{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T17:58:01Z","timestamp":1721671081483},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother. Pharmacol."],"published-print":{"date-parts":[[1995]]},"DOI":"10.1007\/bf00686831","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T09:30:00Z","timestamp":1101720600000},"page":"471-482","source":"Crossref","is-referenced-by-count":16,"title":["Synergistic and additive combinations of several antitumor drugs and other agents with the potent alkylating agent adozelesin"],"prefix":"10.1007","volume":"35","author":[{"given":"Kathy S.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Folz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl G.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijoy K.","family":"Bhuyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/000331978403500703","volume":"35","author":"DM Aviado","year":"1984","unstructured":"Aviado DM, Dettelbach HR (1984) Pharmacology of pentoxifylline, a hemorheologic agent used in the treatment of intermittent claudication. Angiology 35: 407","journal-title":"Angiology"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0304-3835(91)90070-X","volume":"61","author":"L Ayash","year":"1991","unstructured":"Ayash L, Korbut T, Herman TS, Teicher BA (1991) Combination of the minor groove binder U-73975 or the intercalator mitoxantrone with antitumor alkylating agents in MCF-7 or MCF-7\/CP cells. Cancer Lett 61: 7","journal-title":"Cancer Lett"},{"key":"CR3","first-page":"6010","volume":"47","author":"RJ Bergerson","year":"1987","unstructured":"Bergerson RJ, Ingeno MJ (1987) Microbial iron chelator induced cell cycle synchronization in L1210 cells: potential in combination chemotherapy. Cancer Res 47: 6010","journal-title":"Cancer Res"},{"key":"CR4","first-page":"5687","volume":"52","author":"BK Bhuyan","year":"1992","unstructured":"Bhuyan BK, Smith KS, Adams EG, Petzold GL, McGovren JP (1992) Lethality, DNA alkylation and cell cycle effects of adozelesin (U-73975) on rodent and human cells. Cancer Res 52: 5687","journal-title":"Cancer Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0021-9258(18)60316-3","volume":"237","author":"RW Bucher","year":"1962","unstructured":"Bucher RW, Sutherland EW (1962) Adenosine 3?,5?-phosphate in biological materials. J Biol Chem 237: 1244","journal-title":"J Biol Chem"},{"key":"CR6","first-page":"520","volume":"33","author":"H Burris","year":"1992","unstructured":"Burris H, Earhart R, Kuhn J, Shaffer D, Smith G, Weiss G, Kasunic D, Padbury G, Campbell L, Von Hoff D (1992) A phase I trial of adozelesin, a novel DNA sequence-specific alkylating agent. Proc Am Assoc Cancer Res 33: 520","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CR7","first-page":"119","volume":"47","author":"T-T Chang","year":"1987","unstructured":"Chang T-T, Gulati S, Chou T-C, Colvin M, Clarkson B (1987) Comparative cytotoxicity of various drug combinations for human leukemic cells and normal hematopoietic precursors. Cancer Res 47: 119","journal-title":"Cancer Res"},{"key":"CR8","first-page":"61","volume-title":"Synergism and antagonism in chemotherapy","author":"T-C Chou","year":"1991","unstructured":"Chou T-C (1991) The median effect principle and the combination index for quantitation of synergism and antagonism. In: Chou, T-C, Rideout, DC (eds) Synergism and antagonism in chemotherapy. Academic Press, New York, p 61"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","volume":"22","author":"T-C Chou","year":"1984","unstructured":"Chou T-C, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enz Regul 22: 27","journal-title":"Adv Enz Regul"},{"key":"CR10","first-page":"38","volume-title":"New avenues in developmental cancer chemotherapy","author":"T-C Chou","year":"1987","unstructured":"Chou T-C, Talalay P (1987) Application of the median effect principle for assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. In: Harrap, KR, Connors, TA (eds) New avenues in developmental cancer chemotherapy. Academic Press, New York, p 38"},{"key":"CR11","first-page":"6919","volume":"50","author":"P D'Arpa","year":"1990","unstructured":"D'Arpa P, Beardmore C, Liu LF (1990) Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 50: 6919","journal-title":"Cancer Res"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-0142(19810101)47:1<1::AID-CNCR2820470102>3.0.CO;2-2","volume":"47","author":"VT DeVita","year":"1981","unstructured":"DeVita VT (1981) The consequences of the chemotherapy of Hodgkin's disease: the 10th Annual David A. Karnofsky Lecture. Cancer 47: 1","journal-title":"Cancer"},{"key":"CR13","first-page":"6806","volume":"50","author":"BJ Dezube","year":"1990","unstructured":"Dezube BJ, Eder JP, Pardee AB (1990) Phase I trial of escalating pentoxifylline dose with constant dose of thio-TEPA. Cancer Res 50: 6806","journal-title":"Cancer Res"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0360-3016(89)90376-3","volume":"17","author":"MD Dion","year":"1989","unstructured":"Dion MD, Hussey DH, Osborne JW (1989) The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys 17: 101","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"CR15","first-page":"2463","volume":"46","author":"HJ Fingert","year":"1986","unstructured":"Fingert HJ, Chang JD, Pardee AB (1986) Cytotoxicity, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Res 46: 2463.","journal-title":"Cancer Res"},{"key":"CR16","first-page":"4375","volume":"48","author":"HJ Fingert","year":"1988","unstructured":"Fingert HJ, Pu AT, Chen Z, George PB, Alley MC, Pardee AB (1988) In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thio-TEPA. Cancer Res 48: 4375","journal-title":"Cancer Res"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1073\/pnas.82.7.2158","volume":"82","author":"E Frei","year":"1985","unstructured":"Frei E, Cucchi CA, Rosowsky A, Tantravahi R, Bernal S, Ervin TJ, Ruprecht RM, Haseltine WA (1985) Alkylating agent resistance: in vitro studies with human cell lines. Proc Natl Acad Sci USA 82: 2158","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR18","first-page":"4572","volume":"50","author":"P Frost","year":"1990","unstructured":"Frost P, Abruzzese JL, Hunt BH, Lee D, Ellis M (1990) Synergistic cytotoxicity using 2?-deoxy-5-azacytidine and cisplatin or 4-hydroperoxy-cyclophosphamide with human tumor cells. Cancer Res 50: 4572","journal-title":"Cancer Res"},{"key":"CR19","first-page":"6365","volume":"49","author":"C Holm","year":"1989","unstructured":"Holm C, Covey JM, Kerrigan D, Pommier Y (1989) Differential requirement of DNA replication for the cytoxicity of DNA topoisomerases I and II inhibitors in Chinese hamster DC3F cells. Cancer Res 49: 6365","journal-title":"Cancer Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.6494915","volume":"226","author":"LH Hurley","year":"1984","unstructured":"Hurley LH, Reynolds VL, Swenson DH, Petzold GL, Scahill TA (1984) Reaction of the antitumor antibiotics CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity. Science 226: 843","journal-title":"Science"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1021\/ja00256a041","volume":"109","author":"RC Kelly","year":"1987","unstructured":"Kelly RC, Gebhard I, Wicnienski N, Aristoff PA, Johnson PD, Martin DG (1987) Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065 and analogs. J Am Chem Soc 109: 6837","journal-title":"J Am Chem Soc"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1073\/pnas.79.9.2942","volume":"79","author":"CC Lau","year":"1982","unstructured":"Lau CC, Pardee AB (1982) Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci USA 79: 2942","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0014-5793(78)80627-9","volume":"88","author":"V Levi","year":"1978","unstructured":"Levi V, Jacobson EL, Jacobson MK (1978) Inhibition of poly(ADP-ribose)polymerase by methylated xanthines and cytokinins. FEBS Lett 88: 144","journal-title":"FEBS Lett"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00169971","volume":"5","author":"LH Li","year":"1987","unstructured":"Li LH, Wallace TL, DeKoning T, Warpehoski M, Kelly RC, Prairie MD, Krueger WC (1987) Structure and activity relationship of several CC-1065 analogs. Invest New Drugs 5: 329","journal-title":"Invest New Drugs"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00175081","volume":"9","author":"LH Li","year":"1991","unstructured":"Li LH, Kelly RC, Warpehoski MA, McGovren JP, Gebhard I, DeKoning TF (1991) Adozelesin, a selected lead among cyclopropapyrroloindole analogs of the DNA-binding antibiotic, CC-1065. Invest New Drugs 9: 137","journal-title":"Invest New Drugs"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/ijc.2910490513","volume":"49","author":"YJ Lidor","year":"1991","unstructured":"Lidor YJ, Shpall EJ, Peters WP, Bast RC (1991) Synergistic cytotoxicity of different alkylating agents for epithelial ovarian cancer. Int J Cancer 49: 704","journal-title":"Int J Cancer"},{"key":"CR27","first-page":"1817","volume":"52","author":"RB Lock","year":"1992","unstructured":"Lock RB (1992) Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation and mitotic progression of CHO cells exposed to etoposide. Cancer Res 52: 1817","journal-title":"Cancer Res"},{"key":"CR28","first-page":"285","volume":"3","author":"S Loewe","year":"1953","unstructured":"Loewe S (1953) The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3: 285","journal-title":"Arzneimittelforschung"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.7164\/antibiotics.33.902","volume":"33","author":"DG Martin","year":"1980","unstructured":"Martin DG, Chidester CG, Duchamp DJ, Mizsak SA (1980) Structure of CC-1065 (NSC 298223), a new antitumor antibiotic. J Antibiot 33: 902","journal-title":"J Antibiot"},{"key":"CR30","first-page":"6790","volume":"52","author":"EF McClay","year":"1992","unstructured":"McClay EF, Albright KD, Jones JA, Eastman A, Christen RD, Howell SB (1992) Modulation of cisplatin resistance in human malignant melanoma. Cancer Res 52: 6790","journal-title":"Cancer Res"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7164\/antibiotics.37.63","volume":"37","author":"JP McGovren","year":"1984","unstructured":"McGovren JP, Clarke GL, Pratt EA, DeKoning TF (1984) Preliminary toxicity studies with the DNA-binding antibiotic CC-1065. J antibiot 37: 63","journal-title":"J antibiot"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1016\/S0021-9258(18)53096-9","volume":"268","author":"PM O'Connor","year":"1993","unstructured":"O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW (1993) G2 delay induced by nitrogen mustard in human cells affects cyclin A\/CDK2 and cyclin B\/cdc2 kinase activities differently. J Biol Chem 268: 8298","journal-title":"J Biol Chem"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1056\/NEJM198312013092202","volume":"309","author":"GW Santos","year":"1983","unstructured":"Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H, Mellits D, Sensenbrenner LL, Stuart RK, Yeager AM (1983) Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 309: 1347","journal-title":"N Engl J Med"},{"key":"CR34","first-page":"200","volume-title":"Antibiotics and chemotherapy","author":"FM Schabel","year":"1978","unstructured":"Schabel FM, Trader MW, Laster WR, Wheeler GP, Witt MH (1978) Patterns of resistance and therapeutic synergism among alkylating agents. In: Schabel FM (ed) Antibiotics and chemotherapy. S. Karger, Basel, p 200"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0163-7258(83)90042-6","volume":"20","author":"FM Schabel","year":"1983","unstructured":"Schabel FM, Griswold DP, Corbett TH, Laster WR (1983) Increasing therapeutic response rates to anticancer drugs by applying basic principles of pharmacology. Pharmacol Ther 20: 282","journal-title":"Pharmacol Ther"},{"key":"CR36","first-page":"7537","volume":"50","author":"DR Shalinsky","year":"1990","unstructured":"Shalinsky DR, Andreef M, Howell SB (1990) Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro. Cancer Res 50: 7537","journal-title":"Cancer Res"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/tcm.1770100106","volume":"10","author":"C Shin","year":"1990","unstructured":"Shin C, Strayer JM, Wani MA, Snakpa RM (1990) Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo. Teratogenesis, Carcinog Mutagen 10: 41","journal-title":"Teratogenesis, Carcinog Mutagen"},{"key":"CR38","first-page":"440","volume":"33","author":"KS Smith","year":"1992","unstructured":"Smith KS, Folz B, Adams EG, Bhuyan BK (1992) 2-Drug combinations of the potent alkylating agent adozelesin. Proc Am Assoc Cancer Res 33: 440","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CR39","first-page":"2821","volume":"42","author":"D Swenson","year":"1982","unstructured":"Swenson D, Li AH, Hurley LH, Rokem JS, Petzold GL, Dayton BD, Wallace TL, Lin AH, Krueger WC (1982) Mechanism of interaction of CC-1065 with DNA. Cancer Res 42: 2821","journal-title":"Cancer Res"},{"key":"CR40","first-page":"4379","volume":"46","author":"BA Teicher","year":"1986","unstructured":"Teicher BA, Cuechi CA, Lee JB, Flatow JL, Rosowsky A, Frei E (1986) Alkylating agents: in vitro studies of corss-resistance patterns in human tumor cell lines. Cancer Res 46: 4379","journal-title":"Cancer Res"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00689576","volume":"25","author":"BA Teicher","year":"1989","unstructured":"Teicher BA, Holden SA, Jones SM, Eder JP, Herman TS (1989) Influence of scheduling on two-drug combinations of alkylating agents in vivo. Cancer Chemother Pharmacol 25: 161","journal-title":"Cancer Chemother Pharmacol"},{"key":"CR42","first-page":"1555","volume":"11","author":"BA Teicher","year":"1991","unstructured":"Teicher BA, Holden SA, Herman T-S, Epelbaum R, Pardee AB, Dezube B (1991) Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo. Anticancer Res 11: 1555","journal-title":"Anticancer Res"},{"key":"CR43","first-page":"1823","volume":"52","author":"Y Tsao","year":"1992","unstructured":"Tsao Y, D'Arpa P, Liu LF (1992) The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2\/cyclin B. Cancer Res 52: 1823","journal-title":"Cancer Res"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ijc.2910290114","volume":"29","author":"J Vesely","year":"1982","unstructured":"Vesely J (1982) Synergistic effect of cisplatin and 5-aza-2?-deoxycytidine on mouse leukemia cells in vivo and in vitro. Int J Cancer 29: 81","journal-title":"Int J Cancer"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1016\/S0040-4039(00)84921-7","volume":"27","author":"MA Warpehoski","year":"1986","unstructured":"Warpehoski MA (1986) Total synthesis of U-71184, a potent new antitumor agent modeled on CC-1065. Tet Lett 27: 4103","journal-title":"Tet Lett"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1021\/jm00398a017","volume":"31","author":"MA Warpehoski","year":"1988","unstructured":"Warpehoski MA, Gebhard I, Kelly RC, Krueger WC, Li LH, McGovren JP, Prairie MD, Wicnienski N, Wierenga W (1988) Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065. J Med Chem 31: 590.","journal-title":"J Med Chem"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5962\/bhl.title.7320","volume-title":"Effect of more than one inhibitor. Enzyme and metabolic inhibitors","author":"JL Webb","year":"1963","unstructured":"Webb JL (1963) Effect of more than one inhibitor. Enzyme and metabolic inhibitors. Academic Press, New York, p. 66, 488."},{"key":"CR48","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01961163","volume":"19","author":"DM Wolfrom","year":"1991","unstructured":"Wolfrom DM, Rao AR, Welsch CW (1991) Caffeine inhibits development of benign mammary gland tumors in carcinogentreated female Sprague-Dawley rats. Breast Cancer Res Treat 19: 269","journal-title":"Breast Cancer Res Treat"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00686831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00686831\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00686831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T01:25:52Z","timestamp":1705368352000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00686831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995]]}},"alternative-id":["BF00686831"],"URL":"https:\/\/doi.org\/10.1007\/bf00686831","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995]]}}}