{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:58:05Z","timestamp":1762160285460},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pflugers Arch."],"published-print":{"date-parts":[[1984,1]]},"DOI":"10.1007\/bf00670531","type":"journal-article","created":{"date-parts":[[2004,11,28]],"date-time":"2004-11-28T04:01:59Z","timestamp":1101614519000},"page":"22-27","source":"Crossref","is-referenced-by-count":57,"title":["Tityus? toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane"],"prefix":"10.1007","volume":"400","author":[{"given":"Jacques","family":"Barhanin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\ufffdle","family":"Ildefonse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oger","family":"Rougier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely Vilela","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\ufffd R.","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Lazdunski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"117","volume":"312","author":"W Almers","year":"1981","unstructured":"Almers W, Fink R, Palade PT (1981) Calcium depletion in frog muscle tubules: The decline of calcium currents under maintained depolarization. J Physiol 312:117?207","journal-title":"J Physiol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.1983.sp014715","volume":"339","author":"W Almers","year":"1983","unstructured":"Almers W, Stanfield PR, St\u00fchmer W (1983) Slow changes in currents through sodium channels in frog muscle membrane. J Physiol 339: 253?271","journal-title":"J Physiol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1016\/S0021-9258(18)33546-4","volume":"257","author":"J Barhanin","year":"1982","unstructured":"Barhanin J, Giglio JR, L\u00e9opold P, Schmid A, Sampaio SV, Lazdunski M (1982)Tityus serrulatus venom contains two classes of toxins:Tityus ? toxin is a new tool with a very high affinity for studying the Na+ channel. J Biol Chem 257:12553?12558","journal-title":"J Biol Chem"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0021-9258(18)33101-6","volume":"258","author":"J Barhanin","year":"1983","unstructured":"Barhanin J, Schmid A, Lombet A, Wheeler KP, Lazdunski M, Ellory JC (1983a) Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel. J Biol Chem 258:700?702","journal-title":"J Biol Chem"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/j.1460-2075.1983.tb01521.x","volume":"2","author":"J Barhanin","year":"1983","unstructured":"Barhanin J, Pauron D, Lombet A, Norman RI, Vijverberg HPM, Giglio JR, Lazdunski M (1983b) Electrophysiological characterization, solubilization and purification of theTityus ? toxin receptor associated with the gating component of the Na+ channel from rat brain. EMBO J 2:915?920","journal-title":"EMBO J"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1085\/jgp.63.2.257","volume":"63","author":"J Bastian","year":"1974","unstructured":"Bastian J, Nakajima S (1974) Action potentials in the transverse tubules and its role in the activation of the skeletal muscle. j Gen Physiol 63:257?278","journal-title":"j Gen Physiol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00581298","volume":"374","author":"J Caill\u00e9","year":"1978","unstructured":"Caill\u00e9 J, Ildefonse M, Rougier O (1978) Existence of a sodium current in the tubular membrane of frog twitch muscle fibre: implication in excitation-contraction. Pfl\u00fcgers Archiv 374:167?177","journal-title":"Pfl\u00fcgers Archiv"},{"key":"CR8","first-page":"389","volume":"5","author":"J Caill\u00e9","year":"1981","unstructured":"Caill\u00e9 J, Ildefonse M, Rougier O, Roy G (1981) Surface and tubular membrane sodium currents in frog twitch muscle fibre, implication in excitation-contraction coupling. Adv Physiol Sci 5:389?409","journal-title":"Adv Physiol Sci"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.pa.20.040180.000311","volume":"20","author":"WA Catterall","year":"1980","unstructured":"Catterall WA (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Am Rev Pharmacol Toxicol 20:15?43","journal-title":"Am Rev Pharmacol Toxicol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1432-1033.1980.tb04466.x","volume":"104","author":"R Chicheportiche","year":"1980","unstructured":"Chicheportiche R, Balerna M, Lombet A, Romey G, Lazdunski M (1980) Synthesis of new, highly radioactive tetrodotoxin derivatives and their binding properties to the sodium channel. Eur J Biochem 104:617?625","journal-title":"Eur J Biochem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0079-6107(76)90023-7","volume":"29","author":"LL Constantin","year":"1975","unstructured":"Constantin LL (1975) Contractile activation in skeletal muscle. Prog Biophys Mol Biol 29:197?224","journal-title":"Prog Biophys Mol Biol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","volume":"20","author":"F Couraud","year":"1982","unstructured":"Couraud F, Jover E, Dubois JM, Rochat H (1982) Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. Toxicon 20: 9?16","journal-title":"Toxicon"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/S0021-9258(18)32376-7","volume":"258","author":"M Fosset","year":"1983","unstructured":"Fosset M, Jaimovich E, Delpont E, Lazdunski M (1983) [3H]Nitrendipine-receptors in skeletal muscle. Properties and preferential localization in transverse tubules. J Biol Chem 258:6086?6092","journal-title":"J Biol Chem"},{"key":"CR14","unstructured":"Garcia LG (1976) Etude des neurotoxines du venin du scorpion mexicainCentruroides suffusus. Dissertation Facult\u00e9 des Sciences Nice, France"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1113\/jphysiol.1972.sp009803","volume":"222","author":"M Ildefonse","year":"1972","unstructured":"Ildefonse M, Rougier O (1972a) Voltage-clamp analysis of the early current in frog skeletal muscle fibre using the double sucrose gap method. J Physiol (London) 222:373?395","journal-title":"J Physiol (London)"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1972.sp010040","volume":"227","author":"M Ildefonse","year":"1972","unstructured":"Ildefonse M, Roy G (1972b) Kinetic properties of the sodium current in striated muscle fibres on the basis of the Hodgkin-Huxley theory. J Physiol 227:419?431","journal-title":"J Physiol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.67.4.399","volume":"67","author":"E Jaimovich","year":"1976","unstructured":"Jaimovich E, Venosa RA, Schrager P, Horowicz P (1976) Density and distribution of tetrodotoxin receptors in normal and detubulated frog Sartorius muscle. J Gen Physiol 67:399?416","journal-title":"J Gen Physiol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1073\/pnas.79.12.3896","volume":"79","author":"E Jaimovich","year":"1982","unstructured":"Jaimovich E, Ildefonse M, Barhanin J, Rougier O, Lazdunski M (1982)Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage-clamp analysis and biochemical characterization of the receptor. Proc Natl Acad Sci USA 79:3896?3900","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00585159","volume":"397","author":"E Jaimovich","year":"1983","unstructured":"Jaimovich E, Chicheportiche R, Lombet A, Lazdunski M, Ildefonse M, Rougier O (1983) Differences in the properties of Na+ channels in muscle surface and T-tubular membranes revealed by tetrodotoxin derivatives. Pfl\u00fcgers Arch 397:1?5","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0006-291X(80)80082-9","volume":"95","author":"E Jover","year":"1980","unstructured":"Jover E, Couraud F, Rochat H (1980) Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes. Biochem Biophys Res Commun 95:1607?1614","journal-title":"Biochem Biophys Res Commun"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.ph.44.030182.002335","volume":"44","author":"M Lazdunski","year":"1982","unstructured":"Lazdunski M, Renaud JF (1982) The action of cardiotoxins on cardiac plasma membranes. Ann Rev Physiol 44:463?473","journal-title":"Ann Rev Physiol"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00582392","volume":"393","author":"H Meves","year":"1982","unstructured":"Meves H, Rubly N, Watt DD (1982) Effect of toxins isolated from the venom of the scorpionCentruroides sculpturatus on the Na currents of the Node of Ranvier. Pfl\u00fcgers Arch 393:56?62","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.80.13.4164","volume":"80","author":"RI Norman","year":"1983","unstructured":"Norman RI, Schmid A, Lombet A, Barhanin J, Lazdunski M (1983) Purification of the binding protein forTityus ? toxin identified with the gating component of the voltage-sensitive Na+ channel. Proc Natl Acad Sci 80:4164?4168","journal-title":"Proc Natl Acad Sci"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1016\/S0021-9258(18)43399-6","volume":"256","author":"M Rosemblatt","year":"1981","unstructured":"Rosemblatt M, Hidalgo C, Vergara C, Ikemoto N (1981) Immunological and biochemical properties of transverse tubular membranes isolated from rabbit skeletal muscle. J Biol Chem 256:8140?8148","journal-title":"J Biol Chem"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00362729","volume":"301","author":"O Rougier","year":"1968","unstructured":"Rougier O, Vassort G, St\u00e4mpfli R (1968) Voltage-clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique. Pfl\u00fcgers Arch 301:91?108","journal-title":"Pfl\u00fcgers Arch"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0041-0101(83)90011-9","volume":"21","author":"SV Sampaio","year":"1983","unstructured":"Sampaio SV, Laure CJ, Giglio JR (1983) Isolation and characterization of toxic proteins from the Brazilian scorpionTityus serrulatus. Toxicon 21:265?277","journal-title":"Toxicon"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"13862","DOI":"10.1016\/S0021-9258(18)33527-0","volume":"257","author":"S Seiler","year":"1982","unstructured":"Seiler S, Fleisher S (1982) Isolation of plasma membrane vesicles from rabbit skeletal muscle and their use in ion transport studies. J Biol Chem 257:13862?13871","journal-title":"J Biol Chem"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1021\/bi00265a037","volume":"21","author":"KP Wheeler","year":"1982","unstructured":"Wheeler KP, Barhanin J, Lazdunski M (1982) Specific binding of toxin II fromCentruroides suffusus to the sodium channel in electroplaque membranes. Biochemistry 21:5628?5634","journal-title":"Biochemistry"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00582058","volume":"397","author":"KP Wheeler","year":"1983","unstructured":"Wheeler KP, Watt DD, Lazdunski M (1983) Classification of Na channel receptors specific for various scorption toxins. Pfl\u00fcgers Arch 397: 164?165","journal-title":"Pfl\u00fcgers Arch"}],"container-title":["Pfl\ufffdgers Archiv European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00670531.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00670531\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00670531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T22:12:31Z","timestamp":1625004751000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00670531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["BF00670531"],"URL":"https:\/\/doi.org\/10.1007\/bf00670531","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}