{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:38:14Z","timestamp":1760819894390},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch."],"published-print":{"date-parts":[[1984,7]]},"DOI":"10.1007\/bf00582600","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T19:49:13Z","timestamp":1155844153000},"page":"297-303","source":"Crossref","is-referenced-by-count":51,"title":["The effect ofTityus serrulatus scorpion toxin \u03b3 on Na channels in neuroblastoma cells"],"prefix":"10.1007","volume":"401","author":[{"given":"Henk P. M.","family":"Vijberberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pauron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Lazdunski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00582600_CR1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1085\/jgp.63.5.533","volume":"63","author":"CM Armstrong","year":"1974","unstructured":"Armstrong CM, Bezanilla F (1974) Charge movement associated with the opening and closing of the activation gates of the Na channels. J Gen Physiol 63:533\u2013552","journal-title":"J Gen Physiol"},{"key":"BF00582600_CR2","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1016\/S0021-9258(18)33546-4","volume":"257","author":"J Barhanin","year":"1982","unstructured":"Barhanin J, Giglio JR, L\u00e9opold P, Schmid A, Sampaio SV, Lazdunski M (1982)Tityus serrulatus venom contains two classes of toxins.Tityus \u03b3 toxin is a new tool with very high affinity for studying the Na channel. J Biol Chem 257:12553\u201312558","journal-title":"J Biol Chem"},{"key":"BF00582600_CR3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/j.1460-2075.1983.tb01521.x","volume":"2","author":"J Barhanin","year":"1983","unstructured":"Barhanin J, Pauron D, Lombet A, Norman RI, Vijverberg HPM, Giglio JR, Lazdunski M (1983a) Electrophysiological characterization, solubilization and purification of theTityus \u03b3 toxin receptor associated with the gating component of the Na channel from rat brain. EMBO Journal 2:915\u2013920","journal-title":"EMBO Journal"},{"key":"BF00582600_CR4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0021-9258(18)33101-6","volume":"258","author":"J Barhanin","year":"1983","unstructured":"Barhanin J, Schmid A, Lombet A, Wheeler KP, Lazdunski M, Ellory JC (1983b) Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel. J Biol Chem 258:700\u2013702","journal-title":"J Biol Chem"},{"key":"BF00582600_CR5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF00670531","volume":"400","author":"J Barhanin","year":"1984","unstructured":"Barhanin J, Ildefonse M, Rougier O, Sampaio SV, Giglio JR, Lazdunski M (1984)Tityus \u03b3 toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane. Pfl\u00fcgers Arch 400:22\u201327","journal-title":"Pfl\u00fcgers Arch"},{"key":"BF00582600_CR6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1975.sp010810","volume":"244","author":"MD Cahalan","year":"1975","unstructured":"Cahalan MD (1975) Modification of sodium channel gating in frog myelinated nerve fibres byCentruroides sculpturatus scorpion venom. J Physiol 244:511\u2013534","journal-title":"J Physiol"},{"key":"BF00582600_CR7","first-page":"1","volume-title":"The cell surface and neuronal function","author":"MD Cahalan","year":"1980","unstructured":"Cahalan MD (1980) Molecular properties of sodium channels in excitable membranes. In: Cotman CW, Poste G, Nicolson GL (eds) The cell surface and neuronal function. Elsevier\/North-Holland Biomedical Press, Amsterdam, pp 1\u201347"},{"key":"BF00582600_CR8","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1016\/S0021-9258(17)30094-7","volume":"254","author":"G Carpenter","year":"1979","unstructured":"Carpenter G, King L Jr, Cohen S (1979) Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor. J Biol Chem 254:4884\u20134891","journal-title":"J Biol Chem"},{"key":"BF00582600_CR9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.pa.20.040180.000311","volume":"20","author":"WA Catterall","year":"1980","unstructured":"Catterall WA (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann Rev Pharmacol Toxicol 20:15\u201343","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"BF00582600_CR10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","volume":"20","author":"F Couraud","year":"1982","unstructured":"Couraud F, Jover E, Dubois JM, Rochat H (1982) Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. Toxicon 20:9\u201316","journal-title":"Toxicon"},{"key":"BF00582600_CR11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF00582045","volume":"397","author":"SL Hu","year":"1983","unstructured":"Hu SL, Meves H, Rubly N, Watt DD (1983) A quantitative study of the action ofCentruroides sculpturatus toxins III and IV on the Na currents of the node of Ranvier. Pfl\u00fcgers Arch 397:90\u201399","journal-title":"Pfl\u00fcgers Arch"},{"key":"BF00582600_CR12","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1085\/jgp.73.6.839","volume":"73","author":"LYM Huang","year":"1979","unstructured":"Huang LYM, Catterall WA, Ehrenstein G (1979) Comparison of ionic selectivity of batrachotoxin-activated channels with different tetrodotoxin dissociation constants. J Gen Physiol 73:839\u2013854","journal-title":"J Gen Physiol"},{"key":"BF00582600_CR13","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1073\/pnas.79.6.2082","volume":"79","author":"LYM Huang","year":"1982","unstructured":"Huang LYM, Moran N, Ehrenstein G (1982) Batrachotoxin modifies the gating kinetics of sodium channels in internally perfused neuroblastoma cells. Proc Natl Acad Sci USA 79:2082\u20132085","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF00582600_CR14","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1016\/S0021-9258(17)34512-X","volume":"253","author":"Y Jacques","year":"1978","unstructured":"Jacques Y, Fosset M, Lazdunski M (1978) Molecular properties of the action potential Na+ ionophore in neuroblastoma cells. J Biol Chem 253:7383\u20137392","journal-title":"J Biol Chem"},{"key":"BF00582600_CR15","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1073\/pnas.79.12.3896","volume":"79","author":"E Jaimovich","year":"1982","unstructured":"Jaimovich E, Ildefonse M, Barhanin J, Rougier O, Lazdunski M (1982)Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage clamp analysis and biochemical characterization of the receptor. Proc Natl Acad Sci USA 79:3896\u20133900","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF00582600_CR16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1113\/jphysiol.1976.sp011274","volume":"255","author":"RD Keynes","year":"1976","unstructured":"Keynes RD, Rojas E (1976) The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon. J Physiol 255:157\u2013189","journal-title":"J Physiol"},{"key":"BF00582600_CR17","first-page":"153","volume-title":"Membrane transport processes, vol 2","author":"BI Khodorov","year":"1978","unstructured":"Khodorov BI (1978) Chemicals as tools to study nerve fiber sodium channels; effects of batrachotoxin and some local anesthetics. In: Tosteson DC, Ovchinnikov YA, Latorre R (eds) Membrane transport processes, vol 2. Raven Press, New York, pp 153\u2013174"},{"key":"BF00582600_CR18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2736(81)90128-0","volume":"648","author":"BI Khodorov","year":"1981","unstructured":"Khodorov BI, Neumcke B, Schwarz W, St\u00e4mpfli R (1981) Fluctuation analysis of Na+ channels modified by batrachotoxin in myelinated nerve. Biochim Biophys Acta 648:93\u201399","journal-title":"Biochim Biophys Acta"},{"key":"BF00582600_CR19","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/0306-4522(79)90159-3","volume":"4","author":"BI Khodorov","year":"1979","unstructured":"Khodorov BI, Revenko SV (1979) Further analysis of the mechanism of action of batrachotoxin on the membrane of myelinated nerve. Neuroscience 4:1315\u20131330","journal-title":"Neuroscience"},{"key":"BF00582600_CR20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00592631","volume":"303","author":"E Koppenh\u00f6fer","year":"1968","unstructured":"Koppenh\u00f6fer E, Schmidt H (1968a) Die Wirkung von Skorpiongift auf die Ionenstr\u00f6me des Ranvierschen Schn\u00fcrrings. I. Die Permeabilit\u00e4tenP Na undP K. Pfl\u00fcgers Arch 303:133\u2013149","journal-title":"Pfl\u00fcgers Arch"},{"key":"BF00582600_CR21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00592632","volume":"303","author":"E Koppenh\u00f6fer","year":"1968","unstructured":"Koppenh\u00f6fer E, Schmidt H (1968b) Die Wirkung von Skorpiongift auf die Ionenstr\u00f6me des Ranvierschen Schn\u00fcrrings. II. Unvollst\u00e4ndige Natrium-Inaktivierung. Pfl\u00fcgers Arch 303:150\u2013161","journal-title":"Pfl\u00fcgers Arch"},{"key":"BF00582600_CR22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1749-6632.1980.tb15395.x","volume":"358","author":"M Lazdunski","year":"1980","unstructured":"Lazdunski M, Balerna M, Barhanin J, Chicheportiche R, Fosset M, Frelin C, Jacques Y, Lombet A, Pouyss\u00e9gur J, Renaud JF, Romey G, Schweitz H, Vincent JP (1980) Molecular aspects of the structure and mechanism of the voltage dependent sodium channel. Ann NY Acad Sci 358:169\u2013182","journal-title":"Ann NY Acad Sci"},{"key":"BF00582600_CR23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1085\/jgp.71.5.489","volume":"71","author":"KS Lee","year":"1978","unstructured":"Lee KS, Akaike N, Brown AM (1978) Properties of internally perfused voltage-clamped, isolated nerve cell bodies. J Gen Physiol 71:489\u2013507","journal-title":"J Gen Physiol"},{"key":"BF00582600_CR24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00582392","volume":"393","author":"H Meves","year":"1982","unstructured":"Meves H, Rubly N, Watt DD (1982) Effect of toxins isolated from the venom of the scorpionCentruroides sculpturatus on the Na currents of the node of Ranvier. Pfl\u00fcgers Arch 393:56\u201362","journal-title":"Pfl\u00fcgers Arch"},{"key":"BF00582600_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1113\/jphysiol.1978.sp012303","volume":"278","author":"WH Moolenaar","year":"1978","unstructured":"Moolenaar WH, Spector I (1978) Ionic currents in cultured mouse neuroblastoma cells under voltage-clamp conditions. J Physiol 278:265\u2013286","journal-title":"J Physiol"},{"key":"BF00582600_CR26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1113\/jphysiol.1979.sp012852","volume":"292","author":"WH Moolenaar","year":"1979","unstructured":"Moolenaar WH, Spector I (1979) The calcium current and the activation of a slow potassium conductance in voltage-clamped mouse neuroblastoma cells. J Physiol 292:307\u2013323","journal-title":"J Physiol"},{"key":"BF00582600_CR27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0005-2736(80)90230-8","volume":"597","author":"GN Mozhayeva","year":"1980","unstructured":"Mozhayeva GN, Naumov AP, Nosyreva ED, Grishin EV (1980) Potential-dependent interaction of toxin from venom of the scorpionButhus eupeus with sodium channels in myelinated nerve fibre. Biochim Biophys Acta 597:587\u2013602","journal-title":"Biochim Biophys Acta"},{"key":"BF00582600_CR28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.1974.54.4.813","volume":"54","author":"T Narahashi","year":"1974","unstructured":"Narahashi T (1974) Chemicals as tools in the study of excitable membranes. Physiol Rev 54:813\u2013889","journal-title":"Physiol Rev"},{"key":"BF00582600_CR29","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1152\/ajplegacy.1972.222.4.850","volume":"222","author":"T Narahshi","year":"1972","unstructured":"Narahshi T, Shapiro BJ, Deguchi T, Scuka M, Wang CM (1972) Effects of scorpion venom on squid axon membranes. Am J Physiol 222:850\u2013857","journal-title":"Am J Physiol"},{"key":"BF00582600_CR30","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.80.13.4164","volume":"80","author":"RI Norman","year":"1983","unstructured":"Norman RI, Schmid A, Lombet A, Barhanin J, Lazdunski M (1983) Purification of binding protein forTityus \u03b3 toxin identified with the gating component of the voltage-sensitive Na+ channel. Proc Natl Acad Sci USA 80:4164\u20134168","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF00582600_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.77.1.1","volume":"77","author":"GS Oxford","year":"1981","unstructured":"Oxford GS (1981) Some kinetic and steady-state properties of sodium channels after removal of inactivation. J Gen Physiol 77:1\u201322","journal-title":"J Gen Physiol"},{"key":"BF00582600_CR32","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1073\/pnas.79.21.6732","volume":"79","author":"FN Quandt","year":"1982","unstructured":"Quandt FN, Narahashi T (1982) Modification of single Na+ channels by batrachotoxin. Proc Natl Acad Sci USA 79:6732\u20136736","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF00582600_CR33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-291X(75)90226-0","volume":"64","author":"G Romey","year":"1975","unstructured":"Romey G, Chicheportiche R, Lazdunski M, Rochat H, Miranda F, Lissitzky S (1975) Scorpion neurotoxin \u2014 A presynaptic toxin which affects both Na and K channels in axons. Biochem Biophys Res Comm 64:115\u2013121","journal-title":"Biochem Biophys Res Comm"},{"key":"BF00582600_CR34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0041-0101(83)90011-9","volume":"21","author":"SV Sampaio","year":"1983","unstructured":"Sampaio SV, Laure CJ, Giglio JR (1983) Isolation and characterization of toxic proteins from the Brazilian scorpionTityus serrulatus. Toxicon 21:265\u2013277","journal-title":"Toxicon"},{"key":"BF00582600_CR35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00582058","volume":"397","author":"KP Wheeler","year":"1983","unstructured":"Wheeler KP, Watt DD, Lazdunski M (1983) Classification of Na channel receptors specific for various scorpion toxins. Pfl\u00fcgers Arch 397:164\u2013165","journal-title":"Pfl\u00fcgers Arch"}],"container-title":["Pfl\u00fcgers Archiv European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00582600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00582600\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00582600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T13:59:28Z","timestamp":1627739968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00582600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,7]]}},"alternative-id":["BF00582600"],"URL":"https:\/\/doi.org\/10.1007\/bf00582600","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}