{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:10:57Z","timestamp":1771956657302,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother. Pharmacol."],"published-print":{"date-parts":[[1993]]},"DOI":"10.1007\/bf00686151","type":"journal-article","created":{"date-parts":[[2004,11,28]],"date-time":"2004-11-28T16:05:05Z","timestamp":1101657905000},"page":"376-380","source":"Crossref","is-referenced-by-count":10,"title":["Development of a model of melphalan-induced gastrointestinal toxicity in mice"],"prefix":"10.1007","volume":"31","author":[{"given":"Sharon","family":"Castellino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertrude B.","family":"Elion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen W.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Dewhirst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Kurtzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell C.","family":"Cattley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darell D.","family":"Bigner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"3569","volume":"46","author":"SG Allan","year":"1986","unstructured":"Allan SG, Smyth JF, Hay FG, Leonard RCF, Wolf CR (1986) Protective effect of sodium-2-mercaptoethanesulfonate on the gastrointestinal toxicity and lethality ofcis-diamminedichloro platinum. Cancer Res 46: 3569","journal-title":"Cancer Res"},{"key":"CR2","first-page":"332","volume":"31","author":"JT Beck","year":"1990","unstructured":"Beck JT, Matthes S, Steenbergen C, Wormley J, Peters WP, Jones RB (1990) Mesna prevents acute lethality and tissue injury from high dose cyclophosphamide in rats. Proc Am Assoc Cancer Res 31: 332","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00005072-198107000-00005","volume":"40","author":"DE Bullard","year":"1981","unstructured":"Bullard DE, Schold SC Jr, Bigner SH, Bigner DD (1981) Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. J Neuropathol Exp Neurol 40: 410","journal-title":"J Neuropathol Exp Neurol"},{"key":"CR4","first-page":"507","volume-title":"Cancer chemotherapy handbook","year":"1980","unstructured":"Dorr RT, Fritz WL (eds) (1980) Cancer chemotherapy handbook. Elsevier, New York, p 507"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/0006-2952(86)90444-2","volume":"35","author":"DM Dulik","year":"1986","unstructured":"Dulik DM, Fenselau C, Hilton J (1986) Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione-S-transferase. Biochem Pharmacol 35: 3405","journal-title":"Biochem Pharmacol"},{"key":"CR6","first-page":"2455","volume":"50","author":"HS Friedman","year":"1990","unstructured":"Friedman HS, Colvin OM, Aisaka K, Popp J, Bossen EH, Ramer KA, Powell JB, Hilton J, Gross SS, Levi R, Bigner DD, Griffith OW (1990) Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. Cancer Res 50: 2455","journal-title":"Cancer Res"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00177417","volume":"1","author":"MB Hersh","year":"1983","unstructured":"Hersh MB, Ludden TM, Kuhn JG, Knight WA (1983) Pharmacokinetics of high dose melphalan. Invest New Drugs 1: 331","journal-title":"Invest New Drugs"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1200\/JCO.1983.1.6.359","volume":"1","author":"HM Lazarus","year":"1983","unstructured":"Lazarus HM, Hertzig RH, Graham-Pole J, Wolff SN, Phillips GL, Strandjord S, Hurd D, Forman W, Gordon EM, Coccia B, Gross S, Herzig GP (1983) Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer. J Clin Oncol 1: 359","journal-title":"J Clin Oncol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/bjc.1991.10","volume":"63","author":"FYF Lee","year":"1991","unstructured":"Lee FYF (1991) Glutathione diminishes the anti-tumor activity of 4-HC by stabilizing its spontaneous breakdown to alkylating metabolites. Br J Cancer 63: 45","journal-title":"Br J Cancer"},{"key":"CR10","first-page":"554A","volume":"5","author":"ES Levine","year":"1991","unstructured":"Levine ES, Friedman HS, Griffith OW, Colvin OM, Lieberman M (1991) Glutathione modulation affects 4-hydroperoxycyclophosphamide cardiotoxicity. FASEB J 5: 554A","journal-title":"FASEB J"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1073\/pnas.87.5.1715","volume":"87","author":"J Martensson","year":"1990","unstructured":"Martensson J, Meister A (1990) Glutathione is required for intestinal function. Proc Natl Acad Sci USA 87: 1715","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-2952(87)90392-3","volume":"36","author":"RF Ozols","year":"1987","unstructured":"Ozols RF, Louie KG, Plowman J, et al. (1987) Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochem Pharmacol 36: 147","journal-title":"Biochem Pharmacol"},{"key":"CR13","unstructured":"Schmitt LH, Fradkin R, Sullivan R, Flowers A (1965) Comparative pharmacology of alkylating agents. Cancer Chemother Rep [Suppl 2, Parts I, II, III)."},{"key":"CR14","first-page":"2764","volume":"48","author":"SK Skapek","year":"1988","unstructured":"Skapek SK, Colvin OM, Griffith OW, Elion GB, Bigner DD, Friedman HS (1988) Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. Cancer Res 48: 2764","journal-title":"Cancer Res"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-2952(82)90249-0","volume":"31","author":"K Suzukake","year":"1982","unstructured":"Suzukake K, Petro BJ, Vistica DT (1982) Reduction in glutathione content ofl-PAM-resistant L1210 cells confers drug sensitivity. Biochem Pharmacol 31: 121?124","journal-title":"Biochem Pharmacol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/1097-0142(19881001)62:7<1275::AID-CNCR2820620705>3.0.CO;2-I","volume":"62","author":"BA Teicher","year":"1988","unstructured":"Teicher BA, Crawford JM, Holden SA, Lin Y, Cathcart KNS, Luchette CA, Flatow J (1988) Glutathione monoethyl ester can selectively protect liver from high dose BCNU or cyclophosphamide. Cancer 62: 1275","journal-title":"Cancer"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00686151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00686151\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00686151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T10:10:47Z","timestamp":1554459047000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00686151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993]]}},"alternative-id":["BF00686151"],"URL":"https:\/\/doi.org\/10.1007\/bf00686151","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993]]}}}