{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:33Z","timestamp":1790270733230,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1990,1]]},"DOI":"10.1007\/bf00586456","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T03:01:14Z","timestamp":1101178874000},"page":"15-23","source":"Crossref","is-referenced-by-count":32,"title":["Functional and morphological effects of interleukin-1? on the perfused rat pancreas"],"prefix":"10.1007","volume":"33","author":[{"given":"L. D.","family":"Wogensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kolb-Bachofen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Dinarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mandrup-Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1096\/fasebj.2.2.3277884","volume":"2","author":"CA Dinarello","year":"1988","unstructured":"Dinarello CA (1988) Biology of interleukin-1. FASEB J 2: 108?115","journal-title":"FASEB J"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jnr.490180126","volume":"18","author":"M Schultzberg","year":"1987","unstructured":"Schultzberg M, Svenson SB, Unden A, Bartfai T (1987) Interleukin-1-like immunoreactivity in peripheral tissues. J Neurosci Res 18: 184?189","journal-title":"J Neurosci Res"},{"key":"CR3","first-page":"438","volume":"35","author":"T Mandrup-Poulsen","year":"1988","unstructured":"Mandrup-Poulsen T (1988) On the pathogenesis of insulin dependent diabetes mellitus. Dan Med Bull 35: 438?460","journal-title":"Dan Med Bull"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/acta.0.1190307","volume":"118","author":"GA Spinas","year":"1988","unstructured":"Spinas GA, Palmer JP, Mandrup-Poulsen T, Andersen H, Nielsen JH, Nerup J (1988) The bimodal effect of interleukin-1 on rat pancreatic beta-cells ? stimulation followed by inhibition ? depends upon dose, duration of exposure and ambient glucose concentration. Acta Endocrinol (Copenh) 118: 307?311","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"Suppl. 1","key":"CR5","first-page":"16","volume":"11","author":"J Nerup","year":"1988","unstructured":"Nerup J, Mandrup-Poulsen T, M\u00f8lvig J, Helqvist S, Wogensen L, Egeberg J (1988) Mechanisms of pancreatic ?-cell destruction in type 1 diabetes. Diabetes Care 11 [Suppl. 1]: 16?23","journal-title":"Diabetes Care"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1172\/JCI113593","volume":"82","author":"E Samols","year":"1988","unstructured":"Samols E, Stagner JI, Ewart RBL, Marks V (1988) The order of islet microvascular cellular perfusion is B-A-D in the perfused rat pancreas. J Clin Invest 82: 350?353","journal-title":"J Clin Invest"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1530\/acta.0.1170302","volume":"117","author":"LD Wogensen","year":"1988","unstructured":"Wogensen LD, Mandrup-Poulsen T, Markholst H, Lernmark \u00c5, Holst JJ, Dinarello CA, Nerup J (1988) Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas. Acta Endocrinol (Copenh) 117: 302?306","journal-title":"Acta Endocrinol (Copenh)"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/acta.0.1120367","volume":"112","author":"A Svenningsen","year":"1986","unstructured":"Svenningsen A, Dyrberg T, Markholst H, Binder C, Lernmark \u00c5 (1986) Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. Acta Endocrinol 112: 367?371","journal-title":"Acta Endocrinol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1172\/JCI112495","volume":"77","author":"CA Dinarello","year":"1986","unstructured":"Dinarello CA, Cannon JG, Mier JW, Bernheim HA, LoPreste G, Lynn DL, Love RN, Webb AC, Auron PE, Reuben RC, Rich A, Wolff SM, Putney SD (1986) Multiple biological activities of human recombinant interleukin-1. J Clin Invest 77: 1734?1739","journal-title":"J Clin Invest"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-5793(89)80259-5","volume":"246","author":"H Dalb\u00f8ge","year":"1989","unstructured":"Dalb\u00f8ge H, Bayne S, Christensen T, Hein\u00e6s KR (1989) Cloning and expression of an interleukin-1? precursor and its conversion to interleukin-1?. FEBS 246: 89?93","journal-title":"FEBS"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0090-6980(76)90161-1","volume":"11","author":"P Christensen","year":"1976","unstructured":"Christensen P, Leyssac PP (1976) A specific radioimmunoassay for PGE2 using antibody with high specificity and a Sephadex LH-20 microcolumn for the separation of prostaglandins. Prostaglandins 11: 399?420","journal-title":"Prostaglandins"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1748-1716.1983.tb07177.x","volume":"117","author":"P Christensen","year":"1983","unstructured":"Christensen P, Green K, Leyssac PP (1983) The relationship between urinary prostaglandin excretion rates and urine flow in conscious rats. Evaluation of the radioimmunoassay by gas chromatography-mass spectrometry. Acta Physiol Scand 117: 41?47","journal-title":"Acta Physiol Scand"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-5320(69)90033-1","volume":"26","author":"A Spurr","year":"1969","unstructured":"Spurr A (1969) A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 26: 31?43","journal-title":"J Ultrastruct Res"},{"key":"CR14","first-page":"114","volume":"47","author":"S Farber","year":"1982","unstructured":"Farber S (1982) Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulation necrosis. Lab Invest 47: 114?123","journal-title":"Lab Invest"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/hep.1840030209","volume":"3","author":"RP Cornell","year":"1983","unstructured":"Cornell RP (1983) Role of the liver in endotoxin-induced hyperinsulinemia and hyperglucagonemia in rats. Hepatology 3: 188?192","journal-title":"Hepatology"},{"key":"CR16","first-page":"E156","volume":"239","author":"MR Yelich","year":"1980","unstructured":"Yelich MR, Filkins JP (1980) Mechanism of hyperinsulinemia in endotoxicosis. Am J Physiol 239: E156-E161","journal-title":"Am J Physiol"},{"key":"CR17","first-page":"49","volume":"14","author":"MR Yelich","year":"1984","unstructured":"Yelich MR, Filkins JP (1984) Role of calcium in the insulin hypersecretory state of the endotoxic rat pancreas. Circ Shock 14: 49?62","journal-title":"Circ Shock"},{"key":"CR18","first-page":"E115","volume":"242","author":"JP Filkins","year":"1982","unstructured":"Filkins JP, Yelich MR (1982) Mechanism of hyperinsulinemia after reticuloendothelial system phagocytosis. Am J Physiol 242: E115-E120","journal-title":"Am J Physiol"},{"key":"CR19","first-page":"R794","volume":"253","author":"A Rey del","year":"1987","unstructured":"del Rey A, Besedovsky H (1987) Interleukin-1 affects glucose homeostasis. Am J Physiol 253: R794-R798","journal-title":"Am J Physiol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0148607188012002212","volume":"12","author":"JJ Pomposelli","year":"1988","unstructured":"Pomposelli JJ, Flores EA, Bistrian BR (1988) Role of biochemical mediators in clinical nutrition and surgical metabolism. J Parent Ent Nutrition 12: 212?218","journal-title":"J Parent Ent Nutrition"},{"key":"CR21","first-page":"4","volume":"46","author":"MR Yelich","year":"1987","unstructured":"Yelich MR, Umporowicz DM, McCulla EA, Filkins JP (1987) Interleukin-1 (IL-1) in vivo potentiates immunoreactive insulin (IRI) secretion in the in vitro perfused rat pancreas. FED PROC 46: 4 (Abstract)","journal-title":"FED PROC"},{"key":"CR22","first-page":"377","volume-title":"Monokines and other non-lymphocytic cytokines","author":"A Reuter","year":"1988","unstructured":"Reuter A, Bernier J, Gysen P, Gevaert Y, Gathy R, Lopez M, Dupont G, Damas P, Franchimont (1988) A RIA for tumor necrosis factor (TNF?) and interleukin 1? (IL-1?) and their direct determination in serum. In: Powanda MC (ed) Monokines and other non-lymphocytic cytokines. Alan R. Liss, New York, pp 377?381"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJM198808183190703","volume":"319","author":"E Girardin","year":"1988","unstructured":"Girardin E, Grau GE, Dayer JM, Roux-Lombard P, The J5 Study Group, Lambert PH (1988) Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 319: 397?400","journal-title":"N Engl J Med"},{"issue":"Suppl.1","key":"CR24","first-page":"202","volume":"37","author":"GA Spinas","year":"1988","unstructured":"Spinas GA, Palmer JP, Egeberg J, Mandrup-Poulsen T, Andersen HU, Nielsen JH, Nerup J (1988) Differential effects of interleukin-1 on pancreatic alpha and beta cells. Diabetes 37 [Suppl.1]: 202 (Abstract)","journal-title":"Diabetes"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1073\/pnas.86.1.182","volume":"86","author":"M Scanlon","year":"1989","unstructured":"Scanlon M, Laster SM, Wood JG, Gooding LR (1989) Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments. Proc Natl Acad Sci USA 86: 182?186","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR26","first-page":"55","volume":"95","author":"T Mandrup-Poulsen","year":"1987","unstructured":"Mandrup-Poulsen T, Egeberg J, Nerup J, Bendtzen K, Nielsen JH, Dinarello CA (1987) Ultrastructural studies of time course and cellular specificity of interleukin-1 mediated islet cytotoxicity. Acta Path Microbiol Immunol Scand (C) 95: 55?63","journal-title":"Acta Path Microbiol Immunol Scand (C)"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1210\/endo-124-3-1492","volume":"124","author":"S Sandler","year":"1989","unstructured":"Sandler S, Bendtzen K, Borg LAH, Eizirik DL, Strandell E, Welsh N (1989) Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1? indicate a perturbation in the mitochondrial function. Endocrinology 124: 1492?1501","journal-title":"Endocrinology"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2337\/diab.38.10.1211","volume":"38","author":"J Palmer","year":"1989","unstructured":"Palmer J, Helqvist S, Spinas GA, M\u00f8lvig J, Mandrup-Poulsen T, Andersen HU and Nerup J (1989) Interaction of beta-cell activity and interleukin-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes 38: 1211?1216","journal-title":"Diabetes"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1073\/pnas.85.11.3865","volume":"85","author":"FC Schuit","year":"1988","unstructured":"Schuit FC, In'T Veld PA, Pipeleers DG (1988) Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci US A 85: 3865?3869","journal-title":"Proc Natl Acad Sci US A"},{"issue":"Suppl.1","key":"CR30","first-page":"21","volume":"37","author":"M Goodman","year":"1988","unstructured":"Goodman M, Wang Y, Lumerman J, Sussman KE, Lafferty K, Drazin B (1988) Studies on the mechanism causing the impairment of glucose-stimulated insulin release in rat pancreatic islets exposed to human recombinant interleukin-?. Diabetes 37 [Suppl.1]: 21 (Abstract)","journal-title":"Diabetes"},{"key":"CR31","first-page":"3","volume-title":"Handbook of experimental pharmacology, Vol 66: Glucagon II","author":"JE Gerich","year":"1983","unstructured":"Gerich JE (1983) Glucose in the control of glucagon secretion. In: Lefebvre PJ (ed) Handbook of experimental pharmacology, Vol 66: Glucagon II. Springer, Berlin Heidelberg New York, pp 3?18"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1210\/endo-124-2-720","volume":"124","author":"WS Zawalich","year":"1989","unstructured":"Zawalich WS, Dierolf B, Zawalich K (1989) Interleukin-1 induces time-dependent potentiation in isolated rat islets: possible involvement of phosphoinositide hydrolysis. Endocrinology 124: 720?726","journal-title":"Endocrinology"},{"key":"CR33","first-page":"140","volume":"102","author":"MS Roh","year":"1987","unstructured":"Roh MS, Drazenovich KA, Barbose JJ, Dinarello CA (1987) Direct stimulation of the adrenal cortex by interleukin-1. Surgery 102: 140?146","journal-title":"Surgery"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0005-2760(84)90304-7","volume":"794","author":"J Turk","year":"1984","unstructured":"Turk J, Colca JR, Kotagal N, McDaniel ML (1984) Identification and quantitation of lipoxygenase and cyclooxygenase products. I. Biochim Biophys Acta 794: 110?114","journal-title":"Biochim Biophys Acta"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0005-2760(84)90305-9","volume":"794","author":"J Turk","year":"1984","unstructured":"Turk J, Colca JR, Kotagal N, McDaniel ML (1984) Identification and quantitation of lipoxygenase and cyclooxygenase products. II. Biochim Biophys Acta 794: 125?136","journal-title":"Biochim Biophys Acta"},{"key":"CR36","first-page":"83","volume-title":"Handbook of exerimental pharmacology, Vol 66: Glucagon II","author":"AS Luyckx","year":"1983","unstructured":"Luyckx AS, Lefebre PJ (1983) Prostaglandins and glucagon secretion. In: Lefebvre PJ (ed) Handbook of exerimental pharmacology, Vol 66: Glucagon II. Springer, Berlin Heidelberg New York, pp 83?96"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00586456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00586456\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00586456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T18:40:28Z","timestamp":1554835228000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00586456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["BF00586456"],"URL":"https:\/\/doi.org\/10.1007\/bf00586456","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}