{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:35:15Z","timestamp":1789803315251,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch."],"published-print":{"date-parts":[[1986,6]]},"DOI":"10.1007\/bf00584030","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T01:38:38Z","timestamp":1101173918000},"page":"620-628","source":"Crossref","is-referenced-by-count":13,"title":["Effects of toxins VI and VII from the scorpionCentruroides sculpturatus on the Na currents of the frog node of Ranvier"],"prefix":"10.1007","volume":"406","author":[{"given":"J.","family":"Marc Simard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Meves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0003-9861(74)90082-4","volume":"164","author":"DR Babin","year":"1974","unstructured":"Babin DR, Watt DD, Goos SM, Mlejnek RV (1974) Amino acid sequences of neurotoxic protein variants from the venom ofCentruroides sculpturatus Ewing. Arch Biochem Biophys 164:694?706","journal-title":"Arch Biochem Biophys"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0003-9861(75)90371-9","volume":"166","author":"DR Babin","year":"1975","unstructured":"Babin DR, Watt DD, Goos SM, Mlejnek RV (1975) Amino acid sequence of neurotoxin I fromCentruroides sculpturatus Ewing. Arch Biochem Biophys 166:125?134","journal-title":"Arch Biochem Biophys"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/j.1460-2075.1983.tb01521.x","volume":"2","author":"J Barhanin","year":"1983","unstructured":"Barhanin J, Pauron D, Lombet A, Norman RI, Vijverberg HPM, Giglio JR, Lazdunski M (1983) Electrophysiological characterization, solubilization and purification of theTityus ? toxin receptor associated with the gating component of the Na+ channel from rat brain. EMBO 2:915?920","journal-title":"EMBO"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1975.sp010810","volume":"244","author":"MD Cahalan","year":"1975","unstructured":"Cahalan MD (1975) Modification of sodium channel gating in frog myelinated nerve fibres byCentruroides sculpturatus scorpion venom. J Physiol (Lond) 244:511?534","journal-title":"J Physiol (Lond)"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","volume":"20","author":"F Couraud","year":"1982","unstructured":"Couraud F, Jover E, Dubois JM, Rochat H (1982) Two types of scorpion toxin receptor sites, one related to activation, the other to inactivation of the action potential sodium channel. Toxicon 20:9?16","journal-title":"Toxicon"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1113\/jphysiol.1959.sp006281","volume":"148","author":"FA Dodge","year":"1959","unstructured":"Dodge FA, Frankenhaeuser B (1959) Sodium current in the myelinated nerve fibre ofXenopus laevis investigated with the voltage clamp technique. J Physiol (Lond) 148:188?200","journal-title":"J Physiol (Lond)"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF00586331","volume":"313","author":"H Drouin","year":"1969","unstructured":"Drouin H, The R (1969) The effect of reducing extracellular pH on the membrane currents of the Ranvier node. Pfl\ufffdgers Arch 313:80?88","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1085\/jgp.51.2.221","volume":"51","author":"B Hille","year":"1968","unstructured":"Hille B (1968) Charges and potentials at the nerve surface; divalent ions and pH. J Gen Physiol 51:221?236","journal-title":"J Gen Physiol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF00582045","volume":"397","author":"SL Hu","year":"1983","unstructured":"Hu SL, Meves H, Rubly N, Watt DD (1983) A quantitative study of the action ofCentruroides sculpturatus toxins III and IV on the Na currents of the node of Ranvier. Pfl\ufffdgers Arch 397:90?99","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1073\/pnas.79.12.3896","volume":"79","author":"E Jaimovich","year":"1982","unstructured":"Jaimovich E, Ildefonse M, Barhanin J, Rougier O, Lazdunski M (1982)Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage-clamp analysis and biochemical characterization of the receptor. Proc Natl Acad Sci USA 79:3896?3900","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/bi00301a018","volume":"23","author":"E Jover","year":"1984","unstructured":"Jover E, Bablito J, Couraud F (1984) Binding of ?-scorpion toxin: A physicochemical study. Biochemistry 23:1147?1152","journal-title":"Biochemistry"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00592631","volume":"303","author":"E Koppenh\ufffdfer","year":"1968","unstructured":"Koppenh\ufffdfer E, Schmidt H (1968) Die Wirkung von Skorpiongift auf die Ionenstr\ufffdme des Ranvierschen Schn\ufffdrrings. Pfl\ufffdgers Arch 303:133?149","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00582392","volume":"393","author":"H Meves","year":"1982","unstructured":"Meves H, Rubly N, Watt DD (1982) Effect of toxins isolated from the venom of the scorpionCentruroides sculpturatus on the Na currents of the node of Ranvier. Pfl\ufffdgers Arch 393:56?62","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR14","first-page":"185","volume":"79","author":"H Meves","year":"1984","unstructured":"Meves H, Simard JM, Watt DD (1984) Biochemical and electrophysiological characteristics of toxins isolated from the venom of the scorpionCentruroides sculpturatus. J Physiol (Paris) 79:185?191","journal-title":"J Physiol (Paris)"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0005-2736(80)90230-8","volume":"597","author":"GN Mozhayeva","year":"1980","unstructured":"Mozhayeva GN, Naumov AP, Nosyreva ED, Grishin EV (1980) Potential-dependent interaction of toxin from venom of the scorpionButhus eupeus with sodium channels in myelinated fibre. Biochim Biophys Acta 597:587?602","journal-title":"Biochim Biophys Acta"},{"key":"CR16","first-page":"21","volume":"1","author":"GN Mozhayeva","year":"1982","unstructured":"Mozhayeva GN, Naumov AP, Negulyaev YA (1982) Interaction of H+ ions with acid groups in aconitine-modified sodium channels. Gen Physiol Biophys 1:21?35","journal-title":"Gen Physiol Biophys"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1152\/ajplegacy.1972.222.4.850","volume":"222","author":"T Narahashi","year":"1972","unstructured":"Narahashi T, Shapiro BI, Deguchi T, Scuka M, Wang CM (1972) Effects of scorpion venom on squid axon membranes. Am J Physiol 222:850?857","journal-title":"Am J Physiol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF00586967","volume":"309","author":"W Nonner","year":"1969","unstructured":"Nonner W (1969) A new voltage clamp method for Ranvier nodes. Pfl\ufffdgers Arch 309:176?192","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-291X(75)90226-0","volume":"64","author":"G Romey","year":"1975","unstructured":"Romey G, Chicheportiche R, Lazdunski M, Rochat H, Miranda F, Lissitzky S (1975) Scorpion neurotoxin ? a presynaptic toxin which affects both Na+ and K+ channels in axons. Biochem Biophys Res Commun 64:115?121","journal-title":"Biochem Biophys Res Commun"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00582600","volume":"401","author":"HPM Vijverberg","year":"1984","unstructured":"Vijverberg HPM, Pauron D, Lazdunski M (1984) The effect ofTityus serrulatus scorpion toxin ? on Na channels in neuroblastoma cells. Pfl\ufffdgers Arch 401:297?303","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR21","unstructured":"Vogel W, Jonas P (1984)Tityus scorpion toxin modifies Na channels in frog nerve. Abstract from the 8th International Biophysics Congress, 29 July?4 August, 1984, Bristol, UK"},{"key":"CR22","first-page":"519","volume":"23","author":"GK Wang","year":"1983","unstructured":"Wang GK, Strichartz GR (1983) Purification and physiological characterization of neurotoxins from venoms of the scorpionsCentruroides sculpturatus andLeiurus quinquestriatus. Mol Pharmacol 23:519?533","journal-title":"Mol Pharmacol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1021\/bi00265a037","volume":"21","author":"KP Wheeler","year":"1982","unstructured":"Wheeler KP, Barhanin J, Lazdunski M (1982) Specific binding of toxin II fromCentruroides suffusus suffusus to the sodium channel in electroplaque membranes. Biochemistry 21:5628?5634","journal-title":"Biochemistry"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00582058","volume":"397","author":"KP Wheeler","year":"1982","unstructured":"Wheeler KP, Watt DD, Lazdunski M (1982) Classification of Na channel receptors specific for various scorpion toxins. Pfl\ufffdgers Arch 397:164?165","journal-title":"Pfl\ufffdgers Arch"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1085\/jgp.61.6.687","volume":"61","author":"AM Woodhull","year":"1973","unstructured":"Woodhull AM (1973) Ionic blockage of sodium channels in nerve. J Gen Physiol 61:687?708","journal-title":"J Gen Physiol"},{"key":"CR26","first-page":"101","volume":"4","author":"LD Zaborovskaya","year":"1985","unstructured":"Zaborovskaya LD, Khodorov BI (1985) Effect ofTityus ? toxin on the activation process in sodium channels of frog myelinated nerve. Gen Physiol Biophys 4:101?104","journal-title":"Gen Physiol Biophys"}],"container-title":["Pfl\ufffdgers Archiv European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00584030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00584030\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00584030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T07:18:57Z","timestamp":1585984737000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00584030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["BF00584030"],"URL":"https:\/\/doi.org\/10.1007\/bf00584030","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}