{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:29:47Z","timestamp":1758893387881},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1988]]},"DOI":"10.1007\/bf00555505","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T16:22:32Z","timestamp":1100881352000},"page":"39-45","source":"Crossref","is-referenced-by-count":13,"title":["The specificity of the lymphocyte transformation test in a patient with hypersensitivity reactions to pyrazolone compounds. A 10-week follow-up study before and after rechallenge"],"prefix":"10.1007","volume":"35","author":[{"given":"N. W.","family":"Brattig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. -J.","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(67)91362-1","volume":"1","author":"I Sarkany","year":"1967","unstructured":"Sarkany I (1967) Lymphocyte transformation in drug hypersensitivity. Lancet 1: 743?745","journal-title":"Lancet"},{"key":"CR2","first-page":"168","volume":"40","author":"B Halpern","year":"1967","unstructured":"Halpern B, Ky NT, Amache N (1967) Diagnosis of drug allergy in vitro with the lymphocyte transformation test. J Allergy Clin Immunol 40: 168?181","journal-title":"J Allergy Clin Immunol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM197008062830602","volume":"283","author":"F Paronetto","year":"1970","unstructured":"Paronetto F, Popper H (1970) Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane. N Engl J Med 283: 277?280","journal-title":"N Engl J Med"},{"key":"CR4","first-page":"1089","volume":"120","author":"RJ Warrington","year":"1979","unstructured":"Warrington RJ, Tse KS (1979) Lymphocyte transformation studies in drug hypersensitivity. Can Med Assoc J 120: 1089?1094","journal-title":"Can Med Assoc J"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/ajcp\/73.2.172","volume":"73","author":"BP Barna","year":"1980","unstructured":"Barna BP, Gogate P, Deodhar SD, Moeder M (1980) Lymphocyte transformation and radioallergosorbent tests in drug hypersensitivity. Am J Clin Pathol 73: 172?176","journal-title":"Am J Clin Pathol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1001\/jama.1982.03330200061015","volume":"248","author":"R Patterson","year":"1982","unstructured":"Patterson R, Anderson J (1982) Allergic reactions to drugs and biologic agents. J Am Med Assoc 248: 2637?2645","journal-title":"J Am Med Assoc"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0091-6749(86)90175-2","volume":"77","author":"VDM Stejskal","year":"1986","unstructured":"Stejskal VDM, Olin RG, Forsbeck M (1986) The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. J Allergy Clin Immunol 77: 411?426","journal-title":"J Allergy Clin Immunol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1159\/000234254","volume":"82","author":"VDM Stejskal","year":"1987","unstructured":"Stejskal VDM, Forsbeck M, Olin R (1987) Side chain-specific lymphocyte responses in workers with occupational allergy induced by penicillins. Int Arch Allergy Appl Immunol 82: 461?464","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0028-1106763","volume":"98","author":"D Maas","year":"1979","unstructured":"Maas D, Schubothe H (1979) Ein Lupus erythematodes-\u00e4hnliches Syndrom mit antimitochondrialen Antik\u00f6rpern. Dtsch Med Wochenschr 98: 131?139","journal-title":"Dtsch Med Wochenschr"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/BF01477051","volume":"58","author":"P Schuff-Werner","year":"1980","unstructured":"Schuff-Werner P, Berg PA (1980) Immunreaktionen beim Pseudo-Lupus-Syndrom. Klin Wochenschr 58: 935?941","journal-title":"Klin Wochenschr"},{"key":"CR11","first-page":"380","volume":"110","author":"K Neftel","year":"1980","unstructured":"Neftel K, Diehm P, Gerber H, de Weck AL, Stucki P (1980) Durch (+)-Cyanidanol-3 (Catergen) induzierte immunh\u00e4molytische An\u00e4mie. Schweiz Med Wochenschr 110: 380?382","journal-title":"Schweiz Med Wochenschr"},{"key":"CR12","first-page":"227","volume":"47","author":"N Brattig","year":"1981","unstructured":"Brattig N, Diao G-J, Berg PA (1981) (+)-Cyanidanol-3 induced fever and its pathogenesis. In: Conn HO (ed): International workshop on (+)-Cyanidanol-3 in disease of the liver. J R Soc Med 47: 227?233","journal-title":"J R Soc Med"},{"key":"CR13","first-page":"105","volume-title":"Drug reactions and the liver","author":"PA Berg","year":"1981","unstructured":"Berg PA, Brattig N (1981) Role of immune mechanisms in drug induced diseases. In: Davis M, Tredger JM, Williams R (eds) Drug reactions and the liver. Pitman Medical, London, pp 105?110"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0140-6736(78)92585-0","volume":"2","author":"D Vergani","year":"1978","unstructured":"Vergani D, Tsantoulas D, Eddlestone ALWF, Davis M, Williams R (1978) Sensitisation to halothane-altered liver components in severe hepatic necrosis after halothane anaesthesia. Lancet 2: 801?803","journal-title":"Lancet"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJM198007103030202","volume":"303","author":"D Vergani","year":"1980","unstructured":"Vergani D, Mieli-Vergani G, Alberti A, Neuberger J, Eddleston ALWF, Davis M, Williams R (1980) Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N Engl J Med 303: 66?71","journal-title":"N Engl J Med"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0192-0561(84)90018-3","volume":"6","author":"N Brattig","year":"1984","unstructured":"Brattig N, Diao G-J, Berg PA (1984) Immuno enhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis. Int J Immunopharmacol 6: 205?215","journal-title":"Int J Immunopharmacol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0009-9120(86)80043-1","volume":"19","author":"F Falcioni","year":"1986","unstructured":"Falcioni F, Brattig NW, Berg PA (1986) A simple and sensitive fluorometric immunoassay for the measurement of immunoglobulins in culture medium of mitogen-stimulated lymphocytes. Clin Biochem 19: 289?293","journal-title":"Clin Biochem"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1084\/jem.143.5.1100","volume":"143","author":"L Shou","year":"1977","unstructured":"Shou L, Schwartz SA, Good RA (1977) Suppressor cell activity after ConA treatment of lymphocytes from normal donors. J Exp Med 143: 1100?1110","journal-title":"J Exp Med"},{"key":"CR19","first-page":"247","volume-title":"Immune reactions in liver diseases","author":"PA Berg","year":"1979","unstructured":"Berg PA, Schuff-Werner P, Henning H (1979) Immune reactions to drugs and metabolites in man. In: Eddlestone ALWF, Weber JLP, Williams P (eds) Immune reactions in liver diseases. Pitman Medical, London, pp 247?258"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00542049","volume":"21","author":"U Breyer-Pfaff","year":"1982","unstructured":"Breyer-Pfaff U, Harder M, Egberts EH (1982) Plasma levels of parent drug and metabolites in the intravenous aminopyrine breath test. Eur J Clin Pharmacol 21: 521?526","journal-title":"Eur J Clin Pharmacol"},{"key":"CR21","first-page":"73","volume":"5","author":"T Namihisa","year":"1975","unstructured":"Namihisa T, Yamaguchi K, Kitami N (1975) Der Lymphozytentransformationstest bei allergischen Arzneimittelsch\u00e4den der Leber. Leber Magen Darm 5: 73?78","journal-title":"Leber Magen Darm"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJM197504172921601","volume":"292","author":"JM Gimenez-Camarasa","year":"1975","unstructured":"Gimenez-Camarasa JM, Carcia-Calderon P, de Moragas JM (1975) Lymphocyte transformation test in fixed drug eruption. N Engl J Med 292: 819?821","journal-title":"N Engl J Med"},{"key":"CR23","first-page":"107","volume":"5","author":"RMM Victorino","year":"1981","unstructured":"Victorino RMM, Hodgson HJF (1981) The short lived suppressor cell assay and its relationship with mitogen responsiveness in normal individuals. J Clin Lab Immunol 5: 107?111","journal-title":"J Clin Lab Immunol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0091-6749(86)90083-7","volume":"78","author":"M Koponen","year":"1986","unstructured":"Koponen M, Pichler WJ, De Weck AL (1986) T cell reactivity to penicillin: phenotypic analysis of in-vitro activated cell subsets. J Allergy Clin Immunol 78: 645?652","journal-title":"J Allergy Clin Immunol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1248\/cpb.22.1297","volume":"22","author":"S Ozeki","year":"1974","unstructured":"Ozeki S, Tejima K (1974) Drug interaction. II. Binding of some pyrazolone and pyrazolidine derivatives to bovine serum albumin. Chem Pharm Bull 22: 1297?1301","journal-title":"Chem Pharm Bull"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0306-9877(80)90100-0","volume":"6","author":"P Kallos","year":"1980","unstructured":"Kallos P, Schlumberger HD (1980) The pathomechanism of acetylsalicylic acid intolerance. A hypothesis. Med Hypotheses 6: 487?490","journal-title":"Med Hypotheses"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1164\/arrd.1972.106.3.485","volume":"106","author":"JT Dove","year":"1972","unstructured":"Dove JT, Chapares SD, Hedrick SR (1972) Failure to demonstrate transformation of lymphocytes of patients with isoniazid-associated hepatitis. Am Rev Resp Dis 106: 485?490","journal-title":"Am Rev Resp Dis"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00555505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00555505\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00555505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T21:18:26Z","timestamp":1554412706000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00555505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988]]}},"alternative-id":["BF00555505"],"URL":"https:\/\/doi.org\/10.1007\/bf00555505","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988]]}}}