"},{"key":"CR13","first-page":"327","volume":"192","author":"MG Myers","year":"1975","unstructured":"Myers MG, Lewis PJ, Reid JL, Dollery CT (1975) Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man. Pharmacol Exp Ther 192: 327","journal-title":"Pharmacol Exp Ther"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1399-6576.1982.tb01883.x","volume":"76","author":"T Svenson","year":"1982","unstructured":"Svenson T (1982) Emerging aspects of the adrenergic nervous system. Acta Anaesth Scand 76: 8?11","journal-title":"Acta Anaesth Scand"},{"issue":"Suppl 25","key":"CR15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2165\/00003495-198300252-00087","volume":"2","author":"A Westerlund","year":"1983","unstructured":"Westerlund A (1983) A comparison of the central nervous system side effects caused by lipophilic and hydrophilic beta blockers. Drugs 2 (Suppl 25): 280?281","journal-title":"Drugs"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00005344-197901000-00009","volume":"1","author":"PA Zweiten van","year":"1979","unstructured":"van Zweiten PA, Timmermans PBMWM (1979) Comparison between the acute hemodynamic effects and brain penetration of atenolol and metoprolol. J Cardiovasc Pharmacol 1: 85?96","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00543714.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00543714\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00543714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T22:35:43Z","timestamp":1554417343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00543714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985]]},"references-count":16,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1985]]}},"alternative-id":["BF00543714"],"URL":"https:\/\/doi.org\/10.1007\/bf00543714","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985]]}}}