{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:02:27Z","timestamp":1790456547527,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Tr"],"published-print":{"date-parts":[[1993]]},"DOI":"10.1007\/bf00683196","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T08:40:35Z","timestamp":1101717635000},"page":"95-102","source":"Crossref","is-referenced-by-count":39,"title":["The role and prognostic significance of p53 gene alterations in breast cancer"],"prefix":"10.1007","volume":"27","author":[{"given":"Richard M.","family":"Elledge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne A. W.","family":"Fuqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Craig","family":"Allred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1126\/science.1905840","volume":"253","author":"M Hollstein","year":"1991","unstructured":"Hollstein M, Sidransky D, Vogelstein B, Harris CC: p53 mutations in human cancers. Science 253:49?53, 1991","journal-title":"Science"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/ijc.2910460515","volume":"46","author":"J B\u00e1rtek","year":"1990","unstructured":"B\u00e1rtek J, B\u00e1rtkov\u00e1 J, Voitesek B, Staskov\u00e1 Z, Rejthar A, Kovarik J, Lane DP: Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. Int J Cancer 46:839?844, 1990","journal-title":"Int J Cancer"},{"key":"CR3","first-page":"2605","volume":"51","author":"AM Davidoff","year":"1991","unstructured":"Davidoff AM, Kerns B-JM, Iglehart JD, Marks JR: Maintenance of p53 alterations throughout breast cancer progression. Cancer Res 51:2605?2610, 1991","journal-title":"Cancer Res"},{"key":"CR4","first-page":"6194","volume":"51","author":"RJ Osborne","year":"1991","unstructured":"Osborne RJ, Merlo GR, Mitsudomi T, Venesio T, Liscia DS, Cappa APM, Chiba I, Takahashi T, Nau MM, Callahan R, Minna JD: Mutations in the p53 gene in primary human breast cancers. Cancer Res 51:6194?6198, 1991","journal-title":"Cancer Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/jnci\/84.11.845","volume":"84","author":"AD Thor","year":"1992","unstructured":"Thor AD, Moore DH II, Edgerton SM, Kawasaki ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen L-C, Mayall BH, Smith HS: Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst 84:845?855, 1992","journal-title":"J Natl Cancer Inst"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jnci\/85.3.200","volume":"85","author":"DC Allred","year":"1993","unstructured":"Allred DC, Clark GM, Elledge RM, Fuqua SAW, Brown RW, Chamness GC, Osborne CK, McGuire WL: Accumulation of mutant p53 is associated with increased proliferation and poor clinical outcome in node-negative breast cancer. J Natl Cancer Inst 85:200?206, 1993","journal-title":"J Natl Cancer Inst"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1073\/pnas.88.23.10657","volume":"88","author":"IB Runnebaum","year":"1991","unstructured":"Runnebaum IB, Nagarajan M, Bowman M, Oto D, Sukumar S: Mutations in p53 as potential molecular markers for human breast cancer. Proc Natl Acad Sci USA 88:10657?10661, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR8","first-page":"3918","volume":"52","author":"R Mazars","year":"1992","unstructured":"Mazars R, Spinardi L, BenCheikh M, Simony-Lafontaine J, Jeanteur P, Theillet C: p53 mutations occur in aggressive breast cancer. Cancer Res 52:3918?3923, 1992","journal-title":"Cancer Res"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/jnci\/84.4.246","volume":"84","author":"SS Sommer","year":"1992","unstructured":"Sommer SS, Cunningham J, McGovern RM, Saitoh S, Schroeder JJ, Wold LE, Kovach JS: Pattern of p53 gene mutations in breast cancers of women of the midwestern United States. J Natl Cancer Inst 84:246?252, 1992","journal-title":"J Natl Cancer Inst"},{"key":"CR10","first-page":"5291","volume":"52","author":"C Coles","year":"1992","unstructured":"Coles C, Condie A, Chetty U, Steel CM, Evans J, Prosser J: p53 mutations in breast cancer. Cancer Res 52:5291?5298, 1992","journal-title":"Cancer Res"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1073\/pnas.89.15.7262","volume":"89","author":"UM Moll","year":"1992","unstructured":"Moll UM, Riou G, Levine AJ: Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion. Proc Natl Acad Sci USA 89:7262?7266, 1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR12","first-page":"1707","volume":"5","author":"G Shaulsky","year":"1990","unstructured":"Shaulsky G, Ben-Ze'ev A, Rotter V: Subcellular distribution of the p53 protein during the cell cycle of Balb\/c 3T3 cells. Oncogene 5:1707?1711, 1990","journal-title":"Oncogene"},{"key":"CR13","first-page":"6304","volume":"51","author":"MB Kastan","year":"1991","unstructured":"Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304?6311, 1991","journal-title":"Cancer Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0092-8674(92)90644-R","volume":"69","author":"J Momand","year":"1992","unstructured":"Momand J, Zambetti GP, Olson DC, George D, Levine AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237?1245, 1992","journal-title":"Cell"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0092-8674(79)90293-9","volume":"17","author":"DIH Linzer","year":"1979","unstructured":"Linzer DIH, Levine AJ: Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43?52, 1979","journal-title":"Cell"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","volume":"63","author":"M Scheffner","year":"1990","unstructured":"Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129?1136, 1990","journal-title":"Cell"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/S0140-6736(88)90584-3","volume":"ii","author":"J Mackay","year":"1988","unstructured":"Mackay J, Steel CM, Elder PA, Forrest APM, Evans HJ: Allele loss on short arm of chromosome 17 in breast cancers. Lancet ii:1384?1385, 1988","journal-title":"Lancet"},{"key":"CR18","first-page":"5794","volume":"51","author":"T Sato","year":"1991","unstructured":"Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y: Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res 51:5794?5799, 1991","journal-title":"Cancer Res"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1073\/pnas.88.11.5006","volume":"88","author":"AM Davidoff","year":"1991","unstructured":"Davidoff AM, Humphrey PA, Iglehart JD, Marks JR: Genetic basis for p53 overexpression in human breast cancer. Proc Natl Acad Sci USA 88:5006?5010, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR20","first-page":"3804","volume":"52","author":"P Rady","year":"1992","unstructured":"Rady P, Scinicariello F, Wagner RF Jr, Tyring SK: p53 mutations in basal cell carcinomas. Cancer Res 52:3804?3806, 1992","journal-title":"Cancer Res"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.1978757","volume":"250","author":"D Malkin","year":"1990","unstructured":"Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, Friend SH: Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233?1238, 1990","journal-title":"Science"},{"key":"CR22","first-page":"136","volume":"23","author":"A-L B\u00f8rresen","year":"1992","unstructured":"B\u00f8rresen A-L, Andersen TI, Holm R, Eyfj\u00f6rd J, Friend S: TP53 germline and somatic mutation in human breast cancer [abstract]. Breast Cancer Res Treat 23:136, 1992","journal-title":"Breast Cancer Res Treat"},{"key":"CR23","first-page":"1043","volume":"7","author":"W Warren","year":"1992","unstructured":"Warren W, Eeles RA, Ponder BAJ, Easton DF, Averill D, Ponder MA, Anderson K, Evans AM, DeMars R, Love R, Dundas S, Stratton MR, Trowbridge P, Cooper CS, Peto J: No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. Oncogene 7:1043?1046, 1992","journal-title":"Oncogene"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/bjc.1991.44","volume":"63","author":"J Prosser","year":"1991","unstructured":"Prosser J, Elder PA, Condie A, MacFadyen I, Steel CM, Evans HJ: Mutations in p53 do not account for heritable breast cancer: A study in five affected families. Br J Cancer 63:181?184, 1991","journal-title":"Br J Cancer"},{"key":"CR25","first-page":"2984","volume":"52","author":"D Sidransky","year":"1992","unstructured":"Sidransky D, Tokino T, Helzlsouer K, Zehnbauer B, Rausch G, Shelton B, Prestigiacomo L, Vogelstein B, Davidson N: Inherited p53 gene mutations in breast cancer. Cancer Res 52:2984?2986, 1992","journal-title":"Cancer Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/BF00217135","volume":"89","author":"R Lidereau","year":"1992","unstructured":"Lidereau R, Soussi T: Absence of p53 germ-line mutations in bilateral breast cancer patients. Human Genetics 89:250?252, 1992","journal-title":"Human Genetics"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0092-8674(90)90113-S","volume":"62","author":"D Michalovitz","year":"1990","unstructured":"Michalovitz D, Halevy O, Oren M: Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62:671?680, 1990","journal-title":"Cell"},{"key":"CR28","first-page":"3965","volume":"52","author":"R Kikuchi-Yanoshita","year":"1992","unstructured":"Kikuchi-Yanoshita R, Konishi M, Ito S, Seki M, Tanaka K, Maeda Y, Iino H, Fukayama M, Koike M, Mori T, Sakuraba H, Fukunari H, Iwama T, Miyaki M: Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and nonfamilial adenomatous polyposis patients. Cancer Res 52:3965?3971, 1992","journal-title":"Cancer Res"},{"key":"CR29","first-page":"1393","volume":"52","author":"K Fujimoto","year":"1992","unstructured":"Fujimoto K, Yamada Y, Okajima E, Kakizoe T, Sasaki H, Sugimura T, Terada M: Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res 52:1393?1398, 1992","journal-title":"Cancer Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gcc.2870040102","volume":"4","author":"CC Fromentel de","year":"1992","unstructured":"de Fromentel CC, Soussi T: TP53 tumor suppressor gene: A model for investigating human mutagenesis. Genes Chrom Cancer 4:1?15, 1992","journal-title":"Genes Chrom Cancer"},{"key":"CR31","first-page":"945","volume":"5","author":"T Soussi","year":"1990","unstructured":"Soussi T, de Fromentel CC, May P: Structural aspects of the p53 protein in relation to gene evolution. Oncogene 5:945?952, 1990","journal-title":"Oncogene"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/0888-7543(89)90129-8","volume":"5","author":"M Orita","year":"1989","unstructured":"Orita M, Suzuki Y, Sekiya T, Hayashi K: Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874?879, 1989","journal-title":"Genomics"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/jnci\/84.14.1109","volume":"84","author":"J Isola","year":"1992","unstructured":"Isola J, Visakorpi T, Holli K, Kallioniemi O-P: Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients. J Natl Cancer Inst 84:1109?1114, 1992","journal-title":"J Natl Cancer Inst"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1349-7006.1991.tb02710.x","volume":"82","author":"K Iwaya","year":"1991","unstructured":"Iwaya K, Tsuda H, Hiraide H, Tamaki K, Tamakuma S, Fukutomi T, Mukai K, Hirohashi S: Nuclear p53 immunoreaction associated with poor prognosis of breast cancer. Jpn J Cancer Res 82:835?840, 1991","journal-title":"Jpn J Cancer Res"},{"key":"CR35","first-page":"259","volume":"110","author":"AM Davidoff","year":"1991","unstructured":"Davidoff AM, Herndon JE II, Glover NS, Kerns B-JM, Pence JC, Iglehart JD, Marks JR: Relation between p53 overexpression and established prognostic factors in breast cancer. Surgery 110:259?264, 1991","journal-title":"Surgery"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/path.1711640113","volume":"164","author":"JL Ostrowski","year":"1991","unstructured":"Ostrowski JL, Sawan A, Henry L, Wright C, Henry JA, Hennessy C, Lennard TJW, Angus B, Horne CHW: p53 expression in human breast cancer related to survival and prognostic factors: An immunohistochemical study. J Pathol 164:75?81, 1991","journal-title":"J Pathol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ijc.2910410204","volume":"41","author":"G Cattoretti","year":"1988","unstructured":"Cattoretti G, Rilke F, Andreola S, D'Amato L, Delia D: p53 expression in breast cancer. Int J Cancer 41:178?183, 1988","journal-title":"Int J Cancer"},{"key":"CR38","first-page":"6304","volume":"51","author":"MB Kastan","year":"1991","unstructured":"Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304?6311, 1991","journal-title":"Cancer Res"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","volume":"358","author":"DP Lane","year":"1992","unstructured":"Lane DP: p53, guardian of the genome. Nature 358: 15?16, 1992","journal-title":"Nature"},{"key":"CR40","first-page":"6385","volume":"51","author":"JC Law","year":"1991","unstructured":"Law JC, Strong LC, Chidambaram A, Ferrell RE: A germ line mutation in exon 5 of the p53 gene in an extended cancer family. Cancer Res 51:6385?6387, 1991","journal-title":"Cancer Res"},{"key":"CR41","first-page":"1691","volume":"6","author":"D Carbone","year":"1991","unstructured":"Carbone D, Chiba I, Mitsudomi T: Polymorphism at codon 213 within the p53 gene. Oncogene 6:1691?1692, 1991","journal-title":"Oncogene"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0378-1119(88)90196-5","volume":"70","author":"VL Buchman","year":"1988","unstructured":"Buchman VL, Chumakov PM, Ninkina NN, Samarina OP, Georgiev GP: A variation in the structure of the protein-coding region of the human p53 gene. Gene 70:245?252, 1988","journal-title":"Gene"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00683196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00683196\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00683196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T10:09:14Z","timestamp":1554458954000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00683196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993]]},"references-count":42,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1993]]}},"alternative-id":["BF00683196"],"URL":"https:\/\/doi.org\/10.1007\/bf00683196","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993]]}}}