{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:05:20Z","timestamp":1768280720453,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1976]]},"DOI":"10.1007\/bf00606556","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T13:00:16Z","timestamp":1101301216000},"page":"405-410","source":"Crossref","is-referenced-by-count":16,"title":["Disparity between clinical and immune responses in a controlled trial of azathioprine in rheumatoid arthritis"],"prefix":"10.1007","volume":"9","author":[{"given":"K. M.","family":"Goebel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"B\ufffdrngen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1172\/JCI107455","volume":"52","author":"W.T. Butler","year":"1973","unstructured":"Butler, W.T., Rossen, R.D.: Effects of corticosteroids on immunity in man. J. clin. Invest.52 2629?2640 (1973)","journal-title":"J. clin. Invest."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2165\/00003495-197203050-00004","volume":"3","author":"M.D. Cridland","year":"1972","unstructured":"Cridland, M.D.: Antineoplastic and immunosuppressive drugs. III. Adverse effects and therapeutic problems. Drugs3 352?365 (1972)","journal-title":"Drugs"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.3.5934.763","volume":"III","author":"H.L.F. Currey","year":"1974","unstructured":"Currey, H.L.F., Harris, J., Mason, R.M., Woodland, J.M., Beveridge, T., Roberts, C.J., Vere, D.W., Dixon, A.St.J., Davies, J., Owen-Smith, B.: Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis. Brit. med. J.1974 III 763?766","journal-title":"Brit. med. J."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00290602","volume":"18","author":"E. Ganner","year":"1973","unstructured":"Ganner, E., Osment, J., Dittrich, P., Huber, H.: Chromosomes in patients treated with azathioprine. Hum. Genet.18 231?236 (1973)","journal-title":"Hum. Genet."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0609.1973.tb00035.x","volume":"10","author":"K.M. Goebel","year":"1973","unstructured":"Goebel, K.M., Gassel, W.D., Goebel, F.D.: Evaluation of azathioprine in autoimmune thrombocytopenia and lupus erythematodes. Scand. J. Haemat.10 28?34 (1973)","journal-title":"Scand. J. Haemat."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/BF01468937","volume":"52","author":"K.M. Goebel","year":"1974","unstructured":"Goebel, K.M., Goebel, F.D., Gassel, W.D., Neitzert, A., Mueller, K.: Immune response in patients with autoimmune thrombocytopenia and autoimmune haemolytic anaemia receiving azathioprine. Klin. Wschr.52 916?920 (1974)","journal-title":"Klin. Wschr."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/bmj.4.5785.463","volume":"IV","author":"J. Harris","year":"1971","unstructured":"Harris, J., Jessop, J.D., Saintonge, D.M.: Further experience with azathioprine in rheumatoid arthritis. Brit. med. J.1971 IV 463?464","journal-title":"Brit. med. J."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1749-6632.1966.tb12897.x","volume":"129","author":"G.H. Hitchings","year":"1966","unstructured":"Hitchings, G.H., Elion, G.B.: Some aspects of immunosuppression. Ann. N. Y. Acad. Sci.129 799?803 (1966)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"CR9","first-page":"152","volume":"99","author":"J.M. Jones","year":"1975","unstructured":"Jones, J.M., Martinez, A.J., Joshi, V.V., McWilliams, N.: Systemic lupus erythematosus. Clinical neuropathologic correlation. Arch. Path.99 152?157 (1975)","journal-title":"Arch. Path."},{"key":"CR10","first-page":"888","volume":"10","author":"M.L. Kripke","year":"1974","unstructured":"Kripke, M.L., Borsos, T.: Immunsuppression and carcinogenesis. Israel J. med. Sci.10 888?903 (1974)","journal-title":"Israel J. med. Sci."},{"key":"CR11","first-page":"781","volume-title":"Arthritis & allied conditions","author":"J. Lansbury","year":"1966","unstructured":"Lansbury, J.: Methods for evaluating rheumatoid arthritis. In: Arthritis & allied conditions (ed. J.L. Hollander), pp. 781?845. Philadelphia: Lea & Febinger 1966"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1172\/JCI107031","volume":"51","author":"J. Levy","year":"1972","unstructured":"Levy, J., Barnett, E.V., Mac Donals, N.S., Klinenberg, J.R., Pearson, C.M.: The effects of azathioprine on gammaglobulin synthesis in man. J. clin. Invest.51 2233?2238 (1972)","journal-title":"J. clin. Invest."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/bmj.1.5641.420","volume":"I","author":"M. Mason","year":"1969","unstructured":"Mason, M., Currey, H.L.F., Barnes, C.G., Dunne, J.F., Zazleman, B.L., Strickland, I.D.: Azathioprine in rheumatoid arthritis. Brit. med. J.1969 I 420?422","journal-title":"Brit. med. J."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/BF01938382","volume":"30","author":"G. Moore","year":"1974","unstructured":"Moore, G., Harley, J.P., Otero, R.: Immunosuppressive activity of azathioprine in experimental infection of the mouse with trichinella spiralis. Experientia (Basel)30 952?953 (1974)","journal-title":"Experientia"},{"key":"CR15","first-page":"745","volume":"41","author":"S. Rampon","year":"1974","unstructured":"Rampon, S., Bussiere, J.L., Prin, Ph., Sauvezie, P., Leroy, V., Missioux, D., Doly, J., Suss, P., Jourde, H., Lapalus, F.: A propos de 250 observations de scintigraphie osseuse par le pyrophsphate d'etain marque au technetium 99 m. Rev. Rhum.41 745?751 (1974)","journal-title":"Rev. Rhum."},{"key":"CR16","first-page":"1501","volume":"22","author":"D. Ricken","year":"1971","unstructured":"Ricken, D., Marsteller, H.J., Baack, G.: Immunsuppressive Behandlung der prim\u00e4r chronischen Polyarthritis und des Lupus erythematodes disseminatus. Med. Welt22 1501?1506 (1971)","journal-title":"Med. Welt"},{"key":"CR17","first-page":"175","volume":"9","author":"M.W. Ropes","year":"1958","unstructured":"Ropes, M.W., Benett, G.A., Cobb, S.: Revision of diagnostic criteria for rheumatoid arthritis. Bull. rheum. Dis.9 175?176 (1958)","journal-title":"Bull. rheum. Dis."},{"key":"CR18","unstructured":"Savage, O.: Measurements in rheumatoid arthritis. Proc. roy. Soc. Med.59 (Suppl. 85), (1966)"},{"key":"CR19","first-page":"93","volume-title":"Medikament\u00f6se Immunsuppression","author":"F. Scheiffarth","year":"1971","unstructured":"Scheiffarth, F., Warnatz, H.: Medikament\u00f6se Immunsuppression der prim\u00e4r-chronischen Polyarthritis. In: Medikament\u00f6se Immunsuppression (eds. D. Ricken, K. Schumacher), pp. 93?104. Stuttgart: Thieme 1971"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.1975.tb36034.x","volume":"256","author":"H.R. Schumacher","year":"1975","unstructured":"Schumacher, H.R.: Synovial membrane and fluid morphologic alterations in early rheumatoid arthritis: Microvascular injury and virus-like particles. Ann. N. Y. Acad. Sci.256 39?65 (1975)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.7326\/0003-4819-82-3-405","volume":"82","author":"C.R. Stiller","year":"1975","unstructured":"Stiller, C.R., Russel, A.S., Dossetor, J.B.: Autoimmunity: Present concepts. Ann. intern. Med.82 405?410 (1975)","journal-title":"Ann. intern. Med."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJM196707272770401","volume":"277","author":"M.A. Swanson","year":"1967","unstructured":"Swanson, M.A., Schwartz, R.S.: Immunosuppressive therapy. The relation between clinical response and immunologic competence. New Engl. J. Med.277 163?170 (1967)","journal-title":"New Engl. J. Med."},{"key":"CR23","first-page":"344","volume":"32","author":"G. Tausch","year":"1973","unstructured":"Tausch, G., Siegmeth, W.: Weitere Ergebnisse der Langzeittherapie mit Azathioprine bei erosiven F\u00e4llen von chronischer Polyarthritis. Z. Rheumaforsch.32 344?354 (1973)","journal-title":"Z. Rheumaforsch."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/art.1780160319","volume":"16","author":"M.B. Urowitz","year":"1973","unstructured":"Urowitz, M.B., Gordon, D.A., Smythe, H.A., Pruzanski, W., Ogryzlo, M.A.: Azathioprine in rheumatoid arthritis. Arthr. and Rheum.16 411?418 (1973)","journal-title":"Arthr. and Rheum."},{"key":"CR25","first-page":"274","volume":"1","author":"M.B. Urowitz","year":"1974","unstructured":"Urowitz, M.B., Hunter, T., Bookman, A.A.M., Gordon, D.A., Smythe, H.A., Ogryzlo, M.A.: Azathioprine in rheumatoid arthritis. A double blind study comparing full dose to half dose. J. Rheum.1 274?281 (1974)","journal-title":"J. Rheum."},{"issue":"Suppl.","key":"CR26","first-page":"282","volume":"1","author":"W. Wirth","year":"1974","unstructured":"Wirth, W., M\u00fcller, U.St., Th\u00f6ne, F.: Untersuchungen zum Wirkungsmechanismus sogenannter Immunsuppressiva. Arzneimittelallergie (Suppl.)1 282?287 (1974)","journal-title":"Arzneimittelallergie"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00606556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00606556\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00606556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T03:24:08Z","timestamp":1554434648000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00606556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976]]},"references-count":26,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[1976]]}},"alternative-id":["BF00606556"],"URL":"https:\/\/doi.org\/10.1007\/bf00606556","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976]]}}}