{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:01:42Z","timestamp":1760644902423},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1985,9]]},"DOI":"10.1007\/bf00572437","type":"journal-article","created":{"date-parts":[[2004,11,20]],"date-time":"2004-11-20T17:31:33Z","timestamp":1100971893000},"page":"222-226","source":"Crossref","is-referenced-by-count":7,"title":["A caffeine analogue (1,3,7-trimethyl-6-thioxo-2-oxopurine) with a negative inotropic and chronotropic effect"],"prefix":"10.1007","volume":"330","author":[{"given":"G.","family":"Fassina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Gaion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Caparrotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Carpenedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"181","volume":"22","author":"CP Bianchi","year":"1980","unstructured":"Bianchi CP, Narayan S, Friedman H (1980) Dissociation of caffeine effect on calcium influx from twitch potentiation. Pharmacologist 22:181","journal-title":"Pharmacologist"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-2952(81)90062-9","volume":"30","author":"RF Bruns","year":"1981","unstructured":"Bruns RF (1981) Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem Pharmacol 30:325?333","journal-title":"Biochem Pharmacol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0021-9258(18)60316-3","volume":"237","author":"RW Butcher","year":"1962","unstructured":"Butcher RW, Sutherland EW (1962) Adenosine 3?5?-phosphate in biological materials. Purification and properties of cyclic 3?5?-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3?5?-phosphate in human urine. J Biol Chem 237:1244?1250","journal-title":"J Biol Chem"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0165-6147(80)90064-4","volume":"1","author":"DP Cardinali","year":"1980","unstructured":"Cardinali DP (1980) Methylxanthines: possible mechanism of action in brain. Trends in Pharmacol Sci 1:405?407","journal-title":"Trends in Pharmacol Sci"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/0006-2952(75)90104-5","volume":"24","author":"F Carpenedo","year":"1975","unstructured":"Carpenedo F, Gaion RM, Fassina G (1975) Calcium and papaverine interaction with soluble cardiac phosphodiesterase. Biochem Pharmacol 24:2069?2073","journal-title":"Biochem Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0079-6107(80)90002-4","volume":"35","author":"RA Chapman","year":"1979","unstructured":"Chapman RA (1979) Excitation-contraction coupling in cardiac muscle. Proc Biophys Mol Biol 35:1?52","journal-title":"Proc Biophys Mol Biol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1113\/jphysiol.1976.sp011326","volume":"256","author":"RA Chapman","year":"1976","unstructured":"Chapman RA and Leoty C (1976) The time dependent and dosedependent effects of caffeine on the contraction of the ferret heart. J Physiol 256:287?314","journal-title":"J Physiol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1476-5381.1984.tb10092.x","volume":"81","author":"MG Collis","year":"1984","unstructured":"Collis MG, Keddie JR, Torr SR (1984) Evidence that the positive inotropic effects of the alkylxanthines are not due to adenosine receptor blockade. Br J Pharmacol 81:401?407","journal-title":"Br J Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0165-6147(79)90046-4","volume":"1","author":"BB Fredholm","year":"1980","unstructured":"Fredholm BB (1980) Are methylxanthine effects due to antagonism of endogenous adenosine? Trends Pharmacol Sci 1:129?132","journal-title":"Trends Pharmacol Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough MJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265?275","journal-title":"J Biol Chem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0165-6147(82)91153-1","volume":"3","author":"CG Persson","year":"1982","unstructured":"Persson CG (1982) Xanthine for asthma. Present status. Trends Pharmacol Sci 3:312?313","journal-title":"Trends Pharmacol Sci"},{"key":"CR12","first-page":"592","volume-title":"The pharmacological basis of therapeutics","author":"TW Rall","year":"1980","unstructured":"Rall TW (1980) Central nervous system stimulants: xanthines. In: Goodman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. MacMillan, New York, pp 592?607"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-663-05268-5_14","volume-title":"Methods in clinical pharmacology vol 3. Theophylline and other methylxanthines","author":"H Scholz","year":"1982","unstructured":"Scholz H (1982) On the mechanism of action of theophylline on the heart and other organs. In: Rietbrock N, Woodcock BG, Staib AH (eds) Methods in clinical pharmacology vol 3. Theophylline and other methylxanthines. Vieweg, Braunschweig Wiesbaden, pp 99?105"},{"issue":"suppl A","key":"CR14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/eurheartj\/4.suppl_A.161","volume":"4","author":"H Scholz","year":"1983","unstructured":"Scholz H (1983) Pharmacological actions of various inotropic agents. Eur Heart J 4 (suppl A):161?172","journal-title":"Eur Heart J"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0031-6989(83)80055-1","volume":"15","author":"E Scotini","year":"1983","unstructured":"Scotini E, Carpenedo F, Fassina G (1983) New derivatives of methylxanthines: effect of thiocaffeine, thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacol Res Comm 15:131?143","journal-title":"Pharmacol Res Comm"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0076-6879(74)38033-0","volume":"38","author":"WJ Thompson","year":"1974","unstructured":"Thompson WJ, Brooker G, Appleman MM (1974) Assay of cyclic nucleotide phosphodiesterase with radioactive substrates. Meth Enzymol 38:205?214","journal-title":"Meth Enzymol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1085\/jgp.52.5.760","volume":"52","author":"A Weber","year":"1968","unstructured":"Weber A (1968) Mechanism of the action of caffeine on sarcoplasmic reticulum. J Gen Physiol 52:760?772","journal-title":"J Gen Physiol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/0024-3205(82)90676-2","volume":"31","author":"PH Wu","year":"1982","unstructured":"Wu PH, Phillis JW, Nye MJ (1982) Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: evaluation of structure-activity relationships. Life Sci 31:2857?2867","journal-title":"Life Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00572437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00572437\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00572437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T07:19:41Z","timestamp":1624951181000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00572437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["BF00572437"],"URL":"https:\/\/doi.org\/10.1007\/bf00572437","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}