{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T09:17:41Z","timestamp":1693127861298},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother. Pharmacol."],"published-print":{"date-parts":[[1991]]},"DOI":"10.1007\/bf00687321","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T09:10:38Z","timestamp":1101719438000},"page":"122-126","source":"Crossref","is-referenced-by-count":3,"title":["Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2?-deoxyuridine derivative"],"prefix":"10.1007","volume":"29","author":[{"given":"Setsuo","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Satake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Unemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Wataya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikoya","family":"Hayatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"205","volume":"55","author":"FJ Ansfield","year":"1971","unstructured":"Ansfield FJ, Ramirez G (1971) Phase I and II studies of 2?-deoxy-5-(trifluoromethyl)-uridine (NSC-75520). Cancer Chemother Rep 55: 205","journal-title":"Cancer Chemother Rep"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0305-7372(81)80014-X","volume":"8","author":"B Ardalan","year":"1981","unstructured":"Ardalan B, Glazer R (1981) An update on the biochemistry of 5-fluorouracil. Cancer Treat Rev 8: 157","journal-title":"Cancer Treat Rev"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/1097-0142(197208)30:2<390::AID-CNCR2820300214>3.0.CO;2-E","volume":"30","author":"NG Blokhina","year":"1972","unstructured":"Blokhina NG, Vozny EK, Garin AM (1972) Results of treatments of malignant tumors with ftorafur. Cancer 30: 390","journal-title":"Cancer"},{"key":"CR4","first-page":"335","volume":"18","author":"L Bosch","year":"1958","unstructured":"Bosch L, Harbers E, Heidelberger C (1958) Studies on fluorinated pyrimidines: V. Effects on nucleic acid metabolism in vitro. Cancer Res 18: 335","journal-title":"Cancer Res"},{"key":"CR5","first-page":"13","volume":"69","author":"GA Caballero","year":"1985","unstructured":"Caballero GA, Ausman RK, Quebbeman EJ (1985) Long-term, ambulatory, continuous infusion of 5-FU for the treatment of advanced adenocarcinomas. Cancer Treat Rep 69: 13","journal-title":"Cancer Treat Rep"},{"key":"CR6","first-page":"3694","volume":"39","author":"CK Carrico","year":"1979","unstructured":"Carrico CK, Glazer RI (1979) Effects of 5-fluorouracil on the synthesis and translation of polyadenylic acid containing RNA from regenerating rat liver. Cancer Res 39: 3694","journal-title":"Cancer Res"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0006-291X(81)80182-9","volume":"102","author":"PV Danenberg","year":"1981","unstructured":"Danenberg PV, Heidelberger C, Mulkins MA, Peterson AR (1981) Incorporation of 5-fluoro-2?-deoxyuridine into DNA of mammalian tumor cells. Biochem Biophys Res Commun 102: 654","journal-title":"Biochem Biophys Res Commun"},{"key":"CR8","first-page":"247","volume":"32","author":"DL Dexter","year":"1972","unstructured":"Dexter DL, Wolberg WH, Ansfield FJ, Helson L, Heidelberger C (1972) The clinical pharmacology of 5-trifluoromethyl-2?-deoxyuridine. Cancer Res 32: 247","journal-title":"Cancer Res"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"13299","DOI":"10.1016\/S0021-9258(17)44116-0","volume":"258","author":"BJ Dolnick","year":"1983","unstructured":"Dolnick BJ, Pink JJ (1983) 5-Fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate resistant KB cells. J Biol Chem 258: 13299","journal-title":"J Biol Chem"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1021\/ja01573a087","volume":"79","author":"R Duschinsky","year":"1957","unstructured":"Duschinsky R, Pleven E, Heidelberger C (1957) The synthesis of 5-fluoropyrimidines. J Am Chem Soc 79: 4559","journal-title":"J Am Chem Soc"},{"key":"CR11","first-page":"273","volume":"6","author":"Y Fujiwara","year":"1970","unstructured":"Fujiwara Y, Oki T, Heidelberger C (1970) Fluorinated pyrimidines: XXXVII. Effects of 5-trifluoromethyl-2?-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture. Mol Pharmacol 6: 273","journal-title":"Mol Pharmacol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/S0021-9258(19)76419-9","volume":"236","author":"KY Hartman","year":"1961","unstructured":"Hartman KY, Heidelberger C (1961) Studies on fluorinated pyrimidines: XIII. Inhibition of thymidylate synthase. J Biol Chem 236: 3006","journal-title":"J Biol Chem"},{"key":"CR13","first-page":"1979","volume":"24","author":"C Heidelberger","year":"1964","unstructured":"Heidelberger C, Anderson SW (1964) Fluorinated pyrimidines: XXI. The tumor-inhibitory activity of 5-trifluoromethyl-2?-deoxyuridine. Cancer Res 24: 1979","journal-title":"Cancer Res"},{"key":"CR14","first-page":"1226","volume":"23","author":"C Heidelberger","year":"1963","unstructured":"Heidelberger C, Ansfield FJ (1963) Experimental and clinical use of fluorinated pyrimidines in cancer chemotherapy. Cancer Res 23: 1226","journal-title":"Cancer Res"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm00331a001","volume":"7","author":"C Heidelberger","year":"1964","unstructured":"Heidelberger C, Parsons DG, Remy DC (1964) Synthesis of 5-trifluoromethyluracil and 5-trifluoromethyl-2?-deoxyuridine. J Med Chem 7: 1","journal-title":"J Med Chem"},{"key":"CR16","first-page":"590","volume":"72","author":"K Ikenaka","year":"1981","unstructured":"Ikenaka K, Fukushima M, Nakanura H, Okamoto M, Shirasaka T, Fujii S (1981) Metabolism of pyrimidine nucleotides in various tissues and tumor cells from rodents. Gann 72: 590","journal-title":"Gann"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/oxfordjournals.jbchem.a128453","volume":"60","author":"Y Imai","year":"1966","unstructured":"Imai Y, Ito A, Sato R (1966) Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem (Tokyo) 60: 417","journal-title":"J Biochem (Tokyo)"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/0006-291X(72)90892-3","volume":"48","author":"RJ Langenback","year":"1972","unstructured":"Langenback RJ, Danenberg PV, Heidelberger C (1972) Thymidylate synthase: mechanism of inhibition by 5-fluoro-2?-deoxy-uridylate. Biochem Biophys Res Commun 48: 1565","journal-title":"Biochem Biophys Res Commun"},{"key":"CR19","first-page":"3005","volume":"42","author":"PP Major","year":"1982","unstructured":"Major PP, Egan E, Herrick K, Kufe DW (1982) 5-Fluorouracil incorporation in DNA of human breast carcinoma cells. Cancer Res 42: 3005","journal-title":"Cancer Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/jm00182a029","volume":"23","author":"C Nakayama","year":"1980","unstructured":"Nakayama C, Wataya Y, Meyer RB, Santi DV (1980) Thymidine phosphorylase. Substrate specificity for 5-substituted 2?-deoxyuridines. J Med Chem 23: 962","journal-title":"J Med Chem"},{"key":"CR21","first-page":"63","volume":"19","author":"R Nayak","year":"1978","unstructured":"Nayak R, Nartin D, Stolfi R, Furth J, Spiegelman S (1978) Pyrimidine nucleosides enhance the anticancer activity of FU and augment its incorporation into nuclear RNA. Proc Am Assoc Cancer Res 19: 63","journal-title":"Proc Am Assoc Cancer Res"},{"key":"CR22","first-page":"14","volume":"1","author":"P Reyes","year":"1965","unstructured":"Reyes P, Heidelberger C (1965) Fluorinated pyrimidines: XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides. Mol Pharmacol 1: 14","journal-title":"Mol Pharmacol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1073\/pnas.69.7.1855","volume":"69","author":"DV Santi","year":"1972","unstructured":"Santi DV, McHenry CS (1972) 5-Fluoro-2?-deoxy-uridylate: covalent complex with thymidylate synthase. Proc Natl Acad Sci USA 69: 1855","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/1097-0142(197507)36:1<123::AID-CNCR2820360108>3.0.CO;2-C","volume":"36","author":"P Seifert","year":"1975","unstructured":"Seifert P, Baker HL, Reed ML (1975) Comparison of continuously infused 5-fluorouracil with bolus injection in the treatment of patients with colorectal adenocarcinoma. Cancer 36: 123","journal-title":"Cancer"},{"key":"CR25","first-page":"739","volume":"69","author":"A Shah","year":"1985","unstructured":"Shah A, MacDonald W, Goldie J, Gudauskas G, Brisebois B (1985) 5-FU infusion in advanced colorectal cancer: a comparison of three dose schedules. Cancer Treat Rep 69: 739","journal-title":"Cancer Treat Rep"},{"key":"CR26","first-page":"450","volume":"43","author":"CP Spears","year":"1982","unstructured":"Spears CP, Shahinian AH, Moran RG, Heidelberger C, Corbett TH (1982) In vivo kinetics of thymidylate synthase inhibition in 5-fluorouracil-sensitive and-resistant murine colon adenocarcinomas. Cancer Res 43: 450","journal-title":"Cancer Res"},{"key":"CR27","first-page":"4144","volume":"44","author":"CP Spears","year":"1984","unstructured":"Spears CP, Gustavsson BG, Mitchell MS, et al (1984) Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res 44: 4144","journal-title":"Cancer Res"},{"key":"CR28","first-page":"1847","volume":"44","author":"RC Swayer","year":"1984","unstructured":"Swayer RC, Stolfi RL, Martin DS, Spiegelman S (1984) Incorporation of 5-fluorouracil into murine bone marrow DNA in vivo. Cancer Res 44: 1847","journal-title":"Cancer Res"},{"key":"CR29","first-page":"2529","volume":"28","author":"M Umeda","year":"1968","unstructured":"Umeda M, Heidelberger C (1968) Comparative studies of fluorinated pyrimidines with various cell lines. Cancer Res 28: 2529","journal-title":"Cancer Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/jm00221a021","volume":"20","author":"Y Wataya","year":"1977","unstructured":"Wataya Y, Santi DV, Hansch C (1977) Inhibition ofLactobacillus casei thymidylate synthetase by 5-substituted 2?-deoxyuridylates. Preliminary quantitative structure-activity relationship. J Med Chem 20: 1469","journal-title":"J Med Chem"},{"key":"CR31","first-page":"3014","volume":"35","author":"DS Wilkinson","year":"1975","unstructured":"Wilkinson DS, Tlsty TD, Hanas RJ (1975) The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. Cancer Res 35: 3014","journal-title":"Cancer Res"},{"issue":"5","key":"CR32","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1248\/cpb.35.2090","volume":"35","author":"J Yamashita","year":"1987","unstructured":"Yamashita J, Takeda S, Matsumoto H, Terada T, Unemi N, Yasumoto M (1987) Studies on antitumor agents: VI. Sybtheses and antitumor activities of acyl derivatives of 2?-deoxy-5-trifluoromethyluridine. Chem Pharm Bull (Tokyo) 35 (5): 2090","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"6","key":"CR33","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1248\/cpb.35.2373","volume":"35","author":"J Yamashita","year":"1987","unstructured":"Yamashita J, Takeda S, Matsumoto H, Unemi N, Yasumoto M (1987) Studies on antitumor agents: VII. Antitumor activities ofO-alkoxyalkyl derivatives of 2?-deoxy-5-trifluoromethyluridine. Chem Pharm Bull (Tokyo) 35(6): 2373","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1021\/jm00121a025","volume":"32","author":"J Yamashita","year":"1989","unstructured":"Yamashita J, Takeda S, Matsumoto H, Unemi N, Yasumoto M (1989) Studies on antitumor agents: VIII. Antitumor activities ofO-alkyl derivatives of 2?-deoxy-5-(trifluoromethyl)uridine and 2?-deoxy-5-fluorouridine. J Med Chem 32: 136","journal-title":"J Med Chem"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00687321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00687321\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00687321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:34:18Z","timestamp":1625013258000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00687321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991]]}},"alternative-id":["BF00687321"],"URL":"https:\/\/doi.org\/10.1007\/bf00687321","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991]]}}}