{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:05:50Z","timestamp":1772881550321,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1988]]},"DOI":"10.1007\/bf00558267","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T18:03:11Z","timestamp":1100887391000},"page":"287-294","source":"Crossref","is-referenced-by-count":45,"title":["Pharmacokinetics of low-dose oral modified release, soluble and intravenous aspirin in man, and effects on platelet function"],"prefix":"10.1007","volume":"35","author":[{"given":"F.","family":"Bochner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M. A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.STR.11.1.9","volume":"11","author":"M Ali","year":"1980","unstructured":"Ali M, McDonald JWD, Thiessen JJ, Coates PE (1980) Plasma acetyl-salicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin. Stroke 11: 9?13","journal-title":"Stroke"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/bmj.296.6618.320","volume":"296","author":"Antiplatelet Trialists' Collaboration","year":"1988","unstructured":"Antiplatelet Trialists' Collaboration (1988) Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J 296: 320?331","journal-title":"Br Med J"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/cs0710625","volume":"71","author":"F Bochner","year":"1986","unstructured":"Bochner F, Lloyd J (1986) Is there an optimal dose and formulation of aspirin to prevent arterial thromboembolism in man? Clin Sci 71: 625?631","journal-title":"Clin Sci"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01061504","volume":"2","author":"HG Boxenbaum","year":"1974","unstructured":"Boxenbaum HG, Riegelman S, Elashoff RM (1974) Statistical estimations in pharmacokinetics. J Pharmacokinet Biopharm 2: 123?148","journal-title":"J Pharmacokinet Biopharm"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00007691-198506000-00014","volume":"7","author":"RA Brandon","year":"1985","unstructured":"Brandon RA, Eadie MJ, Smith MT (1985) A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin. Ther Drug Monit 7: 216?221","journal-title":"Ther Drug Monit"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1073\/pnas.75.10.5181","volume":"75","author":"JW Burch","year":"1978","unstructured":"Burch JW, Baenziger NL, Stanford N, Majerus PW (1978) Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Nat Acad Sci USA 75: 5181?5184","journal-title":"Proc Nat Acad Sci USA"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00007691-198010000-00010","volume":"2","author":"BE Cham","year":"1980","unstructured":"Cham BE, Ross-Lee L, Bochner F, Imhoff DM (1980) Measurement and pharmacokinetics of acetylsalicylic acid by a novel high performance liquid chromatographic assay. Ther Drug Monit 2: 365?372","journal-title":"Ther Drug Monit"},{"key":"CR8","volume-title":"Biostatistics: A foundation for analysis in the health sciences","author":"WW Daniel","year":"1983","unstructured":"Daniel WW (1983) Biostatistics: A foundation for analysis in the health sciences (3rd edn). Wiley & Sons, New York","edition":"3rd edn"},{"issue":"Suppl","key":"CR9","first-page":"78","volume":"10","author":"JAG Emmett","year":"1987","unstructured":"Emmett JAG, Brandon RA, Ulcoq A, Eadie MJ, Bunce IH (1987) Plasma aspirin concentrations to inhibit platelet aggregation in diabetes. Clin Exp Pharmacol Physiol 10 [Suppl]: 78?79","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.STR.8.3.301","volume":"8","author":"WS Fields","year":"1977","unstructured":"Fields WS, Lemak NA, Frankowski RF, Hardy RJ (1977) Controlled trial of aspirin in cerebral ischemia. Stroke 8: 301?316","journal-title":"Stroke"},{"key":"CR11","first-page":"286","volume-title":"Methods in enzymology","author":"FA Fitzpatrick","year":"1982","unstructured":"Fitzpatrick FA (1982) A radioimmunoassay for thromboxane B2 In: Lands WEM, Smith Wh (eds) Methods in enzymology. Academic Press, London, p 286"},{"key":"CR12","first-page":"141","volume":"142","author":"AS Gallus","year":"1985","unstructured":"Gallus AS (1985) Aspirin and the other platelet aggregating inhibiting drugs. Med J Aust 142: 141?147","journal-title":"Med J Aust"},{"key":"CR13","doi-asserted-by":"crossref","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"M Gibaldi","year":"1982","unstructured":"Gibaldi M, Perrier D (1982) Pharmacokinetics (2nd edn). Marcel Dekker, New York","edition":"2nd edn"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0140-6736(81)91733-5","volume":"1","author":"SP Hanley","year":"1981","unstructured":"Hanley SP, Cockbill SR, Bevan J, Heptinstall S (1981) Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and thromboxane synthesis. Lancet 1: 969?971","journal-title":"Lancet"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1445-5994.1987.tb00040.x","volume":"17","author":"CM Herd","year":"1987","unstructured":"Herd CM, Rodgers SE, Lloyd JV, Bochner F, Duncan EM, Tunbridge LJ (1987) A dose-ranging study of the antiplatelet effect of enteric coated aspirin in man. Aust NZ J Med 17: 195?200","journal-title":"Aust NZ J Med"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-2125.1985.tb02695.x","volume":"19","author":"FC Ho","year":"1985","unstructured":"Ho FC, Triggs EJ, Bourne DWA, Heazlewood VJ (1985) The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites. Br J Clin Pharmacol 19: 675?684","journal-title":"Br J Clin Pharmacol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/cpt1972132258","volume":"13","author":"G Levy","year":"1972","unstructured":"Levy G, Tsuchiya T, Amsel LP (1972) Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man. Clin Pharmacol Ther 13: 258?268","journal-title":"Clin Pharmacol Ther"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1056\/NEJM198308183090703","volume":"309","author":"DH Lewis","year":"1983","unstructured":"Lewis DH, Davis JW, Archibald DG, Steinke WE, Smitheram TC, Doherty JE III, Schnaper HW, LeWinter MM, Linares E, Pouget JM, Sabharwal SC, Chesler E, DeMots H (1983) Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. N Engl J Med 309: 396?403","journal-title":"N Engl J Med"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/239102a0","volume":"239","author":"R Menguy","year":"1972","unstructured":"Menguy R, Desbaillets L, Masters YF, Okabe S (1972) Evidence for a sex-linked difference in aspirin metabolism. Nature 239: 102?103","journal-title":"Nature"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJM198411083111902","volume":"311","author":"AK Pedersen","year":"1984","unstructured":"Pedersen AK, FitzGerald GA (1984) Dose-related kinetics of aspirin. N Engl J Med 311: 1206?1211","journal-title":"N Engl J Med"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jps.2600740217","volume":"74","author":"AK Pedersen","year":"1985","unstructured":"Pedersen AK, FitzGerald GA (1985) Preparation and analysis of deuterium labelled aspirin: Application to pharmacokinetic studies. J Pharm Sci 74: 188?192","journal-title":"J Pharm Sci"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM198101083040203","volume":"304","author":"FE Preston","year":"1981","unstructured":"Preston FE, Whipps S, Jackson CA, French AJ, Wyld PJ (1981) Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin. N Engl J Med 304: 76?79","journal-title":"N Engl J Med"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF01059549","volume":"8","author":"S Riegelman","year":"1980","unstructured":"Riegelman S, Collier P (1980) The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time. J Pharmacokin Biopharm 8: 509?533","journal-title":"J Pharmacokin Biopharm"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02395209","volume":"27","author":"MS Roberts","year":"1984","unstructured":"Roberts MS, McLeod LJ, Cossum PA, Vial JH (1984) Inhibition of platelet function by a controlled release acetylsalicylic acid formulation ? single and chronic dosing studies. Eur J Clin Pharmacol 27: 67?74","journal-title":"Eur J Clin Pharmacol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/BF00637504","volume":"23","author":"LM Ross-Lee","year":"1982","unstructured":"Ross-Lee LM, Elms MJ, Cham BE, Bochner F, Bunce IH, Eadie MJ (1982) Plasma levels of aspirin following effervescent and enteric coated tablets, and their effect on platelet function. Eur J Clin Pharmacol 23: 545?551","journal-title":"Eur J Clin Pharmacol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/jps.2600570807","volume":"57","author":"M Rowland","year":"1968","unstructured":"Rowland M, Riegelman S (1968) Pharmacokinetics of acetylsalicylic acid and salicylic acid after intravenous administration in man. J Pharm Sci 57: 1313?1319","journal-title":"J Pharm Sci"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jps.2600610312","volume":"61","author":"M Rowland","year":"1972","unstructured":"Rowland M, Riegelman S, Harris PA, Sholkoff SD (1972) Absorption kinetics of aspirin in man following oral administration of an aqueous solution. J Pharm Sci 61: 379?385","journal-title":"J Pharm Sci"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/215413a0","volume":"215","author":"M Rowland","year":"1967","unstructured":"Rowland M, Riegelman S, Harris PA, Sholkoff SD, Eyring EJ (1967) Kinetics of acetylsalicylic acid disposition in man. Nature 215: 413?414","journal-title":"Nature"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0378-4347(00)80270-4","volume":"225","author":"RH Rumble","year":"1981","unstructured":"Rumble RH, Roberts MS, Wanwimolruk S (1981) Determination of aspirin and its major metabolites in plasma by high-performance liquid chromatography without solvent extraction. J Chromatogr 225: 252?260","journal-title":"J Chromatogr"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/clpt.1983.47","volume":"33","author":"DJ Siebert","year":"1983","unstructured":"Siebert DJ, Bochner F, Imhoff DM, Watts S, Lloyd JV, Field J, Gabb BW (1983) Aspirin kinetics and platelet aggregation in man. Clin Pharmacol Ther 33: 367?374","journal-title":"Clin Pharmacol Ther"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0378-4347(87)80200-1","volume":"420","author":"DM Siebert","year":"1987","unstructured":"Siebert DM, Bochner F (1987) Determination of plasma aspirin and salicylic acid concentrations after low aspirin doses by high performance liquid chromatography with post column hydrolysis and fluorescence detection. J Chromatogr 420: 425?431","journal-title":"J Chromatogr"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/cs0740491","volume":"74","author":"D Sils","year":"1988","unstructured":"Sils D, Rodgers SE, Lloyd JV, Wilson KM, Siebert DM, Bochner F (1988) Inhibition of platelet aggregation and thromboxane production by low concentrations of aspirin in vitro. Clin Sci 74: 491?497","journal-title":"Clin Sci"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF01062109","volume":"6","author":"K Yamaoka","year":"1978","unstructured":"Yamaoka K, Nakagawa T, Uno T (1978) Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 6: 547?557","journal-title":"J Pharmacokinet Biopharm"},{"key":"CR34","first-page":"66","volume":"76","author":"MB Zucker","year":"1970","unstructured":"Zucker MB, Peterson J (1970) Effect of acetylsalicylic acid, other nonsteroidal anti-inflammatory agents, and dipyridamole on human blood platelets. J Lab Clin Med 76: 66?75","journal-title":"J Lab Clin Med"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00558267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00558267\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00558267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T04:55:25Z","timestamp":1624942525000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00558267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988]]}},"alternative-id":["BF00558267"],"URL":"https:\/\/doi.org\/10.1007\/bf00558267","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988]]}}}